Sex steroid receptors in the myometrium in cesarean section

The levels of estradiol and progesterone receptors in the myometrium of 19 patients subjected to planned cesarean section were studied. Nine of these patients had competent cicatrices on the uterus, which was confirmed by preoperative studies and during the operation. For comparison, the myometrium of patients at the same terms of gestation subjected to planned abdorninal delivery without history of cesarean section was examined. No significant differences were revealed in estradiol and progesterone reception in the myometria of parturients with and without competent cicatrices on the uterus. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 5, pp. 573–575, May, 1998     

Impact of 8-isoestrone analogs on estradiol binding in uterine tissue from ovariectomized rats

8-Isoanalogs of estrone were studied for their ability to influence estradiol binding in the cytosolic fraction of uterine tissue from ovariectomized rats and for their uterotropic activity 24 h after injection into such rats. Two groups of estrone 8-isoanalogs with opposite biological effects were identified: those increasing estradiol binding in the cytosolic fraction of uterine tissue and those decreasing this binding. Uterogenic activity was exhibited by all of the compounds tested, with the exception of compound I. No correlation was found between the uterogenic activity of the isoanalogs and hormone-receptor interactions. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N ^o 2, pp. 165–167, February, 1995     

Interaction of selected pregna-D'-pentaranes with cytosolic receptors of myometrium and endometrium in various disease states

The relative capacities of several pregna-D'-pentaranes to combine with cytosolic receptors of the myometrium and endometrium in various disease states are investigated, and one of the compounds, 6α-methyl-16α, 17α-cyclohexanoprogesterone, is identified as holding particular promise for clinical use in replacement therapy and as a contraceptive agent. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N ^o 2, pp. 163–165, February, 1995     

Adaptation of the membrane receptor apparatus of blood cells after the combined use of cryodestruction and plasma beam in experimental cirrhosis of the liver

It is shown that cryodestruction combined with resection with a plasma beam aggravates alterations of the functions of the blood cell receptor complex affected by cirrhosis, leading to hypoinsulinemia, inhibited capacity of cells to utilize glucose, a lowered metabolic activity of insulin receptors, and other changes. Three weeks after surgery the energy metabolism of the blood cells returns to the normal level, while the activity of insulin receptors and of hexokinase exceeds the control level. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N ^o 6, pp. 647–650, June, 1995 Presented by V. N. Yarygin, Member of the Russian Academy of Medical Sciences     

Relative binding capacity of pentarane substances with plasma membrane receptors of uterine cells of oophorectomized rats

The relative capacity of substances of the pentarane group for binding with progesterone receptors of the plasma membranes of uterine cells of oophorectomized rats is studied. Introduction of an extra carbocycle D' in the progesterone molecule at the 16α and 17α sites and further modification of the molecule cause an increase of the relative binding capacity of these compounds. Analysis of the findings identifies substance III, showing the highest activity toward all the discussed parameters and a promising candidate for further preclinical studies. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol., 118, N ^o 7, pp. 31–32, July, 1994     

Effect of paraoxon and sulfhydryl reagents on3H-quinuclidinol benzoate and3H-methylscopolamine with synaptic membranes of rat brain

Paraoxon is shown to reduce the density of M-choline receptors in the cortex of rat brain. Inhibition of³H-QNB is noncompetitive and reversible in nature. Sulfhydryl reagents do not affect this process. The mechanism of action of PO is thought to include direct effects on brain muscarine receptors. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N ^o 7, pp. 51–53, July, 1994     

Role of estrogens in the regulation of prolactin receptors in liver cells of female rats

Strong expression of prolactin receptors in sinusoidal domains and cytoplasmic granules of hepatocytes, which is independent of cell location in the hepatic lobule and is positively regulated by estrogens, is revealed in pubertal female rats. In estrogen-treated animals, Prolactin receptors are also exposed in the perinuclear space of some hepatocytes surrounding the central veins. Estrogens regulate the intensity of prolactin receptors expression in hepatocytes, but not the number of cells containing these receptors. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N ^o 9, pp. 264–267, September, 1994 Presented by I. P. Ashmarin, Member of the Russian Academy of Medical Sciences     

Distribution of immunoregulatory carbohydrate receptors for lectins on membranes of neurons and syngeneic peripheral lymphocytes

Common immunoregulatory carbohydrate receptors on the membranes of neurons and sysngeneic peripheral lymphocytes of mice are detected by using lectins. Brain neuron membranes possess no receptors characteristic of immature lymphocytes. The common immunoregulatory receptors on brain neurons and mononuclear cells of peripheral immune organs are shown to represent one the mechanisms of integration of the nervous and immune systems. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N ^o 2, pp. 155–157, February, 1994 Presented by A. P. Romodanov, Member of the Russian Academy of Medical Sciences     

Vestibuloprotective activity of seal serum proteins

Cat and rat experiments show that the protein fraction isolated from blood serum of the Greenland seal has a protective activity against motion sickness. This activity is comparable to that of the classical vestibuloprotector scopolamine and is greater than that of diprazine. Radioligand assay of the receptor binding showed that the serum protein fraction has the highest affinity for α₂-adrenoceptors, μ-opioid, and benzodiazepine receptors. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol 117, N ^o 4, pp. 444–445, April, 1994     

A different mechanism of inhibition by buspirone and its camphorimide analogs of serotonin 5-HT3 effects

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 116, N ^o 8, pp. 167–169, August, 1993     

On the involvement of endogenous μ- and δ-opiate receptor agonists in the antiarrhythmic effect of adaptation

Rats adapted to stress showed a decreased severity and incidence of cardiac arrhythmias induced by epinephrine, and these effects of adaptation were abolished by naloxone. It is suggested that stress adaptation mitigates arrhythmia by activating the endogenous opioid system and stimulating the μ-opiate receptors. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N ^o 1, pp. 24–25, January, 1996 Presented by R. S. Karpov, Member of the Russian Academy of Medical Sciences     

Excitatory effects from stimulation of ileac presynaptic α-adrenergic receptors in nonanesthetized rabbits

Stimulation of α-adrenergic receptors with Mezaton can either decrease or increase spike activity of the ileum. These effects of Mezaton are both abolished by preinjecting rabbits with dihydroergotoxin. If Mezaton is administered when M-cholinergic receptors are blocked, the ileac spike activity is only weakened, but when this drug is given after blockage of N-cholinergic receptors, its excitatory effect can still be observed. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N ^o 2, pp. 117–119, February, 1994 Presented B.I. Tkachenko, Member of the Russian Academy of Medical Sciences     

Effect of immune “sessile” receptors on the choline receptors of the lymphocyte membrane in mice immunized with certain antigens

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 115, N ^o 2, pp. 384–386, April, 1993     

A water-soluble form of estradiol with estrogenic and cardiotropic activity

It is demonstrated that a water-soluble form of estradiol (disodium salt of estradiol diphosphate), apart from having an estrogenic influence on the uterus, is effective against severe blood loss and has a cardiotropic actiity. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N ^o 1, pp. 51–53, January, 1995 Presented by P. V. Sergeev, Member of the Russian Academy of Medical Sciences     

Tolerance for opiate analgesia: Complex effect of antagonists of receptors for excitatory amino acids

The effect of excitatory amino acid receptor antagonists on the development of the conditioned reflex component of the tolerance for morphine analgesia is studied. It is demonstrated that the antagonists of NMDA and non NMDA receptors reduce the development of associated component of the tolerance, while the magnitude of the nonassociative component changes after co-administration of morphine with NMDA receptor antagonists. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N ^o 5, pp. 494–496, May, 1994 Presented by D. A. Kharkevich, Member of the Russian Academy of Medical Sciences     

The hyperglycemia syndrome in extreme conditions (Burn trauma and crush syndrome): Major aspects of pathogenesis

Using animal models of burn trauma and crush syndrome, the authors show that the main mechanism by which a hyperglycemia syndrome develops in these conditions is an altered interaction of insulin with its receptors in plasma membranes. As a result, the entry of glucose into cells is disrupted, hexokinase activity is lowered, and changes occur in the rates of enzymatic reactions involved in glucose transformations. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N ^o 1, pp. 22–25, January, 1994     

The role of lectins in allergic reactivity

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 115, N ^o 4, pp. 407–410, April, 1993     

Aldosterone binding with corticosteroid brain receptors in rats: Effect of behavioral typology and stress

Differences in³H-aldosterone binding with hippocampus cytosol receptors were found to be dependent on the behavioral type of male Wistar rats in the “emotional resonance” test. These differences were not observed in the cytosol analysis of the remaining part of the brain. Control rats and rats subjected to short-term stress by painful electrical stimulation showed a long-term drop of³H-aldosterone binding with hippocampus cytosol in active as compared to passive animals preferring a closed space. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N ^o 7, pp. 49–51, July, 1995 Presented by I. P. Ashmarin, Member of the Russian Academy of Medical Sciences     

The target cell plasma membrane and steroid hormones: the beginning or end of the debate?

Drawing on experience gained in previous studies, the authors propose their own approach to defining the role the plasma membrane of the target cell plays in the mechanism of action of steroid hormones. The properties of membrane receptors for glucocorticoids on lymphoid cells are identified and examined, and possible ways in which the hormonal signal is transformed into a biological response of the target cell are described. The results provide a theoretical basis for the development of novel diagnostic techniques and pharmaceutical preparations. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N ^o 10, pp. 342–348, October, 1995     

Chronobiological characteristics of the activity of the cellular genetic apparatus in surviving sections of rat brain

Diurnal variation of the incorporation of labeled precursors of RNA and proteins into spinal, stem, and cortical populations from the nervous system of rats is studied on surviving sections of the brain. It is shown that in the absence of an effect of other parts of the nervous system, afferentation, and humoral factors isolated nerve cell populations preserve the diurnal rhythm of activity of the genetic apparatus that correlates with the motor activity and the light reception (light-dark cycle) of animals. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N ^o 6, pp. 645–647, June, 1994