过去30年间关于短肠综合征研究的全球趋势文献计量分析

背景与目的：短肠综合征是一类因广泛小肠切除而引起的罕见疾病,近年来逐渐引起学者关注。然而目前却暂无该病文献计量学方面的相关研究。因此,本研究通过文献计量分析这一方法描述近30年来短肠综合征研究的热点和趋势。方法：通过Web of Science核心合集（WoSCC）数据库检索1991—2021年间与短肠综合征相关的出版文献,并以纯文本格式导入VOSviewer和CiteSpace软件。数据使用文献计量方法进行处理,对作者、国家、机构、高被引文献、共被引、关键词和参考文献进行文献可视化分析。结果：共检索到3 439篇文献,包括12 457位作者,2 557家机构,74个国家/地区和779种期刊,文献共引用了来自8 713种期刊合计43 194位作者的64 834篇文章。其中,美国的贡献最为卓越,Wales PW是产出最多的作者,多伦多大学是发文最多的机构,Journal of Pediatric Surgery是该领域的核心期刊。关键词分析显示,Short Bowel Syndrome、Intestinal Failure、Children、Parenteral Nutrition是高频...     

Knowledge mapping and research trends of stem cell in wound healing: A bibliometric analysis

Wound nonhealing is a common and difficult problem in clinic. Stem cells are pluripotent cells, and their undifferentiated and self-replicating characteristics have attracted much attention in the regenerative medicine-related researches. New treatment approaches might result from an understanding of the function of stem cells in wound healing. Using bibliometric techniques, this study proposed to analyse the research status, hotspots, and research trends in stem cell and wound healing. By using the Web of Science Core Collection (WoSCC), we conducted an in-depth review of publications on stem cells in wound healing from 1999 to 2023. We used scientometric analysis methods to examine annual trends, institutions, countries, journals, authors, keywords, co-occurrence references and their closed relationship, revealing present hotspots and potential future advancements in this field. We analysed 19 728 English studies and discovered a consistent rise in annual publications. The United States and China were the two countries with the most publications. The most three influential institutions in the field were Shanghai Jiao Tong University, Sun Yat-sen University, and University of Pittsburgh. International Journal of Molecular Sciences and Biomaterials were considered the most influential journals in this field. International Journal of Molecular Sciences had the most publications, and the most quantity of citations and the highest H-index were found in Biomaterials. The dual-map overlay revealed that publications in Molecular/Biology/Genetics and Health/Nursing/Medicine co-cited journals received the majority of the citations for studies from Molecular/Biology/Immunology and Medicine/Medical/Clinical. In terms of publication production and influence, Fu X stood out among the authors, and Pittenger MF took the top spot in co-citations. According to the keywords from the analysis, future research should concentrate on the mechanisms through which stem cells promote wound healing. We conducted a thorough analysis of the general information, knowledge base and research hotspots in the field of stem cells and wound healing from 1999 to 2023 by using the VOSviewer, CiteSpace, and other bibliometric analysis tools. It not only provided valuable insights for scholars, but also served as a reliable reference that drives further development in the field and stimulates the interest of researchers.     

全球1999—2021年间关于胰岛素瘤的文献计量分析

背景与目的：胰岛素瘤是胰腺最常见的功能性内分泌肿瘤。然而很少有关于胰岛素瘤的文献计量学研究。因此本研究将通过文献计量分析这一方法描述近20年来胰岛素瘤领域研究的热点和趋势。方法：通过Web of Science核心数据库（WoSCC）检索1999—2021年间与胰岛素瘤相关的出版文献，并以纯文本格式导入VOSviewer和CiteSpace软件。数据使用文献计量方法进行处理，对作者、国家、机构、高被引文献、共被引、关键词和参考文献进行文献可视化分析。结果：共检索到3 863篇文献，包括19 310位作者，3 268个组织，83个国家/地区和1 005种期刊，文献共引用了来自7 494种期刊合计55 619位作者的85 078篇文章。其中，相关研究主要在美国进行，Lernmark A是最高产的作者，华盛顿大学是最主要的贡献机构，Journal of Biological Chemistry是胰岛素瘤领域发文的主要期刊。关键词分析显示，目前重点主要集中在“Pancreatic Neuroendocrine Tumor”“ENTS Consensus Guideline”“Marker”“M...     

基于CiteSpace的机器人结直肠手术临床应用现状与热点可视化分析

背景与目的：结直肠癌是一种临床上常见的恶性肿瘤,其手术治疗是近年来外科领域的研究热点之一。近年来,越来越多的学者开始关注机器人手术在结直肠外科领域的应用和研究。本研究通过利用CiteSpace软件对近年来机器人结直肠手术研究文献进行可视化分析,探讨世界范围内机器人手术在结直肠手术的发展历程与诊治方法的演进过程,分析其研究热点和发展趋势,了解当前热点并确定潜在的新研究方向,为后续的研究提供新的线索和思路。方法：检索1999年1月1日—2023年9月30日之间Web of Sciences核心合集（WoSCC）数据库与在中国知网（CNKI）数据库中机器人结直肠手术的相关中英文文献,采用CiteSpace 5.8.R3软件分析该领域文献的发文国家（地区）、高产机构、作者及合作关系等,对关键词进行聚类、突现、时线图和时区图分析,绘制可视化的知识图谱。结果：共纳入3 135篇文献,其中WoSCC数据库2 760篇、CNKI数据库375篇。分析结果显示,该领域发文量逐年增多,尤其在2011年之后上升幅度增大,2021年达到最高峰。目前,发文量居前列的分别是美国（758篇）、意大利（253篇）、中国...     

Research relating to three-dimensional (3D) printing in spine surgery: a bibliometric analysis

Purpose

Although numerous publications on three-dimensional printing (3DP) in spine surgery have been published, bibliometric analysis studies are scarce. Thus, this study aimed to present a bibliometric analysis of the status, hot spots, and frontiers of 3DP in spine surgery and associated research disciplines.

Methods

All publications relating to the utilization of 3DP in spine surgery from 1999 to May 9, 2022, were retrieved from the Web of Science. The bibliometric analysis was performed using CiteSpace software, and information on the country, institution, author, journal, and keywords for each publication was collected.

Results

A total of 270 articles were identified. From 2016 onward, a significant increase in publications on spinal surgery was observed. China was the most productive and influential country (98 publications) and H-index (22), followed by the USA and Australia. The most productive institution was Capital Medical University (9 publications). P. S. D’urso (8 publications, 46 citations) and R. J. Mobbs (8 publications, 39 citations) were the most prolific authors. European Spine Journal contributed the highest number of publications. The eight main clusters were: “rapid prototyping” #0, “3D printed” #1, “spine fusion” #2, “scoliosis” #3, “spine surgery” #4, “patient-specific” #5, “nervous system” #6, and “neuronavigation” #7. The strongest keyword bursts in 3DP in spine surgery were “fixation,” “drill template,” “instrumentation,” “fusion,” “complication,” and “atlantoaxial instability.”

Conclusion

This analysis provides information on research trends and frontiers in the application of 3DP in spine surgery, as well as research and collaboration partners, institutions, and countries.

     

The association between compensation and chronic disabling back pain

BackgroundLow back pain (LBP) is a common and major health problem. Although it is known that psychosocial factors are important predictors of LBP outcome, some factors, including financial compensation, have not been fully studied in Japan. This cross-sectional study aimed to examine the association between LBP compensation (workers’ compensation and automobile insurance claims) and lifetime experience of chronic LBP and back pain disability (chronic disabling LBP) in a Japanese adult population.MethodsIn February 2011, 1,063,083 adults aged 20–79 years registered as Internet research volunteers were invited to complete an online questionnaire. We analyzed the data from 52,650 respondents who had ever experienced LBP. Multiple logistic regression analysis was used to examine the association between LBP compensation and lifetime experience of chronic disabling LBP, adjusting for age, sex, smoking habits, educational level, cause of LBP, history of radiating pain below the knee, and history of low back surgery.ResultsAmong the respondents, 2,039 (3.9 %) had experienced chronic disabling LBP. The prevalence of a history of receiving workers’ compensation or automobile insurance claims was 1.1 % for each. In multiple logistic regression, the odds of chronic disabling LBP were significantly higher among those who received LBP-related compensation (workers’ compensation or automobile insurance claims) compared with respondents who did not receive compensation.ConclusionsThe prevalence of compensated LBP was low. However, a history of compensated LBP was significantly associated with experiencing chronic disabling LBP.     

Spine loading in patients with low back pain during asymmetric lifting exertions

Background contextRecurrent low back pain (LBP) is a common and costly problem that might be related to increased spine loads in those with LBP. However, we know little about how the spine is loaded when those with LBP perform lifting exertions.PurposeDocument spine loading patterns of patients with LBP performing symmetric and asymmetric lifting exertions compared with asymptomatic individuals performing the same tasks.Study designSpine loadings during lifting exertions that varied in asymmetric origin as well as horizontal and vertical distance from the spine were compared between asymptomatic subjects and patients with LBP.MethodsSixty-two patients with LBP and 61 asymptomatic individuals performed a variety of lifting exertions that varied in lift origin horizontal and vertical position (region), lift asymmetry position and weight lifted. An electromyography-assisted model was used to evaluate spine loading in each subject during the lifting exertions. Differences in spine loading between the LBP and asymptomatic subjects were noted as a function of the experimental variables.ResultsPatients with LBP experienced greater spine compression and shear forces when performing lifting tasks compared with asymptomatic individuals. The least taxing conditions resulted in some of the greatest differences between LBP and asymptomatic individuals.ConclusionsGreater levels of antagonistic muscle coactivation resulted in increases in spine loading for patients with LBP. Specific lifting conditions that tend to exacerbate loading can be identified by means of physical workplace requirements. These findings may impact acceptable return-to-work conditions for those with LBP.     

胰腺癌免疫治疗研究热点的文献计量学可视化分析

背景与目的 胰腺癌是恶性程度较高的消化系统肿瘤之一，因其起病隐匿，早期常无典型症状，且肿瘤的侵袭性较强，故预后较差。随着对胰腺癌分子发病机制的深入研究，免疫治疗已成为胰腺癌治疗的新焦点。文献计量学是一种分析某一领域文献、直观地总结文献的趋势并预测研究热点的常用方法。本文旨在通过文献计量和知识图谱可视化分析胰腺癌免疫治疗的研究现状、热点和趋势，为后续的研究提供方向。方法 从Web of Science核心合集中提取相关出版物从开始到2022年5月发表的有关胰腺癌免疫治疗的文献，使用CtieSpace和VOSviewer等软件对该领域文献的国家、机构、作者、参考文献和关键词进行文献计量可视化分析。结果 共纳入2009—2022年发表与胰腺癌免疫治疗相关的英文文献2 230篇，自2016年文献数量每年都在稳定增长。这些文献的7 365位作者来自75个国家/地区的884个机构，共有7 943篇共被引参考文献。发文量最多的国家为美国（n=964），其次是中国（n=552）；发文量最多的机构为美国约翰霍普金斯大学（n=67）和德克萨斯大学MD安德森癌症中心（n=65）；发文量最多的作者为美国约翰霍普金斯大学的Elizabeth M Jaffee（n=41）和Lei Zheng（n=31）。共被引次数最多的文献为“Genomic analyses identify molecular subtypes of pancreatic cancer”（n=161），共被引参考文献时间线图显示，聚类“肿瘤微环境”是从2016年开始一直持续到现在的热点。关键词的突发检测揭示了胰腺癌免疫治疗领域的发展，最初的热点主要是“疫苗”，而近年来重点转移到“伊匹单抗”“检查点阻断”“上皮间质转化”“星状细胞”“巨噬细胞”“错配修复缺陷”和“肿瘤微环境”等。结论 与胰腺癌免疫治疗的相关研究呈持续上升趋势，是胰腺癌治疗的重要研究方向，目前美国在这一研究领域尚处于绝对领先地位。相关研究表明独特的肿瘤微环境可能是胰腺癌恶性程度较高且对放化疗不敏感的主要原因，深入研究胰腺癌肿瘤微环境（TME）的致病机理是目前研究的重点。除此之外，聚焦于“上皮间质转化”和“免疫检查点抑制”等的研究较为普遍，现有的研究表明单一的治疗手段对胰腺癌的治疗效果有限，免疫联合疗法或化疗联合免疫疗法可以进一步提高胰腺癌的临床疗效，是未来临床研究的趋势。     

Sex life and sexual function in men and women before and after total disc replacement compared with posterior lumbar fusion

Background contextSex life and sexual function may be affected by low back pain (LBP). Sexual dysfunction after anterior lumbar fusion is reported in both men and women, but focus is mainly on impaired male biological function (retrograde ejaculation) as this may cause infertility. This has led to concern as to whether anterior surgery should be employed in men, at least in younger age groups.PurposeTo investigate how chronic low back pain (CLBP) of assumed discogenic origin affects sex life and sexual function in patients considered for surgical treatment, whether this is affected by surgical treatment (total disc replacement [TDR] or posterolateral fusion [PLF]/posterior lumbar interbody fusion [PLIF]), and if so, are there differences between the surgical procedures undertaken.Study designA randomized controlled trial comparing TDR and instrumented lumbar spine fusion, performed either as a PLF or PLIF.Patient sampleOne hundred fifty-two patients were included in this randomized controlled trial to compare the effect on CLBP of either TDR via an anterior retroperitoneal approach or instrumented posterior lumbar fusion, PLF or PLIF.Outcome measuresGlobal assessment of back pain, back pain (visual analog scale [VAS] 0-100), function (Oswestry Disability Index [ODI] 0–100), quality of life (EQ5D [EuroQol] 0–1), and answers on specific sexual function.MethodsOutcome was assessed using data from the Swedish Spine Register (SweSpine). In ODI, one question, ODI 8, reflects the impact of back pain on sex life. This question was analyzed separately. Patients also answered a gender-specific questionnaire preoperatively and at the 2-year follow-up to determine any sexual dysfunction regarding erection, orgasm, and ejaculation. Follow-up was at 1 and 2 years.ResultsBefore surgery, 34% reported that their sex life caused some extra LBP, and an additional 30% that their sex life was severely restricted by LBP. After surgery, sex life improved in both groups, with a strong correlation to a reduction of LBP. The gender-specific questionnaire used to measure sexual function after 2 years revealed no negative effect of TDR or Fusion in men regarding erection or retrograde ejaculation. However, 26% of all men in the Fusion group, compared with 3% in the TDR group, reported postoperative deterioration in the ability to achieve orgasm, despite a reduction of LBP.ConclusionsImpairment of sex life appears to be related to CLBP. An improvement in sex life after TDR or lumbar fusion was positively correlated to a reduction in LBP. Total disc replacement in this study, performed through an anterior retroperitoneal approach, was not associated with greater sexual dysfunction compared with instrumented lumbar fusion performed either as a PLF or as a PLIF. Sexual function, expressed as orgasm, deteriorated in men in the Fusion group postoperatively, in spite of this group reporting less LBP after 2 years.     

Using few and scattered time points for analysis of a variable course of pain can be misleading: an example using weekly text message data

Background contextBecause low back pain (LBP) is a fluctuating condition, the diversity in the prediction literature may be due to when the outcome is measured.PurposeThe objective of this study was to investigate the prediction of LBP using an outcome measured at several time points.Study design/settingA multicenter clinical observational study in Sweden.Patient sampleData were collected on 244 subjects with nonspecific LBP. The mean age of the subjects was 44 years, the mean pain score at inclusion was 4.4/10, and 51% of the sample had experienced LBP for more than 30 days the previous year.Outcome measuresThe outcome used in this study was the “number of days with bothersome pain” collected with weekly text messages for 6 months.MethodsIn subjects with nonspecific LBP, weekly data were available for secondary analyses. A few baseline variables were chosen to investigate prediction at different time points: pain intensity, the presence of leg pain, duration of LBP the previous year, and self-rated health at baseline. Age and gender acted as additional covariates.ResultsIn the multilevel models, the predictive variables interacted with time. Thus, the risk of experiencing a day with bothersome LBP varied over time. In the logistic regression analyses, the predictive variable's previous duration showed a consistent predictive ability for all the time points. However, the variables pain intensity, leg pain, and self-rated health showed inconsistent predictive patterns.ConclusionsAn outcome based on frequently measured data described the variability in the prediction of future LBP over time. Prediction depended on when the outcome was measured. These results may explain the diversity of the results of the predictor studies in the literature.     

Atherosclerosis and Disc Degeneration/Low-Back Pain – A Systematic Review

ObjectivesAtherosclerosis can obstruct branching arteries of the abdominal aorta, including four paired lumbar arteries and the middle sacral artery that feed the lumbar spine. The diminished blood flow could result in various back problems. The aim of this systematic literature review was to assess associations between atherosclerosis and disc degeneration (DD) or low-back pain (LBP).Data sourcesA systematic search of the Medline/PubMed database for all original articles on atherosclerosis and DD/LBP published until October 2008. The search was performed with the medical subject headings atherosclerosis, cardiovascular risk factor, or vascular disease and keywords “disc degeneration”, “disc herniation”, and “back pain” on the basis of MeSH tree and as a text search. In addition reference lists were studied and searched manually. Observational studies investigating the association of atherosclerosis or its risk factors and lumbar DD/LBP were selected.Review methodsThe following data were extracted: study characteristics, duration of follow-up, year of publication, findings of atherosclerosis/cardiovascular risk factors and DD/LBP. Disc herniation was regarded as a form of disc degeneration and cardiovascular risk factors were regarded as surrogate for atherosclerosis in epidemiological studies.ResultsOne hundred and seventy-nine papers were identified. After exclusion of case reports, letters, editorials, papers not related to the lumbar spine, and animal studies, 25 papers were included. Post-mortem studies showed an association between atheromatous lesions in the aorta and DD, as well as between occluded lumbar arteries and life-time LBP. In clinical studies, aortic calcification was associated with LBP, and stenosis of lumbar arteries was associated with both DD and LBP. In epidemiological studies, smoking and high serum cholesterol levels were found to have the most consistent associations with DD and LBP.ConclusionAortic atherosclerosis and stenosis of the feeding arteries of the lumbar spine were associated with DD and LBP. Cardiovascular risk factors had weaker associations, being clearly apparent only in cohorts on elderly people or in large study samples. More prospective clinical studies are needed to further clarify the association of atherosclerosis and low-back disorders.     

Causal assessment of occupational carrying and low back pain: results of a systematic review

Background contextOccupational low back pain (LBP) is a common musculoskeletal disorder that results in high healthcare use and a heavy societal burden from morbidity and medical costs. The etiology of LBP is unclear, although numerous physical activities in the workplace have been implicated in its development. Determining the causal relationship between LBP and specific occupational activities requires a rigorous methodological approach.PurposeTo conduct a systematic review of the scientific literature focused on establishing a causal relationship between occupational carrying and LBP.Study designSystematic review of the literature was performed.SampleStudies reporting an association between occupational carrying and LBP.Outcome measuresNumerical association between different levels of exposure to occupational carrying and the presence or severity of LBP.MethodsA systematic review was performed to identify, evaluate, and summarize the literature related to establishing a causal relationship between occupational carrying and LBP by using the commonly used Bradford-Hill framework. The literature was searched using Medline, Embase, CINAHL, Cochrane Library, the Occupational Safety and Health (OSH-ROM) database, gray literature (eg, studies not published in peer-reviewed journals), hand-searching occupational health journals, reference lists of included studies, and content experts. Study quality was evaluated using a modified version of the Newcastle-Ottawa Scale. Levels of evidence supporting specific Bradford-Hill criteria were evaluated for different categories of carrying and types of LBP outcomes.ResultsThis search yielded 2,766 citations. A total of nine high-quality studies reported on occupational carrying and LBP, including four case-control studies and five prospective cohort studies. These nine studies reported strong and consistent evidence against a statistical association between carrying and LBP. Three studies assessed dose-response, of which only one reported a dose-response trend that was not statistically significant. Five studies were able to assess temporality, but none reported results fulfilling this aspect of causality. The biological plausibility of carrying and LBP was not discussed in any of the nine studies. None of these studies attempted to evaluate the experiment criterion by devising studies in which the exposure to carrying and level of LBP could be measured before and after implementing a strategy aimed at reducing carrying in the workplace to determine its effect on LBP.ConclusionsThis review failed to identify high-quality studies that supported any of the Bradford-Hill criteria to establish causality between occupational carrying and LBP. Based on these results, it is unlikely that occupational carrying is independently causative of LBP in the populations of workers studied.     

Neuromuscular exercises on pain intensity,functional disability,proprioception, and balance of military personnel with chronic low back pain

BackgroundDue to their occupational status, military personnel are a high-risk group for low back pain (LBP).PurposeThe aim of this study was to investigate the effect of neuromuscular exercises on the severity of pain, functional disability, proprioception, and balance in military personnel with LBP.MethodsMilitary personnel with LBP were randomly assigned into two groups: intervention (n=15) and control (n=15). The intervention group performed 60 minutes of neuromuscular exercises three times per week for eight weeks while the control group continued their routine physical activities.ResultsThe mean post-intervention pain intensity, disability, and proprioception error significantly decreased in the intervention group. Whereas their mean post-interventions static and dynamic balance scores significantly increased.ConclusionsThe results indicate eight weeks of neuromuscular exercise decreased pain intensity and improved functional ability, static and dynamic balance, and proprioception among military staff suffering chronic low back pain.     

Low back pain in 1,100 Iranian pregnant women: prevalence and risk factors

BackgroundLow back pain (LBP) is a common and costly problem in pregnancy. It is one of the main reasons for disability, absence from work, and responsible for huge direct and indirect economical impact.PurposeThe purpose of this study was to determine the prevalence and risk factors of LBP during pregnancy.Study designA cross-sectional study was carried out on Iranian pregnant women.Patient sampleEleven hundred randomly selected pregnant women.Outcome measuresA structured questionnaire including demographic, lifestyle, as well as prevalence and characteristics of LBP was used. Visual Analog Scale and Oswestry low back disability questionnaires were also used to assess the pain intensity and functional disability, respectively.MethodsAfter ethical approval from Medical Ethics Board at the Mazandaran University of Medical Sciences and Health Services, a cross-sectional study was conducted on 1,100 pregnant women from 18 health centers in Sari district, at northern Iran.ResultsPoint, last-month, last 6-month, last-year, and lifetime prevalence of LBP were 40.2%, 55.9%, 59.4%, 76.2%, and 84.1%, respectively. Prolonged standing and rest were found to be the most significant aggravating and relieving factors (76.3% and 87.7%, respectively). LBP was significantly correlated with history of previous LBP and LBP in previous pregnancy (p=.000 in both cases).ConclusionThe prevalence of LBP in pregnant women appears to be high and future research should focus on different preventive strategies during pregnancy.     

Multiple somatic symptoms in employees participating in a randomized controlled trial associated with sickness absence because of nonspecific low back pain

Background contextThe prevalence of multiple somatic symptoms is high in primary and hospital outpatient populations. Multiple somatic symptoms may be present in patients sick-listed because of low back pain (LBP) and may be associated with increased risk of not returning to work (RTW).PurposeTo explore whether multiple somatic symptoms in a subset of patients with nonspecific LBP was associated with RTW, sickness absence (SA), or other social benefits.Study designThe study was a cohort study based on a randomized clinical trial with a prospective 2-year follow-up period. Patients were referred from general practices to the Spine Center, Regional Hospital Silkeborg, Denmark.Patient samplePatients were 285 sick-listed employees (4–12 weeks), with nonspecific LBP as their prime reason for SA. Exclusion criteria were unemployment, radiculopathy, LBP surgery within the past year, previous lumbar fusion, suspected cauda equina syndrome, progressive paresis or other serious back disease, pregnancy, known substance abuse, or primary psychiatric diagnosis.Outcome measuresSelf-reported health was assessed by the LBP rating scale and questions about pain and health in general. Disabilities were measured by the Roland Morris Questionnaire, the Short Form-36, and the Fear-Avoidance Beliefs Questionnaire. Work-related questions comprised expectations about RTW and risk of losing job because of SA. The Common Mental Disorder Questionnaire (subscale SCL-SOM) was used to assess multiple somatic symptoms (12 items). We categorized multiple somatic symptoms into four groups based on the SCL-SOM sum score: <6, 6 to 12, 13 to 18 and >18. Status of SA (>2 weeks) and RTW were gathered from a national database (DREAM).MethodsThe patients (N=285) were randomized into either multidisciplinary or brief intervention at the Spine Center (2004–2008). Both interventions comprised clinical examination and advice by a physiotherapist and a rheumatologist. Data were collected from questionnaires at baseline (inclusion) and 1 year after inclusion. Data on SA benefits were gathered from the DREAM database that contains data on all social transfer payments (such as sick leave benefits and other disability benefits) registered on a weekly basis.ResultsAll health factors, female gender, and poor work ability were significantly associated with a higher level of multiple somatic symptoms. The percentage of persons with SA increased significantly with the symptom score after 1 year, and the duration of SA remained significantly longer after 2 years of follow-up between the multiple somatic symptoms groups. The percentages with RTW after 1 and 2 years were negatively associated with a higher level of multiple somatic symptoms at baseline. We found no difference between the intervention groups.ConclusionsA higher level of multiple somatic symptoms was significantly associated with poor health and work ability at baseline and with longer duration of SA and unsuccessful RTW through a 2-year follow-up period.     

Identification of intrinsic and reflexive contributions to trunk stabilization in patients with low back pain: a case–control study

European Spine Journal - The goal of this study was to assess differences in low back stabilization and underlying mechanisms between patients with low back pain (LBP) and healthy controls. It has...     

Clinicians’ views about the experience of disability due to low back pain. Results from a focus group study

European Spine Journal - For clinicians, treating the cause of non-pathological low back pain (LBP) is central. For patients, it is how LBP limits their activities of daily living. Little is known...     

基于文献计量学的甲状腺癌诊疗进展历程的循证可视化研究

背景与目的：甲状腺癌是全球最常见的内分泌系统恶性肿瘤,其发病率逐年剧增,已位居女性恶性肿瘤的第四位,其卫生负担逐年加重。近年来,随着医疗技术的发展及甲状腺癌诊疗模式的转变,甲状腺癌患者的生存预后得到明显改善。本文通过结合本研究团队既往针对甲状腺癌的文献计量学研究的基础,运用聚类分析和主题挖掘的方法,以不同时间范围作为研究对象,分析世界范围内甲状腺癌的发展历程与诊治模式的动态演进过程,以期预测未来甲状腺癌研究热点,以及为后续甲状腺癌诊疗的发展方向提供参考。方法：回顾性收集Web of Science Core Collection (Wo SCC)数据库中甲状腺癌相关的研究,应用VOSviewer 1.6.18软件对纳入文献的研究主题、关键词、作者信息、发表年份等变量提取后进行聚类及时序分析和主题挖掘,通过文献计量学的方法探索已发表甲状腺癌相关的研究主题,以及不同时间范围内甲状腺癌诊疗模式的动态演变过程,并预测未来研究热点。结果：最终共纳入甲状腺癌相关研究主题的文献32 074篇,其中,最早的文献发表于1955年。随着时间的推移,发文量迅速增加。世界范围内,基于已发表文献的甲状腺癌发展聚...     

Catastrophization,fear of movement,anxiety, and depression are associated with persistent,severe low back pain and disability

BACKGROUND CONTEXTPsychological characteristics are important in the development and progression of low back pain (LBP); however, their role in persistent, severe LBP is unclear.PURPOSETo investigate the relationship between catastrophization, depression, fear of movement, and anxiety and persistent, severe LBP, and disability.STUDY DESIGN/ SETTINGOne-year prospective cohort study.PATIENT SAMPLEParticipants were selected from the SpineData registry (Denmark), which enrolls individuals with LBP of 2 to 12 months duration without radiculopathy and without satisfactory response to primary intervention.OUTCOME MEASURESPsychological characteristics, including catastrophization, depression, fear of movement, and anxiety, were examined at baseline using a validated screening questionnaire. Current, typical, and worst pain in the past 2 weeks were assessed by 11-point numeric rating scales and an average pain score was calculated. Disability was measured using the 23-item Roland-Morris Disability Questionnaire.METHODSParticipants completed baseline questionnaires on initial presentation to the Spine Center (Middelfart, Denmark), and follow-up questionnaires were sent and returned electronically. Statistical analysis involved multivariable Poisson regression to investigate the association between psychological factors and the number of episodes of severe pain or disability. This study received no direct funding.RESULTSOf the 952 participants at baseline, 633 (63.4%) provided data 1 year later. Approximately half of the participants reported severe LBP (n=299, 47.2%, 95% confidence interval [CI] 43.3%–51.2%) or disability (n=315, 57.6%, 95% CI 53.3%–61.8%) at a minimum of one time point, and 14.9% (n=94, 95% CI 12.2%–17.9%) and 24.3% (n=133, 95% CI 20.8%–28.1%) experienced severe LBP or disability at two time points, respectively. Multivariable Poisson regression showed a relationship between catastrophization, depression, fear of movement, and anxiety and a greater number of time points with severe LBP and disability, after adjusting for age, gender, body mass index, and duration of symptoms. However, when all psychological factors were added to the regression model, only catastrophization and depression remained significantly associated.CONCLUSIONSThis study showed that persistent, severe LBP, and disability is common in a secondary care population with LBP and is associated with a variety of psychological risk factors, in particular catastrophization and depression, highlighting the importance of considering these factors in the design and evaluation of outcomes studies for LBP.     

The crunch factor's role in golf-related low back pain

Background contextThe golf swing exposes the spine to complex torsional, compressive, and shearing loads that increase a player's risk of injury. The crunch factor (CF) has been described as a measure to evaluate the risk of low back injuries in golfers and is based on the notion that lateral flexion and axial trunk rotation jointly contribute to spinal degeneration. However, few studies have evaluated the appropriateness of this measure in golfers with low back pain (LBP).PurposeTo objectively examine the usefulness of the CF as a measure for assessing the risk of low back injury in golfers.Study designField-based research using a cross-sectional design.MethodsThis research used three-dimensional motion analysis to assess the golf swings of 12 golfers with LBP and 15 asymptomatic controls. Three-dimensional kinematics were derived using Vicon Motus, and the CF was calculated as the instantaneous product of axial trunk rotation velocity and lateral trunk flexion angle.ResultsMaximum CFs and their timings were not significantly different between the symptomatic and asymptomatic groups. Furthermore, for those golfers who produced higher CFs (irrespective of the group), the increased magnitude could not be attributed to an increased axial angular trunk velocity or lateral flexion angle, but rather to a concomitant increase in both of these variables.ConclusionsThe findings suggested that although the fundamental concepts that underpin the CF seem sensible, this measure does not appear to be sensitive enough to distinguish golfers with LBP from the asymptomatic players.