视盘周围血管密度和视网膜神经纤维层厚度与眼轴长度和屈光度的相关性分析

目的应用光学相干断层扫描血管成像(optical coherence tomography angiography,OCTA)观察视盘周围血管密度和视网膜神经纤维层(retinal nerve fibre layer,RNFL)厚度与眼轴长度和屈光度之间的关系。方法纳入受试者40名40眼,测量屈光度和眼轴长度,通过OCTA检查各上方、下方、鼻侧、颞侧四个象限及整体视盘周围血管密度,测量相应区域的视盘周围RNFL厚度,分析两者之间及两者分别与眼轴长度和屈光度之间的相关性。结果视盘周围整体RNFL厚度与眼轴长度呈显著负相关(r=-0.760,P<0.001),与屈光度呈显著正相关(r=0.625,P<0.001)。且上方、下方和鼻侧象限的视盘周围RNFL厚度均与眼轴长度呈显著负相关(r=-0.506、-0.667、-0.700,均为P<0.01),与屈光度呈显著正相关(r=0.409、0.506、0.556,均为P<0.01)。视盘周围整体及颞侧象限的血管密度与眼轴长度均呈显著负相关(均为P<0.05),与屈光度均呈显著正相关(均为P<0.05)。视盘周...     

正常人黄斑厚度及视盘旁神经纤维频域OCT分析

目的 应用频域OCT(spectral domain Optical Coherence Tomography,SD-OCT)分析正常人眼黄斑厚度、体积及视盘旁神经纤维的分布情况.方法 应用频域OCT对62名124只眼正常人(21～58岁)黄斑及视盘旁进行快速扫描,测量正常眼中心/小凹厚度(Central point thickness,CPT),黄斑部直径为3mm圆形区域内9个分区内平均厚度(Th)及体积(V);同时测量视盘旁直径为3.4mm圆形区域神经纤维分布情况.入组标准:矫正视力20/20,眼压正常,没有已知眼病.结果 124只正常眼中心小凹平均厚度为(215.11±15.475)μm,中心区为(255.56±16.709)μm),黄斑区厚度图呈开口向颞侧的马蹄形,在所有ETDRS区域中,鼻外象限厚度最大(352.87±15.886)μm;中心凹鼻侧厚度及体积大于颞侧(P<0.05);在内环区域,上下方视网膜厚度及体积无明显差异;在外环区域,上下方视网膜厚度及体积差异有统计学意义(P<0.05);视盘旁神经纤维的分布,颞下方神经纤维分布最多,鼻侧神经纤维最少差异有统计学意义.结论 应用频域OCT测量,正常人眼黄斑部中心小凹厚度为(215.11±15.475)μm,中央区为(255.56±16.709)μm,神经纤维层厚度与以往时域OCT测量结果基本一致.频域OCT成像清晰,能够精确测量黄斑视网膜厚度及视盘旁神经纤维分布情况,可为临床诊治黄斑及视神经病变提供客观、定量的指标.

Abstract：

Objective To determine normal values for macular thickness, volume and peripapillary retinal nerve fiber layer thickness(RNFL)measured by spectral domain Optical Coherence Tomography (SD-OCT)in subjects with no known retinal disease and to examine the relationship of RNFL with macular thickness. Methods Sixty-two healthy adults(124 eyes, 21-58 years old)with no known eye disease,best-corrected visual acuity 20/20, and normal intraocular pressure were enrolled. All subjects underwent a complete ophthalmologic examination to rule out any retinal diseases or glaucoma. All the OCT scans were performed by a single operator, Central point thickness(CPT)and retinal thickness(Th)in 9 Early Treatment Diabetic Retinopathy Study(ETDRS)subfields, including central subfield(CSF), were analyzed. Statistical analyses were carried out using the analysis of variance. RNFL thickness was measured around the optic nerve head using 16 automatically averaged, consecutive circular B-scans with 3.4 mm diameter. The automatically segmented RNFL thickness was divided into 7 segments. Results Overall, the mean CPT was(215.11±15.475)μ m, and mean CSF was(255.56± 16.709)μ m. The macular thickness mapping in normal persons was "horse shoe" shaped open to the temporal side. Among the ETDRS subfields, the outer nasal quadrant had the maximum thickness(352.87± 15.886)μ m. The nasal quadrant had a larger thickness and volume than temporal side(P 0.05); in the inner circle area, there was no difference between the superior and inferior retinal average thickness; on the contrary, there was a significant difference between the superior and inferior retinal average thickness and volume in outer circle area. While the distribution of peripapillary retinal nerve fiber also had marked difference. The inferior-temporally side had the most, while the nasal side had the least. Conclusions Normative values for macular thickness in otherwise healthy eyes ware measured to be(215.11 ±15.475)μ m(CPT)and(255.56± 16.709)μ m(CSF)using commercially available Spectralis SD-OCT. Normal RNFL results with SD-OCT are comparable to those reported with time-domain OCT. Due to the legible imaging characters, the SD-OCT can measure normal macular thickness and the distribution of peripapillary retinal nerve fiber accurately, which can provide objective and quantitative indexs for diagnosis and therapy of macular disease and optical neuropathy.     

病理性近视视盘及其相关结构的形态学改变

病理性近视眼的视盘及其相关结构的形态学改变,包括视网膜神经纤维层厚度改变、视盘形态改变等,由此可引起相应的视功能改变.病理性近视眼因后巩膜葡萄肿的形成及生物力学特性的改变,可能导致视神经的结构和功能发生异常.这其中一些变化可能与青光眼的发生密切相关,或者对青光眼诊断造成困扰.     

中低度近视青少年患者视盘参数特征:基于SD-OCT研究

目的 观察并分析12～18岁中低度近视青少年患者视盘参数特征.方法 应用频域光学相干断层扫描(SD-OCT)对2019年7月至12月就诊于新疆医科大学第五附属医院眼科的157例157眼12～18岁中低度近视青少年患者行视盘检测.根据等效球镜(SE)分为对照组(52眼)和低度近视组(60眼)、中度近视组(45眼).对SD...     

大视杯人群视盘面积和视网膜神经纤维厚度的关联性分析

目的研究大视杯人群视盘面积和视网膜神经纤维厚度的关系。方法选择39例大视杯受试者(60眼),杯盘面积比介于0.36～0.75之间。用光学相干断层成像术(OCT)对患者的视盘参数和视网膜神经纤维平均厚度进行测量。根据视盘面积的大小,把患者分为大视盘组(视盘面积≥2.8mm2)和小视盘组(视盘面积<2.8mm2)。结果小视盘组视盘面积为:2.38mm2±0.29mm2,杯盘面积比:0.50±0.13,神经纤维厚度为:87.73μm±18.59μm。大视盘组视盘面积为:3.26mm2±0.36mm2,杯盘面积比:0.58±0.10,神经纤维厚度为:100.67μm±18.56μm。大视盘组神经纤维厚度显著大于小视盘组神经纤维厚度(P<0.01)。结论大视杯人群中,视盘面积是反映视网膜神经纤维厚度的重要因素之一。视盘越大,神经纤维厚度越大。     

正常人黄斑厚度及视盘旁神经纤维频域OCT分析

Objective To determine normal values for macular thickness, volume and peripapillary retinal nerve fiber layer thickness(RNFL)measured by spectral domain Optical Coherence Tomography (SD-OCT)in subjects with no known retinal disease and to examine the relationship of RNFL with macular thickness. Methods Sixty-two healthy adults(124 eyes, 21-58 years old)with no known eye disease,best-corrected visual acuity 20/20, and normal intraocular pressure were enrolled. All subjects underwent a complete ophthalmologic examination to rule out any retinal diseases or glaucoma. All the OCT scans were performed by a single operator, Central point thickness(CPT)and retinal thickness(Th)in 9 Early Treatment Diabetic Retinopathy Study(ETDRS)subfields, including central subfield(CSF), were analyzed. Statistical analyses were carried out using the analysis of variance. RNFL thickness was measured around the optic nerve head using 16 automatically averaged, consecutive circular B-scans with 3.4 mm diameter. The automatically segmented RNFL thickness was divided into 7 segments. Results Overall, the mean CPT was(215.11±15.475)μ m, and mean CSF was(255.56± 16.709)μ m. The macular thickness mapping in normal persons was "horse shoe" shaped open to the temporal side. Among the ETDRS subfields, the outer nasal quadrant had the maximum thickness(352.87± 15.886)μ m. The nasal quadrant had a larger thickness and volume than temporal side(P 0.05); in the inner circle area, there was no difference between the superior and inferior retinal average thickness; on the contrary, there was a significant difference between the superior and inferior retinal average thickness and volume in outer circle area. While the distribution of peripapillary retinal nerve fiber also had marked difference. The inferior-temporally side had the most, while the nasal side had the least. Conclusions Normative values for macular thickness in otherwise healthy eyes ware measured to be(215.11 ±15.475)μ m(CPT)and(255.56± 16.709)μ m(CSF)using commercially available Spectralis SD-OCT. Normal RNFL results with SD-OCT are comparable to those reported with time-domain OCT. Due to the legible imaging characters, the SD-OCT can measure normal macular thickness and the distribution of peripapillary retinal nerve fiber accurately, which can provide objective and quantitative indexs for diagnosis and therapy of macular disease and optical neuropathy.     

近视对OCT测量视网膜神经纤维层厚度的影响

目的探讨近视对光学相干断层扫描(OCT)测量视网膜神经纤维层厚度(retinal nerve fiber layer thickness,RNFLT)的影响。方法选取近视患者77例133眼分别行OCT氉测量RNFLT与屈光度测量,各测量3次,对屈光度与全周RNFLT进行简单相关分析与直线回归分析,对全周RNFLT与屈光度、年龄进行偏相关分析。结果屈光度的绝对值与全周RNFLT呈负相关。进一步进行两者的回归分析,回归方程为:RNFLT=-0.954×屈光度的绝对值+107.472。对全周RNFLT与屈光度、年龄进行多重线性回归分析,回归方程为:RNFLT=-0.800×屈光度绝对值-0.16 6×年龄+111.707。结论屈光度的绝对值与RNFLT呈负相关,近视度数每增加1.0D,全周RNFLT减少0.800μm,年龄每增加1岁,全周RNFLT减少0.166μm。     

近视儿童青少年盘周神经纤维层厚度的研究

目的：通过测量6～18 岁正视和近视儿童青少年盘周神经纤维层（RNFL）厚度,分析盘周平均RNFL厚度及相关的影响因素,研究不同屈光状态下盘周RNFL厚度分布地形图特点。方法：横断面研究。采用频域光学相干断层扫描仪测量6～18岁正视和近视儿童青少年盘周RNFL厚度,测量眼部及全身生物学指标（包括身高、体质量、体质量指数、头围、胸围、腰围、血压等）。根据等效球镜度（SE）分为不同的屈光组（包括正视组、低度近视组、中度近视组和高度近视组）,分析不同屈光状态下盘周不同区域RNFL厚度和地形图及厚度变化的影响因素。盘周RNFL厚度与各测量指标之间的相关性采用一元和多元逐步回归,各个组之间的差异采用单因素方差分析。结果：1 056 名正视和近视儿童青少年盘周各区域平均RNFL厚度为（104 ± 10）μm,正视组为（107 ± 9）μm,低度近视组为（105 ± 9）μm,中度近视组为（101 ±10）μm,高度近视组为（95 ± 8）μm。不同屈光组之间RNFL厚度差异均具有统计学意义（P < 0.01）。多元逐步回归显示RNFL平均厚度与SE（r=0.25,P < 0.001）、眼轴长度（AL）（ r=-0.18,P < 0.001）和晶状体厚度（LT）（ r=0.10,P =0.033）有相关性,与SE和LT呈正相关,与AL呈负相关;与性别、年龄等其他因素无相关性。不同屈光组,盘周RNFL厚度分布地形图不同。所有参与者的颞下象限最厚,为（162 ± 23）μm,鼻侧象限最薄,为（61 ± 10）μm。正视组和不同程度近视组中RNFL厚度均为颞下象限最厚,鼻侧象限最薄,其他区域的厚度地形图在不同的屈光组是不同的。颞侧盘周RNFL厚度随近视程度增加而增加,低度近视组为（87 ± 14）μm,高度近视组为（98 ± 21）μm;而其他区域的RNFL厚度则随着近视度数的增加而降低,尤其是鼻下象限。结论：盘周RNFL平均厚度与SE和LT呈正相关,与AL呈负相关;近视程度不同,盘周各区域RNFL厚度分布不同;颞侧RNFL随近视程度增加而逐渐变厚,其余象限则变薄。     

视网膜色素变性患者视盘神经纤维层厚度及视盘参数的前瞻性研究

目的：探析视网膜色素变性(RP)患者视盘神经纤维层厚度及视盘参数的研究。

方法：临床选择2015-04/2016-04本院收治的视网膜色素变性患者40例80眼为观察组,同期选择体检健康者40例80眼作为研究对照,全部研究对象进行OCT检查,比较RP患眼组与正常对照组的颞侧、上方、鼻侧、下方各象限的视网膜神经纤维层(retinal nerve fiber layer, RNFL)厚度、盘沿体积、视杯体积、杯盘垂直径比、杯盘水平直径比、杯盘面积比、盘沿面积、视杯面积、视盘面积等视盘参数。

结果：RP患眼组的全周、鼻侧、颞侧、上方、下方CP-RNFL厚度显著高于正常对照组,差异有统计学意义(P<0.05); RP患眼组的盘沿体积、视盘体积、C/D垂直直径比、C/D水平直径比、C/D面积比、盘沿面积、视杯面积、视盘面积等视盘参数指标显著高于正常对照组,差异有统计学意义(P<0.05)。

结论：视网膜色素变性患眼的颞侧、鼻侧RNFL厚度、全周RNFL平均厚度与健康体检者相比均增厚,而其视杯体积、杯盘垂直直径比、杯盘水平直径比、杯盘面积比、视杯面积、视盘面积增大。     

OCT检测视网膜神经纤维层厚度与视盘大小的相关性研究

目的探讨光学相干断层扫描(OCT)技术常规扫描模式检测视网膜神经纤维层(RNFL)厚度是否受视盘大小的影响,为其准确客观地应用于临床提供理论依据。方法对年龄在18～30岁的正常人118名(118眼)应用OCT常规扫描模式对盘周RNFL厚度进行检测。应用眼底照相检测视盘面积、水平及垂直直径。分析RNFL厚度与视盘大小的相关性。结果全周平均RNFL厚度值,上方、下方、鼻侧、颞侧象限RNFL厚度值分别为(112.02±10.13)、(135.16±19.04)、(138.56±16.46)、(71.56±14.91)、(97.43±17.98)μm。视盘垂直、水平直径及面积分别为(1.88±0.25)mm2、(1.79±0.19)mm2及(2.67±0.44)mm2。RNFL厚度值与视盘面积有正相关性(P<0.05)。结论OCT常规扫描模式检测RNFL厚度受视盘大小的影响。     

Assessment of changes in optic disc parameters and peripapillary retinal nerve fiber layer thickness in myopic patients and its correlation with axial length and degree of myopia

Purpose:The present study aimed to assess the changes in optic disc and peripapillary retinal nerve fiber layer (RNFL) parameters in myopic patients and its correlation with axial length (AL) and spherical equivalent (SE) using optical coherence tomography (OCT).Methods:This was a cross-sectional study carried out from August 2019 to September 2021 in the ophthalmology department of a tertiary care hospital in eastern India. Myopic patients in the age group of 20–40 years and SE between − 0.5 to − 10 Diopters (D) were included in the study. Patients were divided into two groups on the basis of degree of myopia and AL. Appropriate statistical analysis was done at the end of the study period.Results:The study included 307 eyes of 307 myopic patients. There were 181 females (58.96%) and 126 males (41.04%). The mean age of the patients enrolled for the study was 28.78 ± 5.76 years. Statistically significant difference (P < 0.001) was found between SE and AL in between the subgroups of A and B. With every 1 D increase in SE, the average peripapillary RNFL thickness decreased by 0.61 µ while with every 1 mm increase in AL, the average peripapillary RNFL thickness was found to reduce by 1.03 µ.Conclusion:Analysis of optic nerve head parameters and RNFL thickness by OCT for the diagnosis should be compared with a normative control group that has been matched for refractive error and AL instead of comparison with a normative database that has only been age matched.     

Effect of myopia and optic disc area on ganglion cell-inner plexiform layer and retinal nerve fiber layer thickness

Purpose:The aim of this work was to study the impact of myopia and different optic disc areas on ganglion cell-inner plexiform layer (GCIPL) and retinal nerve fiber layer (RNFL) thickness profiles in myopic patients by spectral-domain optical coherence tomography (SD-OCT).Methods:This was a cross-sectional study of 100 eyes of 50 myopic individuals. All patients underwent complete ophthalmic evaluation and SD-OCT examination. According to spherical equivalent (SE), patients were divided into M1, M2, and M3 (low, moderate, and high myopia group). According to optic disc area values, patients were divided into D1, D2 and D3 (small, medium and large disc groups). Average GCIPL and RNFL thickness recorded globally and separately for all quadrants and also according to 12 clock hours and analyzed with respect to different myopic groups, optic disc area groups, and axial length.Results:Quadrantic RNFL thickness profiles and their average RNFL thickness were significantly thinner in high myopic group compared to low myopic group, except for the temporal quadrant (P < 0.05). Average RNFL and RNFL thickness of all quadrants were significantly thicker in the large disc group than in the small disc group (P < 0.05). Average GCIPL and GCIPL thicknesses of all sectors were significantly thinner in high myopic group compared to low myopic group (P < 0.05). No significant correlation was observed between GCIPL and disc area changes. Average RNFL thickness correlated significantly with SE (3.667 μm/diopter), axial length (–5.3805 μm/mm) and optic disc area (9.4617 μm/mm²). Also, average GCIPL thickness correlated statistically significantly with SE (1.6807 μm/diopter) and axial length (–2.626 μm/mm).Conclusion:Myopia and axial length significantly reduce RNFL and GCIPL thickness profiles but the optic disc area significantly increases RNFL thickness, but not GCIPL thickness.     

The effects of optic disc factors on retinal nerve fiber layer thickness measurement in children

PURPOSE: We analyzed the effect of the changes of the optic disc area (ODA) caused by the axial length and the refractive error, and the consequent changes of the distance from the optic disc margin to the circular scan (OD-CS) of Optical coherence tomography (OCT) on the measurement of the retinal nerve fiber layer thickness(RNFLT) were examined. METHODS: One hundred two eyes of 51 children (age range 4 to 15 years) were measured using OCT including the RNFLT. For the ODA and the OD-CS, the relative area formed by the ODA and the circular scan was obtained. In addition, the correlation of the refractive error and the axial length to the optic disc factors was assessed. RESULTS: As hyperopia progresses to myopia, the axial length became longer, the ODA became smaller (r=-0.442, p=0.000) and the OD-CS showed a tendency to increase (r=0.471, p=0.000). As the OD-CS became longer, the measured average RNFLT decreased significantly (r=-0.248, p=0.012), and the ODA and the OD-CS showed a significant correlation to the RNFL thickness that was measured in the nasal and inferior areas, the S2, N2 and N3 areas and the I1 area. CONCLUSIONS: As ODA becomes smaller and the OD-CS becomes longer, the RNFLT measured in the nasal and inferior areas, the S2, N2, N3, I1 area has a tendency to be thinner. Hence, consideration of the disc area is required when interpreting the RNFLT of these eyes.     

不同程度近视患者视网膜神经纤维层厚度、黄斑外环区视网膜厚度观察

目的　观察不同程度近视患者视盘旁视网膜神经纤维层（ｒｅｔｉｎａｌｎｅｒｖｅｆｉｂｅｒｌａｙ-ｅｒ,ＲＮＦＬ）厚度、黄斑外环区视网膜厚度变化,并分析其特点。方法　参与检测的受检者共２０９例３９９眼分４组,分别为中低度近视组５２例（９８眼）、高度近视组４７例（９１眼）、高度近视青光眼组５７例（１０４眼）及５３人（１０６眼）健康志愿者为正常对照组。采用光学相干断层扫描仪测量视盘旁上方、颞侧、下方、鼻侧四个象限的ＲＮＦＬ厚度,视盘周围全周ＲＮ-ＦＬ厚度,黄斑外环区四个象限的视网膜厚度。采用Ｐｅａｒｓｏｎ相关分析法分析近视患者屈光度数与ＲＮＦＬ厚度及黄斑外环区视网膜厚度的相关性。结果　各组视盘旁ＲＮＦＬ厚度以上象限和下象限较厚,其次为颞侧象限,而鼻侧象限最薄。正常对照组与中低度近视组各象限ＲＮＦＬ厚度比较差异无统计学意义（Ｆ＝１．７３２,Ｐ＞０．０５）,其余各近视眼组患眼各象限ＲＮＦＬ厚度均有差异（Ｆ＝３６１．７１、４７８．９２、３９５．１６,均为Ｐ＜０．０５）。近视患者屈光度数与上、下、鼻侧ＲＮＦＬ厚度呈负相关（ｒ＝－０．２７９、－０．３１９、－０．２１３,均为Ｐ＜０．０５）,与颞侧象限ＲＮＦＬ厚度呈正相关（ｒ＝０．３２６,Ｐ＜０．０５）。高度近视青光眼组与高度近视眼组之间比较黄斑外环区颞侧、上方视网膜厚度减少,差异有统计学意义（Ｆ＝４７５．１２,Ｐ＜０．０５）。结论　光学相干断层扫描能够检测高度近视青光眼的ＲＮＦＬ厚度及黄斑外环区厚度的变化,为青光眼的早期诊断提供了一定的帮助。     

Correlations between the optic nerve head morphology and ocular biometrics in highly myopic eyes

AIM: To analyze peripapillary atrophy β/γ zone (PPA-β/γ) and the optic disc ovality index, and to assess their associations with the axial length (AL), refractive error, best corrected visual acuity (BCVA), choroidal thickness (CT), and age in highly myopic eyes. METHODS: This was a retrospective observational case series. The study included 667 patients consecutively examined for highly myopic eyes [spherical equivalent ≤-6.0 diopters (D) and AL≥26 mm] with or without myopic retinopathy. Each patient went through a comprehensive ophthalmological examination that included spectral domain optical coherence tomography (SD-OCT) of the macula, A-mode ultrasonography, and a cycloplegic refraction test. The ovality index and PPA-β/γ area were measured from optic disc photographs. RESULTS: A significant association was seen between PPA-β/γ area and the ovality index (P=0.000, r=-0.232). The PPA-β/γ area increased significantly with a longer AL, older age, worse BCVA, higher refractive error, and thinner choroid (P<0.01). The oval disc was significantly correlated with a longer AL, older age, worse BCVA, higher refractive error, larger PPA-β/γ area, and thinner choroid (P<0.01). CONCLUSION: The PPA-β/γ zone and ovality index in highly myopic eyes show distinct associations with the AL, refractive error, BCVA, age, and CT.     

Five rules to evaluate the optic disc and retinal nerve fiber layer for glaucoma.

A systematic approach for the examination of the optic disc and retinal nerve fiber layer is described that will aid in the detection of glaucoma. This approach encompasses 5 rules: evaluation of optic disc size, neuroretinal rim size and shape, retinal nerve fiber layer, presence of parapapillary atrophy, and presence of retinal or optic disc hemorrhages. A systematic process enhances the ability to detect glaucomatous damage as well as the detection of progression, and facilitates appropriate management.     

OCT测量视网膜神经纤维层厚度及视盘参数在青光眼早期诊断中的应用

青光眼是一种进行性视神经疾病,它能引起视神经结构改变,最终导致不可逆的视功能损害。青光眼的早期诊断对保护视功能有重要意义。光学相干断层扫描仪是一种准确性和可重复性高的视网膜神经纤维层厚度和视盘参数检测技术,为早期诊断青光眼,监测视神经损害及指导青光眼的治疗提供了新的思路。我们主要阐述该技术在青光眼早期诊断中的应用。     

OCT在病理性近视眼视盘神经纤维层厚度检测中的应用

目的：应用频域光学相干断层扫描成像（optical coherence tomography,OCT）技术研究病理性近视眼视盘神经纤维层厚度的变化特点及其与眼轴、性别和年龄的关系,为病理性近视合并原发性开角型青光眼的早期诊断提供帮助。方法：选取对照组正常眼96眼（眼轴23～24mm）和观察组病理性近视眼153眼（眼轴25～27mm 80眼,〉27mm 73眼）; 应用频域OCT检测视盘神经纤维层的厚度; 比较对照组与观察组视盘神经纤维层厚度的差异; 使用多元线性回归分析观察组视盘全周的平均厚度与眼轴、性别和年龄的关系。结果：观察组视盘神经纤维层的全周平均、上下及鼻侧象限平均厚度值均变薄,与对照组相比均具有统计学意义（P〈0.05）,颞侧象限相比较无统计学意义（P〉0.05）; 观察组视盘神经纤维层的全周平均厚度与眼轴的偏相关系数为-1.31,与性别的偏相关系数为5.21,与年龄的偏相关系数为-0.12。结论：病理性近视眼的视盘神经纤维层厚度较正常眼变薄,眼轴、性别和年龄是病理性近视眼视盘神经纤维层平均厚度的影响因素,对诊断合并病理性近视患者的青光眼视神经损害时应注意排除病理性近视对视盘神经纤维层厚度产生的影响。