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Mustafa Akçam 《Indian pediatrics》2010,47(2):119-126
Helicobacter pylori (HP) infection causes morbidity in several systems, especially in the gastrointestinal tract. The prevalence of disease is inversely related to social-economic and developmental status. It is more common in the developing than in developed countries. In the countries where social-economic status is low, not only HP infection, but also malnutrition and growth failure have a higher prevalence. According to these data, the relationship of nutrition and HP infection is still a question. Does HP infection affect nutritional status? On the contrary, does nutritional status affect HP infection? If so, how? This review was prepared after searching thoroughly almost all of the publications about relationship between HP infections and micronutrients, especially publications pertaining to childhood, from 1990 to 2009 in PubMed. Some valuable adult and experimental publications were also reviewed. These studies related H.pylori to iron, vitamin B12, vitamin C, vitamin A, vitamin E, folate, and selenium. Published studies reveal some evidence that HP has a negative effect on iron, vitamin B12 and vitamin C metabolism, but its influence on others is not clear. 相似文献
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Acquired angioedema and<Emphasis Type="Italic"> Helicobacter pylori</Emphasis> infection in a child 总被引:2,自引:0,他引:2
We describe a 10-year-old boy with acquired Helicobacter pylori infection and simultaneous angioedema which is a rare but life-threatening condition. Our patient was hospitalised with generalised angioedema and severe circulatory shock due to extreme loss of fluids and proteins into interstitial tissues (weight gain 10 kg within 2 days, extreme haemoconcentration – haemoglobin 206 g/l, haematocrit 0.570, leucocytosis 18,300 /µl, high lactate 13.8 mmol/l) and simultaneous failure of the complement system (C3 <0.16 g/l, C4 <0.13 g/l, CH50 45 U/ml, i.e. 50% of normal value, C1 inhibitor 0.21 g/l at the lower limit). All possible known causes of angioedema were excluded (infection, allergy, auto-immune disease, NSAIDs, lymphoproliferative disease) except for the simultaneous H. pylori infection which was proven serologically and histologically. Eradication therapy led to a complete remission of the H. pylori infection. An absence of angioedema and the restoration of the complement system was later observed. To the best of our knowledge, no similar case report of a child has yet been published. Conclusion: Helicobacter pylori infection should be considered in the development of angioedema in childhood. 相似文献
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Objective
Helicobacter pylori is considered as an important etiologic factor in pathogenesis of peptic ulcer disease, chronic gastritis and gastric cancer.
To eradicate this micro-organism, numerous regimens containing various antimicrobial agents have been suggested. However,
H pylori antimicrobial resistance is a leading factor to treatment failure and recurrence of the disease. The aim of the study
was to evaluate the prevalence of H pylori resistance to metronidazole, clarithromycin, tetracycline, amoxicillin, erythromycin
and furazolidone in authors pediatric patients.
Methods Antral biopsy of all pediatric patients with negative history of receiving anti-H pylori regimen and endoscopic findings of
nodular gastritis or peptic ulcer without previous history of NSAID consumption, burning and trauma were performed for H pylori
histology, urease test and culture. All positive cultures were tested for antimicrobial susceptibility.
Results Twenty four patients (14 male and 10 female) between 3.5 and 14 years of age were culture positive. 54.16% of the isolates
were resistant to metronidazole, 8.33% to amoxicillin, 4.16% to erythromycin and 4.16% to clarithromycin. None of authors
patients were resistant to tetracycline and furazolidone.
Conclusion
H. pylori antimicrobial resistance could be a major contributor to failure of H pylori eradication. Continuous prospective surveillance
of H. Pylori is essential. Moreover, culture and antimicrobial susceptibility test is recommended for resistant cases after
the first failure to therapy. 相似文献
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We have read with great interest an article by Kocaoglu et al published in May issue of the World Journal of Pediatrics.[1] A total of 243 children aged between 8-18 years were examined based on growth determinants and existence of Helicobacter pylori (H.pylori) colonization in Turkey.The conclusion of this research is that H.pylori colonization affected children growth;and the longer duration of infection,the worse effect on growth. 相似文献
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Celebi Kocaoglu Ahmet Ozel Mustafa Cayci Ece Selma Solak 《World journal of pediatrics : WJP》2016,12(2):196-201
Background
The effects of Helicobacter pylori (H. pylori) infection on growth are a controversial issue. We investigated the effects of long-term H. pylori infection on height and weight in children.Methods
A total of 200 children of 7-18 years old suffering from dyspeptic complaints were classified into two groups: H. pylori positive and negative groups, respectively. Whether the infection was impoved was followed up while performing urea breath test, and according to exposure time to the infection, the children were further divided into group 1 (≤1.5 months), group 2 (>1.5-≤6 months) and group 3 (>6 months). Antropometric measurements were obtained and repeated every six months.Results
Mean growth velocity scores in the H. pylori positive and negative groups were 0.49±3.85 [95% confidence interval (CI): -0.21-1.18] and 1.98±4.42 (95% CI: 1-2.96), respectively. The difference between both groups was statistically significant (P=0.012). Mean growth velocity scores in groups 1, 2 and 3 were 0.96±3.84, 0.16±4.51 and -0.85±3.09, respectively. Mean growth velocity scores of group 3 were significantly lower than those of groups 0 and 1 (P=0.005 and P=0.041). The mean weight scores in group 3 were similar to those in group 2, but the scores in group 3 were significantly lower than those in group 1 (-1.75±1.05, -1.21±1.37 and -0.88±1.49, respectively).Conclusion
As the duration of exposure is prolonged in children with H. pylori infection, the negative effect of the infection on both height and weight is evident.8.
Refractory iron-deficiency anaemia due to silent<Emphasis Type="Italic"> Helicobacter pylori</Emphasis> gastritis in children 总被引:1,自引:0,他引:1
We describe the cases of three children with chronic active Helicobacter pylori gastritis and iron-deficiency anaemia without evidence of oesophagogastrointestinal bleeding. In all cases, long-standing iron supplementation became effective only after eradication of Helicobacter pylori. CONCLUSION: Iron-deficiency anaemia may be due to clinically inapparent H. pylori gastritis. 相似文献
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An 11-year-old boy with serologically confirmed Chlamydophila pneumoniae infection presented with clinical, laboratory, and echocardiographic changes consistent with myopericarditis. No reports
on C. pneumoniae myopericarditis in children are found in the medical literature. The boy, previously healthy, presented with fever, rash,
constitutional symptoms, elevated acute phase reactants, elevated cardiac enzymes, and high brain natriuretic peptide levels.
Hemodynamic instabilities, including hypotension and mild hypoxia, were noted. Two-dimensional echocardiographic findings
showed mildly depressed left ventricular systolic function and small pericardial effusion. Requiring inotropic support, the
boy was treated with azithromycin 10 mg/kg once daily for 7 days and a single dose of intravenous immunoglobulin 2 g/kg. He
recovered fully with improved left ventricular systolic function before hospital discharge. An early definitive diagnosis
is essential to knowing the etiology of pediatric myocarditis. Specific therapy may play role in the management and prognosis
of this disorder. 相似文献
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Bakr A Yehia S El-Ghannam D Hammad A Ragab M Sarhan A Al-Husseni F Al-Morsy Z 《Indian journal of pediatrics》2008,75(2):135-138
Objective To uncover the frequency and the spectrum of NPHS2 mutations in Egyptian children with non familial steroid-resistant nephrotic syndrome (SRNS).
Methods Sixteen patients were screened by PCR-single-strand conformation polymorphism analysis of NPHS2 gene followed by direct sequencing.
Results
NPHS2 mutations were evident in four patients (25%) who were bearing four novel mutations including two frame shift mutations (R238fs
and P45fs) and two missense mutations (I136L and F216Y). There were no phenotypic or histological characteristics of patients
bearing NPHS2 mutations, apart from the earlier onset of the disease, compared to those who were not bearing mutations.
Conclusion
NPHS2 mutations are prevalent in Egyptian children with non-familial SRNS and this may in part explain the less favorable prognosis
reported in these patients. 相似文献
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Specific aetiological factors are responsible for a significant proportion of cases of perianal sepsis in children. A rarely implicated pathogen is Enterobius vermicularis, an obligate parasite with a ubiquitous presence in children. The authors describe two unequivocal instances of threadworm involvement in perianal sepsis, suggesting a pathophysiological basis. 相似文献
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Deepak Bansal 《Indian pediatrics》2018,55(11):1012-1012
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