T2-weighted balanced SSFP imaging (T2-TIDE) using variable flip angles.

A new technique for acquiring T2-weighted, balanced steady-state free precession (b-SSFP) images is presented. Based on the recently proposed transition into driven equilibrium (TIDE) method, T2-TIDE uses a special flip angle scheme to achieve T2-weighted signal decay during the transient phase. In combination with half-Fourier image acquisition, T2-weighted images can be obtained using T2-TIDE. Numerical simulations were performed to analyze the signal behavior of T2-TIDE in comparison with TSE and b-SSFP. The results indicate identical signal evolution of T2-TIDE and TSE during the transient phase. T2-TIDE was used in phantom experiments, and quantitative ROI analysis shows a linear relationship between TSE and T2-TIDE SNR values. T2-TIDE was also applied to abdominal and head imaging on healthy volunteers. The resulting images were analyzed quantitatively and compared with standard T2-weighted and standard b-SSFP methods. T2-TIDE images clearly revealed T2 contrast and less blurring compared to T2-HASTE images. In combination with a magnetization preparation technique, STIR-weighted images were obtained. T2-TIDE is a robust technique for acquiring T2-weighted images while exploiting the advantages of b-SSFP imaging, such as high signal-to-noise ratio (SNR) and short TRs.     

Estimating T1 from multichannel variable flip angle SPGR sequences

Quantitative estimation of T₁ is a challenging but important task inherent to many clinical applications. The most commonly used paradigm for estimating T₁ in vivo involves performing a sequence of spoiled gradient‐recalled echo acquisitions at different flip angles, followed by fitting of an exponential model to the data. Although there has been substantial work comparing different fitting methods, there has been little discussion on how these methods should be applied for data acquired using multichannel receivers. In this note, we demonstrate that the manner in which multichannel data is handled can have a substantial impact on T₁ estimation performance and should be considered equally as important as choice of flip angles or fitting strategy. Magn Reson Med, 2013. © 2012 Wiley Periodicals, Inc.     

Intuitive design guidelines for fast spin echo imaging with variable flip angle echo trains.

We present a simple and intuitive means for determining the flip angles (FAs) required for smooth transitions between static pseudo steady states (SPSSs) in fast spin echo (FSE) imaging with variable FA (VFA) echo trains. We demonstrate the effectiveness of single and multiple transition pulses to successfully vary refocusing FAs while retaining high signal levels. The graphical interpretation presented here is consistent with previous analytical techniques and permits accurate signal-intensity predictions along the echo train.     

Simultaneous variable flip angle-actual flip angle imaging method for improved accuracy and precision of three-dimensional T1 and B1 measurements

A new time-efficient and accurate technique for simultaneous mapping of T(1) and B(1) is proposed based on a combination of the actual flip angle (FA) imaging and variable FA methods. Variable FA-actual FA imaging utilizes a single actual FA imaging and one or more spoiled gradient-echo acquisitions with a simultaneous nonlinear fitting procedure to yield accurate T(1)/B(1) maps. The advantage of variable FA-actual FA imaging is high accuracy at either short T(1) times or long repetition times in the actual FA imaging sequence. Simulations show this method is accurate to 0.03% in FA and 0.07% in T(1) for ratios of repetition time to T1 time over the range of 0.01-0.45. We show for the case of brain imaging that it is sufficient to use only one small FA spoiled gradient-echo acquisition, which results in reduced spoiling requirements and a significant scan time reduction compared to the original variable FA method. In vivo validation yielded high-quality 3D T(1) maps and T(1) measurements within 10% of previously published values and within a clinically acceptable scan time. The variable FA-actual FA imaging method will increase the accuracy and clinical feasibility of many quantitative MRI methods requiring T(1)/B(1) mapping such as dynamic contrast enhanced perfusion and quantitative magnetization transfer imaging.     

Interleaved balanced SSFP imaging: Artifact reduction using gradient waveform grouping

Purpose

To analyze steady‐state signal distortions in interleaved balanced steady‐state free precession (bSSFP) caused by slightly unbalanced eddy‐current fields and develop a general strategy for mitigating these artifacts.

Materials and Methods

We considered bSSFP sequences in which two gradient waveforms are interleaved in a “groupwise” fashion, ie, each waveform is executed consecutively two or more times before switching to the other waveform (we let “N” count the number of times each waveform is executed consecutively). The steady‐state signal profile over the bSSFP passband was calculated using numerical Bloch simulations and measured experimentally in a uniform phantom. The proposed “grouped” interleaved bSSFP strategy was applied to cardiac velocity mapping using interleaved phase‐contrast imaging with N = 2 and N = 6 in one healthy volunteer.

Results

Simulation and phantom measurements show that signal distortions are systematically reduced with increasing grouping number N. For most tissues, significant suppression was achieved with N = 4, and increasing N beyond this value produced only marginal gains. However, signal distortions for blood remain relatively high even for N > 4. In vivo cardiac velocity mapping using interleaved phase‐contrast imaging with N = 6 demonstrated reduced image artifact levels compared to the N = 2 acquisition.

Conclusion

Gradient waveform “grouping” offers a simple and general strategy for mitigating steady‐state eddy‐current distortions in bSSFP sequences that interleave two different gradients. Blood exhibits significant distortion even with “grouping,” which is a major obstacle for cardiovascular bSSFP approaches that interleave multiple gradient waveforms. The grouping concept may also benefit applications that acquire images during the transient approach to steady state. J. Magn. Reson. Imaging 2009;29:745–750. © 2009 Wiley‐Liss, Inc.     

The central signal singularity phenomenon in balanced SSFP and its application to positive-contrast imaging

Small perturbations of steady-state sequence parameters can induce very large spectral profile deviations that are localized to specific off-resonant frequencies, denoted critical frequencies. Although, a small number of studies have previously considered the use of these highly specific modulations for MR angiography and elastography, many potential applications still remain to be explored. An analysis of this phenomenon using a linear systems technique and a geometric magnetization trajectory technique shows that the critical frequencies correspond to singularities in the steady-state signal equation. An interleaved acquisition combined with a complex difference technique yields a spectral profile containing sharp peaks interleaved with wide stopbands, while a complex sum technique yields a spectral profile similar to that of balanced steady-state free precession. Simulations and phantom experiments are used to demonstrate a novel application of this technique for positive-contrast imaging of superparamagnetic iron-oxide nanoparticles. The technique is shown to yield images with high levels of positive contrast and good water and fat background suppression. The technique can also simultaneously yield images with contrast similar to balanced steady-state free precession.     

Analysis and compensation of eddy currents in balanced SSFP.

Balanced steady-state free precession (SSFP) completely compensates for all gradients within each repetition time (TR), and is thus very sensitive to any magnetic field imperfection that disturbs the perfectly balanced acquisition scheme. It is demonstrated that balanced SSFP is especially sensitive to changing eddy currents that are induced by stepwise changing phase-encoding (PE) gradients. In contrast to the linear k-space trajectory, which has small variations between consecutive encoding steps, other encoding schemes (e.g., centric, random, or segmented orderings) exhibit significant jumps in k-space between adjacent PE steps, and consequently induce rapidly changing eddy currents. The resulting disturbances induce significant image artifacts, such that compensation strategies are essential when nonlinear PE schemes are applied. Although direct annihilation of the induced eddy currents by additional, opposing magnetic fields has been investigated, it is limited by uncertainty regarding the time evolution of induced eddy currents. A generic (and thus system-unrelated) compensation strategy is proposed that consists of "pairing" of consecutive PE steps. Another approach is based on partial dephasing along the slice direction that annihilates eddy-current-induced signal oscillations. Both pairing of the PE steps and "through-slice equilibration" are easy to implement and allow the use of arbitrary k-space trajectories for balanced SSFP.