连续脑电监测对大脑中动脉供血区脑梗死患者预后评估价值

目的：探讨连续脑电监测对大脑中动脉供血区脑梗死患者预后判断的准确性。方法40例大脑中动脉供血区脑梗死患者根据病情进展与否分为恶性组（14例）和良性组（26例），入院24 h内进行连续床旁脑电监测，分析脑电图变化与恶性程度的相关性。结果恶性组患者连续床旁脑电图（ CEEG ）异常检出率为85．71％（12／14），与良性组[65．38％（17／26）]差异有统计学意义（χ2＝10．405，P＝0．001）。恶性组脑电图呈重度异常者4例，入院第2天昏迷，中度异常者6例，轻度异常者2例，正常者2例。结论早期连续脑电监测对大脑中动脉供血区脑梗死患者的预后评估具有一定参考价值。     

连续脑电监测（CEEG）对意识障碍患者脑功能判断和预后的研究

目的探讨连续脑电图监测（CEEG）对神经科重症监护病房（NICN）中有意识障碍患者脑功能损伤评价和预后判断的应用价值。方法选择NICN中有意识障碍患者96例,应用床边中央神经监护系统记录连续脑电图,并按Young氏分级标准确定患者的EEG分级,随访患者2个月的预后,将连续脑电图分级与预后进行相关分析。结果脑电图Ⅰ和Ⅱ级者预后不良率26.9%,脑电图Ⅲ-Ⅵ级预后不良率达79.3%,EEG分级越高,死亡率越高,康复率越低,预后越差。结论连续脑电图监测和分级判断可以准确、客观地评价和预测神经科重症监护病房（NICN）中有意识障碍患者脑功能损伤的预后。     

动态脑电图对昏迷患者预后的评估价值

目的 探讨动态脑电图监测对昏迷患者预后的评估价值.方法 用动态脑电图描记66例昏迷患者并进行临床评定,包括Glasgow评分.结果 脑电图分级与Glasgow评分说明脑电图分级愈高,Glasgow评分愈低,患者昏迷程度愈深.结论 动态脑电图检测对昏迷患者预后的评估有肯定价值,可提高在昏迷预后判断中的准确性和可靠性.     

用心脑电监护仪对脑卒中患者进行预后分析

目的：探讨急性脑卒中的心脑电监护结果和预后的关系。方法：将心电图、双导脑电图的床边动态监护仪与微机联网,对41例急性脑卒中患者的心脑电图进行监护。（此仪器曾获省科技进步二等奖）。结果：心肌呈缺血型改变15例占36．6％,心律失常者9例占22％,脑电图轻度异常16例占39％,中重度异常者25例占53．7％,心脑电图同时异常者22例占53．7％。心电监护结果异常者与正常者预后有显著差异（P＜0．001）,脑电监护显示中重度异常的患者,与轻度异常者预后有显著差异（P＜0．001）。结论：心脑电监护对急性脑卒中预后的判定有极较大价值。     

动态脑电图、脑干听觉及体感诱发电位在评估蛛网膜下腔出血昏迷患者预后的应用分析

目的分析动态脑电图（EEG）、脑干听觉诱发电位（BAEP）、体感诱发电位（SEP）联合应用在判断蛛网膜下腔出血（SAH）昏迷患者预后中的应用。方法选取本院2011年1月~2013年12月收治的50例SAH昏迷患者,以上患者均为发病后1~2 d、1周及1个月后分别检测EEG、BAEP、SEP。结果 EEG结果分为Ⅰ~Ⅴ级,预后不良率分别为28.6%、36.4%、53.8%、66.7%、85.7%。BAEP结果分Ⅰ~Ⅳ级,预后不良率分别为14.3%、28.6%、60.0%、100.0%。SEP结果分Ⅰ~Ⅲ级,预后不良率分别为16.7%、35.3%、100.0%。结论 EEG、BAEP、SEP的异常程度越高,SAH昏迷患者预后越差。EEG、BAEP、SEP联合应用对SAH昏迷患者的预后评价有确定的价值,值得临床推广与应用。     

动态脑电图对皮质或脑干病变昏迷患者预后的评估效果

目的：探讨动态脑电图对皮质或脑干病变昏迷患者预后的评估效果。方法41例皮质或脑干病变昏迷患者均于发病后24h 给予动态脑电图检查,记录患者脑电图分级及预后结果。结果脑电图分级为Ⅰ级、Ⅱ级患者 Glasgow 评分比较无显著差异（P ﹥0.05）,Ⅲ级、Ⅳ级、Ⅴ级患者 Glasgow 评分呈显著下降趋势（P ﹤0.05）;脑电图分级及 Glasgow 评分预测生存准确率对比无显著差异（ P ﹥0.05）;脑电图分级预测死亡准确率高达94.38％,显著高于Glasgow 评分预测死亡准确率80.14％,差异有统计学意义（P ﹤0.05）。结论动态脑电图可准确评估皮质或脑干病变昏迷患者预后,为临床医师诊断及治疗提供可靠依据,提高患者疗效及降低社会负担。     

30例重度颅脑损伤病人脑电监测结果分析

目的研究重度颅脑损伤病人脑电监测结果与预后的关系.方法应用脑电监测仪对30例重度颅脑损伤病人进行动态连续监测,并对不同程度脑电图异常波形进行分级,分析不同分级脑电图结果与预后的关系.结果完全或基本恢复的11例重度颅脑损伤病人首次脑电描记结果均为Ⅰ～Ⅱ级,而首次脑电描记结果Ⅳ～Ⅴ级的7例重度颅脑损伤病人最终均死亡.结论重度颅脑损伤病人脑功能最终恢复结果与脑电图变化的严重程度有关.在治疗过程中,脑电监测结果分级逐渐升高者预后转差.     

急性毒鼠强中毒15例临床及脑电图分析

目的：探讨急性毒鼠强中毒患者脑电图动态变化与临床表现之间的关系,以指导治疗、判断预后。方法：对15例急性毒鼠强中毒患者进行常规的脑电图检查,并对结果异常者进行定期复查,动态观察患者脑电图的变化与临床症状之间的关系。结果：15例患者中,重度中毒患者10例,其脑电图均有异常改变,表现为重度异常者6例,中度异常者4例;中度中毒患者4例,其中脑电图重度异常1例,中度异常3例;轻度中毒患者1例,脑电图表现为轻度异常。结论：毒鼠强中毒患者脑电图异常程度与患者的临床症状相平行。中毒越严重,临床症状越明显,脑电图的异常程度也就越高。随着临床症状的好转,脑电图也恢复正常。因此,脑电图检查对判断毒鼠强中毒患者脑功能的损害状况、指导治疗、评价患者病情的变化及预后的判断具有重要的参考价值。     

连续床边脑电图监测对昏迷患儿预后的评估价值

目的探讨连续脑电图监测对昏迷患儿预后的评估价值。方法采用脑功能监护仪对60例昏迷患儿进行床边脑电图监测（CEEG）,Glasgow评分评估昏迷状况,分析CEEG／Glasgow评分与预后的相关性。结果28例（46．7％）II级脑电图患儿全部预后良好转归;10例（16．7％）III级患几预后良好转归2例,不良转归8例,无死亡;17例脑电图Ⅳ级患儿（28.3％）预后不良转归2例,死亡15例;5例（8．3％）脑电图V级患儿死亡5例。脑电图与预后的Spearman等级相关系数为0．953,P〈0．001;脑电图分级越高,Glasgow评分越低,并且Glasgow评分与预后相关,Spearman系数为0．84,P〈0．001。结论连续床边脑电图检测可实时反映脑功能的状态,对昏迷患儿预后的评估有指导价值。     

40例腔隙性脑梗死脑电图与脑电地形图分析

目的通过观察40例腔隙性脑梗死患者脑电图及脑电地形图表现,分析其脑波规律。方法采用NT9200数字脑电图分析系统采集数据。结果40例腔隙性脑梗死EEG阳性率75％,BEAM阳性率70％,从而表明脑电图及脑电地形图可以反映出缺血性病变早期脑功能变化。结论脑电图与脑电地形图在u患者的诊断、治疗与预后判断中,有其独特作用。     

临床很可能诊断的Creutzfeldt-Jakob病分析

目的探讨Creutzfeldt-Jakob病(CJD)的临床和脑电图演变特征。方法分析4例CJD临床、脑电图、MRI、CSF资料。结果 4例CJD患者的脑电图特点如下:弥漫性低波幅慢波背景上,间断出现或不对称或在某一局部突出的双相或三相性慢波,逐渐变为双侧广泛同步的周期性三相波,随着病情进展,逐渐变得明显而持续,最终成为持续的电静息。EEG早期异常不典型,需反复检测,方可见周期性三相复合波。结论充分认识CJD的临床和脑电图演变特点,CJD的EEG演变过程与临床病情变化具有一致性。     

65例散发性脑炎患者脑电图分析

目的：探讨不同类型散发性脑炎患者的脑电图表现及其对“散脑”患者早期诊断、鉴别诊断、疗效评定及预后方面的作用。方法：回顾性分型分析本院65例散发性脑炎患者的临床及脑电图资料。结果：65例患者中脑电图异常60例（92.3%）,意识障碍型19例（29.2%）,精神异常型17例（26.2%）,癫痫型12例（18.5%）,脑瘤型11例（16.9%）,脑干脑炎型6例（9.2%）。其中意识障碍型脑电图多为中、重度异常,预后差;精神异常型脑电图多为中、轻度异常,预后较好,但易复发;癫痫型脑电图伴有癫痫波发放,多为中、轻度异常,预后较好;脑瘤型脑电图伴有局灶性δ波,多为中、轻度异常,预后较好;脑干脑炎型脑电图多为轻度或正常脑电图,但病情重,预后差。结论：脑电图的分型分析对散发性脑炎的早期诊断、鉴别诊断、疗效评定及预后起着很重要的作用。     

127例酒依赖住院患者脑电图分析

目的：对127例酒依赖住院患者进行脑电图分析。方法：采用南京伟思科技公司生产的VEEG1160A型脑电图仪。按国际10／20系统电极放置法和特殊电极放置，并加用剥夺睡眠诱发实验及反复多次检查。结果：脑电图异常46次／人，异常率为36．2％。脑电图主要表现为慢波化，并以θ及δ波活动占优势，以顶、枕区较明显，额、中央区出现较多不规则β波，以20～21Hz为主。结论：酒精对脑细胞有直接毒性作用，EEG作为研究脑功能的重要手段，是脑细胞功能的最直接反映。     

Effect of barbiturate anesthesia on Discharge patterns in nucleus reticularis thalami

In unanesthetized preparations spontaneous EEG spindles are accompanied by a tonic increase in neuronal firing in the rostral pole of nucleus reticularis thalami. The effect of Brevital on this relationship was investigated in encephàle isolé cats in the present report. Small doses of the drug consistently decreased the firing frequency inbetween the appearance of cortical spindles, whereas the effect on the intraspindle discharge rate as well as the averaged overall firing frequency varied from cell to cell. The ratio of intra- vs. interspindle discharge frequency was enhanced during light and moderate anesthesia, and the tonic spindle-related firing was broken up into bursts which were in phase with individual EEG waves. An increase in dosage to a level producing persistent slow waves in the EEG was followed by continuous irregular reticularis firing with no apparent relationship to the slow EEG waves. Massive doses of Brevital resulting in a flat cortical EEG arrested spontaneous firing completely. The results are viewed as supporting the hypothesis that neurons in the rostral part of nucleus reticularis exert a tonic inhibitory influence on dorsal thalamic cells.     

脑卒中患者脑电图与癫痫发作的相关性研究

目的探讨脑卒中患者脑电图EEG和癫痫发作的相关性研究。方法对73例脑卒中后继发癫痫的患者进行EEG监测,癫痫发作时监测皮层EEG,记录异常放电情况。结果经过EEG监测,73例患者EEG的频率均减慢到7-8 Hz,均出现异常放电情况,且多为α波变慢,波率不规则及背景活动不对称,弥散性或局限性及一侧性出现低中等波幅;慢波增多及单侧的痫样放电,多为中度以上异常。最后总结为局限性异常16例,重度异常13例,中度异常36例,轻度异常8例。结论 EEG监测与癫痫的发作具有较高的相关性,所以EEG作为研究脑功能的医学手段,对预测癫痫的发作有着重要价值。     

Effect of a new eburnamenine derivative (RU 24722) on EEG recovery in the conscious gerbil after cerebral ischemia

The efficacy of a new eburnamenine derivative (RU 24722) on cerebral insufficiency was studied by evaluation of postischemic EEG recovery in the conscious gerbil. Ischemias of different durations were obtained by clamping both common carotids. This method required only brief anesthesia, thereby permitting the recording of EEG recovery in unanesthetized and unrestrained animals during the 24 hr following arterial occlusion. The EEG was analyzed by the Fast Fourier Transform. Mortality rate and clinical status were also evaluated. After a 5-min ischemia the initial return of EEG was characterized by very high amplitude slow waves (1–2 Hz) and the EEG became normal 24 hr after ischemia. No mortality was observed. After a 10-min ischemia the early recovery phase was characterized by a decrease in the power spectrum and a rebound of slow frequency waves after 2–4 hr. After 24 hr the EEG was not yet completely normal and 1 animal out of 10 died. A 15-min ischemia killed 50% of the animals, and the EEGs of the survivors were abnormal even after 24 hr. Treatment with RU 24722 (10 mg/kg/s.c.) significantly improved the electrocortical recovery of gerbils submitted to a 10-min ischemia. In this group the EEG was normalized 6 hr after ischemia in the same way as in the controls submitted to a 5-min ischemia. These findings suggest that RU 24722 may have a therapeutic effect in cerebral insufficiency.     

Electroencephalographic study with buspirone, a novel nonbenzodiazepine anxiolytic, and its major metabolite, 1-(2-pyrimidinyl)piperazine (1-PP), in rabbits

The electroencephalographic (EEG) effects of buspirone and its major metabolite, 1-(2-pyrimidinyl)piperazine (1-PP), were investigated in rabbits with chronic electrode implants, and the effects were compared with those of diazepam. Intravenous administration of buspirone at 0.1 to 1.0 mg/kg evoked an increase in the arousal EEG pattern period (low amplitude fast waves) in the cortical EEG and synchronization of the hippocampal theta waves with decreased voltages, whereas both 1-PP (0.5 to 2.0 mg/kg, i.v.) and diazepam (1.0 and 2.0 mg/kg) evoked an increase in the drowsy EEG pattern periods: high voltage slow waves and spindle bursts in the cortical EEG and desynchronization of the hippocampal theta waves. Buspirone at higher doses caused behavioral excitation in rabbits, whereas both 1-PP and diazepam produced sedation. Buspirone did not affect EEG arousal responses to both auditory stimulation (2,000 Hz, monotone) and electrical stimulation (100 Hz, 0.1 msec, 3-6 V) of the midbrain reticular formation or the posterior hypothalamus. However, 1-PP tended to inhibit the EEG arousal response to auditory stimulation but not brain stimulation, and diazepam markedly suppressed the responses induced by both stimulations. The recruiting response induced by centromedian thalamic stimulation at a low frequency (7 Hz, 0.1 msec, 4-8 V) was not affected by buspirone, 1-PP and diazepam. Neither buspirone nor 1-PP had an effect on the photic driving response to a flash light (2 Hz) in the occipital cortex of the rabbit, whereas the response was suppressed by diazepam. Both buspirone and 1-PP enhanced the duration of after discharges induced by electrical stimulation (50 Hz, 0.5 msec, 4-15 V) of the dorsal hippocampus, whereas diazepam markedly inhibited the afterdischarges. These results suggest that the EEG effect of buspirone is quite different to those of 1-PP and diazepam in qualitative aspects. It is also suggested that buspirone, unlike diazepam, is an effective anxiolytic drug without a sedative effect.     

动态脑电图对脑梗死后继发性癫痫的价值分析

目的探讨脑梗死后继发性癫痫动态脑电图(AEEG)变化、神经功能的缺损情况及临床疗效与预后。方法将76例脑梗死后继发性癫痫患者设为研究组,回顾其AEEG资料,并与对照组76例脑梗死无癫痫发作患者进行比较分析。结果研究组患者AEEG异常率占93.42%,发生在脑叶皮质区的患者继发癫痫的概率高于发生在深部白质区的患者,且研究组临床神经功能恢复较对照组延迟。结论 AEEG对预测癫痫发作、病情变化、预后有着重要的价值。