喉癌组织中微量元素Zn、Cu、Se含量分析的研究

有关喉癌组织微量元素Zn、Cu、Se含量的研究国外有少量报道。国内尚未见报道。我院自1987年开始对喉癌组织及其临近的正常组织进行了配对检测。同时还检测了5例正常喉组织作为对照,报告如下:     

回族血清中微量元素含量与胃癌的相关性研究

目的探讨回族血清中微量元素含量与胃癌的关系。方法采用原子吸收分光光度法对回族胃癌患者和回族非胃癌对照人群血清中锌(Zn)、铜(Cu)、铁(Fe)、镁(Mg)、钙(Ca)、锰(Mn)、镍(Ni)元素含量进行检测,并用SPSS统计软件对实验结果进行配对t检验分析。结果回族胃癌病例组血清中Cu、Cu/Zn、Mn均比对照组高,而Zn、Fe、Ca、Mg、Ni的含量低于对照组。配对t检验结果显示,血清中Cu、Zn、Cu/Zn、Ca、Mg含量差异有统计学意义(P<0.05)。结论回族胃癌的发生、发展与血清内微量元素变化密切相关。高Cu、Cu/Zn比值高以及低Zn、低Ca、低Mg是回族胃癌发生的危险因素。     

血清微量元素变化与胃癌关系的研究

目的　为了解血清微量元素与胃癌的关系。方法　采用原子吸收分光光度法对胃癌患者血清中Cu、Zn、Fe、Mn元素含量进行了分析 ,并与浅表性胃炎、胃溃疡进行了比较。结果　胃炎、胃溃疡、胃癌不同群体 ,血清Zn有显著降低趋势 ,血清Cu有升高趋势 ,其中以胃癌最为显著 ;胃炎、胃溃疡组血Mn低于正常对照组 ,血Cu明显高于正常对照组 ,二者有显著性差异 (P <0 0 1)。结论　胃癌的发生与发展与血清中元素的变化有密切关系     

乳腺肿瘤患者血清中九种微量元素的石墨炉原子吸收测定及相关分析

目的　探讨乳腺良恶性肿瘤及健康妇女血清中微量元素含量及其相关关系。方法　用石墨炉原子吸收光谱法测定 2 13名健康妇女、36例乳腺良性瘤和 38例乳腺恶性瘤手术前后血清中 Zn、Fe、Cu、Mn、Pb、Cd、Cr、Ni和 Mo九种微量元素的含量。结果　三组血清中有五种元素有显著差异 ,其中血清 Zn、Cu、Ni和 Fe的含量乳癌患者明显高于对照组 ,血清 Mo则乳癌患者低于对照组 ,而且血清 Zn、Cu、Ni随病情发展而升高 ,血清 Mo则相反。乳癌患者血清 Cu/ Zn值 (1.4g)高于健康妇女 (1.30 )。结论无论元素的含量还是元素与元素间的相关性 ,乳腺癌、乳腺良性肿瘤和健康妇女三组之间都有明显的差异     

血清微量元素、GPDA活性和Hp感染与胃癌发生的相关性

目的探讨血清微量元素、苷氨酰脯氮酸二肽氮基肽酶活性（GPDA）和幽门螺杆菌（Hp）感染与胃癌发生的关系。方法采用幽门螺杆菌粪便抗原检测法（HpSA法）、终点法和速率法，分别检测117例初治前胃癌患者、45例良性胃部疾病患者及40例正常人粪便中的Hp阳性率和血清微量元素Ca、Mg、Fe、Cu、Zn的含量及GPDA活性，并比较分析。结果胃癌患者血清Fe和Cu／zn含量明显高于正常对照组（均P〈0．05），Zn含量显著低于正常对照组（P〈0．05），Hp和GPDA阳性率分别为70．9％（83／117）和71．8%（84／117）。Hp、GPDA阳性组Zn含量显著低于阴性组（P〈0．05）。结论血清Zn含量降低可能是胃癌发生的癌前因素，Zn含量降低可诱发Hp感染而促发癌变。     

消化道良,恶性疾病的12种微量元素的测定与临床意义

本文测定174例胃肠道疾病,40例原发性肝癌及85例正常人血清Cu、Zn、Ca、Mg、Fe、Sr、Mn、Mo、Cr、Ti、Ni、Se等12种微量元素。结果表明:血清铜升高、锌降低,Cu/Zn比值升高最明显为原发性肝癌,其次为胃肠癌,再次为胃肠息肉,最后为慢性腹泻。慢性腹泻与正常比仅锌下降,钙与锌在各组改变与锌相似。胃肠癌转移组与正常组比,术前组、术后组与正常组之间其Cu/Zn比值升高,且均有统计学意义(P<0.05)。胃肠癌组与息肉组比较,血清钙显著降低(P<0.001),铁无差异;而胃肠癌组与慢性腹泻组比,血清铁降低显著而钙无差异。胃肠癌中65例腺癌病理分化与微量元素无明显关系。由此表明微量元素改变对鉴别消化道良、恶性疾病和临床观察有一定帮助。     

乳腺肿瘤患者血清中九种微量元素的石墨炉原子吸收测定及相关分析

目的：探讨乳腺良恶性肿瘤及健康妇女血清中微量元素含量及其相关关系。方法：E和石墨炉原子吸收光谱法测定213名健康妇女,36例乳腺良性瘤和38例乳腺恶性瘤手术前后血清中Zn,Fe,Cu,Mn,Pb,Cd,Ni和Mo九种微量元素的含量。结果：三组血清中有五种元素有显著差异,其中血清Zn,Cu,Ni和Fe的含量乳癌患者明显高于对照组,血清Mo则乳癌患者低于对照组,而且血清Zn,Cu,Zi随病情发展而升高,血清Mo则相反。乳癌患者血清Cu/Zn值（1．4g),高于健康妇女（1．30）。结论无论元素的含量还是与元素间的相关性,乳腺癌、乳腺良性肿瘤和健康妇女三组之间都有明显的差异。     

包头地区乳腺肿瘤及其复发转移的血清微量元素变化研究

目的探讨9种微量元素与乳腺肿瘤的关系。方法采用原子吸收分光度计对81例健康女性志愿者、94例乳腺良性肿瘤患者、93例乳腺癌患者手术前后和38例乳腺癌复发转移患者血清中Fe、Zn、CU、Mn、Pb、Cd、Cr、Ni、Mo的含量进行测定。结果血清Fe、Zn、Cu、Mn、Pb随乳腺肿瘤病情加重呈明显升高趋势,与乳腺癌呈正相关,而Mo随病情的加重明显降低,与乳腺癌呈负相关。结论有6种微量元素与乳腺肿瘤的发病有显著关系,其中Fe、Zn、Cu、Mn、Pb可能是乳腺癌的危险因素,而Mo为乳腺癌的保护因素。     

头颈部肿瘤放疗后血清Cu、Zn检测的临床意义

对60例头颈部肿瘤放疗前后患者的血清Cu、Zn，Cu／Zn比值进行了检测。结果显示：放疗前血清Cu明显高于正常对照组和放疗后（P＜0．0）；血清Zn低于正常对照组和放疗后（P＜0．05）；放疗后组血清Cu／Zn比值明显高于正常对照和放疗后（P＜0.05）；放疗后组血清Cu、Zn、Cu／Zn比值与正常对照组无明显差异。放疗后复发组血清Cu明显高于放疗后无复发组（P＜0．01）；血清Cu／Zn比值明显高于放疗后无复发组（P＜0.01）。提示血清Cu、Zn、Cu／Zn比值的检测，特别是血清Cu／Zn比值可作为肿瘤治疗预后及肿瘤复发与否的参考指标。     

胃癌患者血清中五种微量元素含量的分析

本文对41例胃癌患者血清中 Cu、zn、Fe、Mn、Cr 五种微量元素的含量进行测定,并与29例胃溃疡病人,48例健康人血清中五种微量元素进行了比较。结果显示:胃癌和胃溃疡患者血清 Zn 低于正常人,血清Cu/Zn 比值在三种人群中差异均有显著性,胃癌患者的血清中 Mn 低于溃疡患者和正常人,胃癌患者和胃溃疡患者的血清 Cr 明显高于正常人,血清 Fe 在这三种人群中差异均无显著性。     

泌尿系肿瘤与肾炎患者血清和尿中铜锌锰镁含量变化的探讨

作者对２４例泌尿系恶性肿瘤病人、４５例肾炎病人的血清、尿液微量元素铜、锌、锰、镁进行了测定，结果显示：较之正常对照组，肾炎病人血清镁、尿、锌值明显升高，血清锌降低；恶性肿瘤病人血清铜、尿锌值明显升高，血清锌、尿锰值下降。这些指标对泌尿系恶性肿瘤的鉴别诊断及治疗有一定参考价值。     

人体正常和良恶性组织中8种微量元素的分析

本文报告人体恶性(63例)、良性(64例)和正常(65例)3种组织中8种微量元素测量结呆。证明恶性组织中铜、镍明显高于正常和良性组织,又以胃肠癌显著。栖前者低于后二者,而两组癌无差异。恶性组锌、锰明显低于正常组。其他癌锌降低显著,且锌有恶性<良性<正常的趋势。初步探讨3种组织中微量元素的变化规律和临床意义。     

微量元素与消化道癌Logistic回归分析及临床意义

 本文测定了130例食管癌，100例胃癌，60例结直肠癌，22例肝癌，56例消化道良性疾患。结果表明：消化道癌患者血清中铜，铁含量，铜/锌比显著高于健康人（P＜0.05～P<0.001），锌，钙含量明显低于健康人（P<0.05～P相似文献   

Some Mineral,trace Element and Heavy Metal Concentrations in Lung Cancer

Objective: We aimed to determine the relationship between some mineral, trace element and heavy metallevels in the patients of lung cancer by measuring serum levels of copper (Cu), lead (Pb), zinc (Zn), iron (Fe),cobalt (Co), cadmium (Cd), manganese (Mn), magnesium (Mg). Methods: A total of 50 lung cancer and humanhealth (30 lung cancer and 20 healthy human) were included in the study. Venous blood samples of each lungcancer were obtained, and serum Cu, Pb, Zn, Fe, Cd, Co, Mn, Mg levels were analysed by Atomic AbsorptionSpectrophotometer measurements. Results: Mg value measured in lung cancer group were lower than the controlgroup and this was statistically significant (P<0.01). Serum Cu level was significantly lower with lung cancercompared to healthy human (P<0.01). Pb level was significantly higher than those of controls (P<0.01). Theserum Zn level was significantly lower in serum of lung cancer group than controls (P<0.01). Serum Mn and Colevels were found increased in lung cancer group than controls (P<0.01). Cd value was higher in lung cancer butit was not statistically significant (p>0.01). The mean concentration of Fe in the serum of lung cancer patientswas higher than in the controls, but the difference was not significant (p>0.01). There was a positive correlationbetween Cd and Pb level, and between Mn and Fe levels in lung cancer. There was a negative correlation betweenCo and Zn levels of healthy human. There was a negative correlation between Co and Mg levels of lung cancer.Conclusions: Serum Cu, Pb, Zn, Fe, Mg, Co, Mn and Cd might be play a role in the patients of lung cancers.Zn may protective as potent lung cancer. In addition, it is suggested that low levels of zinc can induce thepathogenesis of lung cancer.     

Trace elemental analysis of normal, benign hypertrophic and cancerous tissues of the prostate gland using the particle-induced X-ray emission technique.

Trace elemental analysis was carried out in the tissue samples of normal, benign hypertrophic and carcinoma prostate using the particle-induced X-ray emission technique. A proton beam of 3 MeV energy was used to excite the samples. The elements Cl, K, Ca, Ti, Cr, Mn, Fe, Ni, Cu, Zn, Se, and Br were identified and their concentrations were estimated. It is observed that in benign tissues the concentrations of Cl, K, Zn, and Se are lower (P<0.05) and those of Cr, Fe, Ni, and Cu are higher (P<0.05 ) than in normal tissues. The concentrations of K, Ca, Zn, Se, and Br are lower (P<0.01) and those of Ti, Cr, Mn, Fe, Ni, and Cu are significantly higher (P<0.0005) in cancerous tissues than in normal tissues. Free radicals generated by elevated levels of Cr, Fe, Ni, and Cu possibly initiate and promote prostate cancer by oxidative DNA damage. The excess Cu levels in cancerous tissues support the fact that Cu promotes cancer through angiogenesis. The higher levels of Fe observed in cancerous tissues might be a consequence of tumor growth through angiogenesis. Significantly higher levels of Ni and Cr observed in carcinoma tissues support the well-established role of Ni and Cr as carcinogens. It is likely that the observed low levels of Zn and Se in cancerous tissues lead to the development of prostate cancer owing to a decrease in antioxidative defense capacity and impaired immune function of cells and also suggest that the inability to retain high levels of Zn and Se may possibly be an important factor in the development and progression of malignant prostate cells. In order to substantiate the observed elevated or deficient levels of trace elements in initiating, promoting, and inhibiting prostate cancer, several cellular and molecular studies are required.     

血清中微量元素铜,锌,镉,锰与恶性脑瘤关系的研究

本文使用原子吸收分光光度计测定30例恶性脑瘤、50例良性脑瘤患者手术前后血清中微量元素铜、锌、镉、锰含量,并以70例一般神经性疾病患者和98例健康人作对照组。统计结果揭示:1.恶性脑瘤组手术前血清中铜、锌、镉、锰含量显著高于术后(P<0.01),良性脑瘤组除术前血清锰低于术后,余者均显著高于术后(P<0.01),两组脑瘤手术前后铜/锌比差异均无显著性(P>0.05),2.不同病理状态血清铜和铜/锌比改变也有差别,即恶性脑瘤>良性脑瘤>一般脑疾病>健康人,而术后两组脑瘤血清铜水平下降接近正常人,可提示术前血清铜水平在鉴别脑瘤性质及区分一般脑疾病具有潜在的诊断价值;术后血清铜水平对估计恶性和良性脑瘤预后方面有重要意义。     

肿瘤患者血清铜锌及其比值测定的意义

目的探讨恶性肿瘤患者血清铜、锌水平和铜／锌比值的应用价值。方法 本文采用美国ＰＥ公司３０３０型原子吸收分光光度计,对１２３０例恶性肿瘤患者,２１０例良性疾病患者和１００例健康成人,进行血清铜、锌水平和铜／锌比值的测定。结果 恶性肿瘤口才的血清铜水平和铜、锌比值明显高于良性疾病组和健康对照组,而血清锌低于健康对照组,有统计学意义。血清铜／锌比值对卵巢癌诊断阳性率为８１．４８％;宫颈癌为７１．０％;肝     

Variation of urinary and serum trace elements (Ca, Zn, Cu, Se) in bladder carcinoma in China

Backgrounds: Deficiency or excess of trace elements can induce body metabolic disorders and cellulargrowth disturbance, even mutation and cancerization. Since there are few studies of the effect of trace elementsin bladder carcinoma in China, the aim of this study was thus to assess variation using a case control approach.Methods: To determine this, 81 patients with bladder carcinoma chosen as a study group and 130 healthypersons chosen as a control group were all assayed for urinary and serum trace elements (calcium [Ca], zinc[Zn], copper [Cu], selenium [Se]) using an atomic absorption spectrophotometer, and the results were analyzedby independent sample t tests. The correlative factors on questionnaires answered by all persons were analyzedby logistic regression. Results: The results showed urinary Ca, Zn and serum Cu levels of the study group tobe significantly higher (P<0.05) than those of he control group. Serum Ca and Se levels of study group weresignificantly lower (P<0.05) than those of control group. Conclusion: There were higher urinary Zn and serumCu concentrations in bladder carcinoma cases. Bladder carcinoma may be associated with Ca metabolic disorder,leading to higher urinary Ca and lower serum Ca. Low serum Se and smoking appear to be other risk factorsfor bladder carcinoma in China.