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Primary progressive aphasia (PPA) is a distinct clinical entity in which the patient develops language deficits while other cognitive domains remain relatively preserved until late in the course of the illness. The diagnosis can be relatively clear through an appropriate diagnostic approach based on the history and physical examination. There is no cure, but speech therapy is beneficial in this illness.  相似文献   

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Alzheimer disease follows a pattern of gradual cognitive, behavioral, and functional decline. Other causes of dementia have overlapping presentations, but with important differences. Most patients with mild to moderate dementia should be treated with cholinesterase inhibitors to temporarily stabilize symptoms and delay clinically important end points. Memantine, an N-methyl-D-aspartate antagonist, may soon be available to treat moderate to severe dementia.  相似文献   

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