Effect of Sandblasting on Static and Fatigue Strength of Flash Butt Welded 75Cr4 Bandsaw Blades

The aim of the research presented in this article is analysis of the effect of the surface treatment method on the static and fatigue strength of flash butt welded bandsaw blades. A 1-mm-thick 75Cr1 cold-work tool steel sheet used for bandsaw blades was used as the test material. Fractographic studies of the fatigue fractures and fractures formed in static tests were also carried out. The static strength tests showed sandblasting the weld surface had no significant effect on the load capacity of the joint. However, the sandblasted specimens showed a higher repeatability of the load capacity (lower standard deviation). In the case of both analyzed sample variants of specimens, sandblasted and non-sandblasted, the number of cycles at which the sample was damaged decreases with the percentage increase of the stress amplitude. When loading the samples with a stress amplitude value in the range between 400 and 690 MPa, sandblasting of the weld surface increased the average value of destructive cycles by about 10–86% (depending on the stress amplitude) compared to non-sandblasted joints. The sandblasting process introduces compressive stresses in the surface layer of the welds, therefore the variable tensile load acting on the sample requires a greater number of cycles before the fatigue cracks initiate and propagate. In the case of all specimens, a ductile fracture was observed. It was also found that, regardless of the variable stress amplitude, sandblasting has a positive effect on reducing the standard deviation of fatigue test results.     

Short report: Quantification of Plasmodium falciparum gametocytes by magnetic fractionation

A method of gametocyte quantitation in human blood was developed based on magnetic fractionation using commercially available magnetic fractionation columns (MFCs) and exploiting the magnetic susceptibility of mature Plasmodium falciparum gametocytes. The technique uses magnetic microspheres as a calibration standard. Microspheres are added to each blood sample to a known concentration. When exposed to a magnetic field, gametocytes and magnetic microspheres are preferentially captured inside MFCs. After removal of the magnetizing field, the magnetically captured material can be eluted, placed on a microscope slide that is stained, and counted by using conventional methods. The limits of quantitation for P. falciparum gametocytes were determined from serial dilutions of blood samples with known gametocyte density. The upper limit was 1,000 gametocytes/μL. Quantitative analysis above this threshold is difficult because of an over-abundance of gametocytes. The lower limit was 0.1 gametocytes/μL, and there is a significant probability of a false-negative result below this level.     

Amorphous FeCoCrSiB Ribbons with Tailored Anisotropy for the Development of Magnetic Elements for High Frequency Applications

The ferromagnetic resonance (FMR) in the frequency range of 0.5 to 12.5 GHz has been investigated as a function of external magnetic field for rapidly quenched Fe₃Co₆₇Cr₃Si₁₅B₁₂ amorphous ribbons with different features of the effective magnetic anisotropy. Three states of the ribbons were considered: as-quenched without any treatment; after relaxation annealing without stress at the temperature of 350 °C during 1 h; and after annealing under specific stress of 230 MPa at the temperature of 350 °C during 1 h. For FMR measurements, we adapted a technique previously proposed and tested for the case of microwires. Here, amorphous ribbons were studied using the sample holder based on a commercial SMA connector. On the basis of the measurements of the reflection coefficient S_11, the total impedance including its real and imaginary components was determined to be in the frequency range of 0.5 to 12.5 GHz. In order to confirm the validity of the proposed technique, FMR was also measured by the certified cavity perturbation technique using a commercial Bruker spectrometer operating at X-band frequency of 9.39 GHz. As part of the characterization of the ribbons used for microwave measurements, comparative analysis was performed of X-ray diffraction, optical microscopy, transmission electron microscopy, inductive magnetic hysteresis loops, vibrating sample magnetometry, magneto-optical Kerr effect (including magnetic domains) and magnetoimpedance data for of all samples.     

The Behavior of Polyurethane Foam-Filled Glass-Fiber-Reinforced Polymer Crossarm Subjected to Lightning Transient Voltage

The demand for composite materials in high-voltage electrical insulation is escalating over the last decades. In the power system, the composite glass-fiber-reinforced polymer has been used as an alternative to wood and steel crossarm structures due to its superior properties. As a composite, the material is susceptible to multi-aging factors, one of which is the electrical stress caused by continuous and temporary overvoltage. In order to achieve a better insulation performance and higher life expectancy, the distribution of the stresses should firstly be studied and understood. This paper focuses on the simulation work to better understand the stress distribution of the polyurethane foam-filled glass-fiber-reinforced polymer crossarm due to the lightning transient injection. A finite-element-based simulation was carried out to investigate the behavior of the electric field and voltage distribution across the sample using an Ansys Maxwell 3D. Electrical stresses at both outer and inner surfaces of the crossarm during the peak of lightning were analyzed. Analyses on the electric field and potential distribution were performed at different parts of the crossarm and correlated to the physical characteristics and common discharge location observed during the experiment. The results of the electric field on the crossarm indicate that both the outer and internal parts of the crossarm were prone to high field stress.     

The Corticotropin Releasing Factor Receptor 1 in Alcohol Use Disorder: Still a Valid Drug Target?

Corticotropin releasing factor (CRF) is a neuropeptide that plays a key role in behavioral and physiological responses to stress. A large body of animal literature implicates CRF acting at type 1 CRF receptors (CRFR1) in consumption by alcohol‐dependent subjects, stress‐induced reinstatement of alcohol seeking, and possibly binge alcohol consumption. These studies have encouraged recent pilot studies of CRFR1 antagonists in humans with alcohol use disorder (AUD). It was a great disappointment to many in the field that these studies failed to show an effect of these compounds on stress‐induced alcohol craving. Here, we examine these studies to explore potential limitations and discuss preclinical and human literature to ask whether CRFR1 is still a valid drug target to pursue for the treatment of AUD.     

Study on Cracking Law of Earthen Soil under Dry Shrinkage Condition

Earthen sites are easily eroded by the natural environment, resulting in a large number of micro cracks on the surface. In order to explore the internal relationship between environmental factors and the cracking law of soil sites, this paper carries out dry shrinkage tests of different soil layers at the Zhouqiao site, reconstructs the study on cracking law of earthen soil under dry shrinkage-conditioned microstructure of site soil at different depths based on electron microscope pictures and finite element method, and explores the influence of different moisture content on the cracking of soil samples at the site. The results show that under conditions of dry shrinkage, the thickness of the soil layer has the greatest influence on the cracking of site soil samples. Due to the internal water loss and shrinkage of the soil sample, the thinner the soil layer, the more often the soil layer cracks first. The crack rate of the soil sample with a thickness of 1 cm is nearly three times higher than that of the soil sample with a thickness of 5 cm. Through numerical simulation analysis, it is found that the evolution process of soil fractures at the Zhouqiao site is mainly divided into the formation stages of initial stress field, single main fracture, secondary fracture and fracture network. The formation time of the secondary fracture is longer than that of the initial stress field and single main fracture, and the cracking of the upper soil sample is more serious than that of the lower soil sample. Under conditions of dry shrinkage, the particle arrangement of the soil sample is relatively loose, and there are many cracks inside, which provides evaporation and infiltration channels for water, forming unrecoverable weak pores, and finally, the cracks start to sprout at the weak points. The research results provide some reference for the disease mechanism and safety analysis of earthen sites.     

Within- and between-person variability of exhaled breath condensate pH and NH4+ in never and current smokers

Recent studies have suggested that the collection of exhaled breath condensate (EBC) may be a viable method in occupational field studies to sample secretions of the lower airway because it is simple to perform and non-invasive. However, there are unresolved questions about whether certain laboratory conditions may influence the analysis of EBC biomarker measurements. A total of 12 subjects performed 116 EBC tests. The effect of short and long-term sample storage and sample volume on two biomarkers of acid stress, pH and NH4+, in EBC were investigated and did not significantly influence either marker measurement after argon deaeration. We also investigated the variability and the effect of smoking on the biomarkers by collecting six samples each from five adult never smokers and five adult current smokers over a period of 1 month (n=60 total). For pH, the within-person and between-person variability was larger in current smokers compared to never smokers. Similar results were found for NH4+. Cigarette packs smoked per day now was also associated with both pH (p=0.01) and NH4+ (p=0.04) using mixed effects regression analysis. The variability and smoking results suggest that repeated measurements of EBC pH and NH4+ from the same individual may accurately predict the biological state of the airways of current smokers when compared to never smokers.     

Influence of Magnetic Field on Sound Transmission Loss of the Unit Filled with Magnetorheological Fluid

To explore the feasibility of applying magnetorheological fluids (MRFs) in the field of noise control, the influence of the magnetic field intensity and direction on the sound transmission loss (STL) of a unit filled with MRF (MRF unit) were investigated in this study. First, two types of test sample containing the MRF unit were designed and fabricated. The magnetic field applied to the MRF was provided by the permanent magnets used in pairs. The direction of the magnetic field was perpendicular or parallel to the direction of the sound wave propagation. The distribution of the magnetic field intensity of the two types of test samples was simulated using magnetostatic finite element analysis and validated with the magnetic field intensity measured using a Teslameter. For comparison, test samples containing air and water units were also prepared. Then, the STL of the two types of test samples were measured under different magnetic field intensities using the impedance tube method. Finally, the STL curves of the two types of test samples were presented, and the influence of magnetic field intensity and direction on the STL were discussed. The results demonstrate that the magnetic field direction has a significant influence on the STL of the MRF unit. In addition, when the magnetic field direction is parallel to the sound propagation direction, the STL of the test sample containing MRF unit significantly increases with the increase of the magnetic field intensity at low and middle frequencies.     

Study on Microstructural Evolution of DP Steel Considering the Interface Layer Based on Multi Mechanism Strain Gradient Theory

A multi-mechanism constitutive model is proposed in this paper to better describe the effect of the local hardening behavior of the interface layer on the mechanical heterogeneity of dual-phase (DP) steel. The constitutive equations considering the geometrically necessary dislocations (GNDs) and back stress at grain level and sample level were established. Based on the finite element simulation results, the influences of local hardening and microstructure characteristics on the strain–stress evolution, statistical storage dislocations, GNDs, and back stress of DP steel were studied and discussed. Due to the local hardening effect, the ferrite phase was treated as an inhomogeneous matrix reinforced by some small islands of martensite in the simulation. The simulation results show that the thickness of the interface layer has a significant effect on the macroscopic hardening property of DP steel, while the number of interface layers has little effect. Meanwhile, the GNDs and back stress at the grain level also have little effect on the strengthening of DP steel. The contribution of GNDs at the sample level to the flow stress is about 47%.     

Polyamines as a defense mechanism against lipoperoxidation in Trypanosoma cruzi

The polyamines, spermine and spermidine--organic polycations that are absolutely required for eukaryotic cell growth--are shown here to function in Trypanosoma cruzi epimastigotes, as protectors of membrane lipoperoxidation by reactive oxygen species generated either by H2O2/Fe2+ or nifurtimox. In vitro, spermine and spermidine inhibited lipoperoxidation in a dose dependent manner. Spermine was more efficient than spermidine in its inhibitory effect. Lipid peroxidation induced by H2O2 showed an IC50 of 0.55 mM for spermine and 0.9 mM for spermidine while an IC50 of 0.8 mM for spermine and 1.5 mM for spermidine were observed when lipoperoxidation was elicited by nifurtimox. Likewise in vivo, both exogenously added spermine and spermidine or endogenous increase of spermine levels induced by phorbol ester, protected against lipoperoxidation and decreased citotoxicity provoked by nifurtimox. Putrescine and cadaverine, also present in T. cruzi had no effect at all. None of the polyamines had any effect neither on the scavenging of superoxide anion nor on the regulation of antioxidant enzymes such as superoxide dismutase and peroxidases involved in H2O2 detoxification. Here we point out that spermine, by acting as a protector of membrane lipoperoxidation might contribute to survival of T. cruzi continuously exposed to oxidative stress.     

Corrosion Behavior of Zn,Fe and Fe-Zn Powder Materials Prepared via Uniaxial Compression

Powder metallurgy is one of the most prevalent ways for metallic degradable materials preparation. Knowledge of the properties of initial powders used during this procedure is therefore of great importance. Two different metals, iron and zinc, were selected and studied in this paper due to their promising properties in the field of biodegradable implants. Raw powders were studied using scanning electron microscopy (SEM) coupled with energy dispersive spectrometry (EDX). Powders (Fe, Zn and Fe-Zn in a weight ratio of 1:1) were then compressed at the pressure of 545 MPa to the form of pellets with a diameter of 1.7 cm. Surface morphology and degradation behavior in the Hanks´ solution were studied and evaluated. Electrochemical polarization tests along with the static immersion tests carried out for 21 days were employed for corrosion behavior characterization. The highest corrosion rate was observed for pure Zn powder followed by the Fe-Zn and Fe, respectively. A mixed Fe-Zn sample showed similar properties as pure zinc with no signs of iron degradation after 21 days due to the effect of galvanic protection secured by the zinc acting as a sacrificial anode.     

A Pocket-Textured Surface for Improving the Tribological Properties of Point Contact under Starved Lubrication

This paper reports a novel pocket-textured surface for improving the tribological properties of point contact under starved lubrication by possibly storing and releasing oil, and homogenizing the surface contact pressure. The ball-on-disk experimental results confirmed the coefficient of friction (COF) and wear reduction effect of such pocket-texturing. The maximum reduction rate was 40% compared with a flat surface under the same operating conditions. Analyses on experimental results attributed the oil storage effect and enhanced the secondary lubrication effect within the starved lubrication state, to become the main mechanism. In addition, the plate elasticity and the Hertzian contact principles were employed to estimate the pressure and the load acting on the surface. The experimental results and numerical analysis substantiated the design of pocket-textured surface, making it likely to enlarge about 50% of contact surface and to reduce 90% of equivalent stress in comparison to those of conventional surfaces.     

Effects of neuropeptides on adenohypophyseal hormone response to acute stress in male rats.

The effects of bombesin and other unrelated oligopeptides on hormonal changes induced by stress were studied in conscious adult male rats. Restraint in the cold for 1 h increased plasma corticosterone and PRL levels and decreased GH values but had no effect on LH levels. Bombesin (5 microgram), given intracerebroventricularly (ivt) before stress, inhibited the PRL rise without affecting corticosterone, GH, or LH response. A complete blockade of PRL rise was observed with doses of bombesin ranging from 5 microgram to 100 ng ivt, regardless of the duration (15, 30, 45, or 60 min) or the nature (cold exposure or restraint at room temperature) of the stressor agents. Bombesin was 10(3) more potent as a PRL inhibitor when given ivt than when given iv, and its ivt effect was not reversed by naloxone (1 or 10 mg/kg). Among other unrelated peptides tested (beta-endorphin, neurotensin, substance P, and TRH; 5 microgram ivt), only neurotensin decreased plasma PRL levels in rats subjected to restraint in the cold for 1 h. These results show that in conscious male rats, centrally administered bombesin has a very potent and long acting inhibitory effect on PRL release induced by acute stress. Since a bombesin-like peptide has been found in rat brain, its physiological role in PRL regulation remains to be elucidated.     

Identification of histidine kinases that act as sensors in the perception of salt stress in Synechocystis sp. PCC 6803

In plants and microorganisms, salt stress regulates the expression of large numbers of genes. However, the machinery that senses salt stress remains to be characterized. In this study we identified sensory histidine kinases that are involved in the perception of salt stress in the cyanobacterium Synechocystis sp. strain PCC 6803. A library of strains with mutations in all 43 histidine kinases was screened by DNA microarray analysis of genomewide gene expression under salt stress. The results suggested that four histidine kinases, namely, Hik16, Hik33, Hik34, and Hik41, perceived and transduced salt signals. However, Hik33, Hik34, and Hik16 acting with Hik41 regulated the expression of different sets of genes. These histidine kinases regulated the expression of approximately 20% of the salt-inducible genes, whereas the induction of the remaining salt-inducible genes was unaffected by mutations in any of the histidine kinases, suggesting that additional sensory mechanisms might operate in the perception of salt stress. We also used DNA microarrays to investigate the effect of various salts on gene expression. Our results indicate that Hik33 responds to sodium salts and not to KCl, whereas the Hik16/Hik41 system responds only to NaCl.     

Commensurability and stability in nonperiodic systems

We have investigated the response of 3D Bi2Sr2CaCu2O8 vortex structures to a weak perturbation induced by 2D Fe pinning structures acting on one extremity of vortex lines. The pinning patterns were nano-engineered at the sample surface by means of either a Bitter decoration of the vortex lattice or electron-beam lithography. The commensurability conditions between 2D rigid pinning potentials and 3D elastic structures with short-range positional and long-range orientational correlation have been experimentally determined. When the 2D potential is a replica of the nonperiodic vortex structure an amplification of its interaction with the vortex structure takes place. This effect is detected only for the first matching field, becoming negligible for other matching fields. On the other hand, a periodic 2D perturbation is shown to transform the nonperiodic Bragg glass-like structure into an Abrikosov crystal with an effective Debye-Waller factor.     

Accuracy Evaluation of Thermoelastic Stress Analysis with the Use of Experimental and Numerical Methods

Thermoelastic Stress Analysis (TSA) is one of the very few methods allowing the determination of a continuous stress distribution on the object’s surface under variable loading conditions. Such results provide a lot of valuable information in the field of technical condition assessment and residual life prediction. In order to improve the accuracy of the TSA, the Lock-In signal processing method is implemented. This research is aimed at verifying the effectiveness of this improvement and determining the TSA stress detection threshold, as it is important information in terms of the applicability of this method in the low-stress conditions encountered in considerations of fatigue of load-carrying structures. A steel sample with a centrally located hole was subjected to cyclic loads to determine the threshold of stress detection and accuracy of TSA. As a result of the research, the relationship between the magnitude of stress excitations and the underestimation of the measured stresses was developed. Based on the conducted investigations, it was concluded that reasonable TSA results can be acquired for excitations that induce a temperature response above 10 mK (0.5 NEDT). The presented field test example proves that in industrial applications reasonable results can be acquired for thermal responses below the NEDT of the IR camera. It was concluded that it is possible to successfully implement TSA in low-stress applications (temperature response below NEDT).     

The survival roles of children of alcoholics: their measurement and validity

Scales to measure five survival rules proposed by Black (1979) and Wegscheider (1976) as characteristic of children of alcoholics were developed and tested among a sample of 112 adolescents. Scales representing the lost child, the acting out child, and the mascot were highly intercorrelated, but use of the placater role was relatively unrelated to other roles. The relationship between parental drinking and role use was examined using hierarchical multiple regression which controlled for sex, age and three family variables, intimacy, deliberateness and cohesiveness. Parental alcoholism contributed to children adopting the acting out role, did not contribute to explaining variation in the lost child and mascot roles, but was the sole predictor of the adoption of the responsible child role. In the case of the placater role, controlling family deliberateness led to the emergence of a previously masked relationship with parental alcoholism. The survival roles appear to be as much a response to family disorganization as to parental alcoholism.     

现场检测血吸虫病方法质量管理的研究

为了探索血防现场查病质量管理的方法，本研究采用专家预测法和影响质量因素对比试验，初步认为，血清学ＥＩＡ法为试剂存放时间过长；病原学ＫａｔｏＫａｔｚ法为操作者判别虫卵技能和显微镜光源、分辨度差是主要影响因素。据此，在加强技术培训，改善必要的设备、条件和质量管理之后，试点县ＥＩＡ法和ＫａｔｏＫａｔｚ法阳性标本检出率分别提高了２４８０％和６１２４％。在１６个代表县的现场查病质量检验中经Ｋａｐｐａ值测定有１２个县检验结果与标准标本一致程度较好，现场查病质量较以前有明显提高。作者认为采用现场投放标准标本作为检验质量的方法是检验现场查病质量有效而适用的方法，同时也提高了血防管理和技术人员的质控意识     

Investigation of the origin of the impedance cardiogram by means of exchange transfusion with stroma free haemoglobin solution in the dog

PURPOSE OF INVESTIGATION - To determine the contribution of variations in orientation of erythrocytes (orientation effect) to the heart synchronous variations in thoracic impedance in impedance cardiography. DESIGN - The blood of four dogs was gradually replaced by stroma free haemoglobin solution, causing a decrease in resistivity and orientation effect. The decrease in orientation effect was used to determine the contribution of the orientation effect using an extended form of the "parallel conductor" model of the thorax (parallel connection of a tissue admittance Yt and a blood conductance Gb). SUBJECTS - Four adult splenectomised mongrel dogs. MEASUREMENTS and RESULTS - Packed cell volume and resistivity at body temperature of every volume of circulating fluid removed was measured. Real and imaginary parts of the transthoracic impedance and the modulus of the heart synchronous impedance variations were measured just before each exchange. The parallel conductor model was extended to account for the influence on Gb of packed cell volume and orientation of erythrocytes. Applying this extended model, the average variations in Gb at a packed cell volume of 40% were estimated to be 7.46%:3.03% due to volume variations, 4.43% due to orientation effect. After further extending the model to account for the influence of small changes in blood pressure and heart rate, the average volume variations were estimated to range from 2.8% to 3.3% and the average orientation effect from 4.1% to 4.7% at a packed cell volume of 40%. CONCLUSION - Resistivity of the blood is far from constant and the contributions of variations in blood conductivity and volume to the heart synchronous thoracic impedance are of comparable magnitude. The contribution of the volume variations is the sum of the volume variations in the contributing intrathoracic vessels. The effects of variations in orientation are added up in proportion to the relative volumes of the contributing vessels. The extensions of the parallel conductor model brought out all physiological factors determining the heart synchronous thoracic impedance variations: pulse pressures and flows, mean pressures and flows, compliances of all contributing blood vessels, packed cell volume and heart rate, as well as the relevant properties of blood: the relations between volume, flow and orientation effect and the change in orientation effect during decelerating flow.     

Wall shear stress in carotid artery and its role in the development of atherosclerosis

Atherosclerosis is associated with systemic risk factors such as arterial hypertension, hyperlipidemia, diabetes mellitus and smoking. Yet it is a focal disease, predominantly affecting predisposed areas. The principal local hemodynamic factor is wall shear stress, i.e. the frictional force acting tangentially on the endothelial cell surface. The effect of wall shear stress on the endothelium depends on its magnitude and direction, as well as on the local vessel geometry and blood flow characteristics. Wall shear stress is an important determinant of endothelial function and phenotype. The article deals with the influence of wall shear stress on endothelial cell function, atherosclerotic plaque formation, and vascular remodelling in the common carotid artery.