共查询到17条相似文献,搜索用时 62 毫秒
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用抗早孕实验和大鼠子宫离体实验,研究了醋酸棉酚与米索前列醇抗早孕的协同作用。结果表明,早孕小鼠单服米索,其终止早孕作用微弱;当与棉酚合用时,对小鼠的抗早孕作用增强。对离体大鼠子宫,米索有明显的增强宫缩作用,而棉酚则无影响,但早孕大鼠po棉酚80mg·kg-1·d-1,3d后其子宫对米索的敏感性较对照组有显著提高。大鼠于妊娠d 6~8 po棉酚或米索,或两药剂量的一半合并用药,可使子宫蜕膜组织损伤,而以两药合用组最为严重,但子宫孕酮受体含量和分布与对照组相似。结果提示,两药合用有协同抗早孕作用。 相似文献
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醋酸棉酚对雌性大鼠的抗早孕作用 总被引:4,自引:0,他引:4
大鼠于妊娠第6~9天,喂以醋酸棉酚80 mg/kg/d, 有明显的抗早孕作用。皮下注射孕酮5 mg/d或hCG 25 IU/d可拮抗醋酸棉酚的抗早孕作用。醋酸棉酚80 mg/kg/d对去卵巢后给以外源性雌酮和孕酮以维持妊娠的大鼠无抗早孕作用。正常妊娠大鼠,给醋酸棉酚后,血清孕酮水平下降,妊娠中止,若同时注射hCG,孕酮水平回升接近对照动物的水平,药物抗早孕作用消失,但仍低于单给hCG组大鼠血清孕酮水平,说明醋酸棉酚可阻断hCG促黄体分泌孕酮的作用,这可能是醋酸棉酚抗早孕作用的主要机理之一。 相似文献
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本文观察了醋酸棉酚对大鼠孕卵在输卵管内转运和早期发育的影响。结果表明,棉酚可延缓孕卵转运速度、阻滞和破坏胚胎早期发育,以对后者的作用更为显著。这可能是棉酚对雌性大鼠抗着床作用的重要原因之一。 相似文献
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本文观察了醋酸棉酚对大鼠孕卵在输卵管内转运和早期发育的影响。结果表明,棉酚可延缓孕卵转运速度、阻滞和破坏胚胎早期发育,以对后者的作用更为显著。这可能是棉酚对雌性大鼠抗着床作用的重要原因之一。 相似文献
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观察了醋酸棉酚水溶性制剂对离体大鼠输卵管平滑肌收缩活动的影响并对其作用机制作了初步探讨。结果表明,醋酸棉酚可提高大鼠输卵管平滑肌收缩张力,但并非为激动α兴奋性肾上腺素能受体,而与促输卵管组织前列腺素(PGs)的生物合成、释放并与促Ca2+内流机制有关。棉酚的这种药理作用还与性周期有密切关系,对动情期输卵管的作用明显高于间情期。结果还表明,前列腺索E1(PGE1)和前列腺素E2(PGE2)均可提高大鼠输卵管平滑肌收缩活性,以PGE1的作用较强且较持久,此作用可为醋酸棉酚所明显增强。 相似文献
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(+),(-)和(±)棉酚在雌大鼠抗早孕作用的研究 总被引:1,自引:0,他引:1
妊娠第6~9天大鼠,分别ig(±)和(-)棉酚80mg·kg-1·d-1和40mg·kg-1·d-1,结果有明显的抗早孕作用。然而(+)棉酚40mg·kg-1·d-1对大鼠生育无明显影响。(-)棉酚30μg·ml-1能抑制体外培养黄体细胞孕酮的分泌。(+)棉酚10μg·ml-1能促进黄体细胞分泌孕酮。hCG1IU·ml-1能明显刺激体外培养颗粒细胞孕酮的分泌。(±)棉酚10和30μg·ml-1皆能明显降低颗粒细胞对hCG的反应性。 相似文献
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醋酸棉酚有抗雄性生育作用,但对睾丸间质细胞的作用尚未取得一致意见。部分研究者观察到醋酸棉酚对睾丸间质细胞有抑制作用。本室也曾证明,服醋酸棉酚后,青春前期大鼠,睾丸间质细胞的生长发育及其类固醇激素合成酶的活性均受抑制。已有报告,睾丸间质细胞表面具有分子量为20万的LH/hCG受体,该受体的数量及活性决定了间质细胞睾酮分泌活性及对促激素的反应。此受体在大鼠五周龄前逐步发育完善,而在4周龄时已表现出对外源性LH/hCG敏感的反应性。本实验以幼龄大鼠为对象,用放射免疫测定及放射受体分析法研究了醋酸棉酚对睾丸间质细胞的影响。 相似文献
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醋酸棉酚对子宫和卵巢的影响 总被引:2,自引:0,他引:2
Gossypol has been employed in gynecologic clinics for the treatment of endometriosis and functional uterine bleedings with encouraging results. In the present communication the effects of gossypol on the uterus and ovary were studied both experimentally and clinically by histologic and histochemical techniques. It was found that treatment of female rats with gossypol acetic acid at 30 mg/kg/d, six days a week, for 8 weeks caused marked atrophy of the endometrium and a reduction of the glycogen content of the myometrium. Vaginal smears showed a picture of atypical estrous cycle. Simultaneous administration of 1 mg/kg/d of estriol reduced the effect of gossypol acetic acid though the influence of gossypol treatment was still discernible. Treatment of 16 patients suffering from endometriosis or functional uterine bleeding with gossypol acetic acid for 2-3 months induced changes similar to those observed in animal experiments, namely, atrophy of the endometrium and decrease in endometrium glycogen. In 3 other patients treated with gossypol acetic acid for 4~5 months there was a slight increase in Sudan Black B staining and a decrease in alkaline phosphatase, acid phosphatase, PAS staining and RNA of the endometrium. There was also a change of biphasic basal body temperature into monophasic and a lowered estrogen level as revealed by vaginal cytology.One may speculate from the above results that gossypol may act on the uterus directly as well as indirectly through inhibition of the secretory function of the ovary and/or through antagonism against the effect of estrogens in the female. Hence, it may be desirable to conduct further studies on the effect of gossypol on the pituitary-gonadal axis. 相似文献
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醋酸棉酚对子宫和卵巢的影响 总被引:2,自引:0,他引:2
本文用组织学和组织化学的方法,观察了经醋酸棉酚治疗后雌性大鼠子宫内膜和卵巢的变化,同时也研究了某些妇科病人棉酚治疗后子宫内膜的改变。 相似文献
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盐酸苯乙哌啶(R1132)10μg/ml或dl-15甲基PGF2α甲酯(PG05)5或10μg/ml在体外能明显抑制黄体细胞对hCG的反应性,使孕酮分泌下降。假孕大鼠po R1132 10 mg/kg或Sc PG 05 5.1 mg/kg不影响卵巢孕酮分泌,合并给药后却能使其降低。R1132无抗孕酮作用。卵巢分泌孕酮减少可能是抗早孕的主要原因.假孕大鼠po R1132 50 mg/kg或sc PG050.5 mg/kg可抑制卵巢腺苷环化酶的活性.该酶可能是R1132或PG05在大鼠抗早孕作用的重要靶酶。 相似文献
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Racemic, (-) and (+) gossypol, provided by the Department of Organic Chemistry of our institute, was suspended in 2.5% tween 80 solution. Adult male Wistar rats 190~220 g in weight were allotted to 5 groups. Animals in group 1 received 2.5% tween 80 solution as control. Rats in group 2 were treated with racemic gossypol at the dosage of 30 mg/kg for 2 weeks. Animals in group 3 and 4 were given 15 mg/kg of (-) gossypol for 2 weeks and 30 mg/kg of (-) gossypol for 1 week respectively. Rats in group 5 were treated with (+) gossypol at the dosage of 30 mg/kg for 2 weeks.Four weeks from the beginning of gossypol treatment the rats were cohabited with adult females for 7 days. Then the motility of the sperms in the cauda epididymides was estimated The female rats were examined for pregnancy 7 days later.Treatment with (-) gossypol at 30 mg/kg caused significant decreases in body weight of the rats (P<0.05). One of the five rats died 7 days after the last administration, while (+) gossypol and racemic gossypol at the dosage employed had no effect on the body weight. (+) Gossypol at 30 mg/kg for 2 weeks had no effect on the motility of the sperms in the cauda epididymides and no effect on the fertility of the animals: nor was there any effect on the weights of the testis, epididymis, prostate and seminal vesicle. The sperms of the cauda epididymides were found to be dead in the groups treated with 15 and 30 mg/kg of (-)gossypol. Raccmic gossypol given for 2 weeks at 30 mg/kg caused loss of fertility of the male rats which confirmed our previous findings.(?)t may be postulated that (+) gossypol has no antifertility effect nor toxicity at the dosage employed. (-) Gossypol is the active stereoisomer of racemic gossypol. 相似文献