抗凝治疗对小儿肾病血液流变学的影响

对３４例原发性肾病综合征（ＩＮＳ）病儿抗凝治疗后的血液流变学改变及临床疗效进行了观察。结果显示，抗凝治疗后血液流变学指标中血浆比粘度、全血比粘度高切变、全血比粘度低切变、全血还原比粘度、纤维蛋白原、血沉均明显降低，与治疗前比较，差异有极显著性（Ｐ＜０．０１）；与治疗对照组（治疗后）比较，差异有显著性（Ｐ＜０．０１，Ｐ＜０．０５）。同时，临床症状明显改善，完全缓解率较对照组明显提高（Ｐ＜０．０５）。提示抗凝治疗对ＩＮＳ高凝状态有明显改善作用。     

抗凝治疗对小儿肾病血液流变学的影响

对３４例原发性肾病综合征（ＩＮＳ）病儿抗凝治疗后的血液流变学改变及临床疗效进行了观察。结果显示，抗凝治疗后血液流变学指标中血浆比粘度、全血比粘度高切变、全血比粘度低切变、全血还原比粘度、纤维蛋白原、血沉均明显降低，与治疗前比较，差异有极显著性（Ｐ〈０．０１）；与治疗对照组（治疗后）比较，差异有显著性（Ｐ〈０．０１，Ｐ〈０．０５）。同时，临床症状明显改善，完全缓解率较对照组明显提高（Ｐ〈０．０５）。     

茶色素对血液流变学指标影响的观察

目的：观察茶色素对血液流变学指标的影响。方法：２８例老年高粘血症患者服茶色素每次２粒，３次／ｄ，３０ｄ为１个疗程，服药前后检测血液流变学指标，采用自身对照分析。结果：茶色素治疗后，降低纤维蛋白原、红细胞压积和全血比粘度有非常显著性差异（Ｐ＜０．００１～０．０１），降低全血还原粘度、体外血栓湿重和干重有显著性差异（Ｐ＜０．０５），而血浆比粘度、血沉、血沉方程Ｋ值、体外血栓长度和血小板粘附率无显著性差异（Ｐ＞０．０５）。结论：茶色素对老年高粘血症患者血液流变学指标具有明显改善作用     

普恩复治疗脑梗塞50例疗效观察

应用普恩复治疗５０例脑梗塞患者，观察疗效及血液流变学指标，发现治疗组总有效率为９４％，对照组为４８％，治疗组全血粘度、血浆粘度、红细胞压积比、纤维蛋白原、血沉均较治疗前显著降低（Ｐ＜０．０１）；而对照组仅红细胞压积比及血沉明显降低（Ｐ＜０．０５）。提示：普恩复治疗脑梗塞有较好的临床疗效且有明显改善血液流变学作用     

扩张型心肌病患者的血液流变学变化

目的探讨扩张型心肌病患者的血液流变学和血液成分的变化．方法扩张型心肌病患者６０例，空腹抽静脉血．肝素抗凝，测定全血比粘度、血浆比粘度、血沉、血沉Ｋ值、压积和纤维蛋白原，并与正常对照组比较。统计学处理采用ｔ检验。结果扩张型心肌病患者的全血比粘度、红细胞压积和纤维蛋白原显著高于正常对照组．（分别为Ｐ＜０．０１和Ｐ＜０．０５）血沉、血沉Ｋ值和血浆比粘度低于正常对照组（Ｐ＜０．０１）。结论扩张型心肌病患者的血液处于高粘、高凝状态。中图分类号Ｒ５４２２     

脑溢安颗粒剂对脑出血病人的血液流变学与RCD的影响

对４０例脑出血患者采用脑溢安颗粒剂（中药组）和西药（西药组）治疗，观察血液流变学与红细胞变形能力（ＲＣＤ）的变化。结果表明：两组治疗前全血比粘度的高切、低切；全血还原粘度的高切；血浆比粘度以及ＲＣＤ均较正常人对照组高（均Ｐ＜０．０１）。治疗后，中药组上述指标均较治疗前明显降低（Ｐ＜０．０１）；而西药组较治前稍有降低，无统计学意义（Ｐ＞０．０５）；且中药组明显低于西药组（Ｐ＜０．０１）。提示中药脑溢安颗粒剂对降低血液粘度，提高ＲＣＤ，改善脑组织血液灌流，防止脑组织缺血缺氧继发性损伤，保护脑组织，提高疗效等方面均明显优于西药组     

氧透射载体疗法对冠心病血液流变性及甲襞微循环的影响

采用氧透射载体疗法（ＯＴＩＵ）治疗冠心病患者６１例，治疗前后均进行了血液流变性及甲襞微循环的检测。冠心病组治疗后与治疗前比，红细胞和血小板电泳时间有非常显著性缩短（Ｐ＜０．０１）。全血粘度、血浆比粘度、红细胞压积、全血还原粘度有显著性差异（Ｐ＜０．０５）。甲襞微循环加权积分值有显著性降低（Ｐ＜０．０５）。从而证实了ＯＴＩＵ对冠心病的治疗在降低血粘度、改善血液流变性等微循环方面有明显效果。是一种行之有效的方法，值得在临床上推广使用     

糖尿病44例血液流变学检测结果分析

地４４例Ⅱ型糖再会因液流变学检测，并与４０例健康对照组比较，结果表明，糖尿病患者血栓指数Ｑ值，纤维蛋白原和血浆粘度差异有极显著性（Ｐ〈０．０１）。红细胞积、全血粘度２３０Ｓ－切变率和血小板最大聚集度差异有显著性（Ｐ〈０．０５）。糖尿病患乾血液处于浓、粘、糜、缓状态。在降糖治疗的同时行降血粘度抗血小板聚集综合治疗十分重要。     

光量子血疗对冠心病心绞痛患者血液流变学的探讨

我院自１９９３年１月以来采用自血光量子疗法，治疗冠心病心绞痛，临床疗效显著，并在治疗前后观察了血液流变学变化，发现全血比粘度显著下降（Ｐ＜０．０１）；全血比粘度的高切及血球压积也下降（Ｐ＜０．０５）。     

突发性聋的血液流变学与疗效

本文将４０岁以上突发性聋５５例进行血液流变学检测，并与健康对组进行对比分析，其结果显示：除全血比粘度（低切）外．其余各项统计学处理有极显著性差异（Ｐ＜０．０１）．而血液流变学崐与治疗转归有显著性差异（Ｐ＜０．０５）。笔者认为，血液粘滞度增高可能是导致中老年突发性聋的病因之一。     

The Effects of Chinese Medicines on Micro-circulation of Nail Folds and Blood Flow Velocity of Limbs in the Patients with Arteriosclerotic Obliteration

The effects of Chinese medicines on micro-circulation and blood flow velocity in arteries of the lower limbs were observed in 33 patients with arteriosclerotic obliteration (ASO). The results showed that the integral values of micro-circulation after treatment were obviously higher than those before treatment (P < 0.05 or P < 0.01). Blood flow velocity in arteries of the lower limbs determined with the color Doppler ultrasound detecting method after treatment were also obviously higher than those before treatment (P < 0.05 or P < 0.01). In this series of 33 ASO patients, the markedly effective rate was 36.36%, and the total effective rate was 63.64%. The observation indicates that the recipe prescribed according to the principle of supplementing qi and activating blood circulation can effectively improve micro-circulation in ASO patients, and accelerate blood flow in arteries of the lower limbs.     

Clinical Observation on Treatment of Rheumatoid Arthritis with Fengshi Xiandan in 53 Cases

We have successfully developed Fengshi Xiandan ([symbol: see text]) and used it to treat 53 cases of rheumatoid arthritis (RA), with indomethacin used to treat another 53 cases of RA as the controls. The results showed that the rate of cure and obvious effect was 54.7% and the total effective rate was 92.4% in the treatment group, as compared to 26.4% and 66.0% respectively in the control group, with an obvious difference in curative effect between the two groups (P < 0.01). The improvement of all the main clinical symptoms and signs except arthralgia in the treatment group was superior to that in the control group (P < 0.05 or P < 0.01). The improvement of erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), C-reaction protein (CRP), immunoglobulin (Ig), T-lymphocyte subgroups, micro-circulation in nail fold, and red blood cell (RBC) and hemoglobin (Hb) of anemia patients in the treatment group was superior to that in the control group (P < 0.05 or P < 0.01). There was an obvious difference (P < 0.05 or P < 0.01) in superoxide dismutase (SOD) of RBC and lipid peroxide (LPO) of plasma before treatment in the two groups as compared to normal group (P < 0.05 or P < 0.01). The level of SOD and LPO after treatment in the treatment group obviously tended to normal as compared to that before treatment (P < 0.05 or P < 0.01). The reduction of LPO in the treatment group was obviously superior to that in the control group (P < 0.01). The result shows that Fengshi Xiandan ([symbol: see text]) with an obvious curative effect on RA can not only control the symptoms of RA but also improve its pathologic damage and prevent its development.     

痹肿消汤治疗活动期类风湿关节炎的临床研究

对９６例活动期类风湿关节炎（ＲＡ）病人采用痹肿消汤治疗与西药甲氨喋呤（ＭＴＸ）作对照研究。结果表明：治疗一月,痹肿消汤组的病人其晨僵、关节疼痛、关节肿胀、关节压主关节功能障碍等主要症状与体征均较治前显著改善（Ｐ〈０．０１或Ｐ〈０．０５）;而ＭＴＸ组则无明显改善,两组比较差异有显著性（Ｐ〈０．０１或Ｐ〈０．０５）。治疗三月,上述主要症状与体征,两组均较治前有显著改善（Ｐ〈０．０１或Ｐ〈０．０５）,但     

Clinical Study on Electro-acupuncture Treatment for 30 Cases ofMental Depression

To observe the clinical therapeutic effects of electro-acupuncture therapy for mental depression, 30 cases were treated by electro-acupuncture on Baihui (GV20), Yintang (EX-HN3) and the differential points.Maprotiline was used in the control group of 31 cases. After the treatment, the scores in HAMD for both groups were found to be obviously decreased as compared with those before the treatment (P＜0.01),without significant between-group differences (P＞0.05). The total effective rate in the treatment group was 96.7%, and that of the control group was 90.3%, showing no significant between-group differences (P＞0.05). After the treatment, the two groups all showed obvious decrease in the TCM symptomatic integrals (P＜0.01), with significant between-group differences (P＜0.05), the integral of the treatment group showing obvious superiority to that of the control group. And the decrease of the Asberg scores testing the side effect of antidepressants of the treatment group was obviously superior to that of the control group. After the treatment, the cortisol (CORT) content and the endothelin-1 (ET-1) content of the two groups were all obviously decreased (P＜0.01), and basically turned to normal, without significant between-group differences (P＞0.05). Conclusion: Electro-acupuncture therapy can produce the same clinical therapeutic effect as that produced by the tetracyclic drug maprotiline, giving less side effect and better symptomatic improvement.     

丁咯地尔合丹参治疗脑梗死临床研究

目的 :观察丁咯地尔与丹参联合治疗脑梗死的临床疗效及对血液流变学的影响。方法 :将脑梗死患者 1 43例随机分为治疗组 75例 ,对照组 68例 ,治疗组用丁咯地尔 1 5 0 mg,每日 1次静滴 ,丹参针 30 ml,每日 1次静滴 ;对照组用丹参针 30 ml,每日 1次静滴 ,连用 1 4天。两组均在治疗前及治疗后 2周行血液流变学检测 ,治疗前及治疗后 4周进行神经功能缺损评分。结果 :治疗组显效率及有效率均高于对照组 ( P<0 .0 1和 P<0 .0 5 ) ,两组血液粘稠度均低于治疗前 ( P<0 .0 1 ) ,但治疗组优于对照组 ( P<0 .0 1 )。结论 :丁咯地尔合丹参治疗脑梗死显示良好疗效 ,值得临床应用。     

益气活血组方治疗肺心病的临床疗效及机制研究

目的 :研究肺心病患者氧化 -抗氧化系统、血小板及肺血管内皮细胞功能变化及相互关系 ,探讨益气活血组方治疗肺心病的疗效和作用机制。方法 :随机选取肺心病患者 5 7例 ,随机分为治疗组 (30例 )及对照组 (2 7例 ) ,对照组给予常规治疗 ,治疗组除常规治疗外加用益气活血制剂。另选取 13例为健康对照组。记录所有患者的临床疗效 ,检测治疗前后血 L PO、SOD、GMP14 0、CEC、Pa O2 和 Pa CO2 的变化 ,并进行各指标间的相关分析。结果 :1治疗组显效率及 Pa O2 较对照组明显增高。 2两组肺心病治疗前 L PO均升高 ,SOD明显降低 ;治疗前 GMP14 0、CEC均升高 (P均 <0 .0 1) ,治疗后均下降 (P均 <0 .0 1)。益气活血治疗组上述变化较对照组明显 ,两组比较有显著性差异 (P均 <0 .0 1)。 3相关分析结果 ,CEC数量与 Pa O2 呈负相关 ,与 L PO呈正相关 ,与 SOD呈负相关 ,与血小板膜 GMP14 0呈正相关。血小板膜 GMP14 0与 L PO呈正相关 ,与 SOD呈负相关 ,与 Pa O2 呈负相关。结论 :益气活血治疗通过恢复氧化 -抗氧化系统的平衡 ,从而保护肺血管内皮细胞和血小板 ,具有降低肺动脉高压和治疗呼吸衰竭的作用     

痹肿消汤治疗活动期类风湿关节炎的临床研究

对 96例活动期类风湿关节炎 (RA)病人采用痹肿消汤治疗与西药甲氨喋呤 (MTX)作对照研究。结果表明 :治疗一月 ,痹肿消汤组的病人其晨僵、关节疼痛、关节肿胀、关节压痛及关节功能障碍等主要症状与体征均较治前显著改善 (P <0 .0 1或P <0 .0 5 ) ;而MTX组则无明显改善 ,两组比较差异有显著性 (P <0 .0 1或P <0 .0 5 )。治疗三月 ,上述主要症状与体征 ,两组均较治前有显著改善 (P <0 .0 1或P <0 .0 5 ) ,但痹肿消汤组优于MTX组。ESR ,CRP ,RF ,C3,IgG ,IgA ,IgM等炎性及免疫指标治后两组均较治前明显降低 (P <0 .0 1或P <0 .0 5 ) ;痹肿消汤组的ESR ,CRP下降较MTX组更明显 ,更迅速。痹肿消汤组 ,临床治愈与显效率为 78% ,总有效率为 94% ;MTX组 ,临床治愈与显效率为 5 2 2 % ,总有效率为 87% ;痹肿消汤组显效率优于MTX组 (P <0 .0 5 )。上述结果提示痹肿消汤改善RA病人的症状与体征 ,控制急性炎性反应优于MTX组 ,且较MTX组作用更迅速 ;有与MTX相类似的抗免疫作用 ,且无明显的副反应。     

氧化镁对高血压病人血压及胰岛素敏感性的影响

①目的　观察氧化镁对高血压病人血压及胰岛素敏感性的影响。②方法　将６０ 例原发性高血压病人随机分为两组。对照组给予硝苯地平缓释片治疗,治疗组加服氧化镁粉。治疗９０ｄ,观察血压、血清葡萄糖（ＳＧ）、胰岛素（ＩＮＳ）及Ｃ肽（ＣＰ）变化,并计算ＣＰ／ＩＮＳ及胰岛素敏感指数（ＩＳＩ）。③结果　治疗组治疗后收缩压（ＳＢＰ）、舒张压（ＤＢＰ）、ＩＮＳ及ＣＰ降低,ＩＳＩ增高,与治疗前比较差异有极显著性（ｔ＝ ４．１１～１７．５８,Ｐ均＜ ０．００１）;ＳＧ,ＣＰ／ＩＮＳ治疗前后比较差异无显著性（ｔ＝ ０．７８,１．３７,Ｐ＞ ０．０５）。对照组治疗后ＳＢＰ,ＤＢＰ降低（ｔ＝ １７．５０,１２．７０,Ｐ＜０．００１）;ＩＮＳ,ＣＰ,ＩＳＩ,ＳＧ及ＣＰ／ＩＮＳ均无显著变化（ｔ＝ ０．７８～１．５９,Ｐ 均＞ ０．０５）。与对照组比较,治疗组治疗后ＳＢＰ,ＤＢＰ,ＩＮＳ,ＣＰ降低及ＩＳＩ增高更显著（ｔ＝ ２．０９～８．８６,Ｐ＜ ０．０５,０．０１）;ＳＧ,ＣＰ／ＩＮＳ差异无显著性（ｔ＝ １．１９,０．５２,Ｐ＞ ０．０５）。④结论　氧化镁可有效降低高血压病人的血压,改善其胰岛素敏感性。     

Effects of Da Ding Feng Zhu Decoction in 30 Cases of Liver Fibrosis

To study the clinical effects of Da Ding Feng Zhu (大定风珠) Decoction on liver fibrosis. 56 patients withliver fibrosis due to chronic hepatitis B were randomly divided into a treatment group (30 cases treatedwith Da Ding Feng Zhu Decoction) and a control group (26 cases treated with colchicine). The serumlevels of hyaluronic acid (HA), procollagen Ⅲ (PC-Ⅲ), Ⅳ collagen (Ⅳ-C) and Laminin (LN) of thepatients were determined, compared and analyzed before treatment and after 3-month treatment in the twogroups. The results showed that in the treatment group, the levels of HA, PC-Ⅲ, Ⅳ-C and LN after3-month treatment were significantly lowered as compared to that before treatment (P＜0.01). In thecontrol group, only the HA level was obviously lowered (P＜0.05). There was an significant difference(P＜0.05) in PC-Ⅲ and Ⅳ-C and a very significant difference (P＜0.01) in HA after treatment between thetwo groups. It is therefore concluded that Da Ding Feng Zhu Decoction can lower serum indexes of liverfibrosis.