鼻中隔矫正术治疗合并鼻中隔偏曲的变应性鼻炎

目的：探讨鼻中隔矫正术治疗变应性鼻炎的疗效。方法：对67例变应性鼻炎合并鼻中隔偏曲的病人行鼻中隔粘膜下切除术。结果：随访1年，34例病人症状完全缓解，25例病人症状部分缓解，5例病人无效。结论：鼻中隔矫正术对合并鼻中隔偏曲的变应性鼻炎是一种有效的治疗方法。     

手术和微波联合治疗常年性变应性鼻炎并鼻中隔偏曲

目的探讨常年性变应性鼻炎并鼻中隔偏曲的临床治疗方法。方法采用鼻中隔黏膜下矫正术加鼻腔神经微波凝固阻断治疗常年性变应性鼻炎并鼻中隔偏曲患者89例，随访1年。结果显效61例（68．54％），有效23例（25．84％），无效5例（5．62％），总有效率为94．38％。结论鼻中隔黏膜下矫正术加鼻腔神经微波热凝联用治疗常年性变应性鼻炎并鼻中隔偏曲，疗效显著，有较好的临床应用价值。     

鼻中隔偏曲矫正术治疗变应性鼻炎

目的探讨应用鼻中隔矫正术治疗变应性鼻炎合并鼻中隔偏曲的疗效。方法将104例合并鼻中隔偏曲的变应性鼻炎患者随机分为治疗组和对照组。治疗组54例,对照组50例。治疗组患者施行鼻内镜下鼻中隔黏膜下切除术。对照组常规应用抗组胺药、糖皮质激素等药物治疗。结果术后随访1年,治疗组总有效率92．6％,对照组总有效率84．0％,差异有统计学意义（P〈0．01）。结论鼻中隔矫正术治疗合并鼻中隔偏曲的变应性鼻炎疗效确切。     

变应性鼻炎合并鼻中隔偏曲的手术疗效观察

目的探讨鼻内窥镜下鼻中隔矫正术治疗变应性鼻炎合并鼻中隔偏曲的临床疗效。方法对43例变应性鼻炎合并鼻中隔偏曲患者实施鼻内镜下行鼻中隔矫正术,术后随访6个月,对其术前和术后的临床症状和体征进行综合评估并比较。结果术后6个月总有效率为90.69%,无一例发生手术并发症。结论鼻内镜下鼻中隔矫正术是治疗变应性鼻炎合并鼻中隔偏曲的安全、有效方法。     

鼻中隔矫正加双下甲黏膜下骨折移位术治疗变应性鼻炎

目的探讨合并鼻中隔偏曲的变应性鼻炎的治疗方法。方法采用鼻中隔矫正加双下甲黏膜下骨折移位术治疗合并鼻中隔偏曲的变应性鼻炎32例，随访1年。结果显效28例(87．5％)，有效4例(12．5％)。结论鼻中隔矫正术加双下甲黏膜下骨折移位术治疗合并鼻中隔偏曲的变应性鼻炎，是一种较为理想的方法。     

鼻中隔矫正治疗鼻中隔偏曲伴变应性鼻炎的疗效观察

目的 探讨鼻中隔矫正术治疗鼻中隔偏曲伴变应性鼻炎的疗效，并与保守疗法比较。方法 40例患者中，治疗组20例，行鼻中隔矫正术治疗；对照组20例，用保守治疗。结果 随访2年，治疗组症状消失，无1例复发；对照组症状减轻，仍反复发作。结论 鼻中隔矫正术治疗鼻中隔偏曲伴变应性鼻炎的效果保守疗法好。     

鼻内镜下鼻中隔偏曲矫正术治疗变应性鼻炎91例临床分析

目的观察鼻内镜下对变应性鼻炎伴鼻中隔偏曲行矫正术的治疗效果。方法对91例变应性鼻炎伴鼻中隔偏曲的患者在内镜下行鼻中隔偏曲矫正术,对手术前、后症状进行评定。结果 3个月、6个月有效率分别达95.6%和84.62%,1年有效率达72.73%,2年有效率达65.45%。结论对因变应性鼻炎伴鼻中隔偏曲的患者行鼻中隔偏曲矫正术可取得良好效果。     

手术治疗常年性变态反应性鼻炎216例分析

目的：对手术治疗常年性变态反应性（变应性）鼻炎的可行性进行研究。方法：对确诊为常年性变应性鼻炎且愿意行手术治疗的216例患者常规行鼻内窥镜检查及鼻窦冠状位CT．了解鼻腔变异情况后分成4组．分别行单纯鼻中隔黏膜下剥离术、鼻中隔黏膜下矫正术、鼻中隔黏下剥离术加前筛开放术、鼻中隔黏膜下矫正术加前筛开放术和息肉摘除术,术后3个月、6个月、1年及2年随访时根据常年性变应性鼻炎的诊断标准及疗效评定标准判定疗效,并进行临床分析。结果：合并鼻中隔偏曲的113例患者（组2加组4）手术短期（3个月）有效率为94．7％（107／113例）,长期（2年）有效率为86．7％（98／113例）;不合并鼻中隔偏曲的103例患者（组1加组3）手术的短期（3个月）有效率为62．1％（64／103例）．长期（2年）有效率为53．4％（55／103例）,效果较合并鼻中隔偏曲的113例患者（组2加组4）差（P〈0.01）。结论：对经常规药物治疗效果并不理想的常年性变应性鼻炎的患者,如合并鼻中隔偏曲,应积极手术矫正中隔;如不合并鼻中隔偏曲,如患者愿意,可行鼻中隔黏膜下剥离术,可能取得较好效果。     

鼻中隔黏膜下矫正术联合常规药物治疗变应性鼻炎伴鼻中隔偏曲的临床效果分析

目的：探讨鼻中隔黏膜下矫正术联合常规药物治疗变应性鼻炎伴鼻中隔偏曲的临床效果。方法：对照组患者进行常规药物治疗，观察组患者在对照组常规药物治疗的基础上同时进行鼻中隔黏膜下矫正术。比较两组的治疗效果。结果：观察组治疗半年及1年的总有效率分别为92．8％、84．3％，对照组治疗半年及1年的总有效率分别为72．9％、61．4％．观察组两个时间点治疗的总有效率均明显高于对照组（P＜0．05）。结论：鼻中隔黏膜下矫正术联合常规药物治疗变应性鼻炎伴鼻中隔偏曲效果显著，鼻中隔黏膜下矫正术可以改正鼻腔的解剖结构，确保呼吸通畅，防止分泌物滞留，对变应性鼻炎的症状有很大改善，值得在临床推广。     

鼻中隔偏曲矫正术治疗62例变应性鼻炎患者的疗效分析

目的探讨鼻中隔偏曲矫正术治疗变应性鼻炎合并鼻中隔偏曲的临床效果。方法对河池市第三人民医院2011年1月～2012年2月间收治的62例变应性鼻炎合并鼻中隔偏曲患者的临床资料进行回顾性分析,对比62例患者术前及术后症状的评分差异。结果 62例变应性鼻炎合并鼻中隔偏曲患者术后随访3个月总有效率为96.77%,6个月总有效率为82.26%,12个月总有效率为74.91%,3个月与6个月总有效率差异比较P>0.05,无统计学意义,术后3个月与12个月总有效率比较P<0.05,差异显著,具有统计学意义。无嗅觉减退、鼻腔黏连等并发症发生。结论鼻中隔偏曲矫正术能迅速改善变应性鼻炎合并鼻中隔偏曲患者的临床症状,降低鼻腔神经末梢的应激反应,提高临床治疗效果。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.