第1跖骨双截骨联合软组织松解治疗外翻畸形

[目的]讨论第1跖骨截骨联合软组织手术治疗母外翻畸形的手术疗效及其优点。[方法]回顾分析2001年1月~2006年1月本科按本术式治疗母外翻畸形26例病人的临床资料。[结果]本组病人术后未发生严重并发症。外观及功能改善明显。[结论]第1跖骨截骨联合软组织手术治疗母外翻畸形,矫形手术效果较为满意。     

第1跖骨籽骨脱位与(足母)外翻的相关性

[目的]探讨第1跖骨籽骨系统在母外翻发生发展中的作用。[方法]选取正常足100只,母外翻足82只,拍摄负重位足部X线片,测量母外翻角(hallux valgus angle,HVA),第1、2跖骨间角(first interm etatarsal an-gle,IMA),籽骨到第2跖骨轴线的距离,第2跖骨的长度,分析籽骨脱位与母外翻的相关性。[结果]正常足和母外翻足籽骨与第2跖骨轴线的距离与第2跖骨长度的比值分别为0.35±0.02,0.39±0.03(P>0.05),正常足籽骨位置不同分级之间与HVA和IMA无明显相关性,在母外翻足中籽骨脱位与HVA、IMA明显相关。[结论]第1跖骨籽骨系统在母外翻的发生发展中起重要作用,在行母外翻矫正术时应注意籽骨系统的矫正。     

第一跖骨截骨术治疗(足母)外翻

我院自1996～2000年采取第1跖骨截骨术[1]治疗（足母）外翻23例42足,效果满意,现报告如下。1 一般资料本组23例42足,双侧19例,共38足,单例4例4足;其中女性21例（双侧17例,单侧4例）,男性2例均为双侧;年龄25～58岁,平均41.2岁。术前X线片示:（足母）外翻角（HVA）31°～45°,平均38.8°,跖间角（IMA）12°～16.5°,平均14.4°,术前主要症状均为（足母）外翻畸形,（足母）囊炎,穿鞋疼痛,行走困难,但均无骨关节炎。2 治疗方法2.1 截骨方法选择 第1跖骨较其他4根跖骨长者25足,行跖骨颈斜行截骨嵌插术。第1跖骨较其他4根跖骨短或相仿者17足,行路骨基底楔型截骨术。     

改良Wilson氏拇外翻截骨术

Wilson氏(足母)外翻截骨术,由Helal等改良为跖骨干的双斜形截骨术,远端骨片移向跖侧及外侧,以矫正跖骨内翻,防止其向背侧倾斜而致跖骨抬高畸形引起跖间痛。     

改良Austin手术治疗足[][母]外翻34例62足

[目的]探讨改良Austin手术治疗[][母]外翻的手术适应证、手术方法和疗效。[方法]自1998年10月-2006年4月采用改良Austin手术治疗[][母]外翻患者34例62足，男13例22足，女21例40足；年龄32-67岁，平均43岁。术前、术后2周、随访时分别摄负重位x线片，测量[][母]外翻角（HVA）、第1、2跖骨间角（IMA）、近端关节固定角（PASA）、远端关节固定角（DASA），并观察其变化和测量角度数据进行对比分析。手术方法根据患者术前症状和测量角度个体化选择Austin手术改良式即chevron-gerbert或chevron-youngswick截骨术。[结果]全部获得随访，随访时间1-8年，平均3．6年；患者[][母]外翻角（HVA）术前为33.50°±1.02°，术后为13.6°±0.826°；第1、2跖骨间角（IMA）术前为16.0°±0.837°，术后为8.6°±1.078°；根据美国足与踝关节协会AOFAS制定的足[][母]趾功能评分标准评价。AOFAS评分术前为（44．8±5．7）分，术后为（87．6±4．2）分。优46足，良10足，可5足，差1足，优良率90．3％。[结论]改良Austin手术是治疗[][母]外翻畸形的一种操作简单、疗效可靠的手术方法。尤其更适合矫正PASA增大的重度[][母]外翻。对年龄较轻的轻、中度[][母]外翻患者手术应尽量不必干扰[][母]内收肌和籽骨也可达到矫形的目的。     

双侧足母趾籽骨对足母趾外翻矫正手术效果的影响研究

目的 探讨足母趾胫侧籽骨及腓侧籽骨对足母趾外翻矫正手术效果的影响。方法 回顾性分析2010年1月至2013年12月来我院接受近端或远端Chevron截骨矫正治疗的110例足母趾外翻病人。根据病人有无双侧足母趾籽骨分为双侧足母趾籽骨组（30例）和非双侧足母趾籽骨组（80例）。其中,双侧足母趾籽骨组行跖骨近端Chevron截骨矫正治疗4例,跖骨远端Chevron截骨矫正治疗26例;非双侧足母趾籽骨组行跖骨近端Chevron截骨矫正治疗15例,跖骨远端Chevron截骨矫正治疗65例。记录并比较两组病人术前一般资料,手术前后影像学资料测量足母趾外翻角、跖骨间夹角、跖骨远端关节面固有角,比较其手术前后及组间的美国足踝外科医师协会（American Orthopaedic Foot and Ankle Society, AOFAS）踝与后足功能评分。结果 两组病人术后足母趾外翻情况均明显改善。两组病人术后的足母趾外翻角、跖骨间夹角、跖骨远端关节面固有角及AOFAS评分均较术前明显改善;但上述指标组间比较,差异均无统计学意义（P＞0.05）。结论 双侧足母趾籽骨对近端或远端Chevron截骨矫形治疗足母趾外翻畸形手术无明显影响。     

第1跖骨基底斜行闭合截骨治疗中重度(足母)外翻畸形

[目的] 回顾性研究第1跖骨基底长斜行闭合截骨治疗足母外翻的临床效果.[方法]2007年2月～2008年11月间行第1跖骨基底长斜形截骨结合远端软组织松解内侧关节囊重叠缝合治疗<足母>外翻共21例24足,均属中重度足母外翻,第1、2跖间角均大于15°,行第1跖骨基底斜行闭合截骨螺钉内固定术.[结果]平均随访7.6个月,术前平均HVA、IM 1-2角分别为31.30°±6.68°和16.62°±2.65°,术后平均HVA、IM 1-2角分别为12.96°±7.15°和9.80°±2.43°,平均矫正HAV角19.6°、IM角8.2°,术前、术后平均有明显统计学差异(P<0.001),第1跖骨长度与第2跖骨长度比术前、术后分别为(89±6.7)%、(84±5.6)%,有明显统计学差异(P<0.05).[结论] 第1跖骨基底长斜形闭合截骨手术方法治疗中重度<足母>外翻畸形可以取得比较好的矫正结果.     

改良Wilson截骨术治疗(足母)外翻

[目的]探讨微创改良Wilson截骨术治疗(足母)外翻畸形的方法及疗效.[方法]自2002年以来运用进口微创动力设备及器械,施行微创改良Wilson截骨术83例,153足,其与传统手术不同点为手术在0.5 cm切口下操作;截骨部位于跖骨颈部,截骨线与跖骨纵轴垂线的夹角为15～25°,超薄锯片厚0.36 mm,术后不用石膏外固定.[结果]随访69例,126足,随访6～31个月,平均19个月,优良率98.4%,外翻角(HVA)和第1、2跖骨间夹角(IMA)较手术前分别平均减少17.3°和4.8°.[结论]微创改良Wilson手术方法简单,创伤小,愈合快,早期活动功能恢复早,适用于中度(足母)外翻.HVA＜40°,IMA＜16°者选择此手术为最佳.     

McBride手术联合第1、2跖骨近端截骨治疗拇外翻

目的探讨McBride手术联合第1、2跖骨近端截骨治疗拇外翻的疗效。方法在McBride手术基础上,行第1跖骨近端的楔形外翻截骨和第2跖骨近端截骨,第1跖骨截骨处行微型钢板内固定,第2跖骨截骨处不做固定。术后石膏固定4周后即开始逐渐负重功能锻炼。结果26例均获随访,时间12～48个月。40足中优28足,良10足,差2足,优良率95%。与术前比较,拇外翻角平均矫正16.3&#176;&#177;2.2&#176;,第1、2跖骨间夹角平均矫正4.2&#176;&#177;1.8&#176;。无截骨处愈合不良、拇内翻、感染。结论McBride手术重建了足拇指的软组织力量平衡,第1、2跖骨截骨改善了第1跖骨的正常负重、缓解了第2跖骨头的压力,恢复足横弓,是治疗拇外翻的较好术式。     

第一跖骨近端截骨并软组织手术治疗重度[足母]外翻

目的探讨第一跖骨近端楔形截骨结合软组织手术治疗重度[足母]外翻的疗效。方法自2004年至2008年采用第一跖骨近端楔形截骨结合跖趾关节处的远端软组织手术,治疗重度[足母]外翻46例81足。结果参照美国足踝外科学会Maryland评分系统,本组患者随访1～4年,优61足,良16足,可4足,优良率95．10o,平均HVA矫正28°,平均IMA矫正11°。结论第一跖骨近端楔形截骨结合软组织手术治疗重度脾外[足母]畸形,可得到极好矫正,不易复发,手术效果确实可靠,并发症少。     

Vasopressor hormone response following mesenteric traction during major abdominal surgery

Background : We investigated the vasopressor hormone response following mesenteric traction (MT) with hypotension due to prostacyclin (PGI₂) release in patients undergoing abdominal surgery with a combined general and epidural anesthesia. Methods : In a prospective, randomized, placebo-controlled study we administered 400 mg ibuprofen (i.v.) in 42 patients scheduled for abdominal surgery. General anesthesia was combined with epidural anesthesia (T4-L1). Before as well as 5, 15, 30, 45, and 90 min after MT we recorded plasma osmolality, hemodynamics and measured 6-keto-PGFlα (stabile metabolite of PGI₂), TXB₂ (stabile metabolite of thromboxane A₂) active renin, and arginine vasopressin (AVP) plasma concentrations by radioimmunoassay. Catecholamine levels were assessed by high-pressure liquid chromatography (HPLC) with electrochemical detection. Results : Following MT, arterial hypotension occurred along with a substantial PGI₂ release. This was completely abolished by ibuprofen administration. Although plasma levels of 6-keto-PGF_1α (1133 (708) vs. 60 (3) ng/L, median (median absolute deviation), P=0.0001, placebo vs. ibuprofen) remained significantly elevated, blood pressure was restored within 30 min after MT in the placebo group. At the same point in time plasma concentrations of TXB² (164 (87) vs. 58 (1) ng/L, P=0.0001), epinephrine (46 (33) vs. 14 (6) ng/L, P=0.001), AVP (41 ± (18) vs. 12 (7) ng/L, P=0.0004), and active renin (27 (12) vs. 12 (4) ng/L, P = 0.001) were significantly higher in placebo-treated patients. Conclusion : Under combined general and epidural anesthesia arterial hypotension following MT due to endogenous PGI₂ release is associated with enhanced release of AVP, active renin, epinephrine and thromboxane A₂, presumably contributing to hemodynamic stability within 30 min after MT.     

A Teaspoon Pump for Pumping Blood with High Hydraulic Efficiency and Low Hemolysis Potential

Abstract: Virtually all blood pumps contain some kind of rubbing, sliding, closely moving machinery surfaces that are exposed to the blood being pumped. These valves, internal bearings, magnetic bearing position sensors, and shaft seals cause most of the problems with blood pumps. The original teaspoon pump design prevented the rubbing, sliding machinery surfaces from contacting the blood. However, the hydraulic efficiency was low because the blood was able to "slip around" the rotating impeller so that the blood itself never rotated fast enough to develop adequate pressure. An improved teaspoon blood pump has been designed and tested and has shown acceptable hydraulic performance and low hemolysis potential. The new pump uses a nonrotating "swinging" hose as the pump impeller. The fluid enters the pump through the center of the swinging hose; therefore, there can be no fluid slip between the revolving blood and the revolving impeller. The new pump uses an impeller that is comparable to a flexible garden hose. If the free end of the hose were swung around in a circle like half of a jump rope, the fluid inside the hose would rotate and develop pressure even though the hose impeller itself did not "rotate"; therefore, no rotating shaft seal or internal bearings are required.     

A comparison of the inhibitory effects of four volatile anaesthetics on the metabolism of chlorzoxazone, a substrate for CYP2E1, in rabbits

Background: Halothane inhibits in vitro and in vivo activity of cytochrome P-450 (CYP) 2E1. There are several fluorinated volatile anaesthetics besides halothane, and most of them are defluorinated by CYP2E1. It is unclear whether other fluorinated anaesthetics inhibit the in vivo activity of CYP2E1.
Methods: We compared the inhibitory effects of therapeutic concentrations of four inhalational anaesthetics, halothane, enflurane, isoflurane, and sevoflurane, on chlorzoxazone metabolism in rabbits receiving artificial ventilation.
Results: All four inhalational anaesthetics decreased arterial blood pressure and increased plasma chlorzoxazone concentration. However, no significant differences in the plasma chlorzoxazone concentration were found between the four anaesthetics. The estimated chlorzoxazone clearance increased after beginning inhalation with all four agents, but no significant difference in clearance was noted between agents.
Conclusions: At therapeutic concentrations, the in vivo inhibitory effect on chlorzoxazone metabolism was similar for all four inhalational anaesthetics examined, even though their chemical characteristics and extent of hepatic metabolism differ considerably.     

Microspheres Based Detoxification System: A New Method in Convective Blood Purification

Abstract: A variety of protein-bound or hydrophobic substances, accumulating as a result of pathologic conditions such as exogenous or endogenous intoxications, are removed poorly by conventional detoxification methods because of low accessibility (hemodialysis), insufficient adsorption capabilities (hemosorption), low efficiency (peritoneal dialysis), or economic limitations (high-volume plasmapheresis). Combining advantages of existing methods with microspheric technology, a module-based system was designed. Major operating parameters of the latter can be modified to allow for adjustment to individual clinical situations. An extracorporeal blood circuit including a plasmafilter is combined with a secondary high-velocity plasma circuit driven by a centrifugal pump. Different microspheric adsorbers can be combined in one circuit or applied in sequence. Thus, a prolonged treatment can be tailored using specially designed selective adsorber materials. Comparing this system with existing methods (high-flux hemodialysis, molecular adsorbent recycling system), results from our in vitro studies and animal experiments demonstrate the superior efficiency of substance removal.     

Tissue perfusion in relation to cardiac output during continuous positive-pressure ventilation and administration of propranolol or verapamil

Background : Our objective was to determine whether administration of propranolol or verapamil modifies the hemodynamic adaptation to continuous positive-pressure ventilation (CPPV), in particular the regional distribution of cardiac output (CO).
Methods : General hemodynamics and regional blood flows assessed by microsphere technique (15 (μm) were recorded in 16 anesthetized pigs during spontaneous breathing (SB) and CPPV with 8 cm H₂O end-expiratory pressure (CPPV8) before and after intravenous administration of propranolol (0.3 mg · kg⁻¹ followed by 0.15 mg · kg⁻¹ · h⁻¹, n=8) or verapamil (0.1 mg · kg⁻¹ followed by 0.3 mg · kg⁻¹ · h⁻¹, n=8).
Results : CPPV8 depressed CO by 25% without shifts in its relative distribution with the exception of a noteworthy increase in adrenal perfusion. Propranolol increased arterial blood pressure, and due to a fall in heart rate, CO dropped by 25%. The kidneys and, to a lesser extent, the splanchic region and central nervous system received increased fractions of the remaining CO at the expense of skeletal muscle flow. Similar patterns were seen during SB and CPPV8 such that the combination of propranolol and CPPV8 depressed CO by 50%. The circulatory effects of verapamil were less evident but myocardial perfusion tended to increase.
Conclusions : The combination of propranolol or verapamil with CPPV does not result in any specific hemodynamic interaction in anesthetized pigs, except that the combined effect of propranolol and CPPV may severely reduce CO.     

Bariatric Surgery in Some "Central and East-European (former Eastern bloc)"Countries - Current Status and Prediction for the Next Millennium

Background: Obesity is increasing globallly, including in the formerly "Eastern Bloc" countries. Methods: A survey was made of obesity and bariatric surgery. Results: In the 8 East and Central European countries studied, with total population 300 million, roughly 43% of the population was overweight (BMI 25-30), 23% obese (BMI > 30), with about 15 million people morbidly obese (BMI > 40). From 0-10 morbidly obese individuals/100,000/year undergo bariatric surgery. Conclusion: Most countries were found to provide inadequate treatment for obesity.The majority of the morbidly obese are not treated effectively. However, health-care awareness of obesity and bariatric surgeons are slowly increasing.     

Volatile anaesthetics reduce adhesion of blood platelets under low-flow conditions in the coronary system of isolated guinea pig hearts

Background : Inhibitory effects of volatile anaesthetics on platelet aggregation have been demonstrated in several studies. However, the influence of volatile anaesthetics on intracoronary platelet adhesion has not been elucidated so far.
Methods : Isolated hearts of guinea pigs were perfused with buffer in the absence or presence of volatile anaesthetics (0.5 and 1 MAC) at constant coronary flow rates of 5 ml/min for 25 min, then 1 ml/min for 30 min and again 5 ml/min for 10 min. Before, during and after low-flow perfusion, a bolus of human platelets was applied into the coronary system. To simulate thrombogenic conditions, 0.3 U/ml human thrombin was infused during low-flow perfusion and reperfusion. The number of platelets sequestered to the endothelium was calculated from the difference between coronary in- and output of platelets. The myocardial production of lactate and consumption of pyruvate and coronary perfusion pressure were also determined.
Results : At a flow rate of 5 ml/min only about 3% of the applied platelets did not emerge from the coronary system, in any group. In contrast, 13.1±1.2% (mean±SEM) of infused platelets became adherent in low-flow perfusion in the control group without anaesthetic. The adherence was reduced with each 1 MAC isoflurane (to 6.2±1.2%), sevoflurane (to 4.4±0.9%) or halothane (to 3.2±1.5%) (each P <0.05 vs. control). Volatile anaesthetic, 0.5 MAC, did not inhibit platelet adhesion to a statistically significant extent in any case. Perfusion pressure and metabolic parameters were not statistically different between the control and the hearts exposed to anaesthetics.
Conclusion : Volatile anaesthetics in a concentration of 1 MAC can reduce the adhesion of platelets in the coronary system under reduced flow conditions. This action does not arise from vasodilation or inhibition of ischaemic stress.     

Synergistic interaction between the effects of propofol and midazolam with fentanyl on phrenic nerve activity in rabbits

Background: It has been shown that the depressive effects of both propofol and midazolam on consciousness are synergistic with opioids, but the nature of their interactions on other physiological systems, e. g. respiration, has not been fully investigated. The present study examined the effect of propofol and midazolam alone and in combination with fentanyl on phrenic nerve activity (PNA) and whether such interactions are additive or synergistic. Methods: PNA was recorded in 27 anaesthetised and artificially ventilated rabbits. In three groups, propofol, fentanyl and midazolam were administered intravenously in incremental doses to construct dose-response curves for the depressant effects of each one on PNA. In another two groups, the effect of pretreatment with either fentanyl 1 μg · kg^?1 i. v. or midazolam 0.05 mg · kg^?1 i. v. on the effects of propofol and fentanyl respectively on PNA were studied. Results: Propofol and fentanyl caused a dose-dependent depression of PNA with complete abolition at the highest total doses of 16 mg · kg^?1 i. v. and 32 μg · kg^?1 i. v., respectively. In contrast, midazolam in incremental doses to a total of 0.8 mg · kg^?1 reduced mean PNA by 63%, but approximately 12% of PNA remained at a total dose as high as 6.4 mg · kg^?1. The mean ED₅₀s, calculated from dose-response curves, were 5.4 mg · kg^?1, 3.9 μg · kg^?1 and 0.4 mg · kg^?1 for propofol, fentanyl and midazolam, respectively. Initial doses of either fentanyl 1 μg · kg^?1 i. v. or midazolam 0.05 mg · kg^?1 i. v. acted synergistically with subsequent doses of either propofol or fentanyl to abolish PNA at total doses of 8 mg · kg^?1 and 8 μg · kg^?1, respectively. Conclusion: Fentanyl has a synergistic interaction with both propofol and midazolam on PNA and hence potentially on respiration.     

Influence of dopexamine hydrochloride on haemodynamics and regulators of circulation in patients undergoing major abdominal surgery

Background: Catecholaminergic support is often used to improve haemodynamics in patients undergoing major abdominal surgery. Dopexamine is a synthetic vasoactive catecholamine with beneficial microcirculatory properties. Methods: The influence of perioperative administration of dopexamine on cardiorespiratory data and important regulators of macro- and microcirculation were studied in 30 patients undergoing Whipple pancreaticduodenectomy. The patients received randomized and blinded either 2 μg · kg^?1 · min^?1 of dopexamine (n=15) or placebo (n=15, control group). The infusion was started after induction of anaesthesia and continued until the morning of the first postoperative day. Endothelin-1 (ET-1), vasopressin, atrial natriuretic peptide (ANP), and catecholamine plasma levels were measured from arterial blood samples. Measurements were carried out after induction of anaesthesia, 2 h after onset of surgery, at the end of surgery, 2 h after surgery, and on the morning of the first postoperative day. Results: Cardiac index (CI) increased significantly in the dopexamine group (from 2.61±0.41 to 4.57±0.78 1 · min^?1 · m^?2) and remained elevated until the morning of the first postoperative day. Oxygen delivery index (DO₂I) and oxygen consumption index (VO₂I) were also significantly increased in the dopexamine group (DO₂I: from 416±91 to 717±110 ml/m² · m²; VO₂I: from 98±25 to 157±22 ml/m² · m²), being significantly higher than in the control group. pHi remained stable only in the dopexamine patients, indicating adequate splanchnic perfusion. Vasopressive regulators of circulation increased significantly only in the untreated control patients (vasopressin: from 4.37±1.1 to 35.9±12.1 pg/ml; ET-1: from 2.88±0.91 to 6.91±1.20 pg/ml). Conclusion: Patients undergoing major abdominal surgery may profit from prophylactic perioperative administration of dopexamine hydrochloride in the form of improved haemodynamics and oxygenation as well as beneficial influence on important regulators of organ blood flow.     

Systemic analgesia adapted to the children's condition

A concept of balanced analgesia using nonsteroidal anti-inflammatory drugs (NSAIDs), paracetamol (acetaminophen), opioids, and corticosteroids can also be used in patients with pre-existing illnesses. NSAIDs are the most effective treatment for acute pain of moderate intensity in children; however, these drugs should be avoided in patients at increased risk for serious side effects, e.g. patients with renal impairment, bleeding tendency, or extreme prematurity. NSAIDs can be given with minimal risks to the younger child with mild to moderate asthma, and, in these patients, the use of steroids can be encouraged; in addition to their antiemetic and analgesic action, a beneficial effect on asthma symptoms can be expected. In the non-intubated child with cerebral trauma, exaggerated sedation caused by opioids and increased bleeding tendency caused by NSAIDs must be avoided. In neonates and small infants, the oral administration of sucrose or glucose is helpful to minimize pain reaction during short uncomfortable interventions.