布洛陀壮族与汉族2型糖尿病及代谢综合症患病分析

目的 探讨布洛陀壮族与汉族居民2型糖尿病(DM)与代谢综合症(MS)患病特点.方法 选取广西百色市田阳县布洛陀壮族居民3 000人和汉族居民2 000人,检测其身高、体重、血压、空腹血糖、餐后2h血糖和血脂水平,并进行比较.结果 布洛陀壮族居民患DM 256例,患病率为8.53%,(男性9.44%;女性6.76%)汉族DM患病130例,患病率6.50%(男性7.49%;女性4.39%);壮族居民DM患病率高于汉族(P＜0.05),男性高于女性(P＜0.05);布洛陀壮族居民MS患病657例,患病率21.90%(男性23.69%;女性18.43%),汉族居民MS患病362例,患病率18.10%(男性20.19%,女性13.64%);壮族居民MS患病率高于汉族(P＜0.05),男性高于女性(P＜0.01);布洛陀壮族居民总胆固醇(TC)、低密度脂蛋白胆固醇(LDLC)和高血压(PH)异常率高于汉族(P＜0.05);布洛陀壮族DM患者对DM知晓率为37.3%、治疗率为38.7%和控制率为36.2%,均低于汉族患者的48.4%,50.8%,38.4% (P ＜0.05).结论 广西百色市布洛陀壮族居民DM和MS患病率高,血脂异常率高,对DM的知晓率、治疗率和控制率较低.     

延边农村汉族与朝鲜族人群血糖水平及相关因素研究

目的：研究延边农村地区汉族和朝鲜族人群血糖水平及相关因素。方法：对随机抽取的455名50-60岁农村社区内常驻居民，采用面对面询问法收集有关研究变量，观察不同民族体质指数（BMI）、腰围（WC）、德清总胆固醇（TC）、高密度脂蛋白胆固醇（HDL—C）、甘油三酯（TG）、收缩压（SBP）、舒张压（DBP）及血糖（FBG）等指标。结果：朝鲜族人群的高血糖、高血压、高TC、高TG及低HDL—C患病率均高于汉族。血糖与高TG、低HDL--C、中心型肥胖等关系密切。结论：对糖尿病应及早采取多因素干预措施。     

广西省白裤瑶族人群心理应激状况及其对热休克蛋白70的影响

摘要:目的　探索广西白裤瑶族地区人群心理应激状况及其对人热休克蛋白70（Heat Shock Protein 70,HSP70）的影响。方法　采用随机整群抽样法,应用生活事件量表（LES）、简化症状自评量表（SCL-90）、和社会支持评定量表（SSRS）对广西南丹县白裤瑶和壮族人群324人进行问卷调查,同时应用ELISA法测量血样中HSP70的含量。结果　（1）调查对象的生活事件总分≥20分占32.41%,心理问题阳性检出率为26.12%;社会支持总均分为（8.55±1.69）分。壮族人群的焦虑水平为（1.66±0.69）分,高于白裤瑶族（1.43±0.42）分（P＜0.05）。（2）被试者HSP70表达水平在（1.43±0.15）Lg/ml范围,不同民族之间差异有统计学差异。（3）全体调查对象HSP70表达水平与年龄（r＝-0.211,P＜0.05）和焦虑呈负相关（r＝-0.216,P＜0.05）;与文化程度（r＝0.318,P＜0.001）和社会支持呈正相关（r＝0.181,P＜0.05）;采取分层回归分析对文化程度和年龄进行变量控制,壮族人群的社会支持对HSP70表达呈正相关影响（β＝0.263）。结论　广西白裤瑶人群的心理应激和心理卫生状况不容乐观,HSP70表达与焦虑和社会支持等心理因素有相关性。     

中老年腰围与血脂水平及脂代谢异常的关系

目的探讨中老年人群腰围（WC）与血脂水平及脂代谢异常的关系。方法于2008年采用分层整群抽样的方法,抽取成都地区40～79岁的居民5205人进行身高、体重、腰围、血脂等测量,并进行问卷调查。结果中老年腹型肥胖人群三酰甘油（TG）及低密度脂蛋白胆固醇（LDL—C）水平均明显高于非腹型肥胖人群,高密度脂蛋白胆固醇（HDL—C）水平明显低于非腹型肥胖人群;中老年女性腹型肥胖人群总胆固醇（TC）水平明显高于中老年女性非腹型肥胖人群。中老年腹型肥胖人群高TG血症、低HDL—C血症、高LDL—C血症患病率均明显高于非腹型肥胖人群;中老年女性腹型肥胖人群高TC血症患病率高于非腹型肥胖人群,差异均有统计学意义（P〈0．01）。结论中老年人群TG、LDL—C、HDL—C水平及中老年女性人群TC水平,中老年人群高TG血症、低HDL—C血症、高LDL—C血症及中老年女性人群高TC血症患病率均与WC相关,是心血管危险因素之一。进行中老年人群超重肥胖的干预,尤对腹型肥胖人群加强干预,对于脂代谢异常的防治有着重要意义。     

体检人群代谢综合征患病现状分析

目的了解体检人群代谢综合征(MS)的患病现状,为疾病防治提供依据。方法收集2015-07/12在四川大学华西医院健康管理中心行健康检查的38 573例体检人群资料,了解MS患病情况以其危险因素分析。结果 MS患病率总体为14.5%,其中男性MS患病率为20.47%,女性为8.94%,两者比较差异有统计学意义(P0.05)。MS检出率高峰在60岁年龄段,为31.59%。MS患者5项组合356例(5.94%),4项组合1 713例(28.57%),3项组合3 926例(65.49%)。MS的表现形式多样,其中以中心性肥胖,血脂异常(TG增高和或HDL降低),高血压的组合形式所占比例最高,为24.80%。经Logistic回归分析结果显示年龄、男性、腰围、BMI、收缩压、舒张压、血糖、甘油三酯、LDL、尿酸、胱抑素C是MS的危险因素(P0.05),HDL是MS的保护性因素(P0.05)。结论体检人群代谢综合征患病率较高,应积极控制各种危险因素,制定有效的干预措施,降低代谢相关性疾病的患病率。     

苏北农村中老年高血压人群代谢综合征流行病学调查

目的了解苏北农村地区中老年高血压人群中代谢综合征（MS）的患病情况。方法对赣榆、东海县农村45～75岁原发性高血压人群进行流行病学调查,测量身高、体重、腰围、血压、血脂、空腹血糖,分别按照国际糖尿病联盟（IDF）和中华医学会糖尿病分会（CDS）的MS诊断标准计算患病率,并对性别、年龄、高血压水平（Ⅰ、Ⅱ、Ⅲ级）等影响因素进行相关分析。结果共调查11089人（男3985人,女7104人）,IDF标准MS总患病率为44.3%,其中男、女MS患病率分别为25.4%、54.9%;CDS标准MS总患病率为37.0%,2种诊断标准的符合率为79.9%;女性BMI均值达26.1±4.9 Kg/m2,腰围超标者显著多于男性;已接受降压药物治疗的人群MS患病率高于新发高血压人群。结论苏北农村地区中老年高血压人群的MS患病率高于我国一般中老年人群的平均水平;45～75岁区间,男性MS患病率随年龄增加而显著降低,女性变化不大。肥胖女性高血压患者是MS的极高危人群。     

闵行区40～74岁无糖尿病史人群代谢综合征患病特征及影响因素

目的旨在了解闵行区40～74岁无糖尿病史人群代谢综合征（MS）患病特征及影响因素。方法利用闵行区2007年糖尿病筛查资料,以整群抽样的方法抽取闵行区2个街道,共3 947位40～74岁居民,全部进行75g无水葡萄糖耐量（OGTT）、甘油三酯（TG）、高密度脂蛋白（HDL-C）等测定和问卷调查。结果调查对象MS的标化患病率为8.52%,超重或肥胖、糖尿病、糖调节异常、高血压、高TG、低HDL-C标化患病率分别为15.67%、2.45%、5.60%、17.72%、16.47%、2.00%。男性的MS、超重或肥胖、糖尿病和高血压患病率高于女性。MS患病率随着年龄的增长而上升,50岁以上年龄段上升明显,45岁以上年龄段MS的患病率显示性别之间无显著差异。BMI、血压、血糖、TG与HDL-C异常人群的MS患病率明显高于正常人群,有BMI、血压、血糖、TG、HDL-C异常因素人群患MS的风险分别是正常人群的15.71、28.21、10.09、30.31、3.14倍,而MS人群的糖尿病、冠心病和脑卒中的患病率明显高于非MS人群,MS人群患糖尿病、冠心病、脑卒中的风险是非MS人群的10.09、9.94、2.40倍。MS相关影响因素多因素分析显示男性、高龄、有糖尿病家族史、无体力活动是MS的危险因素。结论MS和相关疾病严重威胁着闵行区40岁以上人群的健康。     

四川省西昌市汉族和彝族人群代谢综合征危险因素的研究

目的了解四川省西昌市汉族居民和彝族居民代谢综合征（MS）患病情况及其相关的危险因素。方法应用分层整群抽样,于2007-2008年对西昌市2 130例汉族和1 306例彝族成年人进行横断面调查。结果西昌市彝族成人MS粗患病率为11.9%,年龄标化患病率为10.8%;汉族MS粗患病率为8.3%,年龄标化患病率为7.2%,MS的患病率随年龄的增加而上升。彝族男性MS、血脂紊乱、肥胖和高血糖患病率均高于汉族男性。彝族人群2种以上代谢异常患病率高于汉族。多因素分析结果表明,MS与民族、年龄、性别、体力劳动强度、文化程度、饮酒量以及高血压或糖尿病家族史有密切关系。结论西昌市彝族居民的MS患病率高于汉族,尤其是彝族男性MS患病率最高。年龄、性别、体力劳动强度、文化程度、饮酒量,家族史是MS重要的危险因素。     

文化程度和年龄与女性代谢综合征的关系分析

目的探讨文化程度与成年女性代谢综合征（MS）患病率之间的关系,并进一步分析这种关系的性质,对以往相关研究结论进行验证。方法选取北京市x医院的810名女性职工为分析对象,采用问卷调查和体格检查收集相关资料。文化程度被操作化为受教育程度和受教育年数,并通过方差分析和logistic回归分析检验文化程度是否是MS的独立影响因素。结果以受教育程度为影响变量,腰围、舒张压、收缩压、甘油三酰（TG）和空腹血糖（FPG）水平随着受教育程度的提高而显著降低,高密度脂蛋白胆囤醇（HDL—C）水平随着受教育程度的提高而显著上升（P〈0．05）。以受教育年数为影响变量,受教育年数越多,腰围、舒张压、收缩压、TG和FPG指标水平越低,HDL—C在不同受教育年数的被调查者中差异无统计学意义（P〉0．05）。在多因素logistic回归分析中,受教育程度和受教育年数对MS患病率均有显著的影响作用,但引入文化程度与年龄的交互项后,文化程度的独立影响作用消失。文化程度虽然对被调查者MS患病率有重要影响（相对于初等教育程度者,中等教育程度者MS患病率降低约63％,高等教育程度者降低约92％;受教育年数每增加1年,MS患病率降低约21％）,但并非独立危险因素,年龄作为个体的重要人口学特征与文化程度有着显著的交互作用。结论因此,在防治MS和降低MS患病率方面,除了针对不同文化程度人群采用不同的教育方式和干预措施,还应考虑年龄差异及其影响。     

百色市苗、汉族居民高血压及代谢综合征患病分析

目的 探讨苗、汉族高血压(PH)和代谢综合征(MS)的患病特点.方法 于2009年2-12月分层随机抽取广西省隆林县新州镇和者浪乡苗族1102人和汉族2068人进行调查.结果 苗族PH患病166例,患病率为15.06％(男性129例,患病率为18.75％;女性37例,患病率为8.94％);汉族PH患病486例,患病率为23.50％(男性365例,患病率为27.36％;女性121例,患病率为16.49％);苗族PH患病率低于汉族(x2=31.326,P＜0.01),苗、汉族男性均高于女性(x2=19.452、31.155,P＜0.01);苗族MS患病128例,患病率为11.62％(男性94例,患病率为13.66％;女性34例,患病率为8.21％);汉族MS患病363例,患病率为17.55％(男性275例,患病率为28.11％;女性88例,患病率为11.99％);苗族MS患病率低于汉族(x2=19.365,P＜0.05),苗、汉族男性均高于女性(x2=7.479、24.342,P＜0.01);苗族肥胖、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDLC)和空腹血糖(FBC)异常率均低于汉族(x2=5.425～86.553,P＜0.05或P＜0.01);苗族PH患者对PH的知晓率、治疗率均低于汉族患者(x2=37.991、13.679,P＜0.01).结论 苗族居民PH和MS患病率均低于当地生活的汉族居民,其伴发慢性血管疾病危险因素也较少,对PH知晓率、治疗率低.     

Associations of diet and lifestyle with hyperlipidemia for middle-aged and elderly persons among the Guangxi Bai Ku Yao and Han populations

BACKGROUND: There are fifty-six ethnic groups in China. Han is the largest group and Bai Ku Yao is the isolated subgroup of the Yao minority. Little is known about the difference in the prevalence of hyperlipidemia between the Han and other minority groups in the rural areas. OBJECTIVE: The aim of this study was to compare the associations of diet and lifestyle factors with hyperlipidemia for middle-aged and elderly persons between the Guangxi Bai Ku Yao and Han populations. DESIGN: This is a cross-sectional study. A total of 485 subjects of Bai Ku Yao and 501 subjects of Han Chinese ethnicity aged 40 years and older were surveyed by a stratified cluster random sampling technique. METHODS: Information on demography, dietary intake, and lifestyle factors was collected by standard questionnaires. Blood pressure, height, weight, waist circumference, and serum lipid levels were measured, and body mass index (BMI) was calculated as weight (kg) divided by height (m) squared. RESULTS: The prevalence rates of hypercholesterolemia, hypertriglyceridemia, and hyperlipidemia in Bai Ku Yao and Han were 19.59% vs 36.13% (P<0.001), 13.81% vs 16.97% (P>0.05), and 28.45% vs 43.11% (P<0.001), respectively. Hyperlipidemia was positively correlated with BMI; waist circumference; total energy, total fat, and saturated fatty acids intakes; and negatively associated with sex (women were higher), physical activity, and total dietary fiber intake in Bai Ku Yao (P<0.05 to 0.001), whereas hyperlipidemia was positively associated with BMI; waist circumference; total energy, total fat, and saturated fatty acids intakes; and negatively associated with physical activity and total dietary fiber intake in Han (P<0.05 to 0.001). CONCLUSIONS: The prevalence of hyperlipidemia was significantly lower among ethnic Bai Ku Yao than among ethic Han individuals, which might mainly be attributed to the more favorable dietary patterns, lifestyle choices, and physical activity levels in the former ethnic group.     

不同民族高中学生心理健康测评分析

目的探讨广西壮、瑶、侗、汉族高中学生心理健康水平及个性特点。方法对不同民族高中学生3378人进行心理健康测查。结果壮、瑶族男生各分量表分比较差异无统计学意义;壮族男生躯体化、焦虑、疑心、脱离实际分高于汉族,低于侗族。壮、侗族女生各分量表分比较差异无统计学意义;壮、侗族女生躯体化、焦虑、疑心、脱离实际分高于瑶、汉族女生。男生T分〉60的检出率壮、瑶、侗族比较差异无统计学意义,但均高于汉族;T分〉70的男生中,壮、瑶、侗族高于汉族,侗族高于壮、瑶族。女生T分〉60的检出率壮族高于瑶、汉族。T分〉70的女生民族比较差异无统计学意义。结论壮、瑶、侗族高中生心理健康水平较低;学生因民族不同有各自的心理特点。     

Effects of lipid-probe interactions in biochemical fluorometric methods that assess HDL redox activity

Background

The association of rs3757354 single nucleotide polymorphism (SNP) in the E3 ubiquitin ligase myosin regulatory light chain-interacting protein (MYLIP, also known as IDOL) gene and serum lipid levels is not well known in the general population. The present study aimed to detect the association of rs3757354 SNP and several environmental factors with serum lipid levels in the Guangxi Bai Ku Yao and Han populations.

Method

A total of 627 subjects of Bai Ku Yao minority and 614 participants of Han nationality were randomly selected from our stratified randomized cluster samples. Genotyping of the rs3757354 SNP was performed by polymerase chain reaction and restriction fragment length polymorphism combined with gel electrophoresis, and then confirmed by direct sequencing.

Results

The levels of serum total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein (Apo) AI and ApoB were lower in Bai Ku Yao than in Han (P < 0.05-0.001). The frequency of G allele was 49.92% in Bai Ku Yao and 56.27% in Han (P < 0.05). The frequencies of AA, GA and GG genotypes were 25.52%, 49.12% and 25.36% in Bai Ku Yao, and 19.87%, 47.72% and 32.41% in Han (P < 0.05); respectively. There were no significant differences in the genotypic and allelic frequencies between males and females in both ethnic groups. The levels of HDL-C in Bai Ku Yao were different among the genotypes (P < 0.05), the G allele carriers had higher serum HDL-C levels than the G allele noncarriers. The levels TC, HDL-C and ApoAI in Han were different among the genotypes (P < 0.05 for all), the participants with GA genotype had lower serum TC, HDL-C and ApoAI levels than the participants with AA genotype. These findings were found only in females but not in males. The levels of TG and HDL-C in Bai Ku Yao were correlated with the genotypes, whereas the levels of TC in Han, and TC, LDL-C in Han females were associated with the genotypes (P < 0.05 for all). Serum lipid parameters were also correlated with age, sex, alcohol consumption, cigarette smoking, blood pressure, and body mass index in both ethnic groups (P < 0.05-0.001).

Conclusions

The present study suggests that the MYLIP rs3757354 SNP is associated with serum TC, HDL-C and ApoAI levels in the Bai Ku Yao and Han populations. But the association is different between the two ethnic groups.     

Diet, alcohol consumption, and serum lipid levels of the middle-aged and elderly in the Guangxi Bai Ku Yao and Han populations

Bai Ku Yao is an isolated subgroup of the Yao minority in China. The special customs and cultures including their clothings, intraethnic marriages, corn wine and rum intakes are still completely conserved to the present day. Little is known about the association of diet and alcohol consumption with serum lipid levels in this population. The aim of this study was to compare the differences in diet, alcohol consumption, and serum lipid levels of the middle-aged and elderly between the Guangxi Bai Ku Yao and Han populations. A total of 485 subjects of Bai Ku Yao and 501 participants of Han Chinese aged 40 and over were surveyed by a stratified randomized cluster sampling. Information on dietary intake and alcohol consumption was collected by standard questionnaires. Serum lipid levels were measured. Education level, height, weight, body mass index, waist circumference, blood pressure, hypertension, and total energy, fat, protein, dietary cholesterol, and salt intakes were lower in Bai Ku Yao than in Han (P < .05–.001), whereas physical activity level, carbohydrate, vegetal protein, and total dietary fiber intakes were higher in Bai Ku Yao than in Han (P < .001 for all). Serum total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein (Apo) A1, and Apo B levels were lower in Bai Ku Yao than in Han (P < .001 for all). The levels of triglyceride, HDL-C, Apo A1, and the ratio of Apo A1 to Apo B in Bai Ku Yao were higher, but the levels of LDL-C and Apo B were lower in drinkers than in nondrinkers. The levels of triglyceride, HDL-C, LDL-C, Apo A1, Apo B, and the ratio of Apo A1 to Apo B in Bai Ku Yao were also influenced by the amount of alcohol consumed (P < .05–.001). High-density lipoprotein cholesterol levels in Han were higher and LDL-C levels were lower in drinkers than in nondrinkers (P < .01 for each). Serum total cholesterol, HDL-C, and LDL-C levels in Han were also associated with the amount of alcohol consumed (P < .05–.001). The differences in the lipid levels between the two ethnic groups may partially attribute to the differences in dietary habits and alcohol consumption.     

广东汉、瑶、壮族新婚人群不孕症现况调查

目的:了解广东省汉、瑶、壮3个民族新婚人群不孕症发病现况。方法:应用流行病学整群抽样方法,于2009年9～12月对广东省粤北山区的连南、连山和连州3地2007年结婚夫妇进行问卷调查。结果:4404对夫妇中有550对(12.5%)不孕,其中妻子为汉族的夫妇不孕症发病率为11.7%(411/3527),瑶族为16.7%(101/502),壮族为13.9%(38/274),不同民族新婚人群不孕症发病率有差异(P<0.05),瑶族不孕症发病率是汉族的1.533倍(95%CI=1.086～2.164)。不孕症夫妇就医率仅为7.5%,其中少数民族夫妇低于汉族。夫妻年龄、文化程度、家居环境、夫妻关系以及性生活质量等因素对不孕症发病率有影响(P<0.05)。结论:广东省不孕症流行除了有地域差异以外,还存在民族间的差异。     

汉族和朝鲜族居民不同类型肥胖与心血管代谢危险因素的关系

目的 分析延边地区朝鲜族和汉族居民不同类型肥胖与心血管代谢危险因素的关系.方法 于2006年8月～2008年8月在吉林省延边农村地区随机抽取30～70岁朝鲜族和汉族人群5842人,测其身高、体重、腰围( waist circumference,WC)等指标,同时采集清晨空腹(禁食12h)静脉血,并准确测定生化指标.结果 1)30～70岁人群肥胖粗患率汉族和朝鲜族分别为12.2％和8.7％,年龄调整患病率分别为11.2％和9.8％,汉族均高于朝鲜族(x2=18.09,P＜0.001; U=39.43,P＜0.001);汉族和朝鲜族腹型肥胖粗患病率分别为46.4％和44.8％,年龄调整患病率分别为41.8％和40.9％,调整患病率汉族高于朝鲜族(U=17.64,P＜0.001).2)不同性别及民族心血管代谢危险因素及其聚集性与体质指数(body mass index,BMI)水平、WC关联与否及其程度有所不同.3)Logistic分析结果表明,高血压、高血糖(朝鲜族)、高胆同醇(total cholesterol,TC)(汉族)、低高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)(汉族)、非HDL-C、高甘油三酯(triglyceride,TG)和代谢综合征(metabolic syndrome,MS)在BMI和WC均异常组的aRR值最大;单纯BMI异常组的aRR值大于单纯WC异常组的心血管代谢危险因素为高血压(朝鲜族)、低HDL-C(汉族)和非HDL-C(朝鲜族);而单纯WC异常组的aRR值大于单纯BMI异常组的心血管代谢危险因素则为高血压(汉族)、高血糖、高TC(朝鲜族)、高TG和MS.结论 吉林省延边地区一般人群肥胖患病水平较高,而且不同民族人群不同类型肥胖患病率存在明显的差异.BMI、WC及其合并组表现出不同的心血管代谢风险.     

Association of rs5888 SNP in the scavenger receptor class B type 1 gene and serum lipid levels

Background

Bai Ku Yao is a special subgroup of the Yao minority in China. The present study was undertaken to detect the association of rs5888 single nucleotide polymorphism (SNP) in the scavenger receptor class B type 1 (SCARB1) gene and several environmental factors with serum lipid levels in the Guangxi Bai Ku Yao and Han populations.

Methods

A total of 598 subjects of Bai Ku Yao and 585 subjects of Han Chinese were randomly selected from our stratified randomized cluster samples. Genotypes of the SCARB1 rs5888 SNP were determined by polymerase chain reaction and restriction fragment length polymorphism combined with gel electrophoresis, and then confirmed by direct sequencing.

Results

The levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein (Apo) AI were lower but ApoB was higher in Bai Ku Yao than in Han (P?<?0.05-0.001). The frequencies of C and T alleles were 78.3% and 21.7% in Bai Ku Yao, and 73.7% and 26.3% in Han (P?<?0.01); respectively. The frequencies of CC, CT and TT genotypes were 60.0%, 36.6% and 3.4% in Bai Ku Yao, and 54.2%, 39.0% and 6.8% in Han (P?<?0.01); respectively. The subjects with TT genotype in both ethnic groups had lower HDL-C and ApoAI levels than the subjects with CC or CT genotype (P?<?0.05 for all). Subgroup analyses showed that the subjects with TT genotype in Bai Ku Yao had lower HDL-C and ApoAI levels in males than the subjects with CC or CT genotype (P?<?0.05 for all), and the T allele carriers had higher TC, LDL-C and ApoB levels in females than the T allele noncarriers (P?<?0.05 for all). The participants with TT genotype in Han also had a lower tendency of HDL-C and ApoAI levels in males than the participants with CC or CT genotype, but the difference did not reach statistically significant (P?=?0.063 and P?=?0.086; respectively). The association of serum HDL-C and ApoAI levels and genotypes was confirmed by the multiple linear regression analysis in both ethnic groups. Serum lipid parameters were also correlated with several environmental factors.

Conclusions

The differences in serum lipid levels between the two ethnic groups might partially attribute to the differences in the SCARB1 rs5888 SNP and several environmental factors.     

农村高血压人群空腹血糖水平与体质指数及腰围的关系研究

目的 了解农村中老年高血压人群空腹血糖( fasting blood glucose,FBG)水平的分布及其与体质指数(body mass index,BMI)、腰围(waist circumference,WC)的关系.方法 在连云港市随机抽取20个乡镇,筛查出45 ～75岁原发性高血压患者,对其进行问卷凋查、体格检查和生化检测.结果 共纳入研究对象19 123人,平均FBG为(5.82±1.90) mmol/L,男女FBG水平的差异有统计学意义(P＜0.001);空腹血糖异常率及糖尿病患病率分别为14.05％和13.50％;在调整混杂因素后,多元Logistic回归分析结果显示,随着腰围增大,男女性空腹血糖异常的风险(男性:OR=1.012,95％ CI:1.001～1.024;女性:OR=1.020,95％ CI:1.011～1.030)和糖尿病患病风险(男性:OR=1.036,95％CI:1.023 ～1.050;女性:OR=1.034,95％CI:1.025 ～1.044)均增加;而BMI与血糖水平的相关性并不明显.结论 农村高血压人群空腹血糖水平较高,且腰围与血糖水平相关,提示腹型肥胖者易发生空腹血糖异常或糖尿病,应作为重点预防对象.     

广西南宁市壮族人群类风湿关节炎的流行病学调查

目的了解广西南宁市壮族人群类风湿关节炎（RA）的患病情况。方法采用整群抽样方法对7407名≥16岁壮族人群进行病史询问，由风湿病专科医师对询问阳性者进行体格检查；对疑似RA病例，行血清类风湿因子定量检测和双手X线摄片，并将其结果与6826名当地的汉族人群作比较。结果广西南宁市壮族人群RA患病率为0．27％，而当地的汉族人群患病率为0．28％（P〉0．05）；壮族和汉族人群的RA知晓率分别为5．0％和10．5％（P〉0．05），治疗率分别为0％和5．25％。结论广西南宁市壮族人群RA患病率与汉族人群的差异无统计学意义，而对RA的知晓率、治疗率较低。     

北京市大兴区农村居民高血压、冠心病、脑卒中和糖尿病患病情况及影响因素分析

目的了解北京市大兴区农村居民高血压、冠心病、脑卒中和糖尿病患病情况及影响因素,为制定适合农村社区的慢性病干预措施提供科学依据。方法采用多级随机抽样方法抽取北京市大兴区半壁店地区18周岁以上常住居民4980人,通过体格检查和实验室检查获得体重指数、血糖、血脂等指标结果,通过问卷调查获得高血压、冠心病、脑卒中和糖尿病的患病情况以及吸烟、饮酒情况。结果共调查4980人,其中男性1995人,女性2985人。调查对象高血压、冠心病、脑卒中和糖尿病的患病率分别为24.9%、7.0%、3.9%和3.0%。多因素Logistics回归分析结果显示,高年龄组、男性、以往吸烟、体重指数≥25、腰围长、血压测量值高、高密度脂蛋白异常者高血压患病率高;高年龄组、男性、现在或以往吸烟、空腹血糖异常者冠心病患病率高;以往吸烟、腰围长、血压测量值高、高密度脂蛋白异常脑卒中患病率高,脑卒中患病者中经常饮酒者少;男性、腰围长、空腹血糖异常者糖尿病患病率高。结论农村社区居民高血压等慢性非传染性疾病患病率高,应针对吸烟、饮酒等生活方式进制定干预措施,控制慢性非传染性疾病流行。