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1.
Joe Jabbour Haryana M. Dhillon Heather L. Shepherd Puma Sundaresan Chris Milross Jonathan R. Clark 《Patient education and counseling》2018,101(10):1736-1740
Objective
Is there a relationship between decision-making preferences and psychological distress?Methods
Patients who had received treatment for head and neck cancer (HNC) at four institutions within NSW, Australia were invited to complete a single questionnaire.Results
Five hundred and ninety-seven patients completed the questionnaire. The majority of patients (308, 54%) preferred shared decision making. Significant predictors of a preference towards active decision making were education level (OR 2.1 for tertiary, p?<?0.001), primary cancer site (OR 1.9 for thyroid compared to salivary gland, p?=?0.024) and gender (OR 1.4 for female, p?=?0.028). Mean psychological distress score on Kessler 6 (K6) was 9 (Range: 0–28). Significant predictors of psychological distress were age (p?<?0.001), gender (p?<?0.001), primary site (p?<?0.01), and decision preference (p?<?0.01).Conclusion
HNC patients who are either tertiary educated or female are more likely to prefer active involvement in decision-making. Psychological distress is more likely in patients actively involved in decision making, younger patients, and in females.Practice implications
: Patients experienced paternalistic decision-making, but most preferred active or a shared approached. Clinicians need to be aware of potential for psychological distress in active decision-makers and refer patients for psychosocial support. 相似文献2.
3.
Kamuran Ibis Sezer Saglam Esra Kaytan Saglam Pinar Firat Dilek Yilmazbayhan Alper Toker Berker Ozkan Veysel S. Hancer Murat Buyukdogan Rian Disci Kezban Nur Pilanci 《Pathology, research and practice》2018,214(9):1291-1296
Background
To assess the prognostic importance of carbonic anhydrase IX (CA IX), a hypoxic biomarker, after neoadjuvant treatment in Stage III non-small cell lung cancer (NSCLC) patients.Methods
Tissue CA IX expression was examined after surgical resection in 77 patients who had undergone neoadjuvant treatment. The effects of CA IX overexpression and other clinical factors on disease-free survival and overall survival were investigated.Results
In multivariate analysis, number of neoadjuvant chemotherapy (CT) courses and gender emerged as significant independent predictors for disease-free survival, where administration of 2–3 courses of neoadjuvant chemotherapy (CT) (HR, 3.2 [95% CI 1.3–7.6], p?=?0.009) and female gender were associated with poor survival (HR, 3.2 [95% CI 1.3–7.7], p?=?0.009). The only significant independent predictor for overall survival was recurrence (HR, 5.6 [95% CI 2.4–12.8], p?<?0.001). On the other hand, CA IX overexpression was not associated with disease free survival (p?=?0.560) or overall survival (p?=?0.799).Discussion
Our results do not suggest a prognostic role for CA IX overexpression in stage III NSCLC patients who received neoadjuvant treatment. 相似文献4.
Fani Karagianni Agapi Kataki Eythymios Koniaris Sotirios Karamagkiolas Anastasia Derventzi Evangelos Giotakis Manousos Konstandoulakis George Zografos Ioannis Giotakis 《Pathology, research and practice》2018,214(12):2004-2010
Background
Nasal polyposis (NP) and sinonasal inverted papillomas (SIP) are considered benign lesions capable of recurrence or malignant transformation although not with the same prevalence. Since fluctuations of Caveolin-1 and Notch-1 proteins expression have been reported in many pathologies, the current study aimed to investigate their involvement in the epithelial transformation observed in SIPs compared to NP.Methods
Immunohistochemical expression of Caveolin-1 and Notch-1 proteins was assessed in 104 patients with sinonasal lesions (45 NP, 45 SIP and 14 NP with SIP), semiquantively (percentage times intensity). Proteins expression profiles were evaluated statistically for their correlation with patients demographic and clinicopathological variables (grade of dysplasia, inflammation, recurrence) as well as with markers of proliferation (Ki67) and apoptosis (7-AAD) as determined by flow cytometry analysis.Results
SIP lesions presented increased Caveolin-1 immunopositivity compared to NP (62.2%, vs 40.9%; p?=?0.045). Cytoplasmic staining was observed only in epithelium’s basal and suprabasal layers. Caveolin-1 positivity was not related to Ki67 expression, apoptosis, inflammation or dysplasia, eventhough 81.8% of highly immunopositive lesions were dysplastic (p?=?0.03). Also, smokers presented significantly increased immunopositivy (p?=?0.03). In contrast SIP lesions presented reduced Notch-1 expression compared to NP (68.9% vs 100%; p?<?0.001). Dysplastic lesions presented low Notch-1 immunopositivity (p?<?0.001). Enhancement of Notch-1 gene expression was also associated with inflammation.Conclusions
The herein presented data suggest that the expression profiles of Caveolin-1 and Notch-1 proteins in sinonasal pathologies are distinctive and that could be explored as potential targets for the development of alternative therapeutic approaches. 相似文献5.
Tomasz Powrózek Radosław Mlak Marcin Dziedzic Teresa Małecka-Massalska Dariusz Sagan 《Pathology, research and practice》2018,214(3):368-373
Introduction
MicroRNA (miRNA) are attractive markers of lung cancer, due to their regulatory role in cell cycle. However, we know more about function of miRNA in cancer development, there is still little known about role of their precursors (primary miRNA; pri-miRNA) in tumorgenesis. In present study we investigated potential role of miRNA-944 and its precursor pri-miRNA-944 in development of squamous-cell lung cancer (SCC) and explored interdependence between miRNA precursor and its mature form. This is a first available literature report analyzing pri-miRNA as a cancer diagnostic marker.Material and methods
Expression of miRNA-944 and its precursor was analyzed in 58 fresh-frozen tissues of non-small cell lung cancer and corresponding adjacent non-cancerous tissues using qRT-PCR. Expression of pri-miRNA-944 was correlated with TP63 and miRNA-944. Using ROC analysis diagnostic accuracy of studied markers was evaluated.Results
miRNA-944 and its precursor were significantly overexspressed in SCC compared to adenocarcinoma (AC) and non-cancerous tissue. pri-miRNA-944 strongly and positively correlated with TP63 (r?=?0.739, p?<?0.001) and with mature miRNA-944 expression (r?=?0.691, p?<?0.001). Also, TP63 expression significantly correlated with mature miRNA (r?=?0.785, p?<?0.001). Combined analysis of pri-miRNA-944 and mature miRNA-944 allowed to distinguish SCC tissue form AC with sensitivity of 93.3% and specificity of 100% (AUC?=?0.978), and SCC from non-cancerous tissue with 92.9% sensitivity and 100% specificity (AUC?=?0.992).Conclusion
We assumed that pri-miRNA-944 and miRNA-944 may be involved in early squamous-type differentiation of lung tumors. Moreover, analysis of both markers provided high diagnostic accuracy for SCC detection. 相似文献6.
Nahed A. Soliman Shaimaa M. Yussif Abdelhadi M. Shebl 《Pathology, research and practice》2019,215(5):977-982
Introduction
Syndecan-1 is heparan sulfate proteoglycans (HSPGs) that is used as coreceptors for signaling of growth factors. The comprehensive effect of syndecan-1 is to augment receptor stimulation at little ligand concentrations.The goal of this research
is to study syndecan-1 expression in breast carcinoma and its value in predicting the prognosis in comparison to other clinicopathological parameters.Material &methods
immunohistochemistry study for syndecan-1 is done on 103 cases of invasive breast carcinoma. Its expression is assessed and correlated to other clinicopathological parameters and prognosis.Results
overexpression was significantly related to high histologic grade (p?=?0.001), large tumor size (p?=?0.043), HER2-positive status (p?=?0.001), and ER&PR-negative status (p?=?0.001). It was also have a negative impact on the overall survival (p=0.012) and disease free survival (p?=?0.009). Syndecan-1 expression showed weak positive correlation with Her 2 expression (Correlation Coefficient (co): 0.332, p?=?0.001).Conclusion
syndecan-1 is a good predictor of poor overall survival and recurrence/ metastasis free survival. It is associated with aggressive phenotype as HER2 enriched and Triple negative rather than luminal subtypes of breast carcinoma. So it can be added to the hormonal receptors and HER 2 assay in the routine management of invasive breast cancer after confirmation on a more larger study. 相似文献7.
Yang Liu Jing Ma Kangjie Yu Mingyang Li Fang Liu Qingguo Yan Zhe Wang Shuangping Guo 《Pathology, research and practice》2018,214(4):507-512
Background
Gastrointestinal diffuse large B cell lymphoma (GI DLBCL) is the most common gastrointestinal lymphoma. However, there has not been a comprehensive investigation into the expression patterns of programmed cell death 1 (PD-1) and programmed cell death ligand 1(PD-L1) in GI DLBCL tissues.Methods
PD-1 protein expression in tumor-infiltrating lymphocytes (TILs) was evaluated by immunohistochemical staining, and expression of PD-L1 was evaluated by using PD-L1/PAX5 immunohistochemical double staining in 92 GI DLBCL specimens.Results
The prevalence of positive PD-L1 expression (PD-L1?+?) in GI DLBCL cells and positive PD-L1 expression in non-cancer cells of the GI DLBCL microenvironment (microenvironmental PD-L1, mPD-L1) were 11.96% (11 of 92) and 41.98% (34 of 81), respectively. PD-L1 expression in GI DLBCL was significantly associated with involvement of extranodal sites?≥?2 (P?=?0.034) and mPD-L1 expression was significantly associated with ECOG performance status (score?≥?2) (P?=?0.041). PD-L1 expression and mPD-L1 expression had no prognostic significance (P >?0.05) on disease outcome. PD-1+ TILs were significantly lower in patients with extranodal site involvement (P?=?0.011) and the quantity of PD–1?+?TILs correlated positively with the level of PDL1 expression in non malignant microenvironment cells (P?=?0.001). Patients with high levels of PD-1+ TILs had better prognosis (P?=?0.0005).Conclusions
The expression patterns of PD-L1 in patients with GI DLBCL are different from patients with common DLBCL. Immunotherapies that target the PD-1/PD-L1 pathway may have therapeutic potential in GI DLBCL. 相似文献8.
Daniela Scala Enrica Menditto Giuseppe Caruso Valeria Marina Monetti Valentina Orlando Francesca Guerriero Giuseppe Buonomo Domenico Caruso Maria D’Avino 《Patient education and counseling》2018,101(4):679-686
Objectives
The aim was to determine the impact of a telephone counseling service, provided bi-monthly by pharmacist, on patients’ beliefs about antihypertensive medicines and blood pressure (BP) control.Methods
Either hypertensive patients were randomly assigned to a control group (CG, usual care) or an intervention group (IG). All patients had BP values registered and filled in the Italian version of the Belief Medicine Questionnaire (BMQ). After 12 months, patients filled in the BMQ again and had their self-reported BP registered. The intervention consisted of an educational/counseling session based on patients’ needs assessment provided bi-monthly by a pharmacist for one year via telephone.Results
80 CG and 84 IG patients were recruited. After 12 months, there were significant differences between IG and CG for both BMQ’s Necessity and Concern score (p?<?0.001; p?<?0.001 respectively) and a significant reduction in BP values in IG (p?<?0.001).Conclusions
The intervention improves BP control by modifying patients’ perception about treatments and involving patients as participants in the management of their health.Practice implications
This paper could serve as a guideline for other studies to confirm the effectiveness of this intervention in modifying health behavior, and the role of hospital pharmacist. 相似文献9.
Ting Liu Hong Zhang Xuesong Yang Xiaojie Li Yi Shi Weidong Niu Tingjiao Liu 《Pathology, research and practice》2018,214(2):296-302
Objective
The aim of this study is to investigate the expressions of p16 and HPV16/18(E6) in oral lichen planus (OLP) and malignant transformed OLP (MT-OLP).Study design
The expression of p16 and HPV16/18(E6) in 40 cases of OLP and 6 MT-OLP was assessed by immunohistochemical staining. Twenty four cases of normal oral mucosa were used as controls.Results
Compared to normal oral mucosa, the expression of p16 and HPV16/18(E6) protein increased in OLP and MT-OLP. And there was a correlation between p16 expression and HPV infection in OLP and OLP malignant lesions (p?<?0.0001).Conclusions
The expression of p16 protein might predict HPV16/18 infection in OLP. And HPV16/18(E6) infection might contribute to OLP malignant transformation. 相似文献10.
11.
Karen Nieuwenhuijsen Carel T. Hulshof Judith K. Sluiter 《Patient education and counseling》2018,101(7):1291-1297
Objective
To study the influence of the presentation of results of a preventive medical examination on risk perception and willingness to seek help for work-related fatigue or being overweight.Methods
A factorial design experiment was conducted, presenting workers (n?=?82) with vignettes including eight scenarios of test results with and without an emphasis on the risk of a current or future health condition or a probe to seek help. Participants rated perceived risk and willingness to seek help (0–100 Visual Analogue Scale) as if these were their own results. Differences were tested with paired-sample t-tests.Results
In scenarios emphasizing the risk of a current or future disorder, participants perceived higher risk and were more willing to seek help (p-values?<?.00). Slightly higher willingness to seek help scores was observed in all scenarios that included probes (p?<?.00).Conclusion
Risk perception and willingness to seek help of workers participating in a preventive medical examination were higher when they were told that the test results indicate a risk of a current or future disorder and after being advised to seek help.Practice implications
Healthcare providers should take the potential effects on risk perception and help-seeking into account in preventive settings. 相似文献12.
Sarina R. Isenberg Rebecca A. Aslakson James N. Dionne-Odom Katherine Clegg Smith Sarabdeep Singh Susan Larson John F.P. Bridges Thomas J. Smith Jennifer L. Wolff Debra L. Roter 《Patient education and counseling》2018,101(6):1066-1074
Objective
To examine the association between family companion presence during pre-surgical visits to discuss major cancer surgery and patient-provider communication and satisfaction.Methods
Secondary analysis of 61 pre-surgical visit recordings with eight surgical oncologists at an academic tertiary care hospital using the Roter Interaction Analysis System (RIAS). Surgeons, patients, and companions completed post-visit satisfaction questionnaires. Poisson and logistic regression models assessed differences in communication and satisfaction when companions were present vs. absent.Results
There were 46 visits (75%) in which companions were present, and 15 (25%) in which companions were absent. Companion communication was largely emotional and facilitative, as measured by RIAS. Companion presence was associated with more surgeon talk (IRR 1.29, p?=?0.006), and medical information-giving (IRR 1.41, p?=?0.001). Companion presence was associated with less disclosure of lifestyle/psychosocial topics by patients (IRR 0.55, p?=?0.037). In adjusted analyses, companions’ presence was associated with lower levels of patient-centeredness (IRR 0.77, p 0.004). There were no differences in patient or surgeon satisfaction based on companion presence.Conclusion
Companions’ presence during pre-surgical visits was associated with patient-surgeon communication but was not associated with patient or surgeon satisfaction.Practice implications
Future work is needed to develop interventions to enhance patient-companion-provider interactions in this setting. 相似文献13.
Jana L. Wardian Joshua Tate Irene Folaron Sky Graybill Mark True Tom Sauerwein 《Patient education and counseling》2018,101(8):1490-1495
Objective
We hypothesized that diabetes-related distress would vary by type of diabetes and medication regimen [Type 1 diabetes (T1DM), Type 2 diabetes with insulin use (T2DM-i), Type 2 diabetes without insulin use (T2DM)]. Thus, the aim of this study was to identify groups with elevated diabetes-related distress.Methods
We administered the 17-item Diabetes-related Distress Scale (DDS-17) to 585 patients. We collected demographics, medications, and lab results from patient records.Results
Patients were categorized by type of diabetes and medication: T1DM (n?=?149); T2DM-i (n?=?333); and T2DM (n?=?103). ANOVA revealed significant differences in sample characteristics. ANCOVA were conducted on all four DDS-17 domains [Emotional Burden (EB); Physician-related Distress (PD); Regimen-related Distress (RD); and Interpersonal Distress (ID)]; covariates included in the models were sex, age, duration of diabetes, BMI, and HbA1c. EB was significantly lower in T1DM than T2DM-i, p?<?0.05. In addition, RD was significantly lower in T1DM than either T2DM-i, p?<?0.05 and T2DM, p?<?0.05.Conclusions
EB and RD are higher for those with type 2 diabetes. Thus, interventions to reduce EB and RD need to be considered for patients with type 2 diabetes.Implications
DDS-17 is useful in identifying diabetes-related distress in patients with diabetes. Efforts need to be made to reduce EB and RD. 相似文献14.
Gina Bravo Modou Sene Marcel Arcand Élodie Hérault 《Patient education and counseling》2018,101(7):1256-1261
Objective
To investigate how confidence in surrogates’ ability to make consistent decisions in the future change over time, in the context of an ACP intervention that did not improve surrogates’ ability to predict an older adult’s hypothetical treatment preferences.Methods
The study involved 235 older adults and surrogates, randomly allocated to an ACP or control intervention. At baseline, end of intervention, and six months later, participants were asked how confident they were in the surrogate making decisions in the future that would match the older adult’s wishes.Results
By the end of the intervention, confidence had increased among older adults and surrogates involved in ACP (OR?=?3.1 and 5.8 respectively, p?<?0.001), while less change occurred among controls. Over the following six months, confidence remained stable among older adults but decreased among surrogates (OR?=?0.5, p?=?0.005).Conclusion
ACP increases confidence in surrogates’ ability to make consistent decisions, which may lighten the burden of substitute decision making. Efforts to improve substitute decision-making must continue so that participants’ confidence is not based on the mistaken assumption that surrogates can make consistent decisions.Practice implications
Professionals involved in ACP should inform participants that confidence in the surrogate may increase in the absence of enhanced predictive ability. 相似文献15.
Yuqiao Diao Ping Zhang Ruoheng Dai Jianfa Xu Helin Feng 《Pathology, research and practice》2018,214(7):974-977
Purpose
Previous studies have shown a correlation between the expression of H3K27me3 and pathological characteristics of malignant tumors. This study aimed to investigate the association of H3K27me3 and VEGF expression with clinical outcomes of synovial sarcoma patients.Methods
This study included 48 patients with synovial sarcoma. H3K27me3 and VEGF levels were evaluated by immunohistochemical staining, and their correlation with clinical parameters was analyzed by Spearman’s and Pearson’s test. Univariate and multivariate Cox regression analyses were used to identify potential prognostic factors. Kaplan-Meier method was used to analyze overall survival.Results
Protein levels of both H3K27me3 and VEGF were significantly associated with histologic grade (P?=?0.004, P?=?0.042, respectively), metastasis (P?=?0.009, P?=?0.028, respectively), and AJCC staging (P?<?0.001, P?=?0.003, respectively). H3K27me3 and VEGF expression showed positive correlation (P?<?0.001, R?=?0.618). Both H3K27me3 and VEGF expression were significantly associated with shorter overall survival by univariate analysis, but the association was significant for H3K27me3 [P?=?0.26, HR?=?2.640 (1.124–6.200)] only by multivariate analysis.Conclusions
H3K27me3 and VEGF expression are both significantly associated with overall survival of synovial sarcoma, and H3K27me3 is a significant independent prognostic indicator in patients with synovial sarcoma. 相似文献16.
Vincent Kalumire Cubaka Michael Schriver Peter Vedsted Gregory Makoul Per Kallestrup 《Patient education and counseling》2018,101(9):1601-1610
Objective
To identify, adapt and validate a measure for providers’ communication and interpersonal skills in Rwanda.Methods
After selection, translation and piloting of the measure, structural validity, test-retest reliability, and differential item functioning were assessed.Results
Identification and adaptation: The 14-item Communication Assessment Tool (CAT) was selected and adapted.Validity and reliability testing
Content validation found all items highly relevant in the local context except two, which were retained upon understanding the reasoning applied by patients. Eleven providers and 291 patients were involved in the field-testing. Confirmatory factor analysis showed a good fit for the original one factor model. Test-retest reliability assessment revealed a mean quadratic weighted Kappa?=?0.81 (range: 0.69–0.89, N?=?57). The average proportion of excellent scores was 15.7% (SD: 24.7, range: 9.9–21.8%, N?=?180). Differential item functioning was not observed except for item 1, which focuses on greetings, for age groups (p?=?0.02, N?=?180).Conclusion
The Kinyarwanda version of CAT (K-CAT) is a reliable and valid patient-reported measure of providers’ communication and interpersonal skills. K-CAT was validated on nurses and its use on other types of providers may require further validation.Practice implication
K-CAT is expected to be a valuable feedback tool for providers in practice and in training. 相似文献17.
Małgorzata Wilusz Dominik Cieniawski Grzegorz Wasilewski Marek Kuźniewski Władysław Sułowicz Krystyna Sztefko 《Advances in medical sciences》2018,63(2):367-373
Purpose
Diabetes mellitus and hyperlipidemia are frequently observed after organ transplantation. It is known that in these disorders the fatty acid metabolism is impaired. The aim of this study was to compare the fatty acid profile in the heart and renal transplant recipients who developed metabolic disorders since there is no such research available.Materials and methods
The study included 55 patients treated with tacrolimus (Tac) after heart (n?=?14; mean age: 60.4?±?9.1) or renal (n?=?41; mean age: 51?±?13) transplantation. Diabetes and hyperlipidemia was present in 35.7% and 28.5% of heart transplant recipients, and 19.5% and 41% of renal transplant recipients. Concentrations of fatty acid in phospholipids fraction in serum were measured by gas chromatography.Results
The concentration of C20:5 fatty acid was lower in heart transplant recipients, as compared to renal transplant recipients (p?=?0.001), whereas the level of C20+C18:3 fatty acid and the ratio of n-6/n-3 was higher (p?=?0.01; p?=?0.03, respectively). The observed differences were not related to metabolic disorders. Negative correlation between C16:1 and eGFR was seen in heart transplant recipients (p?=?001). In renal transplant recipients with metabolic disorders, the concentration of C20:5 was correlated positively whereas the n-6/n-3 ratio was correlated negatively with eGFR (p?<?0.001, p?=?0.01, respectively). Hyperlipidemic renal transplant recipients had higher concentration of C20:2 (p?=?0.02), C20:4 (p?=?0.05), n-6 (0.04) and total fatty acid (p?=?0.01) than patients without metabolic disorders.Conclusion
The fatty acid profile differs depending on the transplanted organ, but the differences are not related to the metabolic disorders. The role of fatty acid in kidney function varies between heart transplant recipients and renal transplant recipients and depends on type of fatty acid. 相似文献18.
Xinru Li Jun Pu Jiaxin Liu Yijun Chen Yu Li Peng Hou Bingyin Shi Qi Yang 《Pathology, research and practice》2018,214(7):940-948
Background and aims
The gene of death associated protein kinase 1 (DAPK1) has been reported to be methylated in various cancers including gliomas. However, its prognostic value for gliomas is still controversy, and the methylation at specific CpG sites of DAPK1 has not been investigated. The aim of this study was to prognostically evaluate the methylation level of different CpG sites within DAPK1 promoter region in gliomas.Methods
Based on sodium bisulfite treated DNA products, we made use of DNA pyrosequencing method to evaluate overall and site-specific methylation of DAPK1 in 143 gliomas and 26 benign tumors (meningeomas) or normal brain tissues. We both statistically analyzed the association between methylation levels of each CpG site and the clinicopathological characteristics, and estimated the prognosis predictive value of site-specific methylation for glioma patients.Results
Methylation status of DAPK1 site ?1527, ?1543, and the overall five sites concerned was higher in gliomas than controlled subjects (p?<?0.001). Hypermethylation at site ?1527 or together with site ?1543 associated with better survival in patients taken postoperative therapies (?1527: p?=?0.002; ?1527 & ?1543: p?=?0.023), as well as in patients just underwent radiotherapy after surgery (-1527: p?=?0.015; ?1527 & ?1543: p?=?0.030). However, Cox regression analysis indicated the site-specific methylation was not independent contributor for gliomas prognosis.Conclusion
Analysis of DAPK1 gene promoter by quantitative pyrosequencing provided more detailed information of methylation status of CpG sites. DAPK1 methylation level is associated with gliomas clinical features and outcomes. Interestingly, the hypermethylation at site ?1527 or together with site ?1543 indicated good sensitivity of postoperative therapies, especially radiotherapy. Thus, site specifically analysis of DAPK1 methylation may be a valuable diagnostic and prognostic estimation for gliomas. 相似文献19.
Huabin Luo Shivajirao P. Patil Qiang Wu Ronny A. Bell Doyle M. Cummings Alyssa D. Adams Bertha Hambidge Kay Craven Fei Gao 《Patient education and counseling》2018,101(10):1846-1851