共查询到20条相似文献，搜索用时 15 毫秒
1.
Hairong He Jun Lu Lihong Yang Jie Zheng Fan Gao Yajing Zhai Junqin Feng Yajuan Fan Xiancang Ma 《Clinical neurophysiology》2017,128(5):716-724
Objective
To explore the efficacies of 1-Hz (low frequency) and 10-Hz (high frequency) repetitive transcranial magnetic stimulation (rTMS) in treating auditory hallucinations and negative symptoms of schizophrenia, respectively.Methods
Electronic databases were searched to identify relevant literature. Standard mean difference (SMD) and 95% confidence interval (CI) values were used to evaluate the effects of rTMS. The stability and sensitivity of the results, the source of heterogeneity, and the recommended grade of the evidence were also analyzed.Results
Thirteen studies of 1-Hz rTMS were included. The auditory hallucinations improved more in the rTMS group than in the sham group (SMD = ?0.29, 95%CI = ?0.57 to ?0.01). However, this result was not stable after sensitivity analysis, and publication bias had a substantial impact on the results. Meta-analysis performed for seven studies of 10-Hz rTMS found that improvement of negative symptoms did not differ significantly between the real rTMS and sham groups. Finally, the grade of evidence for this meta-analysis was found to be low.Conclusion
Although there may appear to be a therapeutic effect for 1-Hz rTMS on auditory hallucinations of schizophrenia, this needs to be confirmed by large-scale randomized controlled trials before this finding can be recommended in clinical practice.Significance
1-Hz rTMS might have an effect on auditory hallucinations of schizophrenia. 相似文献2.
J.P. Neverdahl P.M. Omland M. Uglem M. Engstrøm T. Sand 《Clinical neurophysiology》2017,128(12):2411-2418
Objective
To investigate motor cortical excitability, inhibition, and facilitation with navigated transcranial magnetic stimulation (TMS) in migraine in a blinded cross-sectional study.Methods
Resting motor threshold (RMT), cortical silent period (CSP), short-interval intracortical inhibition (SICI), and intracortical facilitation (ICF) were compared in 27 interictal migraineurs and 33 controls. 24 female interictal migraineurs and 27 female controls were compared in subgroup analyses. Seven preictal migraineurs were also compared to the interictal group in a hypothesis-generating analysis. Investigators were blinded for diagnosis during recording and analysis of data.Results
SICI was decreased in interictal migraineurs when compared to healthy controls (p = 0.013), CSP was shortened in female interictal migraineurs (p = 0.041). ICF was decreased in preictal compared to interictal migraineurs (p = 0.023). RMT and ICF were not different between interictal migraineurs and controls.Conclusion
Cortical inhibition was decreased in migraineurs between attacks, primarily in a female subgroup, indicating an importance of altered cortical inhibition in migraine.Significance
Previous studies on motor cortical excitability in migraineurs have yielded varying results. This relatively large and blinded study provides support for altered cortical inhibition in migraine. Measuring intracortical facilitation in the period preceding migraine attacks may be of interest for future studies. 相似文献3.
Vishwanath Sankarasubramanian Andre G. Machado Adriana B. Conforto Kelsey A. Potter-Baker David A. Cunningham Nicole M. Varnerin Xiaofeng Wang Ken Sakaie Ela B. Plow 《Clinical neurophysiology》2017,128(6):892-902
Objective
The standard approach to brain stimulation in stroke is based on the premise that ipsilesional M1 (iM1) is important for motor function of the paretic upper limb, while contralesional cortices compete with iM1. Therefore, the approach typically advocates facilitating iM1 and/or inhibiting contralesional M1 (cM1). But, this approach fails to elicit much improvement in severely affected patients, who on account of extensive damage to ipsilesional pathways, cannot rely on iM1. These patients are believed to instead rely on the undamaged cortices, especially the contralesional dorsal premotor cortex (cPMd), for support of function of the paretic limb. Here, we tested for the first time whether facilitation of cPMd could improve paretic limb function in severely affected patients, and if a cut-off could be identified to separate responders to cPMd from responders to the standard approach to stimulation.Methods
In a randomized, sham-controlled crossover study, fifteen patients received the standard approach of stimulation involving inhibition of cM1 and a new approach involving facilitation of cPMd using repetitive transcranial magnetic stimulation (rTMS). Patients also received rTMS to control areas. At baseline, impairment [Upper Extremity Fugl-Meyer (UEFMPROXIMAL, max = 36)] and damage to pathways [fractional anisotropy (FA)] was measured. We measured changes in time to perform proximal paretic limb reaching, and neurophysiology using TMS.Results
Facilitation of cPMd generated more improvement in severely affected patients, who had experienced greater damage and impairment than a cut-off value of FA (0.5) and UEFMPROXIMAL (26–28). The standard approach instead generated more improvement in mildly affected patients. Responders to cPMd showed alleviation of interhemispheric competition imposed on iM1, while responders to the standard approach showed gains in ipsilesional excitability in association with improvement.Conclusions
A preliminary cut-off level of severity separated responders for standard approach vs. facilitation of cPMd.Significance
Cut-offs identified here could help select candidates for tailored stimulation in future studies so patients in all ranges of severity could potentially achieve maximum benefit in function of the paretic upper limb. 相似文献4.
Reza Rostami Reza Kazemi Michael A. Nitsche Fatemeh Gholipour 《Clinical neurophysiology》2017,128(10):1961-1970
Objective
Previous studies investigated predictors of repetitive transcranial magnetic stimulation (rTMS) response in depressive disorders but there is still limited knowledge about clinical predictors. Moreover, predictors of rTMS response in bipolar depression (BDD) are less studied than unipolar depression (UDD).Methods
We performed a binary logistic regression analysis in 248 patients with depressive disorders (unipolar N = 102, bipolar N = 146) who received 20 sessions of DLPFC rTMS (High-frequency rTMS, low-frequency rTMS, bilateral rTMS) to investigate significant clinical and demographic predictors of rTMS response. We also investigated effects of depression type, response (yes, no) and time on reducing somatic and cognitive-affective symptoms of patients.Results
Depression type (unipolar vs. bipolar) did not have a significant effect on rTMS response. 45% of all patients, 51.5% of UDD patients and 41% of BDD patients, responded to rTMS treatment. Age was the only significant demographic predictor of treatment response in all patients. Cognitive-affective symptoms, compared to somatic symptoms were significant predictors for treatment response to rTMS. Common and unique clinical predictor for UDD and BDD were identified.Conclusions
Younger patients and those with cognitive-affective rather than somatic symptoms benefit more from DLPFC rTMS treatment. rTMS is effective in UDD and BDD patients. Patients should be selected based on clinical and demographic profile.Significance
Findings are based on the largest thus far reported sample of patients with depressive disorders that received DLPFC rTMS. 相似文献5.
Tamara Gedankien Peter J. Fried Alvaro Pascual-Leone Mouhsin M. Shafi 《Clinical neurophysiology》2017,128(12):2419-2427
Objective
We studied the correlation between motor evoked potentials (MEPs) and early TMS-evoked EEG potentials (TEPs) from single-pulse TMS before and after intermittent Theta Burst Stimulation (iTBS) to the left primary motor cortex (M1) in 17 healthy older participants.Methods
TMS was targeted to the hand region of M1 using a MRI-guided navigated brain stimulation system and a figure-of-eight biphasic coil. MEPs were recorded from the right first dorsal interosseous muscle using surface EMG. TEPs were extracted from a 61-channel EEG recording. Participants received 90 single TMS pulses at 120% of resting motor threshold before and after iTBS.Results
Across all participants, the change in N15-P30 TEP and MEP amplitudes were significantly correlated (r = 0.69; p < 0.01). Average TEP responses did not change significantly after iTBS, whereas MEP amplitudes showed a significant increase.Conclusions
Changes in corticospinal reactivity and cortical reactivity induced by iTBS are related. However, the effect of iTBS on TEPs, unlike MEPs, is not straightforward.Significance
Our findings help elucidate the relationship between changes in cortical and corticospinal excitability in healthy older individuals. Going forward, TEPs may be used to evaluate the effects of theta-burst stimulation in non-motor brain regions. 相似文献6.
Hugo Massé-Alarie Louis-David Beaulieu Richard Preuss Cyril Schneider 《Clinical neurophysiology》2017,128(3):442-453
Objective
The study tested whether combining repetitive peripheral magnetic stimulation (RPMS) and motor training of the superficial multifidus muscle (MF) better improved the corticomotor control of spine than training alone in chronic low back pain (CLBP).Methods
Twenty-one participants with CLBP were randomly allocated to [RPMS + training] and [Sham + training] groups for three sessions (S1–S3) over a week where MF was stimulated before training (volitional contraction). Training was also home-practiced twice a day. Changes were tested at S1 and S3 for anticipatory postural adjustments (APAs) of MF and semi-tendinosus (ST), MF EMG activation, cortical motor plasticity (transcranial magnetic stimulation) and pain/disability.Results
The RPMS group showed immediate decrease of pain at S1, then improvement of MF activation, ST APA, M1 facilitation, and pain/disability at S3. Changes were larger when brain excitability was lower at baseline. Disability index remained improved one month later.Conclusions
Combining RPMS with training of MF in CLBP impacted motor planning, MF and lumbopelvic spine motor control and pain/disability one week after the onset of protocol. Brain plasticity might have favoured motor learning and improved daily lumbopelvic spine control without pain generation.Significance
Clinically, RPMS impacted the function by improving the gains beyond those reached by training alone in CLBP. 相似文献7.
Melanie K. Fleming John C. Rothwell Laszlo Sztriha James T. Teo Di J. Newham 《Clinical neurophysiology》2017,128(7):1389-1398
Objective
To assess the impact of electrode arrangement on the efficacy of tDCS in stroke survivors and determine whether changes in transcallosal inhibition (TCI) underlie improvements.Methods
24 stroke survivors (3–124 months post-stroke) with upper limb impairment participated. They received blinded tDCS during a motor sequence learning task, requiring the paretic arm to direct a cursor to illuminating targets on a monitor. Four tDCS conditions were studied (crossover); anodal to ipsilesional M1, cathodal to contralesional M1, bihemispheric, sham. The Jebsen Taylor hand function test (JTT) was assessed pre- and post-stimulation and TCI assessed as the ipsilateral silent period (iSP) duration using transcranial magnetic stimulation.Results
The time to react to target illumination reduced with learning of the movement sequence, irrespective of tDCS condition (p > 0.1). JTT performance improved after unilateral tDCS (anodal or cathodal) compared with sham (p < 0.05), but not after bihemispheric (p > 0.1). There was no effect of tDCS on change in iSP duration (p > 0.1).Conclusions
Unilateral tDCS is effective for improving JTT performance, but not motor sequence learning.Significance
This has implications for the design of future clinical trials. 相似文献8.
Anne Weissbach Tobias Bäumer Peter P. Pramstaller Norbert Brüggemann Vera Tadic Robert Chen Christine Klein Alexander Münchau 《Clinical neurophysiology》2017,128(1):275-280
Objectives
Mutations in the Parkin and PINK1 gene account for the majority of autosomal recessive early-onset Parkinson cases. There is increasing evidence that clinically asymptomatic subjects with single heterozygous mutations have a latent nigrostriatal dopaminergic deficit and could be taken as in vivo model of pre-symptomatic phase of Parkinsonism.Methods
We charted premotor–motor excitability changes as compensatory mechanisms for subcortical dopamine depletions using transcranial magnetic stimulation by applying magnetic resonance-navigated premotor–motor cortex conditioning in 15 asymptomatic, heterozygous Parkin and PINK1 mutation carriers (2 female; mean age 53 ± 8 years) and 16 age- and sex-matched controls (5 female; mean age 57 ± 9 years). Participants were examined at baseline and after acute l-dopa challenge.Results
There were l-dopa and group specific effects during premotor–motor conditioning at an interstimulus interval of 6 ms indicating a normalisation of premotor–motor interactions in heterozygous Parkin and PINK1 mutation carriers after l-dopa intake. Non-physiologically high conditioned MEP amplitudes at this interval in mutation carriers decreased after l-dopa intake but increased in controls.Conclusion
Premotor–motor excitability changes are part of the cortical reorganization in asymptomatic heterozygous Parkin- and PINK1 mutation carriers.Significance
These subjects offer opportunities to delineate motor network adaptation in pre-symptomatic Parkinsonism. 相似文献9.
Alana B. McCambridge James W. Stinear Sarah Peek Winston D. Byblow 《Clinical neurophysiology》2017,128(9):1608-1616
Objective
Cervical propriospinal premotoneurons (PN) relay descending motor commands and integrate peripheral afferent feedback. Effects of anodal transcranial direct current stimulation (a-tDCS) on propriospinal excitability in the upper limbs are unknown.Methods
Healthy right-handed adults received a-tDCS or sham tDCS over primary motor cortex (M1) at 1 mA (Experiment 1, n = 18) or 2 mA current intensity (Experiment 2, n = 15). Propriospinal excitability was assessed by suppression of background electromyography (EMG) in extensor carpi radialis (ECR) from electrical stimulation of the superficial radial nerve during bilateral (Experiment 1 and 2) or unilateral (Experiment 2 only) activation of the left and/or right ECR. EMG suppression could be attributed to an early propriospinal component and late cortical component. Motor evoked potentials (MEP) were obtained as a manipulation check.Results
Before tDCS, propriospinal-mediated cutaneous-induced suppression was present in each arm for early and late components. ECR MEP amplitude increased after 1 mA, but not 2 mA, a-tDCS. Neither 1 mA nor 2 mA a-tDCS modulated either component of ipsilateral or contralateral propriospinal excitability during bilateral or unilateral tasks.Conclusions
Propriospinal-mediated cutaneous-induced suppression was not modulated by a-tDCS in healthy adults.Significance
Reporting non-significant findings is paramount for the development of clinically-relevant tDCS protocols. 相似文献10.
Nicolás M. Phielipp Utpal Saha Tejas Sankar Akihiro Yugeta Robert Chen 《Clinical neurophysiology》2017,128(6):1109-1115
Objective
To evaluate the safety of repetitive transcranial magnetic stimulation (rTMS) in patients with implanted subdural cortical electrodes.Methods
We performed ex-vivo experiments to test the temperature, displacement and current induced in the electrodes with single pulse transcranial magnetic stimulation (TMS) from 10 to 100% of stimulator output and tested a typical rTMS protocol used in a clinical setting. We then used rTMS to the motor cortex to treat a patient with refractory post-herpetic neuralgia who had previously been implanted with a subdural motor cortical electrode for pain management. The rTMS protocol consisted of ten sessions of 2000 stimuli at 20 Hz and 90% of resting motor threshold.Results
The ex-vivo study showed an increase in the coil temperature of 2 °C, a maximum induced charge density of 30.4 μC/cm2/phase, and no electrode displacement with TMS. There was no serious adverse effect associated with rTMS treatment of the patient. Cortical tremor was observed in the intervals between trains of stimuli during one treatment session.Conclusions
TMS was safe in a patient with implanted Medtronic Resume II electrode (model 3587A) subdural cortical electrode.Significance
TMS may be used as a therapeutic, diagnostic or research tool in patients this type of with implanted cortical electrodes. 相似文献11.
Mamede de Carvalho Artiom Poliakov Cristiano Tavares Michael Swash 《Clinical neurophysiology》2017,128(11):2200-2204
Objective
We studied motor unit recruitment to test a new method to identify motor unit firing rate (FR) variability.Methods
We studied 68 ALS patients, with and without upper neuron signs (UMN) in lower limbs, 24 patients with primary lateral sclerosis (PLS), 13 patients with spinal cord lesion and 39 normal subjects. All recordings were made from tibialis anterior muscles of normal strength. Subjects performed a very slight contraction in order to activate 2 motor units in each recording. 5–7 motor unit pairs were recorded in each subject. Mean consecutive differences (MCD) were calculated for each pair of potentials. The mean MCD for each muscle was estimated as the mean from the total number of pairs recorded. A p value < 0.01 was accepted as significant.Results
MCD of FR frequency was less in the subjects with spinal cord lesion and PLS. In addition, the FR frequency of the 1st motor unit in a pair of units was markedly reduced in PLS, and in subjects with spinal cord lesions.Conclusion
These results support a lower threshold and reduced FR fluctuation in spinal motor neurons of spastic patients.Significance
This method can be developed for detection of UMN lesions. 相似文献12.
Chaojun Zheng Yu Zhu Dongqing Zhu Feizhou Lu Xinlei Xia Jianyuan Jiang Xiaosheng Ma 《Clinical neurophysiology》2017,128(6):1008-1014
Objective
To investigate motor unit number estimation (MUNE) as a method to quantitatively evaluate severity and progression of motor unit loss in Hirayama disease (HD).Methods
Multipoint incremental MUNE was performed bilaterally on both abductor digiti minimi and abductor pollicis brevis muscles in 46 patients with HD and 32 controls, along with handgrip strength examination. MUNE was re-evaluated approximately 1 year after initial examination in 17 patients with HD.Results
The MUNE values were significantly lower in all the tested muscles in the HD group (P < 0.05). Despite abnormally low MUNE values, 54.3% (25/46) of patients with HD had normal ipsilateral grip power. There was a significant inverse correlation between MUNE values and disease duration (P < 0.05). A longitudinal follow-up MUNE analysis demonstrated slow progression of motor unit loss in patients with HD within approximately 1 year (P < 0.05), even in patients with an illness duration >4 years.Conclusions
A reduction in the functioning motor units was found in patients with HD compared with that in controls, even in the early asymptomatic stages. Moreover, the motor unit loss in HD progresses gradually as the disease advances.Significance
These results have provided evidence for the application of MUNE in estimating the reduction of motor unit in HD and confirming the validity of MUNE for tracking the progression of HD in a clinical setting. 相似文献13.
Alonso Zea Vera Gewalin Aungaroon Paul S. Horn Anna W. Byars Hansel M. Greiner Jeffrey R. Tenney Todd M. Arthur Nathan E. Crone Katherine D. Holland Francesco T. Mangano Ravindra Arya 《Clinical neurophysiology》2017,128(10):2087-2093
Objective
To examine current thresholds and their determinants for language and motor mapping with extra-operative electrical cortical stimulation (ECS).Methods
ECS electrocorticograph recordings were reviewed to determine functional thresholds. Predictors of functional thresholds were found with multivariable analyses.Results
In 122 patients (age 11.9 ± 5.4 years), average minimum, frontal, and temporal language thresholds were 7.4 (± 3.0), 7.8 (± 3.0), and 7.4 (± 3.1) mA respectively. Average minimum, face, upper and lower extremity motor thresholds were 5.4 (± 2.8), 6.1 (± 2.8), 4.9 (± 2.3), and 5.3 (± 3.3) mA respectively.Functional and after-discharge (AD)/seizure thresholds were significantly related. Minimum, frontal, and temporal language thresholds were higher than AD thresholds at all ages. Minimum motor threshold was higher than minimum AD threshold up to 8.0 years of age, face motor threshold was higher than frontal AD threshold up to 11.8 years age, and lower subsequently. UE motor thresholds remained below frontal AD thresholds throughout the age range.Conclusions
Functional thresholds are frequently above AD thresholds in younger children.Significance
These findings raise concerns about safety and neurophysiologic validity of ECS mapping. Functional and AD/seizure thresholds relationships suggest individual differences in cortical excitability which cannot be explained by clinical variables. 相似文献14.
Simranjit K. Sidhu Joshua C. Weavil Tyler S. Mangum Jacob E. Jessop Russell S. Richardson David E. Morgan Markus Amann 《Clinical neurophysiology》2017,128(1):44-55
Objective
To investigate the influence of group III/IV muscle afferents on the development of central fatigue and corticospinal excitability during exercise.Methods
Fourteen males performed cycling-exercise both under control-conditions (CTRL) and with lumbar intrathecal fentanyl (FENT) impairing feedback from leg muscle afferents. Transcranial magnetic- and cervicomedullary stimulation was used to monitor cortical versus spinal excitability.Results
While fentanyl-blockade during non-fatiguing cycling had no effect on motor-evoked potentials (MEPs), cervicomedullary-evoked motor potentials (CMEPs) were 13 ± 3% higher (P < 0.05), resulting in a decrease in MEP/CMEP (P < 0.05). Although the pre- to post-exercise reduction in resting twitch was greater in FENT vs. CTRL (?53 ± 3% vs. ?39 ± 3%; P < 0.01), the reduction in voluntary muscle activation was smaller (?2 ± 2% vs. ?10 ± 2%; P < 0.05). Compared to the start of fatiguing exercise, MEPs and CMEPs were unchanged at exhaustion in CTRL. In contrast, MEPs and MEP/CMEP increased 13 ± 3% and 25 ± 6% in FENT (P < 0.05).Conclusion
During non-fatiguing exercise, group III/IV muscle afferents disfacilitate, or inhibit, spinal motoneurons and facilitate motor cortical cells. In contrast, during exhaustive exercise, group III/IV muscle afferents disfacilitate/inhibit the motor cortex and promote central fatigue.Significance
Group III/IV muscle afferents influence corticospinal excitability and central fatigue during whole-body exercise in humans. 相似文献15.
Sung Wook Chung Benjamin P. Lewis Nigel C. Rogasch Takashi Saeki Richard H. Thomson Kate E. Hoy Neil W. Bailey Paul B. Fitzgerald 《Clinical neurophysiology》2017,128(7):1117-1126
Objectives
To examine the effects of intermittent TBS (iTBS) and continuous TBS (cTBS) on cortical reactivity in the dorsolateral prefrontal cortex.Methods
10 healthy participants were stimulated with either iTBS, cTBS or sham at F3 electrode. Single- and paired-pulse TMS and concurrent electroencephalography (EEG) were used to assess change in cortical reactivity and long-interval intracortical inhibition (LICI) via TMS-evoked potentials (TEPs) and TMS-evoked oscillations.Results
Significant increases in N120 amplitudes (p < 0.01) were observed following iTBS over prefrontal cortex. Changes in TMS-evoked theta oscillations and LICI of theta oscillations were also observed following iTBS (increase) and cTBS (decrease). Change in LICI of theta oscillations correlated with change in N120 amplitude following TBS (r = ?0.670, p = 0.001).Conclusions
This study provides preliminary evidence that TBS produces direct changes in cortical reactivity in the prefrontal cortex. Combining TBS with TMS-EEG may be a useful approach to optimise stimulation paradigms prior to the conduct of clinical trials.Significance
TBS is able to modulate cortical reactivity and cortical inhibition in the prefrontal cortex. 相似文献16.
Manon Philibert Aude-Marie Grapperon Emilien Delmont Shahram Attarian 《Clinical neurophysiology》2017,128(1):235-240
Objective
To determine whether motor unit number index (MUNIX) is pertinent to monitor the effect of intravenous immunoglobulins (IVIg) in multifocal motor neuropathy (MMN).Methods
MUNIX was assessed longitudinally in 7 MMN patients and 17 healthy controls in the abductor pollicis brevis (APB) and abductor digiti minimi (ADM) muscles. A MUNIX sum-score and a compound muscle action potential (CMAP) sum-score were calculated by summing up the scores of APB and ADM. MMN patients were evaluated on the first day of IVIg infusion, 5 MMN patients were evaluated 22 days after IVIg infusion, and 3 MMN patients were evaluated 1 month after two IVIg infusions.Results
Intraclass correlation coefficient of the MUNIX sum-score in healthy controls was 0.85, showing good test–retest reproducibility. MUNIX and CMAP sum-scores were lower in MMN patients than in healthy controls (p < 0.01 and 0.02, respectively). MUNIX sum-score improved in three of the five patients 22 days after IVIg infusion and in two of the three patients 1 month after 2 IVIg infusions, whereas CMAP sum-score improved in only one patient in both evaluations.Conclusions
In this preliminary study, MUNIX seems to be a reliable and sensitive tool to monitor the short-term efficiency of IVIg in MMN.Significance
MUNIX can help monitor IVIg treatment in MMN. 相似文献17.
Etienne Allart Arnaud Delval Alexandre Caux-Dedeystere Julien Labreuche Romain Viard Renaud Lopes Hervé Devanne 《Clinical neurophysiology》2017,128(5):707-715
Objectives
To assess the contralesional connectivity between the posterior parietal cortex (PPC) and the motor cortex (M1) in stroke patients, and to probe putative relationships with spatial neglect and motor impairment.Methods
In 12 right-side stroke patients and 12 age-matched healthy controls, we used paired-pulse transcranial magnetic stimulation to assess the contralesional connectivity between three left-side PPC sites (the anterior intraparietal sulcus (aIPS), the posterior intraparietal sulcus and the superior parieto-occipital cortex (SPOC)) and M1. The interstimulus interval (ISI) was set to 4 or 6 ms.Results
Although there were no differences between the stroke patient group and the controls, a subgroup analysis showed that stimulation over the SPOC with an ISI of 6 ms facilitated motor-evoked potential responses in patients with neglect (and especially those with severe peripersonal neglect), relative to non-neglect patients. With an ISI of 4 ms, the aIPS exerted an inhibitory influence on M1 in all subjects. The severity of motor impairment was not associated with PPC-M1 connectivity.Conclusions
aIPS-M1 connectivity seems to be unaffected in stroke patients, whereas connectivity from the most posterior parts of the parietal cortex depends on the patient’s neglect status.Significance
These results provide insight into post-stroke changes in contralesional PPC-M1 connectivity. 相似文献18.
Wolf-Julian Neumann Franziska Staub-Bartelt Andreas Horn Julia Schanda Gerd-Helge Schneider Peter Brown Andrea A. Kühn 《Clinical neurophysiology》2017,128(11):2286-2291
Objectives
To investigate the long term association of subthalamic beta activity with parkinsonian motor signs.Methods
We recruited 15 patients with Parkinson’s disease undergoing subthalamic DBS for local field potential recordings after electrode implantation, and at 3 and 8 months post-operatively using the implantable sensing enabled Activa PC + S (Medtronic). Three patients dropped out leaving 12 patients. Recordings were conducted ON and OFF levodopa at rest. Beta (13–35 Hz) peak amplitudes were extracted, compared across time points and correlated with UPDRS-III hemibody scores.Results
Peaks in the beta frequency band (13–35 Hz) in the OFF medication state were found in all hemispheres. Mean beta activity was significantly suppressed by levodopa at all recorded time points (P < 0.007) and individual beta power amplitude correlated with parkinsonian motor impairment across time points and dopaminergic states (pooled data; ρ = 0.25, P < 0.001).Conclusions
Our results indicate that beta-activity is correlated with parkinsonian motor signs over a time period of 8 months.Significance
Beta-activity may be a chronically detectable biomarker of symptom severity in PD that should be further evaluated under ongoing DBS. 相似文献19.
J. Hirschmann J.M. Schoffelen A. Schnitzler M.A.J. van Gerven 《Clinical neurophysiology》2017,128(10):2029-2036
Objective
To investigate the possibility of tremor detection based on deep brain activity.Methods
We re-analyzed recordings of local field potentials (LFPs) from the subthalamic nucleus in 10 PD patients (12 body sides) with spontaneously fluctuating rest tremor. Power in several frequency bands was estimated and used as input to Hidden Markov Models (HMMs) which classified short data segments as either tremor-free rest or rest tremor. HMMs were compared to direct threshold application to individual power features.Results
Applying a threshold directly to band-limited power was insufficient for tremor detection (mean area under the curve [AUC] of receiver operating characteristic: 0.64, STD: 0.19). Multi-feature HMMs, in contrast, allowed for accurate detection (mean AUC: 0.82, STD: 0.15), using four power features obtained from a single contact pair. Within-patient training yielded better accuracy than across-patient training (0.84 vs. 0.78, p = 0.03), yet tremor could often be detected accurately with either approach. High frequency oscillations (>200 Hz) were the best performing individual feature.Conclusions
LFP-based markers of tremor are robust enough to allow for accurate tremor detection in short data segments, provided that appropriate statistical models are used.Significance
LFP-based markers of tremor could be useful control signals for closed-loop deep brain stimulation. 相似文献20.
Nidhi Garg James Howells Con Yiannikas Steve Vucic Arun V. Krishnan Judith Spies Hugh Bostock Emily K. Mathey John D. Pollard Susanna B. Park Matthew C. Kiernan 《Clinical neurophysiology》2017,128(10):2022-2028