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1.
A Vallejo MdC Molano M Monsalvo‐Hernando F Hernndez‐Walias M Fontecha‐Ortega JL Casado 《HIV medicine》2019,20(8):555-560
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C Amiel C Charpentier N Désiré P Bonnard M‐G Lebrette L Weiss G Pialoux V Schneider 《HIV medicine》2011,12(3):138-144
Objectives
Amino acid insertions in the protease gene have been reported rarely, and mainly in patients receiving protease inhibitors (PIs). The aim of the study was to assess the long‐term viro‐immunological follow‐up of HIV‐infected patients harbouring virus with protease insertions.Methods
Cases of virus exhibiting protease insertions were identified in routine resistance genotyping tests. Therapeutic, immunological and virological data were retrospectively collected.Results
Eleven patients harbouring virus with a protease gene insertion were detected (prevalence 0.24%), including three PI‐naïve patients. The insertions were mainly located between codons 33 and 39 and associated with surrounding mutations (M36I/L and R41K). The three PI‐naïve patients were infected with an HIV‐1 non‐B subtype. Follow‐up of these PI‐naïve patients showed that the insert‐containing virus persisted for several years, was archived in HIV DNA, and displayed a reduced viral replicative capacity with no impact on resistance level. Of the eight PI‐experienced patients, 63% were infected with HIV‐1 subtype B; one had been antiretroviral‐free for 5 years and seven were heavily PI‐experienced (median duration of follow‐up 24 months; range 10–62 months). The protease insertion was selected under lopinavir in four patients and under darunavir in one, in the context of major PI‐resistance mutations, and following long‐term exposure to PIs. The insert‐containing virus persisted for a median of 32 months (range 12–62 months) and displayed no specific impact on phenotypic resistance level or viral replicative capacity.Conclusion
Our data, obtained during long‐term follow‐up, show that insertions in the protease gene do not seem to have an impact on resistance level. This finding supports the recommendation of PI‐based regimens, although further work is required to confirm it. 相似文献3.
Virological responses to lamivudine or emtricitabine when combined with tenofovir and a protease inhibitor in treatment‐naïve HIV‐1‐infected patients in the Dutch AIDS Therapy Evaluation in the Netherlands (ATHENA) cohort 下载免费PDF全文
C Rokx L Gras DAMC van de Vijver A Verbon BJA Rijnders the ATHENA National Observational Cohort Study 《HIV medicine》2016,17(8):571-580
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Simultaneously increased expression of microRNA‐155 and suppressor of cytokine signaling 1 (SOCS1) gene in the peripheral blood mononuclear cells of patients with primary Sjögren's syndrome 下载免费PDF全文
Gábor Papp Sándor Sipka Margit Zeher 《International journal of rheumatic diseases》2017,20(5):609-613
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Cardiovascular risk prediction in HIV‐infected patients: comparing the Framingham,atherosclerotic cardiovascular disease risk score (ASCVD), Systematic Coronary Risk Evaluation for the Netherlands (SCORE‐NL) and Data Collection on Adverse Events of Anti‐HIV Drugs (D:A:D) risk prediction models 下载免费PDF全文