共查询到20条相似文献,搜索用时 15 毫秒
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Wei Hong Xin-Min Yu Ming-Qiang Jiang Bo Chen Xin-Bao Wang Li-Tao Yang Yi-Ping Zhang 《World journal of gastroenterology : WJG》2009,15(19):2425-2427
Extramedullary plasmacytoma (EPM) is a plasma cell tumor arising outside of the bone marrow. Solitary EMP is an uncommon neoplasm and rarely occurs in the retroperitoneum and lacks distinctive clinical manifestations. We report a 26-year-old man with a solitary EMP in the retroperitoneum and discuss its clinical features, diagnosis and treatment. 相似文献
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Edwin H. Fendel M.B. Ch.B. Dr. Victor W. Fazio M.B. B.S. 《Diseases of the colon and rectum》1981,24(8):633-635
Extramedullary plasmacytoma (EMP) of the small bowel is a rare entity previously reported as a cause of intestinal obstruction
or bleeding. A case report of this disease entity presenting as an ileocolic fistula is reported. EMP is diagnosed by the
following critiera: 1) absence of paraproteinemia; 2) absence of Bence Jones proteinuiria; 3) normal skeletal survey; and
4) normal bone marrow biopsy specimen. Gastrointestinal plasmacytoma often occurs as a manifestation of multiple myeloma.
EMP of the gastrointestinal tract is a rare cases manifestation of the disease, accounting for 13 per cent of all cases of
EMP. It is a slow-spreading, radiosensitive tumor with a high tendency toward local recurrence. Surgical excision combined
with radiotherapy is the treatment of choice for EMP of the gastrointestinal tract. 相似文献
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Qin Zhang Ji-Wei Yu Wei-Li Yang Xiao-Sun Liu Ji-Ren Yu 《World journal of gastroenterology : WJG》2010,16(14)
Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor in the alimentary tract. To the best of our knowledge, few cases have been reported in the literature about the peripheral lymph node metastasis of GIST. Here we report an unusual case of gastric GIST with inguinal lymph nodes metastasis. After the metastatic lymph nodes were resected, the. Patient started to take imatinib 400 mg/d for 12 mo. There were no signs of tumor recurrence at follow-up after 29 mo.This case suggests that the inguinal lymph nodes can be a potential metastatic site of GIST. 相似文献
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K. Nagai K. Ando H. Yoshida S. Kusaka Y. Hinuma Y. Hakamata K. Ishii N. Kume H. Ochi Y. Wakatsuki M. Yokode M. Murakami T. Kita 《Annals of hematology》1997,74(6):279-281
An elderly patient with an extramedullary lung plasmacytoma and subsequent pleural effusion is described. The presence of
abnormal plasma cells in the pleural fluid led to diagnosis. Histologically similar conditions such as multiple myeloma and
solitary myeloma of bone were ruled out by clinical evaluation. These neoplasms usually occur in the head and neck area and
are not characterized by paraprotein accumulation. Few cases in the lung have been reported. We describe a case of extramedullary
plasmacytoma of the lung with plasmacytoma-induced pleural effusion and the presence of monoclonal paraprotein in both the
serum and urine. Chemotherapy with melphalan was effective in reducing the size of the plasmacytoma, and pleurodesis was used
to manage the pleural effusion.
Received: 16 December 1996 / Accepted: 16 April 1997 相似文献
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Evangelia Iosif Clare Rees Salome Beeslaar Awad Shamali Roberto Lauro Charis Kyriakides 《World journal of gastrointestinal endoscopy》2019,11(4):308-321
BACKGROUND Plasma-cell neoplasms rarely involve the gastrointestinal tract and manifest as gastrointestinal bleeding. Plasmablastic myeloma is an aggressive plasma cell neoplasm associated with poor outcomes. A small number of cases with gastrointestinal involvement is reported in the literature and therefore high index of suspicion is essential for avoiding delays in diagnosis and treatment.CASE SUMMARY Our aim is to present our experience of a 70-year-old patient with a secondary presentation of plasmablastic myeloma manifesting as unstable upper gastrointestinal bleeding and to review the literature with the view to consolidate and discuss information about diagnosis and management of this rare entity. In addition to our case, a literature search(Pub Med database) of case reports of extramedullary plasma cell neoplasms manifesting as upper gastrointestinal bleeding was performed. Twenty-seven cases of extramedullary plasmacytoma(EMP) involving the stomach and small bowel presenting with upper gastrointestinal bleeding were retrieved. The majority of patients were males(67%). The average age on diagnosis was 62.7 years. The most common site of presentation was the stomach(41%), followed by the duodenum(15%). The most common presenting complaint was melena(44%). In the majority of cases, the EMPs were a secondary manifestation(63%) at the background of multiple myeloma(26%), plasmablastic myeloma(7%) or high-grade plasma cell myeloma(4%). Oesophagogastroscopy was the main diagnostic modality and chemotherapy the preferred treatment option for secondary EMPs.CONCLUSION Despite their rare presentation, upper gastrointestinal EMPs should be considered in the differential diagnosis of patients with gastrointestinal bleeding especially in the presence of systemic haematological malignancy. 相似文献
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Qin Zhang Ji-Wei Yu Wei-Li Yang Xiao-Sun Liu Ji-Ren Yu 《World journal of gastroenterology : WJG》2010,16(14):1808-1810
Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor in the alimentary tract. To the best of our knowledge, few cases have been reported in the literature about the peripheral lymph node metastasis of GIST. Here we report an unusual case of gastric GIST with inguinal lymph nodes metastasis. After the metastatic lymph nodes were resected, the. patient started to take imatinib 400 mg/d for 12 mo. There were no signs of tumor recurrence at follow-up after 29 mo. This case suggests that th... 相似文献
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Lopes da Silva R 《Journal of digestive diseases》2012,13(1):10-18
Extramedullary plasmacytoma (EMP) of the small intestine is an unusual plasma cell neoplasm in this anatomic region with only 61 cases described so far. Clinical suspicion is infrequent owing to its location and nonspecific manifestations such as abdominal pain, obstructive symptoms or even bleeding. Diagnosis is reached through histopathological examination coupled with immunohistochemistry of the endoscopic biopsy or surgical resection specimens. Nevertheless, the differential diagnosis between EMP, lymphoma and other kinds of tumors can sometimes be troublesome. The managements include surgery, radiotherapy or chemotherapy. Generally, the prognosis of EMP is favorable, but occasionally it may relapse, or progress to a plasma cell myeloma. EMP should therefore be followed-up for a long period after treatment. In this comprehensive review of the current literature, the patients' characteristics, clinical manifestations, diagnosis, differential diagnosis, treatment and outcome were discussed. 相似文献
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Extramedullary plasmacytoma (EMP) is a rare neoplasm of soft tissue that usually arises in the respiratory tract, nasal cavity, sinuses, and nasopharynx. It is even more uncommon for it to arise either in the testis or heart. We report the presentation of a case where plasmacytomas were found sequentially in the testis, subcutaneous tissue, and heart. EMP usually has a good prognosis except when it involves the heart. Our patient survived for only 15 months post autologous hematopoietic stem cell transplantation. 相似文献
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目的:探讨多发性骨髓瘤(MM)椎管内浸润导致脊髓压迫症(SCCS)的临床表现、诊断及治疗方法。方法:分析6例MM合并SCCS患者的临床特点、MRI及CT表现、不同治疗方法及疗效,并相关文献复习。结果:6例MM合并椎管内髓外浆细胞瘤(EMP)均发生在胸椎节段。患者从感觉双下肢麻木、腰背部疼痛起,在数小时至3 d内即进展至截瘫状态。经MRI或CT检查诊断为椎管内硬膜外占位性病变。6例中5例接受了治疗。2例接受手术及术后化疗者,1例肌力改善,另1例无效;单纯接受化疗1例无效;2例接受放疗者,均恢复行走,其中1例肌力恢复至5级,另1例4级。结论:MM合并SCCS多发生在胸椎节段,病情进展快,需尽快治疗。MRI可明确病变部位,以放疗效果最佳。 相似文献
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RationaleSolitary bone plasmacytoma (SBP) is a rare manifestation of plasma cell tumor. Although axial skeleton is the most frequently affected site of SBP, adjacent disc space involvement is rare. Herein we report a case of SBP in thoracic vertebra with involvement of adjacent disc space.Patient concernsA 57-year-old male presented with a 2-year history of intermittent back pain with activity. The patient''s back pain intensity with activity was a score of 5 of the 10-point visual analog scale).Diagnoses and interventionThe patient underwent a posterior fusion procedure from T6 to T10, and an open biopsy of the vertebral lesion confirmed that final diagnosis of SBP. The patient received postoperative radiotherapy with a total of 4000 Gy to the T7–T9 vertebral levels over a 20-day period.OutcomesFollowing radiotherapy, the patient''s pain intensity was reduced to the visual analog scale score of 1 at the 6-month follow-up.LessonsSBP lacks typical clinical symptoms, and the accurate diagnosis before clinical intervention remains challenging. Due to the disc involvement, SBP often manifests as spinal infection. Hence, differential diagnosis in spinal lesions involving the disc should include SBP. 相似文献
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Anghel G Petti N Remotti D Ruscio C Blandino F Majolino I 《American journal of hematology》2002,71(2):98-104
Plasmacytomas of the testis are rare neoplasias; they may occur as isolated tumors or in concomitance with generalized multiple myeloma. We report the case of a 77-year-old man with previous clinical evidence of multiple myeloma involving skin, ribs, and lungs, and initially treated with surgery, radiotherapy, and chemotherapy attaining partial response. Fourteen months after the onset, the patient presented with left testicular enlargement due to plasmacytoma. Immunohistochemical stains showed monoclonal cytoplasmic IgA-lambda in tumour cells; serum M component showed the same immunoglobulin. Following radiotherapy the tumour mass disappeared. Nonetheless, 2 months later while on chemotherapy, disease recurred with progressive increase of skeletal lesions. The patient is currently alive with disease progression 22 months after onset. On the basis of a review of the literature, the clinical significance of testicular myeloma localization is discussed. 相似文献
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Papadaki HA Skordilis P Minadakis G Roussomoustakaki M Katrinakis G Psyllaki M Tzardi M Kouroumalis E Eliopoulos GD 《Annals of hematology》2003,82(9):589-592
We describe the first case of a primary gastric plasmacytoma stage I completely regressed following Helicobacter pylori (H.pylori) eradication. The patient, a 61-year-old man, had a long history of chronic gastritis and gastric ulcers with recurrent gastrointestinal hemorrhage. Diagnosis of H.pylori infection was based on the positive urease breath test, the elevated titers of serum anti-H.pylori antibodies, and the detection of the bacterium in gastric mucosa biopsy specimens. Diagnosis of gastric plasmacytoma was based on the findings of histopathology, immunocytochemistry and in situ hybridization. Eradication of H.pylori with antibiotics was followed by disappearance of endoscopic and histopathologic features of the gastric tumor 3 months after the completion of the treatment. No relapse has been documented 20 months after the initial diagnosis of plasmacytoma. A possible causal relationship between the tumor and the underlying H.pylori infection is discussed. 相似文献
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M. Yasunaga R. Ryo Y. Konaka S. Sawada H. Taniguchi H. Sawada M. Goto J. Jikai W. Sugano K. Saigo N. Yamaguchi 《Annals of hematology》1994,68(3):145-151
Summary A 25-year-old man noted swelling of the right cervical lymph nodes in October 1983. Diagnosis of malignant lymphoma was made on the basis of pathological examination of biopsies. Despite both chemotherapy and irradiation treatment, blast cells appeared in the peripheral blood and bone marrow in April 1984. Immunophenotypic analysis demonstrated that the blasts in the patient's peripheral blood expressed CD13, CD33, CD41a, and no markers for T or B lymphocytes, suggesting that he had been suffering from megakaryocytic sarcoma. We established a new cell line derived from the blasts in the peripheral blood, designated KH184. KH184 cells expressed glycoprotein (GP) Ib (CD42b) and GPIIb/IIIa (CD41a), while platelet peroxidase (PPO) activity was negative in an ultrastructural study. Both Northern blot and flow cytometric analysis of surface antigens and DNA content revealed that treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) did not induce the maturation of these cells. Various cytokines such as interleukin 3 (IL-3), interleukin 6 (IL-6), and leukemia inhibitory factor (LIF) had no effect in promoting the growth of KH184 cells. KH184 cells expressing CD41a seem to possess unusual characteristics. KH184 cells, human GPIIb- and GPIIIa-positive leukemia cells, which lack response to TPA-induced differentiaton, provide a new and unique model for the characterization of factors that are implicated in the terminal differentiation of megakaryocytes, and should aid in studies of the mechanism underlying the occurrence of megakaryocytic sarcoma. 相似文献
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Andrea Cacciato Insilla Monnalisa Granai Grazia Gallippi Patrizia Giusti Sabina Giusti Simone Guadagni Luca Morelli Daniela Campani 《World journal of gastroenterology : WJG》2014,20(21):6675-6679
Deep infiltrating endometriosis is an often-painful disorder affecting women during their reproductive years that usually involves the structures of the pelvis and frequently the gastrointestinal tract.We present the case of a 37-year-old female patient with an endometrial growth on the sigmoid colon wall causing pain,diarrhea and the presence of blood in the feces.The histology of the removed specimen also revealed the involvement of the utero-vesical fold,the recto-vaginal septum and a pericolic lymph node,which are all quite uncommon findings.To identify the endometrial cells,we performed immunohistochemical staining for CD10and the estrogen and progesterone receptors. 相似文献
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