正常人血液与心肌中元素含量的相关分析

对30例正常人心肌、血浆、红细胞中11种元素含量进行相关分析，发现红细胞钾、钙、镁、锌、硒和血浆镉、锰含量与心肌中的含量呈显著正相关；红细胞铁和血浆钠、铜、锌含量与心肌中的含量呈显著负相关。利用相关分析建立的回归方程，可由血液中元素含量准确地计算心肌中相关元素的含量。红细胞可作为研究心肌中元素含量变化的细胞模型。     

长春地区健康成人心肌19种元素的正常值范围

由吉林省长春地区采集40例健康成人心肌样品,用荧光分光光度法测定硒,用催化极谱法测定钼,用高频感耦等离子体发射光谱法测定铝、硼、钡、钙、镉、钴、铬、铜、铁、钾、镁、锰、钠、磷、锶、钛和锌的含量。取90%可信限,通过计算确定了健康成人心肌19种元素的正常值范围。     

感染马来丝虫微丝蚴中华按蚊元素的分析

应用原子吸收光谱分析仪对中华按蚊的羽化蚊、吸正常人血后0d、5d、8d、12d、18d及感染马来丝虫微丝蚴后5d、8d、12d、18d的中华按蚊虫体内13种元素含量的变化进行了分析。这13种元素由钾、钠、钙、镁等4种常量元素和铁、锌、镍、铝、钢、铅、铜、锰、铬等9种微量元素组成。结果表明，非感染马来丝虫微丝蚴中华按蚊体内元素的含量随蚊虫的发育而增减不一，减少明显的有锌、铁、镁、铜等，而钙、钾等却有所增加。感染蚊与非感染蚊相比较，多种元素的含量明显减少，于感染第5d，有铁、锌、钾、钙、钠、铝、钢、铅、铜、锰等10种；第8d有除钙、镁以外的11种；第12d有除钙、镁、铜、镍外的9种；第18d有钾、镍、铝、镉、铅、锰、铬等7种元素的含量显示出非常明显的差异。     

低硒高镉对大鼠组织中锌和铜分布的影响

用控制硒，镉含量的饲料喂养Ｓ．Ｄ大鼠，观察低硒，高镉对大鼠组织中铜，锌分布的影响。结果表明：低硒使大鼠肝组织中硒，镉，铜，锌含量和肾组织中硒，镉含量均降低；高镉导致大鼠肝硒，铜含量降低而肝肾锌，镉含量升高。锌在组织的分布上，低硒高镉呈现拮抗作用，而在肝脏铜的分布上，低硒高镉表现为协同作用。     

血锌、钙、铜、硒水平对胎盘镉蓄积及转运的影响

目的探讨血锌、钙、铜、硒水平对胎盘镉蓄积及转运的影响。方法 73例待产孕妇根据血镉检测水平分为观察组(31例,血镉1 200 ng/L)与对照组(42例,血镉300~1 200 ng/L)。电感耦合等离子体质谱法检测孕妇血铜、镉及胎盘与脐血中镉水平,火焰原子吸收分光光度法检测血钙、锌,原子荧光分光光度法检测血硒。对比两组各营养元素及胎盘、脐血镉水平。结果两组孕妇血钙水平无差异(P0.05),观察组血锌、铜、硒水平均明显低于对照组,胎盘、脐血镉水平高于对照组(P0.05)。结论血锌、铜、硒水平可能是胎盘镉蓄积与转运的关键影响因素,孕期合理补充营养元素对减少胎盘镉蓄积及转运具有重要意义。     

40例恶性血液病患者血清和脑脊液中微量元素含量的临床分析

对４０例恶性血液病患者血清和脑脊中锌、铜、铁、锰、镉、镍的含量进行测定。结果显示：血清中铁、镉、镍均增高、白血病组铜／锌比值增大。脑脊液中锌、铁、镉、镍增高。急性白血病组中血清及脑脊液中铜、铁、镉、镍几种元素含量的变化与疾病状态有关。     

胃癌患者血清,组织和血细胞锌,铜,硒的含量变化

本文应用原子吸收检测技术对３２例胃癌患者的血清、胃癌组织、红细胞、白细胞和血小板锌、铜、硒的含量进行检测，与胃炎组比较，结果：胃癌组血清锌含量降低（Ｐ＜０．０１），而血清铜含量和血清Ｃｕ／Ｚｎ比值升高（Ｐ＜０．０１），血清硒含量降低（Ｐ＜０．０１）；白细胞锌含量降低（Ｐ＜０．０１），白细胞铜无显著变化；红细胞、血小板锌、铜、硒含无显著变化；胃癌组织中锌、硒含量增加（Ｐ＜０．０５），而铜含量无显著变化；锌、铜、硒及血清Ｃｕ／Ｚｎ比值与胃癌细胞分化程度以及有无肿转移无相关性。测定胃癌患者血清、组织、白细胞锌、铜、硒含量，可以估价体内这些元素的总体状态，为观察病情、估计预后提供依据。     

过量锰对大鼠体内无机元素含量的影响

本文报告了在合成饲料中加入1000×10~(-6)锰后,大鼠肝、肾及毛中锰含量显著上升;心肌硒、锌、铁及铜含量显著下降,此外,肝镁、肾钙及硒含量也明显降低。但动态观察结果也表明,锰对大鼠体内无机元素含量的影响与动物生长时间密切相关。     

人体尿中15种元素检测方法的建立及其评价

目的 建立人体尿中铝、铬、锰、铁、镍、铜、锌、砷、硒、锶、镉、碘、钡、汞、铅15种元素的检测方法,应用于人群尿液样品的检测,并对检测数据进行初步分析评价,为评估人体元素负荷水平提供基础资料。方法 采用整群随机抽样的方法抽取丰台区居民的尿样526份作为检测对象。尿样以样品稀释液稀释10倍,制成测试液;采用电感耦合等离子体质谱仪同时测定15种元素含量。结果 15种元素在测定范围内线性相关系数均大于0.999;方法检出限在0.005～0.115μg/L之间,相对标准偏差（RSD）小于5%,加标回收率在94.0%～109.2%之间;尿样标准物质实际测定值均在标准值范围内,人群尿样中铝、铬、锰、铁、镍、铜、锌、砷、硒、锶、镉、碘、钡、汞、铅元素含量的中位数分别为21.03,0.68,0.74,46.82,5.08,58.81,815.32,29.54,49.91,397.12,2.01,141.23,138.08,0.30和3.87μg/L;几何均数分别为20.91,0.58,0.73,43.72,4.95,41.52,812.02,28.02,49.53,397.04,1.58,137.11,...     

大骨节病区麦面,玉米面和黄豆中某些元素含量的对比分析

在控制测试质量条件下,测定了大骨节病区和非病区麦面、玉米面和黄豆中硒铜锌锰铁钙磷含量。对比分析结果表明:病区麦面中硒铜量低于、铁锰钙量高于、玉米面和黄豆中硒锌量低于非病区。在病区里,黄豆富含铜锌钙磷、钙磷比值较合理,麦面次之,玉米面较差。麦面的铜锌钙磷锰铁量随碾磨度由粗到精依次减少。病区村民常食的麦面(80—90%)—玉米面(10—20%)主食中,锰铁偏多、锌磷不足、硒铜钙缺乏,是一种无机元素较不平衡的食物。文末讨论了提高病区村民主食中缺乏元素供应水平的方法。     

Content of microelements in left ventricular myocardium of patients with ischemic heart disease. Data of roentgenofluorescent analysis with the use of synchrotron irradiation

Contents of 11 microelements (Se, Rb, K, Sr, Ca, Cr, Mn, Fe, Cu, Ni, Zn) in various parts (zone of infarction, of scar, periinfaction zone) of left ventricular myocardium of patients with ischemic heart disease was studied with method of rentgenofluorescent analysis with the use of synchrotron irradiation (overall 2112 analyses). Left ventricular myocardium of victims of accidents without cardiovascular pathology was studied as control. Compared with control dysbalance of various degree was noted in left ventricular myocardium of patients with ischemic heart disease. Four groups of microelements were distinguished: lowered content (Se, Rb, K); close to normal content (Mn, Cu); moderately elevated content (Cr, Sr, Fe); elevated content (Ni, Zn). Several orders of magnitude elevation of Ni and Zn was noted in all parts of left ventricle, especially in the zone of infarction and periinfarction zone.     

克山病患者与健康人心肌元素含量均值向量比较和对应分析

对18例克山病患者及43例健康人心肌 Ba、Ca、Cd、Co、Cr、Cu、Fe、K、Mg、Mn、Na、P、Ti、Zn 和 Se 含量的两个均值向量进行了比较,结果表明其差异非常显著(P<0.01)。对应分析取最大的两个特征根(其和超过全部特征根之和的85%)绘成二维图,可见:克山病组与健康组分界明确;Se、Zn、Cu、P、Mg 和 K 与健康组关系密切;Ca、Co 和 Na 与克山病组关系密切;Ba、Fe、Mn、Ti、Cd 和 Cr 似乎与两组关系都不密切。     

Distribution of chemical elements in various parts of the heart of patients with acute heart failure

By the method of autopsy in patients with ischemic heart disease (IHD) who died of acute heart failure we took samples of myocardium from 6 parts of the heart: left and right atrium, left and right ventricle, region of myocardial infarction, and scar of the left ventricle. Simultaneously we conducted histological study of these parts of myocardium. For the control we investigated content of chemical elements in myocardium of healthy victims of traffic accidents. By the method of roentgen fluorescent analysis with the use of synchrotron emission we detected content of 17 chemical elements: 4 macroelements (S, Cl, K, Ca) and 13 microelements (Cr, Mn, Fe, Ni, Cu, Zn, Se, Br, Rb, Sr, As, Mo, Hg). It was established that in patients with IHD who had died of acute heart failure content of Ca was elevated 4-8 fold in all parts of the heart. In infarction zone compared with other regions of the heart maximal quantity of Sr, Cr, Hg was contained. These elements can be looked upon as markers of infarction. In myocardium of patients with IHD especially in the zone of infarction elevation of activity of processes of lipid peroxidaton has been noted (calculated activity of malone aldehyde as example).     

1，6－二磷酸果糖治疗急性缺血性心功能不全的实验研究

报告了１，６─二磷酸果糖治疗急性缺血性心功能不全时对血波动力学和心肌离子含量的影响。结扎冠状动脉造成心功能不全模型。模型成功后，静脉注射１，６－二磷酸果糖治疗。结果表明，１，６－二磷酸果糖可降低左室舒张未压力，升高心输出量，同时减轻缺血心肌组织中钾、钠、钙、镁、铜、铁、硒等离子含量的异常。     

广西巴马地区大米和玉米中微量元素的检测

目的 检测广西巴马地区老人主食大米和玉米中微量元素含量,并探讨其与长寿的可能关系.方法 随机选取当地老人正在食用的主食大米样品23份和玉米样品25份,利用电感耦合等离子体发射光谱仪测定大米和玉米中Al、Ca、Cd、Co、Cr、Cu、Fe、Mg、K、Mn、Na、P、Pb、Zn的含量.结果 与非长寿区域相比,巴马长寿区域种植的玉米及大米中有害有毒重金属物质Al、Cd、Pb的含量均较低,而Ca、Cu、Fe、Mg、K、Mn、P、Zn等8种微量元素含量丰富,玉米中Al、Pb、Mn、P两组之间比较,差异有统计学意义(P＜0.05),大米中所有元素,两组之间比较差异不显著.结论 巴马长寿区域与非长寿区域老人的主食中大米和玉米的微量元素的组成不同,其与巴马长寿的关系值得进一步研究.     

Myocardial catecholamine content in heart failure--I: Regional distribution in explanted hearts. Comparison between dilated cardiomyopathy and coronary heart disease

To quantify the myocardial catecholamine content in heart failure patients and to assess the regional distribution of catecholamines, we investigated norepinephrine and dopamine concentrations in explanted hearts from 34 patients in end-stage heart failure. 28 patients with cardiomyopathy were compared with six patients with coronary artery disease. In comparison with the right atria of a control group without heart failure, reduced myocardial norepinephrine contents (in pg/micrograms non-collagen protein (NCP] were found in all areas of the explanted hearts: controls: right atrium 17.6 +/- 6.6; cardiomyopathy: right atrium 7.1 +/- 7.9, right ventricle 4.4 +/- 2.7, septum 3.8 +/- 1.5, left ventricle 3.5 +/- 1.4. Coronary artery disease: right atrium 7.0 +/- 6.9, right ventricle 4.2 +/- 2.6, septum 3.6 +/- 1.4, left ventricle 3.4 +/- 1.4. Highest norepinephrine levels were measured in the right atrium. Right ventricle, septum, base and midventricular portion of the left ventricle had lower concentrations and were not different from each other. In contrast to reduced norepinephrine (NE) levels in all patients, dopamine (Dop) was inhomogenously elevated (only in a subgroup of 44%). Catecholamine contents in any two arbitrarily selected areas correlated significantly (NA: r = 0.53-0.77; Dop: r = 0.81-0.93, p less than 0.05 in all cases). The patients with heart failure due to dilated cardiomyopathy and to coronary artery disease did not differ in myocardial catecholamine levels or distribution. In end-stage heart failure a significant loss of myocardial norepinephrine independent from the underlying disease is found. It affects all areas of the hearts but does not equalize catecholamine content in ventricles and atria.(ABSTRACT TRUNCATED AT 250 WORDS)     

The effect of age on the regional distribution of four cations in the rat heart

It has been postulated that the concentration of metals in the heart influences the activity of enzymes and ultimately, cardiac function. In this investigation, the regional distribution of Calcium [Ca], Magnesium [Mg], Copper [Cu] and Zinc [Zn] was analyzed in the hearts of Fischer 344 rats (1, 3, 12, 24 months of age). Samples of right and left atria (RA, LA), right and left ventricles (RV, LV), and septum (S) were homogenized in 5% La, 25% HNOs. The samples were digested, centrifuged, and assayed by atomic absorption spectrophotometry. [Ca] Increased in the RA, LA and LV from 3 to 24 months of age. [Mg] In the RV, LV and S decreased throughout the age span. [CU] in the LV decreased between 3 and 12 months of age, while [Zn] remained constant. The Zn:Cu increased by 56 percent between 3 and 24 months of age. In summary, these data suggest that there are differences in the concentration of metals in the heart as a function of age.     

Concentration of elements in plasma of patients with essential hypertension

Disturbances in macro- and microelements composition may play a significant role in the development of essential hypertension. The aim of the study was to estimate main and trace elements concentration in plasma of hypertensive patients. The study involved 150 subjects, aged 33-60 years, who were allotted into 2 groups: I--50 clinically healthy subjects (controls), II--100 patients with arterial hypertension. Age and sex ratio were similar in the examined groups. Those subjected to the study were not administered any drugs at least 3 months prior to the determination of macro- and microelements. Determinations of trace elements Ca, F, Na, K, Mg, Fe, Zn, Cu, Ni, Mo, Al, Cd, Fb, Mu, Se, Cr, Co, Li, V, B, Ba, were performed with atomic emission spectrometer with plasmic excitation (ICP MS Philips PU). In group II in comparison to group I (controls) higher values of Fe, Pb, Al, Cd, Co, B i Ba were observed, as well as higher Zn/Cu ratio; but lower values of Cu and lower Ca/Pb, Ca/Al, Zn/Fe, Se/Fe, Zn/Al, Zn/Cd, Se/Pb, Se/Al, Se/Cd ratio. Increase of prooxidative and decrease,of antioxidative elements in plasma may significantly contribute to the essential hypertension pathogenesis probably through oxidative stress development.     

Transposition of the great arteries with ventricular septal defect and pulmonary stenosis.

A postmortem investigation was carried out of 19 heart specimens with transposition of the great arteries, ventricular septal defect, and congenital subvalvular pulmonary stenosis. Certain types of obstruction appeared to be closely related to other features of the hearts. In cases with malalignment of the infundibular septum, the obstruction was caused by this septum and the anterolateral muscle bundle of the left ventricle. If the infundibular septum was deviated considerably to the left, the pulmonary stenosis was usually severe because the infundibular septum and anterolateral muscle bundle were joined. This junction resulted in a relatively posterior position of the pulmonary orifice in the left ventricle. A less extreme deviation of the infundibular septum resulted in an obstruction by this septum and by the anterolateral muscle bundle, situated at the right and the left sides of the pulmonary orifice respectively. In some cases of paratricuspid ventricular septal defect an anomalously attached and cleft anterior leaflet of the mitral valve was found. This, together with a leftward deviation of the anterior left ventricular part of the ventricular septum, caused the obstruction.