急性白血病患者血清微量元素谱分析

采用ＤＣＰ－ＡＥＳ检测了４０例急性白血病（初发１８例，化疗后２２例）血清中锌、铜、铁、硒、镍、钛等１５种元素含量。结果显示：初发急性白血病患者血清锌、铁、硒、镍、钛均降低，铜、钙、镁、铜／锌比值均升高。化疗达ＣＲ后，血清锌、铜、铜／锌、硒均可正常，而化疗后ＮＲ组上述元素无改变。血清钙、镍、钛化疗后ＣＲ和ＮＲ组均无改善。表明微量元素与急性白血病转归相关。     

急性白血病患者全血中微量元素研究

 目的 观察急性白血病患者血液中微量元素的动态变化。方法 用原子吸收光谱法测定50例急性白血病患者和40例正常人全血中铜（Cu）、锌（Zn）、锰（Mn）、铁（Fe）、钙（Ca）、镁（Mg）的含量,同时对20例患者缓解前后进行了动态观察。结果 急性白血病初发组及复发组全血Cu、Ca的含量、Cu／Zn比值显著高于正常组及缓解组,全血Zn,Fe,Mg的含量低于对照组及缓解组,全血Mn含量与正常组及缓解组无显著改变。结论 白血病急性期血液中微量元素有明显变化,全血Cu,Zn含量有更显著参考价值。     

原发性肺癌化疗与血清铜锌水平及铜／锌比值关系初探

近年来国内外对肺癌与血清铜(Cu)、锌(Zn)含量和Cu/Zn比值关系作了较多的研究。本文作者对31例原发性肺癌化疗前后的血清微量元素Cu、Zn水平和Cu/Zn比值做了动态观察,以探讨肺癌病人血清铜、锌的变化与化疗的关系。现将结果报告如下。 对象和方法 病例选择:本次共观察原发性肺癌31例,男性20例,女性11例,年龄33～77岁;全部病例均经病理或细胞学诊断,其中鳞癌8例、腺癌13例,未分化小细     

回族血清中微量元素含量与胃癌的相关性研究

目的探讨回族血清中微量元素含量与胃癌的关系。方法采用原子吸收分光光度法对回族胃癌患者和回族非胃癌对照人群血清中锌(Zn)、铜(Cu)、铁(Fe)、镁(Mg)、钙(Ca)、锰(Mn)、镍(Ni)元素含量进行检测,并用SPSS统计软件对实验结果进行配对t检验分析。结果回族胃癌病例组血清中Cu、Cu/Zn、Mn均比对照组高,而Zn、Fe、Ca、Mg、Ni的含量低于对照组。配对t检验结果显示,血清中Cu、Zn、Cu/Zn、Ca、Mg含量差异有统计学意义(P<0.05)。结论回族胃癌的发生、发展与血清内微量元素变化密切相关。高Cu、Cu/Zn比值高以及低Zn、低Ca、低Mg是回族胃癌发生的危险因素。     

头颈部肿瘤放疗后血清Cu、Zn检测的临床意义

对60例头颈部肿瘤放疗前后患者的血清Cu、Zn，Cu／Zn比值进行了检测。结果显示：放疗前血清Cu明显高于正常对照组和放疗后（P＜0．0）；血清Zn低于正常对照组和放疗后（P＜0．05）；放疗后组血清Cu／Zn比值明显高于正常对照和放疗后（P＜0.05）；放疗后组血清Cu、Zn、Cu／Zn比值与正常对照组无明显差异。放疗后复发组血清Cu明显高于放疗后无复发组（P＜0．01）；血清Cu／Zn比值明显高于放疗后无复发组（P＜0.01）。提示血清Cu、Zn、Cu／Zn比值的检测，特别是血清Cu／Zn比值可作为肿瘤治疗预后及肿瘤复发与否的参考指标。     

原发性肺癌与肺结核患者血清铜,锌测定的临床意义

近年来,人体内微量元素的研究有了很大的进展。实验证明某些微量元素缺乏,不利于维持人体正常生理功能,但微量元素的浓度过高亦可产生不良作用。文献报告恶性肿瘤患者血清Cu增高、Zn降低,Cu/Zn升高。但评价不尽一致。鉴于对肺癌、肺结核患者的血清Cu、Zn含量的测定国内报道不多,本文对56例肺癌及24例肺结核患者作了血清     

人体正常和良恶性组织中8种微量元素的分析

本文报告人体恶性(63例)、良性(64例)和正常(65例)3种组织中8种微量元素测量结呆。证明恶性组织中铜、镍明显高于正常和良性组织,又以胃肠癌显著。栖前者低于后二者,而两组癌无差异。恶性组锌、锰明显低于正常组。其他癌锌降低显著,且锌有恶性<良性<正常的趋势。初步探讨3种组织中微量元素的变化规律和临床意义。     

胃癌、不典型增生和正常人血清中视黄醇、α-生育酚、β-胡萝卜素和12种元素的研究

本文测定了45例胃癌、41例胃不典型增生(胃癌癌前病变)和48例对照组血清中视黄醇、α-生育酚、β-胡萝卜素和12种元素(Zn、Cu、Mn、Fe、Ca、Mg、Ni、Cr、Co、Cd、Mo、Se)的含量。结果表明:胃癌病人血清中的β-胡萝卜素和硒、钴含量低于胃不典型增生病人,更低于对照组。此外,胃癌组与胃不典型增生组比较,明显降低的元素有镍、铬;明显升高的元素有锰、钙、镉。胃癌组与对照组比较明显降低的有锌、铁、铬、镉;明显升高的有锰、钙、镁、钼。胃不典型增生组与对照组比较,明显下降的有锰、铁、镉;明显升高的有钼。上述15个指标,经逐步回归判别分析,筛选出10个变量指标(Mn、Fe、Ca、Cr、Mo、Co、Cd、Se、α-生育酚、β-胡萝卜素)用以识别胃癌,其识别符合率为100％。若用逐步回归判别分析,判别血清中Mn、Cr、Mo、Co、Cd五个微量元素的含量,其识别胃癌的符合率亦为97.8％。作者认为对患者血清中微量元素进行逐步回归判别可作为胃癌诊断的参考指标,并认为适当补充硒和β-胡萝卜素将有助于预防胃癌。     

血清中锌、铜代谢变化对恶性淋巴瘤临床意义的研究

锌(Zn)和铜(Cu)都是人体的必需微量元素,有广泛而重要的生物学作用。目前越来越多的资料表明,恶性肿瘤患者伴随着身体许多系统、器官机能的失调,微量元素的代谢和控制也都偏离了正常状态,特别是出现血清 Cu(SCu)升高和血清 Zn(SZn)降低的现象,恶性淋巴瘤患者 SCu 和 SZn的变化,国外已有一些报道(1—3),国     

慢性乙型肝炎、原发性肝癌患者IL—12、IFN—γ水平检测及其临床意义

目的 检测慢性乙型肝炎、原发性肝癌患者血清白细胞介素－12及γ－干扰素浓度,并探讨其临床意义。方法 采用双抗体夹心酶联免疫吸附试验,检测30例慢性乙型肝炎、30例原发性肝癌患者的血清白细胞介素－12及γ－干扰素浓度,并以20例正常献血员作对照。结果 慢性乙型肝炎患者血清白细胞介素－12水平升高,原发性肝癌患者血清白细胞介素－12水平明显升高,与对照组比较有显著性差异;慢性乙型肝炎和原发性肝癌γ－干扰素水平均轻度升高,与对照组比较均无显著性差异。原发性肝癌术后成活者的术前血清白细胞介素－12及γ－干扰素水平较恶化者均升高,有显著性差异。结论 白细胞介素－12和γ－干扰素均参与慢性乙型肝炎、原发性肝癌的发病机制;γ－干扰素更适宜作为原发性肝癌预后判断的1项指标。     

消化道肿瘤患者血清锌,铜水平及铜／锌比值的临床观察

本文应用ICP-光谱法对50例消化道肿瘤病人的血清锌、铜及铜/锌比值作了对照性观察、结果表明肿瘤病人的血清锌低于对照组、血清钢及铜/锌比值高于对照、差异非常显著(P<0.001、P<0.005)。有远位转移组与无转移组相比;静脉营养组与进食组相比,血清锌、铜及铜/锌比值差异不显著(P>0.05～0.10)。因此,认为血清锌低、铜及铜/锌比值增高是本组肿瘤病人的特征,可作为肿瘤监测的一个指标,但是,不能作为判断预后的依据。     

喉癌与微量元素

喉癌与微量元素关系的研究,文献报道不多。本文自1987年开始对血清Zn、Cu、Fe、Se,进行了检测,企图探索与喉癌的关未,从检测结果可以看出喉癌的发生与血清Zn、Cu、Fe、Se的含量有一定关系,可能直接参与了喉癌的发生和发展。     

Analysis of trace elements by proton induced X-ray emission (PIXE) in serum of patients with liver cancer and normal subjects

The levels of trace elements in serum of the patients with liver cancer and the normal subjects were determined by the PIXE technique. The significant increase of serum copper level (SCL) and the decrease of serum zinc level (SZL) in the patients with liver cancer, as compared to those of normal, were observed. Cu/Zn ratio in the patients with liver cancer was significantly higher than that of the normal (P less than 0.01). In the Cartesian coordinate graph of SCL + SZL, the liver cancer patients were separated from the normal by a line joining the intersection of abscissa and ordinate and the point of the sum of the mean value and the standard deviation of the Cu/Zn ratio of the normal subjects. The authors believe that the serum Cu/Zn ratio is likely a supplementary target in the diagnosis and prognosis of liver cancer.     

恶性淋巴瘤患者血清锌,铜和铜锌比值测定及其临床意义

本文测定６３例恶性淋巴瘤患者的血清Ｃｕ、Ｚｎ，并以８６例正常人作对照。用国产ＧＧＸ－２型原子吸收分光光度计测定，同时平行测定牛血清标准参考物质。测定结果经统计学处理，恶性淋巴瘤患者ＳＣｕ升高，ＳＺｎ显著低于正常对照组；与对照组比较，Ｃｕ／Ｚｎ比值明显升高（Ｐ＜０．０１）。ＮＨＤ弥漫型的Ｃｕ／Ｚｎ比值明显高于结节型（Ｐ＜０．０１）。作者认为恶性淋巴瘤的发展程度与Ｃｎ、Ｚｎ的浓度有关，与Ｃｕ／Ｚｎ比值的升高密切相关。比值升高提示病情发展。所以，Ｃｎ／Ｚｎ比值对恶性淋巴瘤的疗效和予后有一定的参考价值。     

Variation of urinary and serum trace elements (Ca, Zn, Cu, Se) in bladder carcinoma in China

Backgrounds: Deficiency or excess of trace elements can induce body metabolic disorders and cellulargrowth disturbance, even mutation and cancerization. Since there are few studies of the effect of trace elementsin bladder carcinoma in China, the aim of this study was thus to assess variation using a case control approach.Methods: To determine this, 81 patients with bladder carcinoma chosen as a study group and 130 healthypersons chosen as a control group were all assayed for urinary and serum trace elements (calcium [Ca], zinc[Zn], copper [Cu], selenium [Se]) using an atomic absorption spectrophotometer, and the results were analyzedby independent sample t tests. The correlative factors on questionnaires answered by all persons were analyzedby logistic regression. Results: The results showed urinary Ca, Zn and serum Cu levels of the study group tobe significantly higher (P<0.05) than those of he control group. Serum Ca and Se levels of study group weresignificantly lower (P<0.05) than those of control group. Conclusion: There were higher urinary Zn and serumCu concentrations in bladder carcinoma cases. Bladder carcinoma may be associated with Ca metabolic disorder,leading to higher urinary Ca and lower serum Ca. Low serum Se and smoking appear to be other risk factorsfor bladder carcinoma in China.     

Copper, zinc, and Cu/Zn ratio in carcinoma of the gallbladder

INTRODUCTION: The exact role of copper and zinc in the etiology of carcinoma of the gallbladder is unclear. Some studies suggest the Cu/Zn ratio is a good indicator of the extent and prognosis in carcinoma of the gastrointestinal tract. The aim of the present study is to estimate the micronutrient profile and Cu/Zn ratio in the serum, tissues, and bile of patients with benign and malignant gallbladder diseases. METHODS: The present study was carried out in 60 patients comprising 30 each of carcinoma of the gallbladder and cholelithiasis, and 30 age and sex matched controls. Copper and zinc levels were estimated in blood, bile, and tissue using a Perkin Elmer Model 2380 Atomic absorption Spectrophotometer. RESULTS: The mean serum zinc levels were significantly lower in patients with carcinoma of the gallbladder than in patients with cholelithiasis and in healthy controls (P < 0.001). The mean serum copper levels were significantly higher in patients with carcinoma of the gallbladder as compared to patients with cholelithiasis and healthy controls (P < 0.001). Biliary and tissue zinc levels were significantly lower in patients with carcinoma of the gallbladder than in patients with cholelithiasis. Biliary and tissue copper levels were higher in patients with carcinoma of the gallbladder than in patients with cholelithiasis. The serum Cu/Zn ratio showed a gradual and significant increase from 1.11 in healthy controls to 1.35 in patients with cholelithiasis and 2.12 in patients with carcinoma of the gallbladder. The biliary and tissue Cu/Zn ratios were also significantly increased in patients with carcinoma of the gallbladder than in patients with cholelithiasis (P < 0.001). CONCLUSIONS: Our data support an association between lower zinc levels and consequently an increased Cu/Zn ratio and carcinoma of the gallbladder. Whether zinc supplementation has a protective effect in preventing carcinoma of the gallbladder needs to be studied further.     

Serum trace elements and Cu/Zn ratio in breast cancer patients

Serum copper, zinc, and the Cu/Zn ratio were measured in 55 patients with breast disease (20 with benign breast diseases and 35 patients with breast cancer) and 30 controls. The mean serum copper levels were higher in breast cancer than in benign breast diseases (167.3 micrograms/dl vs. 117.6 micrograms/dl) (P less than 0.001) and controls (167.3 micrograms/dl vs. 98.8 micrograms/dl) (P less than 0.001). Patients with advanced breast cancer had higher serum copper levels than did patients with early breast cancer (177.9 micrograms/dl vs. 130.4 micrograms/dl) (P less than 0.001). The mean serum zinc levels were lowered only in patients with advanced breast cancer as compared with controls (88.6 micrograms/dl vs. 115.1 micrograms/dl) (P less than 0.001). Serum zinc levels were not decreased in patients with early breast cancer and benign breast diseases. The Cu/Zn ratio was increased in breast cancer patients (1.91 vs. 0.86) (P less than 0.001) but not in patients with benign breast diseases. The precise mechanisms responsible for the alterations in trace element levels in breast cancer patients are still unclear and require further evaluation. However, the serum copper levels and the Cu/Zn ratio may be used as biochemical markers in these patients.     

微量元素与消化道癌Logistic回归分析及临床意义

 本文测定了130例食管癌，100例胃癌，60例结直肠癌，22例肝癌，56例消化道良性疾患。结果表明：消化道癌患者血清中铜，铁含量，铜/锌比显著高于健康人（P＜0.05～P<0.001），锌，钙含量明显低于健康人（P<0.05～P相似文献   

Serum and tissue trace elements in colorectal cancer

Serum copper, zinc, and Cu/Zn ratio were measured using atomic absorption spectrophotometry in 30 patients with colorectal cancer and compared with 30 healthy control subjects. In the patients with colorectal cancer, the tissue copper and zinc levels were also measured in paired histologically normal and malignant colorectal tissue samples obtained at surgery. The mean serum copper levels were higher in patients with colorectal cancer (165.99 vs. 98.84 μg/dl) (P < 0.001). The mean serum zinc levels were lowered only in advanced (Dukes stages C and D) colorectal cancer compared to controls (89.94 vs. 115.08 μ/dl) (P < 0.001). However, the Cu/Zn ratio progressively increased with the advancing stage of malignancy (1.86 vs. 0.86) (P < 0.001). The cancerous colorectal tissue showed a higher concentration of both copper (2.78 vs. 1.79 μg/g) (P < 0.001) and zinc (27.16 vs. 18.98 μg/g) (P < 0.01) compared to non-cancerous colorectal tissue. The exact mechanism responsible for the alterations in trace element levels in patients with colorectal cancer is largely unclear and requires further evaluation. However, the serum copper level and the Cu/Zn ratio are of value in estimating the extent of the carcinoma as well as in determining the prognosis of these patients. © 1993 Wiley-Liss, Inc.     

血清锌,铜与铜／锌比值对肺癌诊断,疗效和预后判断的临床价值

本文对60例肺癌和100例健康对照组用原子吸收法测定了血清锌(SZn)、铜(SCu)含量.肺癌组SZn明显低于对照组.SCu与血清铜/锌(SCu/Zn)比值明显高于健康组(P均<0.001).肺癌组按TNM分期,其SCu与SCu/Zn比值各期均较对照组明显增高,且随病期进展而增高,即Ⅳ期>Ⅲ期>Ⅱ期>Ⅰ期.SCu以1.191ppm,SCu/Zn 以1.38为分界,其特异性分别为 87%和88%;敏感性分别为 88.33%和 81.66%.较同期所测血清癌胚抗原(CEA)36.58%和肿瘤DNA聚合酶[DNA—P(CA)]18.18%为高.提示 SCu、SCu/Zn的测定是肺癌辅助诊断、疗效观察及预后判断的辅助指标.