New antitoagulants

In contrast to older anticoagulant agents vitamin K antagonists and heparins, the new ones are directed towards a single target in general. The main characteristics of the new agents are: their site of action in the coagulation cascade and their mechanism of action which is indirect, antithrombin dependent, most often such as Fondaparinux and Idraparinux or direct such as Dabigatran, Rivaroxaban; the specificity of the new molecules, since they must not interact with other enzymes: trypsin, kallikrein, t-PA, etc...; their mode of administration parenteral and/or oral; their pharmacokinetics and their clearance frequently by the kidney (Hirudin, fondaparinux) or through hepatic metabolism (argatroban); tolerance including for all compounds the bleeding risk or an unexpected hepatic intolerance for Ximelagatran; the availability of a specific antidote and the cost of the drug; one compound is registered in France Arixtra Fondaparinux in major orthopedic surgery and in the treatment of venous thromboembolism and in prophylactic treatment in medical patients. However, the main indications of interest for these new drugs is atrial fibrillation. There is a real need in this indication and the number of patients to treat is growing with the longer life expectancy.     

畅销书摘

父母的生活习惯、意识及观念能影响孩子的一生。父母掌握的正确健康知识越多,孩子的健康就越有保证。这个世界上好像每个人都是养育孩子的专家。家长们几乎都有这样一个很头疼的问题,在养育孩子方面到底该听谁的。于是,面对铺天盖地的儿童健康书籍,他们很难分辨出哪些是适合自己孩子健康成长的科学养育办法。美国健康教育专家     

书讯

《女性生理健康忠告》;《女人健康锦囊》;《女性私密保健指导》;《走出误区健康快乐每一天》;《女性特征器官保健指南》;     

畅销书摘

定价$25元《一生健康》作者:[美]雷·斯丹译者:王宇、郑蕊、赖伟雄出版日期:2010年1月出版社:中国青年出版社本书中,雷·斯丹博士列举出了最前沿的医学证据,助你拥有一个健康的体魄。这些健康生活方式不仅可以降低体重,同时也能够降低血压、胆固醇水平以及心脏病和糖尿病的发病风险。