共查询到20条相似文献，搜索用时 15 毫秒
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《Reumatología clinica》2020,16(4):300-302
Heterotopic ossification is an uncommon disorder that consists of deposition of ectopic bone outside the extraskeletal tissues. In the skin, it can be primary, in association with genetic syndromes, or be secondary to different disorders. The latter include subcutaneous ossification of the legs in chronic venousinsufficiency, an infrequent and unrecognized complication. We report the case of a patient with subcutaneous ossification of both legs secondary to venous insufficiency and review the literature. 相似文献
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Alejandro Isidoro Pérez Cabeza José Luis Górriz Rafael Bravo Marqués Pedro Antonio Chinchurreta Capote Sergio López Tejero José Antonio González Correa Fidel Ernesto Mesa Prado Almudena Valle Alberca Francisco Ruiz Mateas 《Nefrología : publicación oficial de la Sociedad Espa?ola Nefrologia》2021,41(2):216-218
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Carlos Antonio Amado Diago Luis Puente Maestu Beatriz Abascal Bolado Juan Agüero Calvo Mercedes Hernando Hernando Irene Puente Bats Ramón Agüero Balbín 《Archivos de bronconeumología》2018,54(2):74-78
Introduction
Dyspnea is a multidimensional symptom, but this multidimensionality is not considered in most dyspnea questionnaires. The Dyspnea-12 takes a multidimensional approach to the assessment of dyspnea, specifically the sensory and the affective response. The objective of this study was to translate into Spanish and validate the Dyspnea-12 questionnaire.Methods
The original English version of the Dyspnea-12 questionnaire was translated into Spanish and backtranslated to analyze its equivalence. Comprehension of the text was verified by analyzing the responses of 10 patients. Reliability and validation of the questionnaire were studied in an independent group of COPD patients attending the pulmonology clinics of Hospital Universitario Marqués de Valdecilla, diagnosed and categorized according to GOLD guidelines.Results
The mean age of the group (n = 51) was 65 years and mean FEV1 was 50%. All patients understood all questions of the translated version of Dyspnea-12. Internal consistency of the questionnaire was α=0.937 and intraclass correlation coefficient was = .969; P < .001. Statistically significant correlations were found with HADS (anxiety r = .608 and depression r = .615), mMRC dyspnea (r = .592), 6 MWT (r = –0.445), FEV1 (r = –0.312), all dimensions of CRQ-SAS (dyspnea r = –0.626; fatigue r = –0.718; emotional function r = –0.663; mastery r = –0.740), CAT (r = 0.669), and baseline dyspnea index (r = –0.615). Dyspnea-12 scores were 10.32 points higher in symptomatic GOLD groups (B and D) (P < .001).Conclusion
The Spanish version of Dyspnea-12 is a valid and reliable instrument to study the multidimensional nature of dyspnea. 相似文献19.
Pablo Gómez-Fernández Antonio Martín Santana Juan de Dios Arjona Barrionuevo 《Nefrología : publicación oficial de la Sociedad Espa?ola Nefrologia》2021,41(2):137-153
Chronic kidney disease (CKD) and atrial fibrillation (AF) frequently coexist, amplifying the risk of cardiovascular events and mortality. In patients with CKD stage 3 and non-valvular AF, direct oral anticoagulants (DOACs) have shown, compared to vitamin K antagonists (VKA), equal or greater efficacy in the prevention of stroke and systemic embolism, and greater safety. There are no randomized trials of the efficacy and safety of DOACs and VKA in advanced CKD. On the other hand, observational studies suggest that DOACs, compared to warfarin, are associated with a lower risk of acute kidney damage and generation/progression of CKD. This paper reviews the epidemiological and pathophysiological aspects of the CKD and AF association, the evidence of the efficacy and safety of warfarin and ACODs in various stages of CKD with AF as well as the comparison between warfarin and ACODs in efficacy and anticoagulant safety, and in its renal effects. 相似文献
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