极固宁治疗全冠牙体预备后牙本质敏感的临床效果

目的 观察极固宁脱敏剂对活髓牙金属烤瓷全冠牙体预备后牙本质敏感的疗效.方法 将153例共计201颗经金属烤瓷全冠牙体预备后的活髓牙随机分为实验组和对照组,分别使用极固宁脱敏剂处理和空白处理,然后分别测试牙体预备后第14 d的冷诊VAS值、探诊VAS值.结果 实验组的冷诊VAS值(3.35±1.67)和探诊VAS值(2.77±2.48)均小于对照组的冷诊VAS值(4.73±2.25)和探诊VAS值(3.91±2.08)(P＜0.05).结论 极固宁脱敏剂可有效降低活髓牙牙本质敏感.     

对活髓基牙采用三种方法进行护髓处理的疗效评估

【目的】评价氧化锌丁香油糊剂和极固宁TM（Green Or TM）对烤瓷冠桥活髓基牙预备后牙本质过敏症的防治效果。【方法】选取活髓基牙140颗,随机分为氧化锌丁香油糊剂＋临时冠组和极固宁TM＋临时冠组、对照组（单纯临时冠组）。分别在戴临时冠即刻和1周后,烤瓷冠桥粘固即刻对护髓效果进行检测。【结果】在戴临时冠即刻,前两组之间没有显著性差异（P〉0.05）。两实验组与对照组之间均有显著性差异（P〈0.05）。在1周后,烤瓷牙粘固后前两组之间有显著性差异（P〈0.05）。两实验组与对照组之间均有显著性差异（P〈0.05）。【结论】3种方法比较,极固宁TM＋临时冠脱敏效果最好,无论在戴临时冠后还是烤瓷冠桥粘固后护髓效果都令人满意。     

金属烤瓷联合全冠的牙体预备对牙髓组织影响的临床观察

为了探讨金属烤瓷联合全冠在牙体预备后与牙髓炎的关系，我们对３０例１０８颗活髓牙按常规方法进行了牙体预备和修复体制作。经２年的临床追踪观察。结果发现无一例有牙髓感染、牙本质过敏症状者。因此认为在操作时应注意适应证的选择，牙本质的切割量，切割时产生的温度及预备体保护，则可减少或避免对牙髓组织的损伤。同时发现用直接法和间接法完成的暂时冠桥粘固在预备体上，对牙髓组织的影响无明显差异。     

金属烤瓷修复对活髓牙牙髓组织的影响分析

目的:探讨金属烤瓷修复对活髓牙牙髓组织的影响。方法:以近年来行金属烤瓷固定修复的58例患者为研究对象,对全部患者行活髓基牙金属烤瓷固定桥修复,随访观察修复后活髓牙牙髓组织病变情况。结果:共发生牙髓组织病变19例,占总基牙的20.7%(19/92);牙髓组织病变类型主要为慢性牙髓炎、急性牙髓炎和慢性尖周炎等症状。结论:金属烤瓷修复可能于1年内引起慢性牙髓炎、急性牙髓炎和慢性尖周炎等活髓牙牙髓组织病变,主要与基牙、修复体和牙体预备等原因相关。     

Gluma脱敏剂治疗活髓基牙预备后牙本质过敏的临床观察

临床上进行烤瓷附熔金属全冠及其固定桥修复,活髓基牙牙体预备后,往往可产生牙本质过敏症状。我们使用Gluma脱敏剂并与传统的氟化钠甘油脱敏剂做对比,进行临床疗效对比观察,现报告如下。1 临床资料1.1 临床病例选择和分组 选择门诊患者中做烤瓷附熔金属全冠和固定桥修复的患者76例,共180颗活髓牙,牙体预备后均有牙本质过敏症状。其中男性36例,82颗;:女性40例,98颗。上述患者随机分为实验组36例,90颗;对照组38     

活髓牙烤瓷修复中临时冠对基牙牙髓的保护作用

烤瓷熔附金属（porteain-fused-to-matal，PFM）全冠也称金属烤瓷全冠，是一种较为理想的修复体。凼基兼有金属全冠的强度和瓷全冠的美观而倍受医生和忠者的青睐。已成为应用最为广泛的固定修复体。尤其在前牙美容修复加氟斑、变色牙、釉质发育不全等的治疗中，金属烤瓷全冠更发挥出无可替代的作用，修复科临床上应用日渐增多。因为金属烤瓷全冠基牙牙体切削量大，深度可达牙本质深层，甚至接近牙髓，所以不可避免地遇到牙髓保护问题，限制了金属烤瓷全冠的应用。有些医生甚至主张活髓牙一律去髓后才能作金属烤瓷全冠。     

半导体激光治疗活髓牙全冠牙体预备后牙本质敏感的临床观察

目的研究半导体激光治疗全冠牙体预备后牙本质敏感的临床效果。方法将60例患者共计99颗活髓牙经标准金属烤瓷全冠牙体预备后随机分为三组,其中激光组预备体采用半导体激光分区照射180s;脱敏剂组预备体使用MS-COAT脱敏剂脱敏2次;对照组不处理;然后均用间接法制作临时冠,氧化锌丁香油水门汀粘固。最后分别测试牙体预备后10天的冷诊NRS值、电刺激痛感觉阈值。结果激光组的冷诊NRS值（3.76±1.65）和电刺激痛感觉阈值（16.43±3.44）和脱敏剂组的冷诊NRS值（3.83±1.73）和电刺激痛感觉阈值（17.21±4.12）均小于对照组的冷诊NRS值（5.48±1.80）和电刺激痛感觉阈值（13.56±3.26）,差异均有显著性（P〈0.05）,而激光组和脱敏剂组无统计学差异（P〉0.05）。结论半导体激光能有效的治疗金属烤瓷全冠牙体预备后的牙本质敏感。     

烤瓷修复牙体预备对牙髓的影响及处理

目的了解烤瓷修复牙体预备对牙髓的影响。方法回顾200颗基牙的牙体预备、脱敏、盖髓、安抚情况。结果烤瓷冠内基牙是活髓的牙齿,临床远期疗效大于死髓牙。结论烤瓷修复时基牙是活髓的牙,应尽最大可能保留活髓。     

GLUMA脱敏剂在金属烤瓷冠修复中的应用

目的旨在观察金属烤瓷冠桥修复中活髓牙牙体预备后即刻用GLUMA脱敏剂行脱敏治疗，在烤瓷冠桥固定后牙本质过敏症的发生率。方法526颗活髓基牙在行牙体预备后分为两组，实验组273颗牙牙体预备后即刻用GLUMA行脱敏治疗，对照组253颗牙牙体预备后不作任何处理，待烤瓷冠桥固定后观察两组近远期牙本质过敏症的发生率。结果实验组近远期牙本质过敏症的发生率明显低于对照组。结论在金属烤瓷冠桥修复中，使用GLUMA脱敏剂行活髓牙牙体脱敏可明显降低修复后牙本质过敏症的发生率，值得临床推广使用。     

Gluma脱敏剂对活髓牙牙体预备后的脱敏效果

临床上采用烤瓷固定桥修复牙列缺损时,活髓基牙需行牙体预备,切割及高温均会对牙体及牙髓组织产生损伤,使基牙酸痛不适,遇冷热敏感,影响修复效果。我科自2007年8月-2009年1月应用Gluma脱敏剂对牙体预备后的活髓牙进行脱敏,以消除活髓基牙的酸痛不适感,使烤瓷桥的修复效果更加理想。现报告如下。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.