马来酸曲美布汀联合舒肝片治疗功能性消化不良疗效观察

目的 观察马来酸曲美布汀联合舒肝片治疗功能性消化不良的疗效.方法 将61例功能性消化不良(FD)患者分为治疗组(31例)和对照组(30例),治疗组给予马来酸曲美布汀和舒肝片,对照组给予多潘立酮,疗程均为4周.结果 马来酸曲美布汀联合舒肝片组(治疗组)显效率64.5%,总有效率90.3%;多潘立酮组(对照组)显效率26.7%,总有效率53.3%.两组显效率和总有效率相比均具有统计学差异(P<0.01).两组不良反应均较轻.结论 马来酸曲美布汀联合舒肝片可有效改善FD患者的多种症状,其疗效优于多潘立酮组(P<0.01),且不良反应较轻.     

马来酸曲美布汀片与多潘立酮治疗功能性消化不良的临床观察

目的观察马来酸曲美布汀片(双迪)治疗功能性消化不良(FD)的临床疗效。方法102例FD患者随机分为两组,马来酸曲美布汀片组52例,双迪100 mg,3次/日,口服;多潘立酮(吗丁啉)组50例,吗丁啉10 mg,3次/日,口服,疗程均为4周。结果马来酸曲美布汀组有效率88.46%,明显高于多潘立酮组(68.0%)(P<0.05),疗程结束时FD患者早饱、上腹胀痛、嗳气、食欲不振等症状马来酸曲美布汀组明显改善,疗效优于多潘立酮组。治疗过程中两组均未发现明显的不良反应。结论双迪片是治疗FD安全、有效的胃肠动力药物。     

曲美布汀治疗功能性消化不良疗效观察

目的观察曲美布汀治疗功能性消化不良(FD)的临床疗效和安全性。方法100例FD病人随机分为曲美布汀组治疗组60例,曲美布汀200mg,3次/d;对照组多潘立酮10mg,3次/d,疗程均为4周。结果曲美布汀治疗组总有效率86.7%,疗效明显高于多潘立酮对照组(60.0%)(P<0.05);各主要症状明显缓解(P<0.05或0.01);治疗组用药后餐后饱胀、上腹胀满、上腹痛、嗳气等症状改善优于对照组(P<0.05或0.01)。结论曲美布汀能明显缓解FD病人症状的作用,疗效优于多潘立酮,不良反应轻微,是FD有效的药物。     

马来酸曲美布汀治疗功能性消化不良的疗效观察

目的评价马来酸曲美布汀与普瑞博思治疗功能性消化不良(functional dyspepsia,FD)的疗效及安全性。方法76例功能性消化不良患者随机分为两组,治疗组予以马来酸曲美布汀200 mg口服,3次/d;对照组予以普瑞博思10 mg口服,3次/d。疗程均为4周。结果两组治疗4周均可明显改善FD患者的症状,与治疗前相比,有显著性差异(P<0.05);治疗组总有效率为84.2%,对照组总有效率为81.6%,两组疗效无显著性差异(P>0.05)。两组不良反应无显著性差异(P>0.05)。结论马来酸曲美布汀是治疗FD安全有效的药物。     

莫沙必利联合马来酸曲美布汀治疗功能性消化不良的临床效果分析

目的探讨莫沙必利联合马来酸曲美布汀治疗功能性消化不良(FD)的临床效果。方法选取卫辉市华新医院2015年6月至2016年5月收治的100例FD患者作为研究对象,根据治疗方式分为A组和B组,每组50例,A组接受莫沙必利联合马来酸曲美布汀治疗,给予B组莫沙必利治疗,比较两组患者的治疗效果。结果治疗后A组GSRS评分低于B组,差异有统计学意义(P<0.05);A组胃电图正常率高于B组,差异有统计学意义(P<0.05);两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论给予FD患者莫沙必利联合马来酸曲美布汀治疗,可以改善患者症状,安全性高,促进患者康复。     

阿嗪米特联合曲美布汀治疗功能性消化不良效果观察

目的探讨阿嗪米特联合曲美布汀治疗功能性消化不良的临床效果。方法选取2016年2月至2017年2月襄城县人民医院收治的86例功能性消化不良患者,按照随机数表法分为两组,各43例。给予对照组马来酸曲美布汀治疗,给予观察组马来酸曲美布汀联合复方阿嗪米特肠溶片治疗,比较两组治疗效果、消化道症状积分及生活质量,记录治疗期间不良反应发生情况。结果两组治疗总有效率比较,观察组(95.35%)高于对照组(76.74%),差异有统计学意义(P<0.05);治疗后,两组临床症状积分均降低,且观察组较对照组低,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论阿嗪米特联合曲美布汀治疗功能性消化不良可提高临床效果,改善患者症状,提升生活质量,且安全性更高。     

马来酸曲美布汀联合小剂量阿普唑仑治疗功能性消化不良的临床观察

目的：评价马来酸曲美布汀联合小剂量阿普唑仑治疗功能性消化不良（FD）的临床疗效及安全性。方法：将118例患者随机分为马来酸曲美布汀联合小剂量阿普唑仑治疗组与多潘立酮对照组。疗程均为8周，随访3个月。两组患者年龄、性别、体重、临床指征差异均无显著性（P〉0．05）。结果：治疗组症状缓解的总有效率为92．7％，与对照组（60．0％）比较有显著性差异（p〈0．05）。结论：马来酸曲美布汀联合小剂量阿普唑仑治疗FD安全有效。     

曲美布汀联合帕罗西汀治疗功能性消化不良的疗效观察

目的观察曲美布汀联合帕罗西汀治疗功能性消化不良的疗效。方法152例FD患者随机分为两组，观察组79例，给予马来酸曲美布汀分散片及盐酸帕罗西汀联合用药治疗；对照组73例，单用马来酸曲美布汀治疗。观察比较两组的上腹饱胀、早饱、上腹痛等症状的变化。结果观察组和对照组用药4周后临床主要症状均明显缓解（P〈0．01或0．05）。观察组治疗总有效率为91．1％，对照组为76．7％，两组相比，差异有显著性意义（P〈0．05）。两组患者均无严重的不良反应发生。结论曲美布汀联合帕罗西汀可显著提高治疗功能性消化不良的疗效，值得推广。     

复方阿嗪米特联合马来酸曲美布汀治疗功能性消化不良临床效果观察

目的:探讨复方阿嗪米特联合马来酸曲美布汀治疗功能性消化不良临床效果观察。方法:选择消化内科门诊以及住院治疗功能性消化不良的患者100例,所有患者均符合功能性消化不良的罗马Ⅱ诊断标准[1],随机分为对照组和观察组,两组患者在性别、年龄、体质和病情等方面比较,差异无统计学意义(P>0.05),具有可比性。对照组服用马来酸曲美布汀,观察组服用马来酸曲美布汀,在此基础上同时服用复方阿嗪米特肠溶片,疗程均为4周。观察所有患者临床症状改善情况。结果:观察组明显有效于对照组,两组患者具有显著性差异,P<0.05。结论:复方阿嗪米特联合马来酸曲美布汀治疗功能性消化不良临床效果明显好于只用马来酸曲美布汀,适合临床广泛应用。     

马来酸曲美布汀联合氟哌塞吨美利曲辛治疗功能性消化不良疗效观察

目的:研究马来酸曲美布汀单用或者联用氟哌塞吨美利曲辛在功能性消化不良治疗中的作用。方法:将198例功能性消化不良的患者随机分成治疗组(96例)和对照组(102例),治疗组口服马来酸曲美布汀和氟哌塞吨美利曲辛治疗,对照组口服马来酸曲美布汀治疗。疗程为6周。结果:治疗组总有效率明显高于对照组,差异有统计学意义(P<0.05)。结论:马来酸曲美布汀联合使用氟哌塞吨美利曲辛对功能性消化不良能明显提高疗效。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.