儒家式应对思想与生命意义追寻肯定的关系

目的 探讨儒家式应对思想与生命意义的追寻肯定之间的关系.方法 采用生命态度剖面图(LAP)中的"生命意义的追寻与肯定"分量表和儒家应对问卷,整群随机抽取378名大学生进行调查.结果 挫折评价作用、挫折内在乐观性和人的责任性均与生命意义的追寻与肯定及其各因子呈显著正相关(分别为r=0.412,r=0.630,r=0.374,P＜0.01),"命"认识因子仅与生命目的和生命控制呈显著负相关(r=-0.113,r=-0.141,P＜0.05);逐步回归分析表明挫折评价作用、挫折内在乐观性和人的责任性是生命意义的追寻与肯定的主要预测因素.结论 儒家式应对思想能在一定程度上预测个体的生命意义的追寻与肯定水平.

Abstract：

Objective To explore the relationship between Confucian coping and life meaning searching and assertion. Methods 378 undergraduates were assessed by the subscale " Meaning Searching and Assertion" in the life attitude profile scale (LAP) and the Confucian coping questionnaire. Results The role of adversity to individual growing,optimism in the adversity and the responsibility as human being were significantly related to life meaning searching and assertion,as well as each factor( r = 0. 412, r = 0. 630, r = 0. 374, P＜0. 01). The viewpoints to "fate" was significantly related to life purpose and life control( r= -0. 113, r= -0. 141, P＜0. 05). Regression analysis showed the role of adversity to individual growing,optimism in the adversity and the responsibility as human being are main predictor of life meaning searching and assertion. Conclusion Confucian coping can predict the individual level of life meaning searching and assertion.     

Combining the first class with second class to improve the professional skills of medical students *

Medical science is a highly practical subject,which is closely related to human life.Medical institutions take a heavy social responsibility,in addition to the sacred mission of teaching and educating.The professional skills of medical students are one important assessment indicators to become a qualified doctor.Therefore,how to improve the professional skills of medical students in their training process becomes crucial.In     

Virome in immunodeficiency: what we know currently

Over the past few years, the human virome and its complex interactions with microbial communities and the immune system have gained recognition as a crucial factor in human health. Individuals with compromised immune function encounter distinctive challenges due to their heightened vulnerability to a diverse range of infectious diseases. This review aims to comprehensively explore and analyze the growing evidence regarding the role of the virome in immunocompromised disease status. By surveying ...     

On information field of clinical diagnosis

“Field” is a universal phenomenon existing in both nature and society, and determines the existence and significance of all materials or information. The man being has always been generating and carrying a large quantity of life information in his whole life. Each piece of life information has an independent information field. The life information field includes such three subfields as bioinformation field, psychoinformation field and psycho-bioinformation field.The clinical diagnosis information field which is a specific information field within the information field of human activities consists of all information concerning man‘s health. Only after we have cognized and ascertained the clinic diagnosis information field, can we accurately utilize its function to serve the human being.     

Association of Sexual Intercourse with Psychological Suppression and Copying Modes for Vocational School Students

Objective To evaluate the association of sex behavior with sexual related psychological suppression and coping modes among students in three vocational schools in Shanghai. Methods A cross-sectional survey was conducted among 1 368 grade one students from three vocational schools in a district of Shanghai, with Computer Assisted Self- Interview （CASI）. The field work began in the April 2003 for a baseline survey, and completed in the December, 2003. Data on students＇ sexual intercourse, sexual related psychological suppression and psychological coping modes, and communication with parents were collected and analyzed. Binary logistic regression was used to adjust the potential confounding factors. Results After controlling for demographic factors, adolescents with middle or high scores of active psychological coping strategies on sexual related events were less likely to have sexual intercourse （ORadj=0.48, 95%CI=0.30-0. 77 and ORadj=0.49, 95%CI=0.30-0.83, respectively）, while association between psychological suppression on sex related events and sexual intercourse was not statistically significant （ORadj= 0.93, 95%CI=0.63-1.37）; sexual related psychological suppression and active coping modes were positively associated with adolescents＇ communicating with parents for 2-7 h/week about school things, but negatively associated with parents＇ open attitudes towards heterosexual contacts and talking sex related things with others. Conclusion Vocational school students with active psychological coping strategies on sexual related events were less likely to engage in sexual intercourse, so interventions focus on reducing unprotected sexual behaviors should target on psychological coping modes skills training.     

Application of the dermatology life quality index in clinical trials of biologics for psoriasis

The significance of patient-reported outcomes(PROs) is increasingly being acknowledged and quality of life(QOL) has become an integral element of the assessment of overall burden of disease.Psoriasis has been known for its major impact on patients’ QOL and various generic,dermatology-specific and psoriasis-specific self- administered psychometric instruments have been used over the years to assess the QOL of psoriasis patients.However,the Dermatology Life Quality Index(DLQI) is the most widely used QOL measure among these measures in psoriasis-related clinical trials. A number of topical and systemic treatments have been used in the management of psoriasis and lately biologics have emerged as a new and promising treatment modality for difficuIt-to-treat psoriasis.The evidence on the efficacy of these agents has been growing dramatically with QOL being used as one of the primary outcome measures in many clinical trials.The aim of this paper is to give an overview of the use of the DLQI as an outcome measure for assessing the QOL impact of biologies on psoriasis patients.Furthermore,the efficacy of five commonly used biologics has been compared in terms of their ability to improve the QOL assessed by the DLQI.This review has revealed that there is a variation in the efficacy of various biologies in terms of QOL improvement with the mean reduction in the DLQI scores being highest for ustekinumab 90 mg(mean DLQI score reduction=9.5),followed by infliximab(8.5),etanercept 50 mg,twice a week(7.7),adalimumab(6.3),and alefacept(4.0).     

2406名农村初中生心理健康影响因素的分析

Objective To find out the factors that influence the mental health of the rural junior middle school students (JMSS).Methods 2406 JMSS in rural areas in Hunan province were assessed,using self-designed Demographic Data Recording Form, Adolescent Self-Rating Life Events Check List, Scale of APGAR, Perceived Social Support Scale,Simplified Coping Style Questionnaire,Eysenck Personality Questionnaire,Self-Esteem Scale and Scale of Mental Health.Results There were no significant difference between JMSS with different gender(P = 0.509 ), family income (P = 0.267 ), occupation of their fathers (P = 0.473 ), occupation of their mothers (P=0.105 ), education background of their mothers (P = 0.266 ).There were statistically significant difference between JMSS of different age (P = 0.000 ), grade (P = 0.000 ), whether their parents going out to work (P = 0.000 ),whether their parents divorced(P = 0.001 ) and education background of their fathers (P = 0.000 ); whether their parents going out to work (r = 0.095 ), life events (r = 0.522 ), family care (r =-0.146 ), the perceived social support (r =-0.186 ), positive coping style (r =-0.020 ), negative coping style (r = 0.369 ) and psychoticism (r = 0.322 ),internal and external(r =-0.132), emotional stability (r = 0.555 ), lie (r =-0.293 ) and self-esteem (r =-0.329)were significantly corrected with psychological health( P ＜ 0.01 ).Except age, grade, whether their parents going out to work and the education background and occupation of their parents,the remaining variables entered the regression equation,which could explained 51.2% of changes of the psychological health(F=227.809, P=0.000).Conclusion In order to promote the development of J MSS mental health, we can give then more care to reduce negative life events in their life,guide them to culture health personality and use active coping styles when encounter difficulties and setbacks through a series of health education, promote the healthy development of their personality.     

2406名农村初中生心理健康影响因素的分析

Objective To find out the factors that influence the mental health of the rural junior middle school students (JMSS).Methods 2406 JMSS in rural areas in Hunan province were assessed,using self-designed Demographic Data Recording Form, Adolescent Self-Rating Life Events Check List, Scale of APGAR, Perceived Social Support Scale,Simplified Coping Style Questionnaire,Eysenck Personality Questionnaire,Self-Esteem Scale and Scale of Mental Health.Results There were no significant difference between JMSS with different gender(P = 0.509 ), family income (P = 0.267 ), occupation of their fathers (P = 0.473 ), occupation of their mothers (P=0.105 ), education background of their mothers (P = 0.266 ).There were statistically significant difference between JMSS of different age (P = 0.000 ), grade (P = 0.000 ), whether their parents going out to work (P = 0.000 ),whether their parents divorced(P = 0.001 ) and education background of their fathers (P = 0.000 ); whether their parents going out to work (r = 0.095 ), life events (r = 0.522 ), family care (r =-0.146 ), the perceived social support (r =-0.186 ), positive coping style (r =-0.020 ), negative coping style (r = 0.369 ) and psychoticism (r = 0.322 ),internal and external(r =-0.132), emotional stability (r = 0.555 ), lie (r =-0.293 ) and self-esteem (r =-0.329)were significantly corrected with psychological health( P ＜ 0.01 ).Except age, grade, whether their parents going out to work and the education background and occupation of their parents,the remaining variables entered the regression equation,which could explained 51.2% of changes of the psychological health(F=227.809, P=0.000).Conclusion In order to promote the development of J MSS mental health, we can give then more care to reduce negative life events in their life,guide them to culture health personality and use active coping styles when encounter difficulties and setbacks through a series of health education, promote the healthy development of their personality.     

人促甲状腺激素受体的制备及其敏感性测定

Objective　To explore a simple and economical experimental method that can extract human thyroid TSH receptor-G_s protein-Adenylate cycles (AC) signal pathway and measure the sensitivity of TSH receptor.Methods　TSH receptor in cell membraone proteins and G_s protein-AC that coupled with TSH receptor was extracted from human thyroid preserved in low temperature by highspeed centrifugation.The sensitivity of TSH receptor combined with ligand human TSH (hTSH) was presented as the activity of AC.Results　The amount of membrane protein preparation (30～180 μg) was significantly related to the amount of cAMP produced (r=0.987,P＜0.05), the concentration of ligand hTSH (0～2 500 μ IU/ml) and G_s protein stimulator GTP γ S (0～1.0 mmol/L) were highly significantly related to the amount of cAMP produced (r=0.954,P＜0.01 and r=0.986,P＜0.001).Conclusion　The perfect TSH receptor-G_s protein-AC signal pathway was obtained by this method, and the activity of AC can perfectly stand for the sensitivity of TSH receptor combined with ligand hTSH, this simple and economic method can be used in experimental study in thyroid TSH receptor-G_s protein-AC signal pathway.     

Klotho is a serum factor related to human aging

Background Does klotho (KL) protein exist in human serum, and is there any correlation between KL protein in serum with human aging? In order to answer those questions, we identified KL protein in human serum and established the correlation between KL protein in human serum and aging.Methods We prepared a polyclonal antibody against human KL protein that was able to recognize the C-terminal of human secreted KL protein. Western blot and enzyme-linked immunosorbent assay (ELISA) were used to identify KL protein in human serum.Results In Westem blot, the antibody specifically recognized a 60-kD KL protein in both human and mice serum. The population aged from 0 to 91 years screened by ELISA revealed that the level of serum KL declined while age increased, though each individual level was variable and that the trend of decreasing in serum KL had no difference in sex.Conclusion Our data suggest that KL is a serum factor related to human aging.     

抗精子抗体和抗子宫内膜抗体与不孕及流产的关系

目的　探讨抗精子抗体（ＡｓＡｂ）与抗子宫内膜抗体（ＥＭＡｂ）在不孕、流产中的作用及二者关系,进一步 揭示不孕、流产的病因。方法　采用酶联免疫吸附试验（ＥＬＩＳＡ）同时检测３４５例不孕、流产妇女血清中的ＡｓＡｂ与 ＥＭＡｂ,按ＡｓＡｂ检测结果分阳性组和阴性组,比较两组ＥＭＡｂ阳性率的差异。结果　原发不孕及自然流产妇女中, ＡｓＡｂ（－）组ＥＭＡｂ阳性率高达１６．６７％和１９．５１％,而ＡｓＡｂ（＋）组ＥＭＡｂ阳性率高达４３．６４％和４２．８６％,显著高于 ＡｓＡｂ（－）组（Ｐ＜０．０１,Ｐ＜０．０５）。继发不孕妇女中ＡｓＡｂ（－）组ＥＭＡｂ阳性率为１８．１８％,ＡｓＡｂ（＋）组ＥＭＡｂ阳性率 为３２．２％,二者无显著性差异（０．０１＞Ｐ＞０．０５）。结论原发不孕及自然流产妇女中因个体免疫反应差异使某些 人易对体内、外物质发生免疫反应而产生抗体,从而导致不孕或流产。     

亚硝基脲类和亚硝基硫脲类的理化性质及致突变能力

本题选择N,N′-二甲基亚硝基脲(DMNU),N,N′-二乙基亚硝基脲(DENU),及其类似物N,N′-二甲基亚硝基硫脲(DMNTU)、N,N′-二乙基亚硝基硫脲(DENTU)为代表,测定了这些化合物的水解反应速度、脂溶性(HPLC的logk′值)、水解产物和致突变能力。证明了硫脲的脂溶性大于脲的脂溶性。DMNTU对TA100菌株的致突变能力最强,其它较弱。     

气血与足月妊娠分娩关系的探讨

论述足月妊娠分娩的发动和维持依靠气的推动、温煦、气化、固摄功能和血的营养、濡润功能。顺利分娩既要气血充足，还要气顺血和。临床研究结果表明调补气血，是促进产程，预防难产的重要手段。实验研究结果阐明调补气血中药加强产力、促进产程主要是从改善产妇全身情况，提高机体抗应激、抗疲劳、耐缺氧能力，即所谓使产妇气血充足调和，充分发挥气血在分娩过程中的生理作用。     

水疗联合抚触对新生儿的生长发育、黄疸及睡眠的影响

目的探讨新生儿游泳联合抚触对新生儿的生长发育、黄疸及睡眠的影响。方法将经阴道顺产分娩的正常新生儿100例随机分为两组，观察组（水疗联合抚触组）50例，对照组（单纯沫浴组）50例。①测定两组10日、28日的体重、身长、上臂围；②观察记录胎便转黄时间，测定皿清胆红素；③记录24h睡眠时间。结果两组新生儿10日、28日体重、身长、上臂同增长有显著差异（P〈0．05），两组新生儿5日时，胎便转黄时间及黄疸指数比较均有显著性差异（P〈0．01），两组睡眠时间比较有统计学意义（P〈0．05），两组并发症比较无统计学意义（P〉0．05）。结论新生儿水疗联合抚触可促进新生儿的生长发育，能加速胎粪的早排出，减轻生理性黄疸程度，有效地降低新生儿高胆红素血症的发病率，提高睡眠质量。