慢性萎缩性胃炎患者免疫状态与幽门螺杆菌感染相关性探讨

通过测定４２例慢性萎缩性胃为（ＣＡＧ）患者和１０例正常人血清免疫球蛋白、补体及抗幽门螺杆菌（ＨＰ）抗体，发现有ＨＰ感染者血清免疫球蛋白和补体升高，无ＨＰ感染者则降低或正常。结果表明ＣＡＧ患者体液免疫和补体免疫与ＨＰ感染密切相关，从而为临床治疗ＣＡＧ、根除ＨＰ提供了新的方法和思路     

慢性萎缩性胃炎与幽门螺杆菌感染的生物学行为研究

目的 幽门螺杆菌与胃部疾病的关系已受到广泛关注。同认为，幽门螺杆菌（Ｈｐ）不仅是慢性活动性胃炎的致病因子，而且与胃窦部萎缩性胃炎、肠上皮化生、异型增生及胃癌的形成密切相关。本文检测上述疾病Ｈｐ的感染率，目的就是要明确Ｈｐ的污染率，目的就是要明确Ｈｐ与上述疾病的关系，为临床上述对以上疾病的诊断和治疗提供新的线索和方向。方法 对１９８你病例根据胃窦部胃镜及胃粘膜活检结果分为慢性活动性浅表性胃炎组，经度     

慢性萎缩性胃炎患者免疫状态与幽门螺杆菌感染相关性探讨

通过测定42例慢性萎缩性胃炎（CAG）患者和10例正常人血清免疫球蛋白、补体及抗幽门螺杆菌（HP）抗体，发现有HP感染者血清免疫球蛋白和补体升高，无HP感染者则降低或正常。结果表明CAG患者体液免疫和补体免疫与HP感染密切相关，从而为临床治疗CAG、根除N肝提供了新的方法和思路。     

幽门螺杆菌感染及年龄变化与慢性萎缩性胃炎的关系

1999年1月至2003年6月，我院收治慢性萎缩性胃炎(CAG)1542例。将患者按年龄分组，分析其幽门螺杆菌(HP)的检出率及胃黏膜萎缩程度，以探讨HP感染与年龄变化对CAG发生、发展的影响。     

慢性萎缩性胃炎与幽门螺杆菌感染及其主要毒力因子研究进展

慢性萎缩性胃炎（chronic atrophic gastritis,CAG）是胃黏膜上皮长期遭受致病因子的反复损害而导致的以胃黏膜上皮和腺体萎缩,数目减少,胃黏膜变薄,黏膜基层增厚,或伴幽门腺化生和肠腺化生,或有不典型增生为特征的慢性疾病,是消化系统常见病之一。＂正常胃黏膜-炎症-萎缩-肠化-异型增生-胃癌＂的假设已被大量的临床和实验研究所证实,CAG作为胃黏膜病变过程的中间环节,     

萎缩性胃炎患者幽门螺杆菌感染与高胃泌素血症的关系

萎缩性胃炎患者幽门螺杆菌感染与高胃泌素血症的关系唐新华张虹程玲于澎作者对４０例萎缩性胃炎患者进行幽门螺杆菌（Ｈｐ）及血清胃泌素（ＧＡＳ）水平检测，旨在观察其间的相互关系。一、对象：４０例萎缩性胃炎患者为１９９６年６月～１９９６年１０月本院胃镜室受检病...     

慢性萎缩性胃炎幽门螺杆菌检出量与氧自由基关系的研究

检测71例不同程度感染幽门螺杆菌(HP)的慢性萎缩性胃炎患者(患者组)和70例健康成人(对照组)血浆-一氧化氮(P-NO)、血浆维生素C(P-VC)、血浆维生素E(P-VE)、血浆β-胡萝卜素(P-β-CAR)、血浆过氧化脂质(P-LPO)含量及红细胞超氧化物歧化酶(E-SOD)、红细胞过氧化氢酶(E-CAT)、红细胞谷胱甘肽过氧化物酶(E-GSH-PX)活性和红细胞过氧化脂质(E-LPO)含量。结果与对照组比较,患者组的P-VC、P-VE、P-β-CAR、E-SOD、E-CAT和E-GSH-PX水平均值均显著降低(P<0.001),且随HP增多而降低;P-NO、P-LPO和E-LPO平均值均显著升高(P<0.001),且随HP增多而升高。并均呈一定程度的直线回归和相关(P<0.001)。提示慢性萎缩性胃炎患者体内的NO代谢异常,氧化和抗氧化平衡严重失调,氧自由基反应和脂质过氧化反应病理性加剧,且与HP检出量呈正相关。     

慢性萎缩性胃炎与幽门螺杆菌感染的关系

幽门螺杆菌Helicobacter pylori,Hp)是引起慢性胃炎、消化性溃疡及胃癌的重要病因,几乎所有胃部Hp感染者均可引起不同程度胃部炎症改变,少数发展为慢性萎缩性胃炎(chronic atrophic gastritis, CAG) ,甚至胃癌[1-11].关于Hp感染导致CAG的确切发病机制,目前仍不十分清楚.现就CAG与Hp感染关系的研究现状作一综述.     

幽门螺杆菌相关性萎缩性胃炎酸分泌与杆菌定植的关系

目的研究胃酸分泌和粘膜萎缩对胃体和胃窦幽门螺杆菌（ Hp）定植的影响。方法将 95例 Hp阳性的慢性萎缩性胃炎患者分组。组一：胃窦中度萎缩伴胃体轻、中或重度萎缩性胃炎;组二：胃体轻度萎缩伴胃窦轻、中或重度萎缩性胃炎。分别测定基础酸分泌、最大酸分泌和胃泌素, Warthin-Starry染色诊断 Hp,同一组织诊断萎缩并分度。内因子抗体阳性者除外。结果组一中胃窦萎缩固定不变的各组之间,酸分泌显著降低组胃窦部 Hp定植率显著降低（ P< 0.05）;组一中胃体萎缩中度与重度组比较,最大酸分泌差异无统计学意义 (P >0.05),胃体重度萎缩组 Hp定植率较中度萎缩组明显低下 (P< 0.05)。组二中胃体萎缩固定不变的各组之间,酸分泌显著降低组胃体 Hp定植率显著降低 (P< 0.05);组二中胃窦萎缩中度与重度组比较,基础酸、最大酸分泌差异无统计学意义 (P >0.05),胃窦重度萎缩组 Hp定植率较中度萎缩组明显低下（ P< 0.05）。结论慢性萎缩性胃炎的低酸和萎缩明显影响胃窦、体部 Hp的定植,两种影响因素既独立又互补。     

Effect of Hewei-Decoction on chronic atrophic gastritis and eradication of Helicobacter pylori

AIM: To demonstrate the effect of Hewei-Decoction (Decoction for regulating the stomach) on chronic atrophic gastritis (CAG) and eradication of Helicobacter pylori. METHODS: Ninety patients with CAG entering the investigation were divided into six differentiation syndromes, based on their major symptoms and signs. Hewei-Decoction was taken by all the patients orally for 4 or 8 wk. The efficacy was assessed by both the composite accumulation of reduced scores of major symptoms and the eradication of H pylori.X2 test was used to compare the efficacy between H pylori-positive and negative cases, and to disclose the relationship between efficacy and eradication of H pylori. RESULTS: In patients with six different syndrome types, the efficacy of Hewei-Decoction was 91.67% (11/12), 92.86% (13/14), 97.22% (35/36), 87.50% (14/16), 75.00% (6/8), 75.00% (3/4) respectively. The rate of highly efficacious was 58.33% (7/12), 50.00% (7/14), 77.78% (28/36), 62.50% (10/16), 12.50% (1/8) and 25.00% (1/4), respectively. The total efficacy was 91.11% (82/90), and the rate of highly efficacious was 60.00% (54/90). The eradication rate of H pylori was 67.86% (38/56). The therapeutic effect of Hewei-Decoction was better in H pylori positive cases than that in H pylori-negative cases with the total effect of 96.43% vs 82.35% (P<0.05). In 56 H pylori positive cases, the therapeutic effect was better in H pylori eradicated cases than that in H pylori-existent cases with the total effect of 97.37% vs 72.22% (P<0.01). CONCLUSION: Hewei-Decoction is effective in most cases of all the syndrome types. The results indicate that eradication of H pylori is one of the important mechanisms for alleviation of symptoms and signs. Also, the decoction is efficacious in H pylori-negative cases.     

老年人NUD与慢性胃炎,幽门螺杆菌感染关系研究

本文通过对５３例老年非溃疡性消化不良患者胃窦粘膜活检组织的病理学观察、幽门螺杆菌的检测及消化不良症状的调查，旨在探讨慢性胃炎、ＨＰ感染与老年人ＮＵＤ的关系。结果提示：非活动性慢性胃炎在老年人ＮＵＤ发病中不起重要作用，活动性慢性胃炎可引起老年人ＮＵＤ症状；ＨＰ感染可引起部分老年人ＮＵＤ症状，腹胀、嗳气与ＨＰ感染相关。     

Association of Helicobacter pylori infection with atrophic gastritis and intestinal metaplasia

AIMS: To evaluate the effect of Helicobacter pylori infection and aging on atrophy and intestinal metaplasia of the gastric mucosa. METHODS: One hundred and sixty-three patients were divided into three age groups and underwent an upper gastrointestinal endoscopy where no esophagitis, peptic ulcers, or malignancies were detected. Two biopsy specimens were obtained from the anterior and posterior walls of the antrum and of the fundus. These were used to evaluate the grade of gastritis, bacterial culture and histologic evidence of H. pylori infection. RESULTS: Helicobacter pylori infection was found to be directly associated with an increased risk of gastritis grade (odds ratio (OR) = 90 (95% CI; 30-270)). An age of 60 years and older along with H. pylori infection was also strongly associated with an increased risk of atrophy (OR = 6.6, (95% CI; 2.9-15.2)); OR = 9.8, (95% CI; 2.7-35.4)), as was intestinal metaplasia of the gastric mucosa (OR = 5.5, (95% CI; 1.7-17.6)); OR = 7.9, (95% CI; 2.8-46.1)). The prevalence of atrophic gastritis increased with advancing age in H. pylori-infected patients, but no such phenomenon was observed in H. pylori-uninfected patients. The prevalence of intestinal metaplasia significantly increased with advancing age, irrespective of the presence of H. pylori infection. In addition, H. pylori uninfected female patients had a decreased risk of intestinal metaplasia. CONCLUSIONS: These results suggest that atrophic gastritis is not a normal aging process, but instead is likely to be the result of H. pylori infection, while intestinal metaplasia is caused by both the aging process and H. pylori infection. A decreased risk of intestinal metaplasia found in uninfected female subjects may partly explain the lower prevalence of gastric cancer in females than in males.     

慢性多灶萎缩性胃炎患者胃酸分泌与幽门螺杆菌感染及血清胃泌素的关系

目的 研究慢性多灶萎缩性胃炎(BAG)胃酸分泌与幽门螺杆菌(Hp)感染及血清胃泌素的关系.方法 将200例确诊的慢性胃炎患者根据病理结果分为轻度、中度、重度BAG组及对照组(非萎缩性胃炎组),监测各组患者24小时胃内pH值的变化情况,并检测其幽门螺杆菌及血清胃泌素的含量,各组间进行比较.结果 (1)150例BAG患者中,Hp感染阳性率70%,随着胃粘膜萎缩程度的加重,Hp感染阳性率逐渐上升;(2)各组间血清胃泌素值比较:轻度萎缩组与非萎缩性胃炎组比较差异无显著性(P＞0.05),其余各组问比较差异有显著性(P＜0.05;(3)各组pH值分析结果:BAC胃黏膜轻度萎缩时,pH≤2时间百分比较非萎缩性胃炎组升高,pH＞4时间百分比及pH平均值、pH中位值均较非萎缩性胃炎组降低,中度及重度萎缩时pH≤2时间百分比逐渐降低,pH＞4时间百分比及pH平均值、pH中位值逐渐升高.结论 BAG的发生与Hp感染有关,胃粘膜萎缩程度与Hp感染的严重程度有关;BAG胃黏膜轻度萎缩时,血清胃泌素含量无明显变化;中、重度萎缩时,血清胃泌素含量降低;BAc胃黏膜轻度萎缩时,胃酸分泌增多;随着胃黏膜萎缩程度的加重,胃酸分泌逐渐减少.     

Alteration of sister chromatid exchange frequencies in gastric cancer and chronic atrophic gastritis patients with and without H. pylori infection

AIM： To determine, by counting sister chromatid exchange （SCE） frequencies, whether genetic impairment and DNA damage have an effect on the pathogenesis of gastric cancer （GC）. METHODS： Analysis of SCE is a cytogenetic technique used to show DNA damage as a result of an exchange of DNA fragments between sister chromatids. We analyzed SCE frequency in 24 patients with GC, 26 patients with chronic atrophic gastritis （CAG）, and 15 normal controls. The presence of H pylori was confirmed by urease test, toluidine-blue stain and hematoxylin-eosin stain. RESULTS： SCE was significantly increased in H pylori- negative GC patients, and in H pylori-negative CAG patients compared with controls （7.41 ± 1.36 and 6.92 ± 1.20, respectively, vs 5.54 ± 0.8, P 〈 0.001）. There was no difference in the SCE frequency between H pylori- negative GC patients and H pylori-negative CAG patients （P 〉 0.05）. On other hand, the SCE frequencies in H pylori-positive GC patients were higher than those in H pylori-positive CAG patients （9.20 ± 0.94 vs 7.93 ± 0.81, P 〈 0.01）. Furthermore, H pylori-positive GC patients had a higher SCE frequency than H pylori- negative GC patients （9.20 ± 0.94 vs 7.41 ± 1.36, P 〈 0.001）. Similarly, a significant difference was detected between H pylori-positive CAG patients and H pylori-negative CAG patients （7.93 ± 0.81 vs 6.92 ± 1.20, P 〈 0.05）. CONCLUSION： We suggest the increased SCE in patients reflects a genomic instability that may be operative in gastric carcinogenesis.     

老年慢性胃炎与幽门螺杆菌感染的关系

本文报道老年慢性胃炎伴幽门螺杆菌（ＨＰ）感染的情况，并与中青年慢性胃炎伴ＨＰ感染组对照。结果表明：老年ＣＡＧ伴ＨＰ感染的发病率较对照组高，而ＣＡＧ又是老年胃癌的癌前病变，因此彻底治疗ＨＰ感染对预防老年ＣＡＧ的癌变有一定的临床意义。     

中西医结合根除幽门螺杆菌对萎缩性胃炎核因子-κB表达的影响

[目的]观察以胃舒散为主的三联疗法（胃舒散、呋喃唑酮和克拉霉素）治疗幽门螺杆菌（Hp）阳性慢性萎缩性胃炎（CAG）的临床效果及其对核因子-κB（NF-κB）表达的影响。[方法]41例Hp阳性CAG患者服用胃舒散2．0g，呋喃唑酮0．1g，各3次／d，克拉霉素0．25g，2次／d，1周后再继服胃舒散4周。治疗前及治疗结束1年后行内镜及病理组织学检查，取活检观察病理组织学改变及NF-κB表达变化，采用银染色法、^14C-尿素呼气试验或快速尿素酶试验检测Hp。[结果]三联疗法结束1年后，Hp根除率为85．4％；根除Hp能显著减轻患者胃窦部慢性炎症（P〈0．05）和活动程度（P〈0．01），下调NF-κB表达（P〈0．01），但胃炎的萎缩和肠化生等病理无明显改变。[结论]以胃舒散为主的三联疗法对Hp有较高根除率。根除Hp可抑制NF-κB的表达，减轻活动性炎症，但近期观察对萎缩、肠化生等病理改变无明显作用。     

胃窦部幽门螺杆菌清除对萎缩性胃炎病理改变的影响

目的通过对幽门螺杆菌（Hp）相关的萎缩性胃炎病人Hp清除治疗前后胃窦部黏膜病理改变的分析，来确定Hp对其炎症程度、活动性（中性粒细胞浸润）、腺体萎缩和肠上皮化生的影响。方法106例Hp相关的萎缩性胃炎患者接受Hp清除治疗，对其治疗前后胃窦部黏膜的病理变化进行分析，分析标准按96悉尼系统评定。结果在62例治疗成功组中，治疗后胃黏膜的炎症程度及活动性较治疗前明显减轻，但腺体萎缩及肠上皮化生未减轻。在44例治疗失败组中，治疗前后胃黏膜的炎症程度、活动性、腺体萎缩及肠化均没有变化。且随着Hp感染时间的延长，腺体萎缩和肠化还可加重。结论Hp的清除治疗可使萎缩性胃炎患者胃黏膜的炎症程度及活动度减轻，对此类病人应行Hp清除治疗。     

慢性胃炎结节状改变与幽门螺杆菌感染的关系研究

目的　探讨慢性胃炎结节状改变与幽门螺杆菌 (Hp)感染的关系。方法　对 2 0 0 1～2 0 0 2年中胃镜检查发现的慢性胃炎结节状改变患者进行Hp检测 ,对Hp阳性患者 ,进行Hp根除治疗 ,随访 6个月 ,观察其胃镜下的改变。结果　 4 939例胃镜检查患者中共发现 1 3例慢性胃炎结节状改变 ,占检查总人数的 0 2 6 %。平均年龄 2 9岁 ,均为女性患者。主要症状均为上腹部疼痛。所有患者均有Hp感染。Hp根除成功后 ,症状和胃镜下结节状表现消失 ,病理证实胃黏膜下淋巴滤泡也随之消失。结论　慢性胃炎结节状改变可作为Hp阳性胃炎的内镜下的表现之一。