共查询到20条相似文献，搜索用时 31 毫秒
1.
Hairong He Jun Lu Lihong Yang Jie Zheng Fan Gao Yajing Zhai Junqin Feng Yajuan Fan Xiancang Ma 《Clinical neurophysiology》2017,128(5):716-724
Objective
To explore the efficacies of 1-Hz (low frequency) and 10-Hz (high frequency) repetitive transcranial magnetic stimulation (rTMS) in treating auditory hallucinations and negative symptoms of schizophrenia, respectively.Methods
Electronic databases were searched to identify relevant literature. Standard mean difference (SMD) and 95% confidence interval (CI) values were used to evaluate the effects of rTMS. The stability and sensitivity of the results, the source of heterogeneity, and the recommended grade of the evidence were also analyzed.Results
Thirteen studies of 1-Hz rTMS were included. The auditory hallucinations improved more in the rTMS group than in the sham group (SMD = ?0.29, 95%CI = ?0.57 to ?0.01). However, this result was not stable after sensitivity analysis, and publication bias had a substantial impact on the results. Meta-analysis performed for seven studies of 10-Hz rTMS found that improvement of negative symptoms did not differ significantly between the real rTMS and sham groups. Finally, the grade of evidence for this meta-analysis was found to be low.Conclusion
Although there may appear to be a therapeutic effect for 1-Hz rTMS on auditory hallucinations of schizophrenia, this needs to be confirmed by large-scale randomized controlled trials before this finding can be recommended in clinical practice.Significance
1-Hz rTMS might have an effect on auditory hallucinations of schizophrenia. 相似文献2.
Nicolás M. Phielipp Utpal Saha Tejas Sankar Akihiro Yugeta Robert Chen 《Clinical neurophysiology》2017,128(6):1109-1115
Objective
To evaluate the safety of repetitive transcranial magnetic stimulation (rTMS) in patients with implanted subdural cortical electrodes.Methods
We performed ex-vivo experiments to test the temperature, displacement and current induced in the electrodes with single pulse transcranial magnetic stimulation (TMS) from 10 to 100% of stimulator output and tested a typical rTMS protocol used in a clinical setting. We then used rTMS to the motor cortex to treat a patient with refractory post-herpetic neuralgia who had previously been implanted with a subdural motor cortical electrode for pain management. The rTMS protocol consisted of ten sessions of 2000 stimuli at 20 Hz and 90% of resting motor threshold.Results
The ex-vivo study showed an increase in the coil temperature of 2 °C, a maximum induced charge density of 30.4 μC/cm2/phase, and no electrode displacement with TMS. There was no serious adverse effect associated with rTMS treatment of the patient. Cortical tremor was observed in the intervals between trains of stimuli during one treatment session.Conclusions
TMS was safe in a patient with implanted Medtronic Resume II electrode (model 3587A) subdural cortical electrode.Significance
TMS may be used as a therapeutic, diagnostic or research tool in patients this type of with implanted cortical electrodes. 相似文献3.
Korhan Buyukturkoglu Camillo Porcaro Carlo Cottone Andrea Cancelli Matilde Inglese Franca Tecchio 《Clinical neurophysiology》2017,128(5):807-813
Objective
To investigate the EEG-derived functional connectivity at rest (FCR) patterns of fatigued Multiple Sclerosis (MS) patients in order to find good parameters for a future EEG-Neurofeedback intervention to reduce their fatigue symptoms.Methods
We evaluated FCR between hemispheric homologous areas, via spectral coherence between pairs of corresponding left and right bipolar derivations, in the Theta, Alpha and Beta bands. We estimated FCR in 18 MS patients with different levels of fatigue and minimal clinical severity and in 11 age and gender matched healthy controls. We used correlation analysis to assess the relationship between the fatigue scores and the FCR values differing between fatigued MS patients and controls.Results
Among FCR values differing between fatigued MS patients and controls, fatigue symptoms increased with higher Beta temporo-parietal FCR (p = 0.00004). Also, positive correlations were found between the fatigue levels and the fronto-frontal FCR in Beta and Theta bands (p = 0.0002 and p = 0.001 respectively).Conclusion
We propose that a future EEG-Neurofeedback system against MS fatigue would train patients to decrease voluntarily the beta coherence between the homologous temporo-parietal areas.Significance
We extracted a feature for building an EEG-Neurofeedback system against fatigue in MS. 相似文献4.
Catherine F. Sinclair Maria J. Téllez Oscar R. Tapia Sedat Ulkatan Vedran Deletis 《Clinical neurophysiology》2017,128(7):1399-1405
Objective
To describe a novel methodology for intraoperative neuro-monitoring of laryngeal and vagus nerves by utilizing the laryngeal adductor reflex (LAR).Methods
Case series of 15 patients undergoing thyroid and cervical spine surgeries under total intravenous general anesthesia. Vocal fold mucosa was electrically stimulated to elicit a LAR using endotracheal tube based electrodes. Contralateral R1 (cR1) and R2 (cR2) responses were recorded using the endotracheal tube electrode contralateral to the simulating electrode.Results
The LAR was reliably elicited in 100% of patients for the duration of each surgical procedure. Mean onset latency of cR1 response was 22.4 ± 2.5 ms (right) and 22.2 ± 2.4 ms (left). cR2 responses were noted in 10 patients (66.7%). No peri-operative complications or adverse outcomes were observed.Conclusions
The LAR is a novel neuro-monitoring technique for the vagus nerve. Advantages over current monitoring techniques including simplicity, ability to continuously monitor neural function without placement of additional neural probes and ability to assess integrity of both sensory and motor pathways.Significance
The LAR represents a novel method for intraoperatively monitoring laryngeal and vagus nerves. The LAR monitors the entire vagus nerve reflex arc and is thus applicable to all surgeries where vagal nerve integrity may be compromised. 相似文献5.
Anna-Lena Dohrmann Katarina Stengler Ina Jahn Sebastian Olbrich 《Clinical neurophysiology》2017,128(10):1906-1914
Objectives
Aim of this study was to analyze whether electroencephalogram (EEG)-based CNS-arousal markers differ for patients suffering from obsessive compulsive disorder (OCD) that either respond or do not respond to cognitive behavioral therapy (CBT), selective serotonin reuptake inhibitors (SSRIs) or their combination. Further the study aimed to identify specific response-predictors for the different therapy approaches.Methods
CNS-arousal from 51 unmedicated patients during fifteen-minute resting state was assessed using VIGALL (Vigilance Algorithm Leipzig). Clinical Global Impression (CGI) scores were used to assess response or non-response after three to six months following therapy (CBT, n = 18; SSRI, n = 11 or combination, n = 22). Differences between Responders (R) and Non-Responders (NR) were identified using multivariate analysis of covariance (MANCOVA) models.Results
MANCOVA revealed that Responders spent significant less time at the highest CNS-arousal stage 0. Further, low amounts of the highest CNS-arousal stages were specifically predictive for a response to a combined treatment approach.Conclusions
The fact that CNS-arousal markers allowed discrimination between Responders and Non-Responders and also between Responders of different treatment arms underlines a possible clinical value of EEG-based markers.Significance
These results encourage further research on EEG-arousal regulation for determining pathophysiological subgroups for treatment response. 相似文献6.
Sung Wook Chung Benjamin P. Lewis Nigel C. Rogasch Takashi Saeki Richard H. Thomson Kate E. Hoy Neil W. Bailey Paul B. Fitzgerald 《Clinical neurophysiology》2017,128(7):1117-1126
Objectives
To examine the effects of intermittent TBS (iTBS) and continuous TBS (cTBS) on cortical reactivity in the dorsolateral prefrontal cortex.Methods
10 healthy participants were stimulated with either iTBS, cTBS or sham at F3 electrode. Single- and paired-pulse TMS and concurrent electroencephalography (EEG) were used to assess change in cortical reactivity and long-interval intracortical inhibition (LICI) via TMS-evoked potentials (TEPs) and TMS-evoked oscillations.Results
Significant increases in N120 amplitudes (p < 0.01) were observed following iTBS over prefrontal cortex. Changes in TMS-evoked theta oscillations and LICI of theta oscillations were also observed following iTBS (increase) and cTBS (decrease). Change in LICI of theta oscillations correlated with change in N120 amplitude following TBS (r = ?0.670, p = 0.001).Conclusions
This study provides preliminary evidence that TBS produces direct changes in cortical reactivity in the prefrontal cortex. Combining TBS with TMS-EEG may be a useful approach to optimise stimulation paradigms prior to the conduct of clinical trials.Significance
TBS is able to modulate cortical reactivity and cortical inhibition in the prefrontal cortex. 相似文献7.
Hatice Kumru Sergiu Albu John Rothwell Daniel Leon Cecilia Flores Eloy Opisso Josep Maria Tormos Josep Valls-Sole 《Clinical neurophysiology》2017,128(10):2043-2047
Objective
Repetitive application of peripheral electrical stimuli paired with transcranial magnetic stimulation (rTMS) of M1 cortex at low frequency, known as paired associative stimulation (PAS), is an effective method to induce motor cortex plasticity in humans. Here we investigated the effects of repetitive peripheral magnetic stimulation (rPMS) combined with low frequency rTMS (‘magnetic-PAS’) on intracortical and corticospinal excitability and whether those changes were widespread or circumscribed to the cortical area controlling the stimulated muscle.Methods
Eleven healthy subjects underwent three 10 min stimulation sessions: 10 Hz rPMS alone, applied in trains of 5 stimuli every 10 s (60 trains) on the extensor carpi radialis (ECR) muscle; rTMS alone at an intensity 120% of ECR threshold, applied over motor cortex of ECR and at a frequency of 0.1 Hz (60 stimuli) and magnetic PAS, i.e., paired rPMS and rTMS. We recorded motor evoked potentials (MEPs) from ECR and first dorsal interosseous (FDI) muscles. We measured resting motor threshold, motor evoked potentials (MEP) amplitude at 120% of RMT, short intracortical inhibition (SICI) at interstimulus interval (ISI) of 2 ms and intracortical facilitation (ICF) at an ISI of 15 ms before and immediately after each intervention.Results
Magnetic-PAS, but not rTMS or rPMS applied separately, increased MEP amplitude and reduced short intracortical inhibition in ECR but not in FDI muscle.Conclusion
Magnetic-PAS can increase corticospinal excitability and reduce intracortical inhibition. The effects may be specific for the area of cortical representation of the stimulated muscle.Significance
Application of magnetic-PAS might be relevant for motor rehabilitation. 相似文献8.
Valerie Van Cauwenberge Rachida El Kaddouri Karel Hoppenbrouwers Jan R. Wiersema 《Clinical neurophysiology》2017,128(4):529-537
Objective
We investigated cognitive reappraisal in children with ADHD by means of the late positive potential (LPP) and self-report ratings. We expected diminished LPP modulation following reappraisal and lower self-report scores in children with ADHD.Methods
Eighteen children with ADHD and 24 typically developing (TD) children (8–12 years) performed a cognitive reappraisal task, while EEG was recorded, and filled out a questionnaire on cognitive reappraisal.Results
Despite the lack of main reappraisal effects on LPP, the LPP was less positively modulated during reappraisal in ADHD compared to TD children.Conclusions
Children with ADHD reported less use of reappraisal and could be distinguished from TD children based on LPP modulation. However the lack of main effects of reappraisal on LPP in both groups hinders clear interpretation of this finding and questions the suitability of LPP modulation within the current paradigm as a neural index of reappraisal in children 8–12 years old, and warrants further research on the inter-individual variability and sensitivity of LPP modulation as a neural index of emotion regulation in children.Significance
This is the first study investigating the LPP during cognitive reappraisal in children with ADHD. 相似文献9.
Manon Philibert Aude-Marie Grapperon Emilien Delmont Shahram Attarian 《Clinical neurophysiology》2017,128(1):235-240
Objective
To determine whether motor unit number index (MUNIX) is pertinent to monitor the effect of intravenous immunoglobulins (IVIg) in multifocal motor neuropathy (MMN).Methods
MUNIX was assessed longitudinally in 7 MMN patients and 17 healthy controls in the abductor pollicis brevis (APB) and abductor digiti minimi (ADM) muscles. A MUNIX sum-score and a compound muscle action potential (CMAP) sum-score were calculated by summing up the scores of APB and ADM. MMN patients were evaluated on the first day of IVIg infusion, 5 MMN patients were evaluated 22 days after IVIg infusion, and 3 MMN patients were evaluated 1 month after two IVIg infusions.Results
Intraclass correlation coefficient of the MUNIX sum-score in healthy controls was 0.85, showing good test–retest reproducibility. MUNIX and CMAP sum-scores were lower in MMN patients than in healthy controls (p < 0.01 and 0.02, respectively). MUNIX sum-score improved in three of the five patients 22 days after IVIg infusion and in two of the three patients 1 month after 2 IVIg infusions, whereas CMAP sum-score improved in only one patient in both evaluations.Conclusions
In this preliminary study, MUNIX seems to be a reliable and sensitive tool to monitor the short-term efficiency of IVIg in MMN.Significance
MUNIX can help monitor IVIg treatment in MMN. 相似文献10.
E. De Bruijn S.W.R. Nijmeijer P.A. Forbes J.H.T.M. Koelman F.C.T. Van Der Helm M.A.J. Tijssen R. Happee 《Clinical neurophysiology》2017,128(10):1937-1945
Objective
To identify effects of a deviant motor drive in the autospectral power of dystonic muscles during voluntary contraction in cervical dystonia patients.Methods
Submaximal (20%) isometric head-neck tasks were performed with the head fixed, measuring surface EMG of the sternocleidomastoid, splenius capitis and semispinalis capitis in CD patients and controls. Autospectral power of muscle activity, and head forces was analyzed using cumulative distribution functions (CDF). A downward shift between the theta/low alpha-band (3–10 Hz) and the high alpha/beta-band (10–30 Hz) was detected using the CDF10, defined as the cumulative power from 3 to 10 Hz relative to power from 3 to 30 Hz.Results
CDF10 was increased in dystonic muscles compared to controls and patient muscles unaffected by dystonia, due to a 3–10 Hz power increase and a 10–30 Hz decrease. CDF10 also increased in patient head forces.Conclusions
Submaximal isometric contractions with the head fixed provided a well-defined test condition minimizing effects of reflexive feedback and tremor. We associate shifts in autospectral power with prokinetic sensorimotor control.Significance
Analysis of autospectral power in isometric tasks with the head fixed is a promising approach in research and diagnostics of cervical dystonia. 相似文献11.
Chaojun Zheng Yu Zhu Dongqing Zhu Feizhou Lu Xinlei Xia Jianyuan Jiang Xiaosheng Ma 《Clinical neurophysiology》2017,128(6):1008-1014
Objective
To investigate motor unit number estimation (MUNE) as a method to quantitatively evaluate severity and progression of motor unit loss in Hirayama disease (HD).Methods
Multipoint incremental MUNE was performed bilaterally on both abductor digiti minimi and abductor pollicis brevis muscles in 46 patients with HD and 32 controls, along with handgrip strength examination. MUNE was re-evaluated approximately 1 year after initial examination in 17 patients with HD.Results
The MUNE values were significantly lower in all the tested muscles in the HD group (P < 0.05). Despite abnormally low MUNE values, 54.3% (25/46) of patients with HD had normal ipsilateral grip power. There was a significant inverse correlation between MUNE values and disease duration (P < 0.05). A longitudinal follow-up MUNE analysis demonstrated slow progression of motor unit loss in patients with HD within approximately 1 year (P < 0.05), even in patients with an illness duration >4 years.Conclusions
A reduction in the functioning motor units was found in patients with HD compared with that in controls, even in the early asymptomatic stages. Moreover, the motor unit loss in HD progresses gradually as the disease advances.Significance
These results have provided evidence for the application of MUNE in estimating the reduction of motor unit in HD and confirming the validity of MUNE for tracking the progression of HD in a clinical setting. 相似文献12.
Milica G. Kramberger Katarina Giske Lena Cavallin Ingemar Kåreholt Thomas Andersson Bengt Winblad Vesna Jelic 《Clinical neurophysiology》2017,128(9):1575-1582
Objective
The aim of the study was to describe the relationship between electroencephalographic (EEG) findings obtained by standardized visual analysis, subclinical white matter lesions (WML) and brain atrophy in a large memory clinic population.Methods
Patients with Alzheimer’s disease (AD, n = 58), mild cognitive impairment (MCI, n = 141), subjective cognitive impairment (SCI, n = 194) had clinical, MRI based WML severity and regional atrophy assessments, and routine resting EEG recording. Background activity (BA) and episodic and continuous abnormalities were assessed visually in EEG.Results
WML (p = 0.006) and atrophy in medial temporal regions (MTA) (p = <0.001) were associated with slower BA in all diagnoses. WML were associated in SCI with total episodic EEG abnormalities (p = 0.03).Conclusions
EEG is associated with subclinical WML burden and cortical brain atrophy in a memory clinic population.Significance
Even the standard visually assessed EEG can complement a memory clinic diagnostic workup. 相似文献13.
Laura Leyssens Barbara Heinze Bart Vinck Angelique Van Ombergen Robby Vanspauwen Floris L. Wuyts Leen K. Maes 《Clinical neurophysiology》2017,128(2):312-322
Objectives
This study compared two electrode placements (‘standard’ versus ‘nose reference’ placement) for measuring oVEMPs, elicited by air-conducted 500 Hz tone bursts. The test–retest reliability of both positions was evaluated and additionally both electrode placements were applied on a group of vestibular patients.Methods
Eighteen healthy volunteers (range of 20–25 years) participated in the first part and were retested after one week for evaluation of the test–retest reliability. Eleven patients (range of 41–74 years) with a variety of vestibular pathologies were tested once.Results
In the normal group, the nose reference electrode placement resulted in significantly larger peak-to-peak amplitudes (p < 0.001), shorter n10 (p = 0.001) and p15 (p < 0.001) latencies and smaller 95% prediction intervals for the Inter-Ocular Ratio (IOR) ([?68, 68] for the standard position versus [?32, 32] for the nose reference position). Furthermore, an excellent amplitude and IOR test–retest reliability was observed with the nose reference configuration, as shown by the intraclass correlation coefficient (ICC), the coefficient of variation of the method error (CVME) and the minimal detectable differences (MDD). In the patient group, the same significant amplitude difference was found. Moreover, three patients presented with absent oVEMPs when recorded with the standard placement, whereas the nose reference placement could evoke a detectable oVEMP response.Conclusions
This study demonstrated that a nose reference electrode position results in larger oVEMP amplitudes and achieves a better reliability for the most important clinical parameters (amplitude and IOR). Our patient data substantiate the possible clinical benefit of this position, but further systematic patient verification is required.Significance
The nose reference electrode position facilitates the detection of generally very small oVEMP responses and shows a high test–retest reliability, showing promising potential for future use in the vestibular clinic. 相似文献14.
Frédéric Zubler Andreas Steimer Rebekka Kurmann Mojtaba Bandarabadi Jan Novy Heidemarie Gast Mauro Oddo Kaspar Schindler Andrea O. Rossetti 《Clinical neurophysiology》2017,128(4):635-642
Objective
Outcome prognostication in comatose patients after cardiac arrest (CA) remains a major challenge. Here we investigated the prognostic value of combinations of linear and non-linear bivariate EEG synchronization measures.Methods
94 comatose patients with EEG within 24 h after CA were included. Clinical outcome was assessed at 3 months using the Cerebral Performance Categories (CPC). EEG synchronization between the left and right parasagittal, and between the frontal and parietal brain regions was assessed with 4 different quantitative measures (delta power asymmetry, cross-correlation, mutual information, and transfer entropy). 2/3 of patients were used to assess the predictive power of all possible combinations of these eight features (4 measures × 2 directions) using cross-validation. The predictive power of the best combination was tested on the remaining 1/3 of patients.Results
The best combination for prognostication consisted of 4 of the 8 features, and contained linear and non-linear measures. Predictive power for poor outcome (CPC 3–5), measured with the area under the ROC curve, was 0.84 during cross-validation, and 0.81 on the test set. At specificity of 1.0 the sensitivity was 0.54, and the accuracy 0.81.Conclusion
Combinations of EEG synchronization measures can contribute to early prognostication after CA. In particular, combining linear and non-linear measures is important for good predictive power.Significance
Quantitative methods might increase the prognostic yield of currently used multi-modal approaches. 相似文献15.
Alexander A. Tarnutzer Christopher J. Bockisch Elena Buffone Konrad P. Weber 《Clinical neurophysiology》2017,128(8):1532-1541
Objectives
The video-head-impulse test (vHIT) provides a functional assessment of all six semicircular canals (SCC). Occasionally isolated loss of the posterior canal(s) (ILPC) is diagnosed, though this finding is poorly characterized. Here we assessed how accurate that diagnosis is by measuring the co-occurrence of abnormalities on caloric irrigation, vestibular-evoked myogenic-potentials and audiometry.Methods
We identified 52 patients with ILPC (unilateral = 40, bilateral = 12). We determined vHIT-gains and saccade-amplitudes and correlated vHIT-findings with other vestibulo-cochlear tests.Results
The most frequent diagnoses were history of vestibular neuritis (13/52), Menière’s disease (12/52) and vertigo/dizziness of unclear origin (13/52). Unilateral ILPC on vHIT was accompanied by a deficient horizontal canal on calorics, saccular and/or utricular deficits ipsilesionally in 33/40 (83%), while ipsilesional hearing-loss was noted in 24/40 (60%). Involvement of other sensors was highest for vestibular schwannoma (100%) and history of vestibular neuritis (92%). Bilateral deficits in ≥1 vestibulo-cochlear sensor(s) were noted in 2/12 cases with bilateral ILPC.Conclusions
>80% of patients with unilateral ILPC had additional deficits of other parts of the vestibular organ, while this rate was ≤20% for patients with bilateral ILPC.Significance
Dizzy patients should receive testing of the posterior canals and if abnormalities are observed, additional vestibulo-cochlear testing should be obtained. 相似文献16.
Objective
In healthy individuals, the perception of an intense bitter taste decreased the reward value of visual food cues, as reflected by the reduction of a specific event-related brain potential (ERP), frontal late positivity. The current cross-modal ERP study investigated responses of female patients with binge-eating symptoms (BES) to this type of visual-gustatory stimulation.Methods
Women with BES (n = 36) and female control participants (n = 38) viewed food images after they rinsed their mouth with either bitter wormwood tea or water.Results
Relative to controls, the patients showed elevated late positivity (LPP: 400–700 ms) to the food images in the bitter condition. The LPP source was located in the medial prefrontal cortex. Both groups did not differ in the ratings for the fluids (intensity, bitterness, disgust).Conclusions
This ERP study showed that a bitter taste did not decrease late positivity to visual food cues (reflecting food reward) in women with BES.Significance
The atypical bitter responding might be a biological marker of this condition and possibly contributes to overeating. Future studies should additionally record food intake behavior to further investigate this mechanism. 相似文献17.
Tommaso Fedele Claudio Schönenberger Gabriel Curio Carlo Serra Niklaus Krayenbühl Johannes Sarnthein 《Clinical neurophysiology》2017,128(10):1851-1857
Objective
The detectability of high frequency oscillations (HFO, >200 Hz) in the intraoperative ECoG is restricted by their low signal-to-noise ratio (SNR). Using the somatosensory evoked HFO, we quantify how HFO detectability can benefit from a custom-made low-noise amplifier (LNA).Methods
In 9 patients undergoing tumor surgery in the central region, subdural strip electrodes were placed for intraoperative neurophysiological monitoring. We recorded the somatosensory evoked potential (SEP) simultaneously by custom-made LNA and by a commercial device (CD). We varied the stimulation rate between 1.3 and 12.7 Hz to tune the SNR of the N20 component and the evoked HFO and quantified HFO detectability at the single trial level. In three patients we compared Propofol® and Sevoflurane® anesthesia.Results
In the average, amplitude decreased in both in N20 and evoked HFO amplitude with increasing stimulation rate (p < 0.05). We detected a higher percentage of single trial evoked HFO with the LNA (p < 0.001) for recordings with low impedance (<5 kΩ). Average amplitudes were indistinguishable between anesthesia compounds.Conclusion
Low-noise amplification improves the detection of the evoked HFO in recordings with subdural electrodes with low impedance.Significance
Low-noise EEG might critically improve the detectability of interictal spontaneous HFO in subdural and possibly in scalp recordings. 相似文献18.
Eungseok Oh Jinse Park Jinyoung Youn Ji Sun Kim Suyeon Park Wooyoung Jang 《Clinical neurophysiology》2017,128(6):1061-1068
Objective
Our study aimed to determine whether the short latency afferent inhibition (SAI) response could be associated with the severity of olfactory dysfunction in PD patients.Methods
A total of 71 PD patients and 20 controls were enrolled. All PD patients were classified into 3 groups by the severity of the olfactory deficit. Single-pulse transmagnetic stimulation (TMS) parameters and SAI were assessed.Results
The integrated SAI in the PD with anosmia and PD with hyposomia groups was significantly less inhibited than that in the PD with normosmia and control groups [64.79 {Interquartile range (IQR): 59.96, 71.33}, 84.79 {IQR: 75.03, 90.63} versus 36.72 {IQR: 32.28, 48.33}, 42.15 {IQR: 34.60, 44.96}, respectively]. In PD subjects, the severity of olfactory dysfunction also showed a significant negative correlation with the SAI response (r = ?0.829, p < 0.001).Conclusions
Considering that the SAI response partly reflects central cholinergic dysfunction and that our study shows a relationship between the SAI response and the severity of olfactory dysfunction in PD, our findings indicate that cholinergic dysfunction could possibly contribute to the pathogenesis of olfactory dysfunction in early PD.Significance
SAI could be a useful marker to detect severe olfactory dysfunction in PD. 相似文献19.
Fernanda Emanuelle Almeida Castro Amorim Alinne Martiniano Sahdo Lydia Maria Pereira Giuliano Denise Spinola Pinheiro Nadia Iandoli de Oliveira Braga Gilberto Mastrocola Manzano 《Clinical neurophysiology》2017,128(1):262-269
Objective
The study aimed to examine the effect of the stimulus phase of air-conducted sound on ocular vestibular evoked myogenic potentials (oVEMPs).Methods
oVEMPs were recorded after air-conducted sounds (500 Hz, 4 ms duration), presented with initial condensation (positive), rarefaction (negative), and alternant polarities from 12 healthy subjects.Results
Most responses showed a bifid n10 peak separated by ～1.9 ms. The most prominent sub-peak after condensation was shorter than the most prominent sub-peak after rarefaction; however, the first sub-peak was shorter after the rarefaction stimuli. When a third sub-peak appeared, it occurred before the most prominent sub-peak after condensation and after the most prominent sub-peak after rarefaction. The latency difference between this third sub-peak and the closest sub-peak was shorter than the difference among the others sub-peaks, in both cases; the oVEMPs after alternating stimuli was an amalgam of the responses to the different stimuli.Conclusions
The findings suggest that the negative to positive change of the stimulus was the main event responsible for the stimulation, and that when a third sub-peak appeared it was related to the initiation or the end of the stimulus.Significance
These findings suggested that the oVEMP response, obtained by air conducted sound, was secondary to stimulation of the same type of afferent vestibular unit, independent of the stimulus polarity. 相似文献20.
Zhao Li Dong Tian Lingfen Chen Xiaoqing Wang Lijuan Jiang Yude Yu 《Clinical neurophysiology》2017,128(2):384-390