共查询到20条相似文献,搜索用时 15 毫秒
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Purpose
The vascular endothelial growth factor (VEGF) gene polymorphism has been reported to be associated with endometriosis risk. The purpose of the present study was to perform a comprehensive meta-analysis to explore whether VEGF gene polymorphisms confer risk to endometriosis.Methods
By searching PubMed and EMBASE databases, a total of 11 studies were identified. Crude odds ratio (OR) and their corresponding 95% confidence intervals (CI) for VEGF gene polymorphisms and endometriosis risk were calculated.Result
An association of VEGF gene +936TC polymorphism with endometriosis was found (Fixed-effect model: TT?+?TC vs. CC: OR 1.184, 95% CI 1.027?C1.366, P?=?0.020; TC vs. CC: OR 1.187, 95% CI 1.024?C1.375, P?=?0.023. Random-effcet model: TT?+?TC vs. CC: OR 1.203, 95% CI 1.003?C1.443, P?=?0.046; TC vs. CC: OR 1.188, 95% CI 1.021?C1.382, P?=?0.026). No association between VEGF genes ?460CT, +405CG, ?2578AC, ?1154GA polymorphisms and endometriosis was observed.Conclusion
Our results indicate that VEGF +936TC gene polymorphism is a risk factor for endometriosis, and not ?460CT, +405CG, ?2578AC, ?1154GA. 相似文献4.
Renner SP Boosz AS Burghaus S Maihöfner C Beckmann MW Fasching PA Jud SM 《Archives of gynecology and obstetrics》2012,286(3):687-693
Purpose
To construct pain maps in order to describe the distribution of pelvic pain in a group of endometriosis patients and endometriosis-free patients, to assess the feasibility of this method.Methods
A total of 159 patients with pelvic pain who were scheduled for diagnostic laparoscopy.Results
A total of 117 patients with and 42 patients without endometriosis were included. The pain distribution between these two patient groups appeared to differ in some peripheral anatomical structures. In the endometriosis patients, the pain was most frequently located in the rectouterine pouch.Conclusions
In endometriosis patients, pain mapping to assess preoperative pain sensations relative to the anatomic location of endometriotic lesions is feasible. The pain provoked by vaginal examination is frequently perceived as median relative to the actual anatomic location of the endometriotic lesions. Several anatomic and neurophysiological factors may explain this phenomenon. 相似文献5.
Yavuz Simsek Mehmet Gul Ercan Yilmaz Ibrahim Halil Ozerol Elif Ozerol Hakan Parlakpinar 《Archives of gynecology and obstetrics》2014,290(5):999-1006
Purpose
The purpose of this study was to examine the effects of atorvastatin in the treatment of experimental endometriosis.Methods
Endometriosis was induced in 24 female rats. 4 weeks after the procedure dimensions of the foci were recorded. Rats were divided into three groups: in Group 1 (n = 8), a daily dose of 10 mg/kg atorvastatin was given for 14 days. In the second group (n = 8), a single dose of 1 mg/kg leuprolide acetate was injected intraperitoneally. The rats in Group 3 (n = 8) were received 1 mg/kg i.p. 0.9 % NaCl. At the end of the treatment, laparotomy was performed, and the dimensions of the endometriotic foci were recorded. Biochemical, histopathological and immunohistochemical studies were performed and nociception was compared in groups.Results
Atorvastatin treatment exhibited significant analgesic activity in hot plate model (P = 0.022). The serum hs-CRP and tumor necrosis TNF-α levels were similar between the Group 2 and Group 3 (P > 0.05); however atorvastatin caused significant decrease in both serum markers. The histological and immunohistochemical scores were also found to be markedly lower in Group 1 and Group 2 (P < 0.05).Conclusion
Atorvastatin treatment may have a therapeutic potential in the treatment of endometriosis through its anti-inflammatory and anti-nociceptive properties. 相似文献6.
Zechun Lu Weiyi Zhang Shufang Jiang Jie Zou Yali Li 《Archives of gynecology and obstetrics》2014,289(4):823-830
Objective
To evaluate the effects of lesion location on adhesion and angiogenesis of transplanted endometriotic lesions in SCID mice.Methods
Three groups of female SCID mice included intraperitoneal (i.p.) (n = 12), subcutaneous (s.c.) (n = 12), and mock surgery (control) (n = 12). At 2 weeks after ovariectomy, the mice were transplanted with eutopic endometrium from endometriosis patients either subcutaneously or sutured within the peritoneal, or underwent mock surgery. After 4 weeks, the mice were sacrificed to evaluate the adhesion and volume changes of the implanted lesions. Furthermore, semiquantitative immunohistochemical staining was performed to analyze expression of MMP-2 and TIMP-2 as adhesion makers, and vWF, VEGF, and HIF-1α as angiogenesis markers.Results
Adhesion occurred in 9 of 12 mice in the i.p. group, 3 of 12 mice in the s.c. group, and 3 of 12 mice in the control group. Fisher’s exact test showed that the difference of adhesion occurrence between i.p. and s.c. groups was statistically significant (p < 0.05). Graft volume changes were higher in the s.c. group than those in the i.p. group. MMP-2 expression was higher in the s.c. group than that in the i.p. group (p < 0.01). There was no significant difference of TIMP-2 expression between s.c. and i.p. groups. vWF, VEGF, and HIF-1α expression was significantly higher in the s.c. group than that in the i.p. group (p < 0.01).Conclusions
Lesion location might be involved in the pathological changes of endometriosis. The intraperitoneal location is related to endometriotic adhesion, whereas the subcutaneous location is related to the infiltration of endometriotic lesions. 相似文献7.
Matteo Morotti Valentino Remorgida Pier Luigi Venturini Simone Ferrero 《Archives of gynecology and obstetrics》2012,286(6):1571-1575
Purpose
This study aims to present the clinical characteristics of a series of postmenopausal women with endometriosis and to evaluate the preferential location, extension and histopathological features of the lesions.Methods
We retrospectively examined the clinical records of 72 postmenopausal women with endometriosis who underwent surgery between January 1998 and December 2010.Results
The median age of patients at the time of surgery was 58.5?years. Eleven patients (15.3?%) had previous history of endometriosis and five patients had previously undergone surgery for this reason. Only two patients included in the study were using hormone replacement therapy at the time of surgery. The most frequent location of endometriotic lesions was the ovary and among patients with endometriomas, 35?% (20/57) had different grades of metaplasia, hyperplasia, atypia and endometrioid carcinoma arising in endometriosis. The proportions of epithelium, stroma and hemorrhage in endometriotic lesions were higher in patients with concomitant endometrial or ovarian cancer.Conclusions
Endometriosis should be considered in the differential diagnosis of postmenopausal cystic lesions of the ovary. The administration of exogenous estrogen is not a prerequisite for the presence of endometriosis in postmenopausal women, and histological signs of functionally active lesions were also observed in the absence of exogenous hormone intake. 相似文献8.
Hye-yon Cho Sung-won Kang Hong-bae Kim Sung-ho Park Sung Taek Park 《Archives of gynecology and obstetrics》2012,286(5):1221-1225
Objective
This study was designed to evaluate the safety and feasibility of prophylactic adnexectomy during vaginal hysterectomy for benign pathology.Methods
We retrospectively reviewed medical records of all patients who underwent vaginal hysterectomy (VH) between 2008 and 2010. Clinical comparison of patients who underwent VH with adnexectomy (n?=?92) and VH only (n?=?686) was performed. Clinical characteristics (age, parity, body mass index, and previous pelvic surgery), surgical outcomes (uterine weight, operative time, estimated blood loss, pelvic adhesion, hemoglobin change and hospital stay) and intra- and postoperative complications (transfusion, bladder injury and fever) were evaluated.Results
Clinical characteristics except for age (45.44?years for VH only vs. 47.15?years for VH with adnexectomy, P?=?0.007) were not different between the two groups. Similarly, surgical outcomes and complication rates were not different between the two groups.Conclusion
Prophylactic bilateral adnexectomy can be performed safely during VH. 相似文献9.
Evelien M. Sandberg Sara R. C. Driessen Evelien A. T. Bak Nan van Geloven Judith P. Berger Mathilde J. G. H. Smeets Johann P. T. Rhemrev Frank Willem Jansen 《Gynecological surgery》2018,15(1):8
Background
Pelvic endometriosis is often mentioned as one of the variables influencing surgical outcomes of laparoscopic hysterectomy (LH). However, its additional surgical risks have not been well established. The aim of this study was to analyze to what extent concomitant endometriosis influences surgical outcomes of LH and to determine if it should be considered as case-mix variable.Results
A total of 2655 LH’s were analyzed, of which 397 (15.0%) with concomitant endometriosis. For blood loss and operative time, no measurable association was found for stages I (n?=?106) and II (n?=?103) endometriosis compared to LH without endometriosis. LH with stages III (n?=?93) and IV (n?=?95) endometriosis were associated with more intra-operative blood loss (p =?<?.001) and a prolonged operative time (p =?<?.001) compared to LH without endometriosis. No significant association was found between endometriosis (all stages) and complications (p?=?.62).Conclusions
The findings of our study have provided numeric support for the influence of concomitant endometriosis on surgical outcomes of LH, without bowel or bladder dissection. Only stages III and IV were associated with a longer operative time and more blood loss and should thus be considered as case-mix variables in future quality measurement tools.10.
Manabe S Iwase A Goto M Kobayashi H Takikawa S Nagatomo Y Nakahara T Bayasula Nakamura T Hirokawa W Kikkawa F 《Archives of gynecology and obstetrics》2011,284(6):1567-1572
Purpose
Inflammatory mediators, including chemokines, may play crucial roles in the development of endometriosis. Therefore, we investigated the expression and localization of CXCL16 and its receptor, CXCR6, in ovarian endometriotic tissues. We also examined whether CXCL16 induces IL-8 production in endometriotic stromal cells.Methods
We performed immunohistochemical and Western blotting analyses of in vivo and in vitro samples. IL-8 production was assayed using an ELISA.Results
Both CXCL16 and CXCR6 were expressed by endometriotic epithelial cells and stromal cells, but not normal ovarian stroma. A Western blotting analysis using primary cultured endometriotic stromal cells showed a constant expression of CXCL16 and CXCR6 in the proliferative phase, secretory phase and during gonadotropin-releasing hormone agonist therapy. CXCL16 induced IL-8 production in several endometriotic stromal cells in vitro.Conclusions
CXCL16 and CXCR6 might be involved in the pathophysiology of endometriosis through regulation of the inflammatory response. 相似文献11.
Aflatoonian A Yousefnejad F Eftekhar M Mohammadian F 《Archives of gynecology and obstetrics》2012,286(3):771-775
Objective
Safe, simple and cost-effective protocol is an important goal in ART cycles. The aim of this prospective study was whether administration of low-dose hCG in late follicular phase can be used clinically to replace gonadotropin administration in GnRH long protocol.Materials and methods
122 patients who were candidates for ART enrolled the study and randomly divided into two groups. The control group (n?=?62) received standard long protocol and gonadotropin administration continued until the day of hCG injection (10,000?IU) for final follicular maturation. The study group (n?=?60) received GnRH long protocol and when at least ??6 follicles with mean diameter ??12?mm were observed in both ovaries, hMG was displaced by 200?IU per day of hCG until final follicular maturation.Results
There were no significant differences in age, basal FSH, infertility duration and infertility etiology between two groups. There were no statistically significant differences between two groups regarding chemical pregnancy, clinical pregnancy, ongoing pregnancy, and abortion per cycle (50, 40, 40, and 20?% in study group vs. 45.2, 35.5, 35.5, and 21.4?% in control group, respectively). Mean dose of used gonadotropins was significantly higher in control group than that in the study group (2,524?±?893?IU in control group and 1,439?±?433?IU in study group) (p?=?0.000).Conclusion
According to our data, we recommend the use of low-dose hCG in GnRH long protocol because of lower doses of used gonadotropins. 相似文献12.
Objective
Fetal malposition, specifically occiput posterior and transverse (OP/OT), is associated with higher intra-partum morbidity. We tested the hypothesis that young maternal age and pelvic immaturity are risk factors for fetal malposition.Methods
In a cohort study of all nulliparous teen (??18?years) deliveries over a 4-year period at one institution, fetal head position at time of delivery was collected and correlated with maternal characteristics and outcome data. Using Risser staging observations, pelvic maturity age was set at 16, and accordingly, the women were divided into two groups (younger vs. older teens). Analysis was performed using Fisher??s exact, student t test, and logistic regression modeling.Results
Older teen mothers (16?C18?years, n?=?609) had higher rates of malposition (22 vs. 12?%, p?=?0.02) when compared with younger teens (??15?years, n?=?98). Among all women with a malpositioned fetus, older teens had a higher body mass index (BMI: 32.6?±?6.7 vs. 28.5?±?3.5, p?=?0.04) and subsequent need for cesarean delivery (69 vs. 33?%, p?=?0.02) when compared with their younger counterparts. Although younger teens were more successful in having a vaginal delivery (67?%) with an OP/OT position, it was at the expense of a 25?% rate of severe perineal laceration (third/fourth degree).Conclusion
Obesity, and not young maternal age or pelvic immaturity, is associated with fetal malposition. The direct association with increasing pre-pregnancy BMI and the long-term impacts of the high rates of cesarean delivery in this young population underscores the need for more public health focus. 相似文献13.
Kahraman K Kiremitci S Taskin S Kankaya D Sertcelik A Ortac F 《Archives of gynecology and obstetrics》2012,286(1):173-178
Background
PAX2 is a member of paired box gene family and expressed during development of urogenital system. This study aimed to evaluate PAX2 expression pattern in hyperplastic and malignant endometrial tissues in comparison to non-pathological endometrial changes and to investigate the presence of any correlation between the PAX2 expression and tumor behavior.Methods
The study was performed on the archival material of 121 endometrial tissues including complex hyperplasia (n?=?18), complex atypical hyperplasia (n?=?20), and endometrioid type adenocarcinoma (n?=?47) as study groups, and proliferative endometrium (n?=?21) and atrophic endometrium (n?=?16) as control groups. One representative block for each case was selected for immunohistochemical evaluation. Sections with 4??m thickness were cut from the blocks and incubated with PAX2 rabbit anti-human polyclonal antibody.Results
PAX2 nuclear staining was detected in all of the endometrial tissues. The mean percentages of PAX2 staining cells were 80.8, 96.7, 88.6, 92.7, and 99.2% with proliferative endometrium, atrophic endometrium, complex hyperplasia, complex atypical hyperplasia, and adenocarcinoma, respectively (Kruskal?CWallis; P?0.001). The frequency of PAX2 staining increased as the pathology progressed in the manner of complex hyperplasia????complex atypical hyperplasia????adenocarcinoma. In cancer cases, there was no correlation between PAX2 expression levels and the stage, histological grade, myometrial invasion, and lymph node status.Conclusions
PAX2 is expressed in hyperplastic and malignant endometrium as well as proliferative and atrophic endometrium. As the neoplastic lesion progresses from a premalignant state to endometrial cancer, PAX2 expression increases. These findings suggest that PAX2 may contribute to the development of endometrial cancer. 相似文献14.
Jia S Xu L Chan Y Wu X Yang S Yu H Yang H Luo Y Tang W 《Archives of gynecology and obstetrics》2012,285(6):1657-1661
Background
p53 tumour suppressor gene Arg72Pro polymorphism has been associated with endometriosis. However, the current available data were inconsistent. We performed this meta-analysis to estimate the association between p53 Arg72Pro polymorphism and endometriosis.Methods
Electronic screening of PubMed library was conducted to select studies. Studies containing available genotype frequencies of Arg72Pro were chosen, and pooled odds ratio (OR) with 95% confidence interval (CI) was used to assess the association.Results
Six published studies, including 749 endometriosis and 857 controls were identified. The overall results suggested that the variant genotypes were not associated with the endometriosis risk (Pro/Pro?+?Arg/Pro vs. Arg/Arg: OR?=?1.552, 95% CI 0.916–2.632, p?=?0.103). In the stratified analysis, individuals carried the Pro allele in a dominant model had increased risk of endometriosis (OR?=?2.595, 95% CI 1.005–6.702, p?=?0.049) in Asian subjects. The symmetric funnel plot, the Egger’s test (p?=?0.602), and the Begg’s test (p?=?0.167) were all suggestive of the lack of publication bias. However, the association was not significant between this polymorphism and endometriosis in Caucasian (OR?=?1.005, 95% CI 0.755–1.337, p?=?0.972).Conclusion
This meta-analysis suggests that p53 codon 72 Pro/Pro?+?Arg/Pro genotypes are associated with increased risk of endometriosis in Asian. To validate the association between p53 codon 72 polymorphism and endometriosis, further studies with larger participants worldwide are needed. 相似文献15.
Aim
Obesity is traditionally believed to increase the incidence of perioperative complications in abdominal surgery. Recently this paradigm has been challenged mainly by observations from surgical specialties other than gynecology. Our aim was to assess the impact of obesity on perioperative course in women undergoing total abdominal hysterectomy.Methods
We analyzed medical charts of 126 patients who underwent total abdominal hysterectomy for benign gynecological conditions through a low transverse incision in the Department of Obstetrics and Gynecology of the Provincial Specialist Hospital in Czestochowa, Poland. Perioperative course was compared between obese [n?=?55; body mass index (BMI)????30?kg/m2: mean 32.6?±?3.2?kg/m2] and non-obese patients (n?=?71; mean BMI 24.3?±?3?kg/m2).Results
The mean operative time in obese women was significantly prolonged (112?±?32 vs. 100?±?31?min, P?=?0.036). However, complication rates and other perioperative outcomes were comparable between the groups.Conclusion
In our study, mild obesity does not significantly affect the perioperative course in women undergoing total abdominal hysterectomy. 相似文献16.
Ozgur Akbay?r Oguzhan Kuru P?nar Goksedef Ceyhun Numanoglu Aytul Corbac?oglu Ahmet Cetin 《Archives of gynecology and obstetrics》2012,286(5):1241-1245
Aim
To evaluate the feasibility of ovarian preservation at the time of operation in patients with clinical stage I endometrial carcinoma.Materials and methods
The data of 499 consecutive patients with clinical stage 1 endometrial cancer operated between January 2001 and December 2011 were retrospectively reviewed. Clinical and pathologic information and the intraoperative inspection findings of ovaries were evaluated to find the factors associated with the coexisting ovarian malignancy.Results
The mean age of patients was 56.8?±?9.8?years. Coexisting ovarian tumors were detected in 38 patients (7.6?%), and 28 (5.6?%) of them were malignant (12 metastatic and 16 synchronous primaries). Most of the patients were postmenopausal (n?=?371, 74.3?%) and 60 (12?%) of the patients were at the age of 45?years or less. Coexisting malignancy was detected in 9?% (n?=?11) of the premenopausal patients and in 5?% (n?=?3) of the patients aged 45?years or less. Multivariate analysis revealed that serosal invasion, tubal involvement, and positive abdominal cytology were independent risk factors for coexisting ovarian malignancy. The sensitivity, specificity, positive predictive value and negative predictive value of the intraoperative examination for the diagnosis of benign/normal ovary was 99.6, 78.8, 98.5 and 92.9?%, respectively.Conclusion
The incidence of coexisting ovarian malignancy in clinical stage I endometrial carcinoma is low. Although occult metastasis cannot be excluded at all, careful intraoperative inspection of ovaries seems valuable for the prediction of co-existing ovarian malignancy. 相似文献17.
Findik RB Yilmaz FM Yilmaz G Yilmaz H Karakaya J 《Archives of gynecology and obstetrics》2012,286(4):913-916