电针加麦粒灸治疗类风湿性关节炎疗效观察

<正>类风湿性关节炎(RA)是一种以关节和关节周围组织的非感染性炎症为主的自身免疫性疾病。中医称为"历节风""历节病""白虎历节""骨骱痹""顽痹"等,其典型症状为对称性、周围性多个关节慢性炎性病变,表现为受累关节疼痛、肿胀、功能下降,痛无定处、游走不定,或胀痛、机体重着,或疼痛遇寒加重、关节屈伸不利。疼痛感以骨、关节、肌肉等部位为主,犹如被老虎咬     

肾虚与类风湿性关节炎的相关性研究

<正>类风湿关节炎(Rheumatoid Arthritis,RA)是一种以关节滑膜炎为主要特征的慢性自身免疫性疾病,我国RA发病率约为0.3%~0.6%,发病率高,致残率高,严重危害人类健康。RA属中医学"痹证"的范畴,而历代医家对RA有"历节病""尪痹""骨痹""肾痹"等名称。肾虚与痹证有着密切的关系,是痹证发病的重要内因,在RA的发生和发展中起着至关重要的作用。本文就肾虚与类风湿性关节炎的相关     

克痹通络汤合独活寄生汤加减治疗强直性脊柱炎临床观察36例

强直性脊柱炎(简称AS)是主要累及骶骼关节和脊柱关节的慢性进行性炎症,并侵犯四肢和其它脏器.该病大多为隐渐性发病,只有5％的为急性发作,属祖国医学"骨痹""肾痹""龟背风"等范畴.AS可使受累脊柱有迅速发生屈曲畸形骨性强直的趋势,对患者危害较大,严重者可致残,被称为"不死的癌症",目前尚缺乏特效治疗手段.     

雷公藤治疗强直性脊柱炎的研究现状

<正>强直性脊柱炎(ankylosing spondylitis,AS)是一种慢性进行性疾病,主要侵犯骶髂关节、脊柱骨突、脊柱旁软组织及外周关节,并可伴发关节外表现。严重者可发生脊柱畸形和关节强直。强直性脊柱炎归属于中医学"龟背风"、"竹节风"、"骨痹"、"肾痹"、"腰痹"等范畴。雷公藤为卫矛科一年生藤本植物,又名断肠草、黄藤根、南蛇藤等,它作为传统医学中一种常用中草药,具有活血化瘀、清热解毒、消肿散结、杀虫止血等     

尪痹治法介绍

类风湿关节炎是一种以关节受累为主的、有多脏器损害的自身免疫性疾病,临床发病率高,多见于中年女性,我国患病率为0.32%～0.36%。主要表现为对称性、慢性、进行性多关节炎。典型的类风湿关节炎按1987年美国风湿病学学会诊断标准依靠临床表现、自身抗体及X线改变得出,符合其中4项或4项以上者诊断并不困难。类风湿关节炎,中医称之为尪痹、顽痹、骨痹,是痹证的一种。汉·张仲景称为历节,后世称为鹤膝风,近世称为类风湿。《素问·痹论篇》曰:"风寒湿三气杂至,合而为痹。……以冬遇此者为骨痹。……骨痹不已,复感于邪,内舍于肾。……肾痹者,善胀尻以代踵,脊以代头"。本病局部以关节病变     

治疗类风湿关节炎,抑制疼痛是关键

<正>类风湿关节炎是一种致残性强而又较为常见的慢性全身性免疫性疾病,以周围关节的对称性多关节炎为主要特征。如不及早给予有效治疗则严重影响患者关节功能和生活质量。中医学认为,类风湿关节炎属于"历节""骨痹""尪痹"等范畴。其病因病机概括起来不外虚实两端。《济生方》更加明确指出"皆因体虚,腠理空疏,受风寒湿气而成痹也",认为患者正气不足,脏腑经络、     

浅谈脑致骨质疏松

骨质疏松症是最常见的骨骼疾病,是一种以骨量低、骨组织微结构损坏,导致骨脆性增加,易发生骨折为特征的全身性骨病.中医将骨质疏松归入"骨痿""骨痹"范畴,认为骨痿见于没有明显临床表现者,骨痹见于有明显临床表现者,骨痿是骨痹的早期表现.结合中医古籍文献,建立"脑-肾-骨质疏松""脑-脾-骨质疏松""脑-髓-特发性骨质疏松"三...     

阎小萍教授治疗强直性脊柱炎的学术思想及其临床经验——从大辨治注重补肾壮骨

强直性脊柱炎(Ankylosing spondylitis AS)是一种以中轴关节和肌腱韧带附着点的慢性炎症为主的全身性疾病,以炎性腰痛、肌腱端炎、外周关节炎和关节外表现为特点.主要累及骶髂关节、脊柱及四肢关节,表现为关节和关节周围组织、韧带、椎间盘的钙化,椎间关节和四肢关节滑膜的增生,最终发展为骨性强直.本病有明显家族聚集现象,并与HLA-B27密切相关.本病早期主要症状为腰背等关节僵硬、疼痛,活动后可缓解,晚期造成关节强直、畸形,致残率高.目前西医缺乏对本病有确切效果的治疗药物.中国传统医学论著中虽无此病名,但不乏与本病相似的记载,历代医家多将其归属于"骨痹""肾痹""顽痹"等范畴,并在临床治疗中积累了丰富的经验.     

从肝论治膝骨性关节炎研究进展

膝骨性关节炎是一种以关节软骨退变、软骨下骨病变等为特征的慢性关节疾病.随着人口老龄化等问题的出现,膝骨性关节炎发病人数逐年上升,严重影响人们的日常工作与生活.膝骨性关节炎属中医学"膝痹"范畴,病机为"本痿标痹",肝肾不足为其发病基础,明确从肝论治膝骨性关节炎有重要意义.本文以"膝骨性关节炎""膝骨关节炎""从肝论治"为...     

强直性脊柱炎的中医治疗进展

强直性脊柱炎（AS）是以骶髂关节和脊柱慢性、进行性炎症为主的全身性疾病,病情反复活动,终至脊柱强直、畸形,功能严重受损,中医学认为强直性脊柱炎隶属于“。肾痹”、“骨痹”等范畴,过去中医对强直性脊柱炎早有丰富的论述。《素问》：“病在骨,骨重不举,骨髓酸痛,寒气至,名曰骨痹”、“骨痹不已,复感于邪,内舍于肾”及“肾痹者,善胀,尻以代踵,脊以代头”;王冰曰：“督脉为病,脊强反折而不能屈伸也”。     

阴旦汤考证

《备急千金要方》（以下简称《千金方》）中载有阴旦汤,其组方为桂枝汤去生姜加干姜、黄芩,后世医家多宗此说。而在近代出土的敦煌遗书《辅行诀脏腑用药法要》（以下简称《辅行诀》）中,阴旦汤为黄芩汤加生姜。阴旦汤的组方究竟如何变化,笔者试综合历代文献,分析如下。     

经方大剂量探索

时下中医逐渐失去治疗急症阵地,其主要原因是什么？临床疗效为何难以提高？与经方在传承中出现了重大失误不无关系。而经方大剂量是如何被挖掘出来的？经方大剂量到底适用于什么情况？试分析如下。     

思考《伤寒论》成书的疾病背景

从流行性出血热的角度探讨《伤寒论》所论治的具体疾病,结合汉末魏晋时期的整个历史背景,联系当时其他医籍中对伤寒的描述,提出流行性出血热的流行基础形成了六经病证的应对方法,强调研究和理解古典医著必须注重当时的临床事实。     

苏励运用膏方治疗风湿病经验

膏方又称膏滋、煎膏,具有补虚纠偏、寓治于养之功效,其外合时令、内切体质、徐图缓进,非常适合慢性虚损性疾病或亚健康状态的调治。苏励教授善用膏方调治风湿免疫性疾病,现将其运用膏方治疗强直性脊柱炎、干燥综合征、狼疮肾炎的经验整理介绍如下。     

Effects of feeding tyrosine and phenylalanine on the accumulation of phenylethanoid glycosides to Cistanche deserticola cell suspension culture

AIM： To investigate the effects of feeding phenylalanine （Phe） and tyrosine （Tyr） on the accumulation of total phenolic compounds and four phenylethanoid glycosides （PeGs） to a cell suspension culture of the parasitic plant Cistanche deserticola.METHOD： A cell suspension culture of C. deserticola was established and precursors of different concentrations were fed. In each group, the cell was sampled at the 24^th day after inoculation. The content of total phenolic compounds and four PeGs compounds were determined using the Folin-Ciocalteu method and an HPLC method, respectively.RESULTS： In the Phe fed cells, the maximum PeGs yield was achieved when Phe was fed at 1.5 mmol·L^-1 and the yield reached 1.13 times the control cell concentration. In the Tyr fed cells, the maximum yield of PeGs was 1.60 times of control when 0.75 mmol·L^-1 Tyr was fed to the cells. Furthermore, it was found that the salidroside yield was 4.01 times of control group when 5 mmol·L^-1 Tyr was fed.CONCLUSION： Tyr is a better precursor for PeGs accumulation compared with Phe, and the rate limiting enzymes might be involved in the Tyr branch.     

Capillary blood flow in patients with dysmenorrhea treated with acupuncture

OBJECTIVE; To observe capillary blood flow at acu- points during acupuncture treatment of primary dysmenorrhea and gain new insights into its anal- gesic mechanism. METHODS： Patients with primary dysmenorrhea were enrolled and randomly assigned to a treat- ment or control group. Subjects＇ symptoms were differentiated into various Traditional Chinese Medi- cine （TCM） syndromes and treated for 10 sessions with puncturing acupuncture or self-pressing right-hand Hegu （LI 4）, adding other acupoints based on syndrome. Laser speckle was used tocompare the change in the vasomotor amplitude and perfusion of the capillaries in Hegu （LI 4） be- fore and during the treatment. Each subject was re- quired to finish the period pain symptoms observa- tion form, verbal rating scales, numerical rating scale, pain rating index, face rating scale, Zung self-rating depression scale, Zung self-rating anxi- ety scale, and numerical rating scale before and af- ter treatments. RESULTS： After 10 sessions, the symptom scores, pain index （PI）, and visual analog scale （VAS） de- creased significantly in treatment group. The vol- ume of blood flow in Hegu （LI 4） declined slightly. No significant evidence supported that needling caused capillary contraction, but the capillary vaso- motor amplitude at Hegu （LI 4） increased remark- ably. CONCLUSION： Acupuncture can increase the capil- lary blood flow, thus promoting the flow of Qi and blood in terms of TCM theory, which facilitates pain relief.     

Curative effect of Xuebijing injection on severe pulmonary contu- sion

OBJECTIVE： To investigate the curative effects of Xuebijing （XBJ） injection, a Chinese patent medi- cine, on severe pulmonary contusion （PC）. METHODS： Sixty-three patients with PC were ran- domized to conventional therapy plus XBJ injec- tion （n=33） or conventional therapy alone （n=30）. Between groups differences in corticosteroid treat- ment, immune regulation therapy, hemofiltration, infusion volume, transfusion volume and antibiotic period were measured, as were intensive care unit（ICU）-free time, ventilation time, 28-day mortality rate and incidence of ventilation-associated pneu- monia （VAP）. Serum concentrations of procalcito- nin （PCT）, tumor necrosis factor-a （TNF-a）, interleu- kin （IL）-6, and 11_-10, white blood cell （WBC） counts and percentages of human leukocyte antigen DR/ CD14＋ （HLA-DR/CD14＋） peripheral blood mononu- clear cells were compared. Markers of ventilation were determined by blood gas analysis and ventila- tor parameters. RESULTS： WBC counts and serum concentrations of PCT, TNF-a, 11.-6 and IL-10 were reduced signifi- cantly more quickly, and CD14＋ percentage was in- creased significantly earlier, in the XBJ group than in the control group （P〈0.05 each）. The level of ven- tilation and oxygenation index were ameliorated earlier in the XBJ than in the control group （P〈 0.05）. XBJ treatment significantly reduced ICU-free time, ventilation time and incidence of VAP （P〈0.05 each）, but had no effect on 28-day mortality rate （P〉0.05）. CONCLUSION： XBJ treatment can shorten ICU-free and ventilation times and reduce the incidence of VAP, improving outcomes in patients with severe PC. XBJ may act by regulating inflammation and im- munity, alleviating systemic inflammatory response syndrome induced by trauma.     

Effects of Chinese herbs in children with Henoch-Schonlein purpura nephritis：a randomized controlled trial

OBJECTIVE： To research the curative effect of Chi- nese herbs for clearing away heat, promoting diure- sis, nourishing the kidney, and consolidating es- sence in children with Henoch-Schonlein purpura nephritis（HSPN） with internal accumulation of damp-toxin using randomized controlled observa- tions on large samples. To seek the mechanism of the therapy and its scope of indications. METHODS： Overall, 186 children with HSPN were randomly divided into two groups： treatment group（n=126） treated with Chinese herbs for clear- ing heat and promoting diuresis and a control group（n=60） treated with Western Medicine. The treatment was carried out for three courses of 4 weeks each. We recorded changes in patient urine routines, 24 h urinary protein, blood-coagulating series, immunoglobulin and T-cell subgroups, and improvements in main symptoms. We evaluated the alleviation of clinical symptoms and the im- provement of proteinuria, hematuria, and other lab-oratory test results. Finally, we analyzed the patient population suitable for this therapy according to the relationship between the grouping of patient body weight and curative effect. RESULTS： Damp-heat syndrome improved in the treatment group, with a significant difference in to- tal effective rate after a 4-week treatment（χ2= 13.5220, P=0.0002） and in curative rate after a 12-week treatment（χ2=6.3410, P=0.0118）, com- pared to those in the control group.The curative ef- fect in the treatment group was greater than that in the control group but there was no statistical dif- ference between the two groups. The curative ef- fect after a 4-week treatment of patients in the treatment group weighing 30 kg or less based on Traditional Chinese Medicine（TCM） signs and uri- nary protein was significantly greater than that in the control group. However, there was no statistical difference in the curative effect on urinary red cells and various indexes after a 12-week treatment be- tween the two groups. CONCLUSION： Therapy for clearing away heat, pro- moting diuresis, nourishing the kidney, and consoli- dating essence using TCM is effective in children with HSPN from internal accumulation of damp-toxin. The therapy is especially suitable for patients weighing 30 kg or less. The curative effect may be related to the improvement of immune function and blood-coagulation.     

Effect of Morinda officinalis capsule on osteoporosis in ovariectomized rats

AIM： To explore the therapeutic effects ofMorinda officinalis capsules （MOP） on osteoporosis in ovariectomized rats. METHOD： Six-month-old female Sprague-Dawley rats were induced for postmenopausal osteoporosis （PMOP） by bilateral ovariectomy and divided into seven groups as follows： sham-operated group, ovariectomized （OVX） control group, OVX treated with xianlinggubao （XLGB） （270 mg·kg^-1·d^-1） , OVX treated with alendronate sodium （ALN） （3 mg·kg^-1·d^-1）, and OVX treated with Morinda officinalis capsule （MOP） of graded doses （90, 270 and 810 mg·kg^-1·d^-1） groups. Oral treatments were administered daily on the 4th week after ovariectomy and lasted for 12 weeks. The bone mineral density was evaluated by dual-energy X-ray absorptiometry. The tartrate-resistant acid phosphatase （TRAP）, alkaline phosphatase （AKP）, and osteocalcin （OC） levels in the serum and plasma were determined by standard colorimetric and enzyme immunoassays methods. Bone biomechanical properties and morphological parameters were analyzed by three-point bending test and histomorphometry respectively. RESULTS： Morinda officinalis capsules at all doses were able to significantly prevent the OVX-induced loss of bone mass due to diminishing serum AKP and TRAP levels while elevating OC level in the plasma. Morinda officinalis capsules also enhanced the bone strength and prevented the deterioration of trabecular microarchitecture. CONCLUSION： Morinda officinalis capsules possess potent anti-osteoporotic activity in OVX rats which could be an effective treatment for postmenopausal osteoporosis.