盐酸纳美芬联合醒脑静对急性酒精中毒昏迷患者的疗效及血清β-EP,SOD,MDA水平的影响

目的探讨急性酒精中毒昏迷患者应用盐酸纳美芬联合醒脑静治疗后的疗效。方法选取我院2015年2月至2017年2月收治的104例急性酒精中毒昏迷患者,将其随机分为观察组(盐酸纳美芬联合醒脑静)和对照组(盐酸纳美芬)各52例,观察两组患者的治疗效果及其恢复情况。结果与治疗前相比,两组患者的血清β内啡肽(β-EP)、丙二醛(MDA)水平明显降低(P0.05),而超氧歧化酶(SOD)水平明显上升(P0.05)。治疗与对照组相比,观察组患者的治疗有效率(96.15%84.62%)和SOD[(84.69±11.28)k U/L(66.91±8.84)k U/L]水平相对更高(P0.05),而血清β-EP水平[(209.75±17.55)ng/L(239.82±16.94)ng/L]水平、MDA[(6.02±1.19)nmol/L(9.05±1.28)nmol/L]水平相对更低(P0.05),而苏醒时间[(91.42±10.46)min(146.42±25.84)min]和症状消失时间[(4.46±1.34)h(6.58±2.46)h]相对更短(P0.05)。结论盐酸纳美芬联合醒脑静对急性酒精中毒具有良好的疗效和安全性,能够更快、更好的解除患者的病症。     

纳美芬、醒脑静、维生素B6注射液联合治疗酒精中毒80例临床观察

目的观察醒脑静联合纳美芬、维生素B6治疗急性酒精中毒临床疗效.方法将2011年8月份至2012年8月我院治疗的急性乙醇中毒80例给予醒脑静、纳美芬、维生素B6注射液治疗.结果临床治愈72例,显效8例,总有效率100%.结论醒脑静、纳美芬、维生素B6注射液联合应用治疗急性酒精中毒有效.     

醒脑静联合纳洛酮治疗急性酒精中毒126例疗效观察

目的观察醒脑静联合纳洛酮治疗急性酒精中毒效果。方法以我院2007年6月～2009年12月急性酒精中毒患者为观察对象,治疗组126例,应用醒脑静联合纳洛酮治疗;对照组74例,单独应用纳洛酮治疗,比较分析两组症状消失时间及治疗效果。结果两组兴奋期和共济失调期患者中毒症状消失时间无显著差异(P0.05);治疗组昏迷期患者中毒症状消失平均时间显著优于对照组(P0.01);两组病例全部治愈,总有效率为100%;治疗组治愈率73.02%,显著高于对照组(P0.05)。结论醒脑静联合纳洛酮治疗急性酒精中毒疗效确切,标本兼治,无明显毒副作用,应推广应用。     

纳美芬联合醒脑静注射液治疗急性酒精中毒的临床效果观察

目的观察纳美芬与醒脑静注射液联合应用于急性酒精中毒治疗中的临床效果。方法80例急性酒精中毒病人的收治时间在2016年1月至2018年12月间,随机分考察组与治疗组各40例,考察组单用纳美芬治疗,治疗组则联合纳美芬与醒脑静注射液治疗,观察两组效果。结果对两组采取不同方法治疗后,考察组总有效率是85.00%,治疗组是97.50%,两组差别相比有统计学意义(P0.05);两组发生的并发症情况主要有恶心呕吐、头晕头痛、疲劳乏力等,治疗组总发生率为40.00%,考察组为72.50%,两组差别相比有统计学意义(P0.05);考察组治疗后苏醒时间平均为(142.32±17.64)min,治疗组平均为(88.97±16.42)min;考察组2h内苏醒率为62.50%(25/40),治疗组为72.50%(29/40),两组差别相比有统计学意义(P0.05)。结论对急性酒精中毒病人选择纳美芬与醒脑静注射液联合治疗的方式,可快速改善病人症状,有效性高,值得推荐。     

中西医结合治疗急性酒精中毒昏迷期98例疗效观察

目的观察醒脑静注射液结合西药治疗急性酒精中毒昏迷期患者的临床疗效.方法 将188例患者随机分为治疗组98例,治疗液中加醒脑静注射液静脉滴注;对照组90例,常规给予B族维生素,纳络酮针等治疗.结果 治疗组总有效率为93.33%,对照组总有效率78.99%,两组比较有较大差异性(P<0.01).结论 中成药醒脑静注射液结合常规治疗急性酒精中毒昏迷期疗效显著.     

纳美芬治疗急性酒精中毒的疗效观察

目的分析纳美芬在治疗急性酒精中毒昏迷期患者中的疗效和安全性。方法 2009-2012年治疗的117例急性酒精中毒昏迷期的患者随机分为对照组和治疗组,所有患者的身体健康状况、饮酒量等差异均无统计学意义。两组均采用常规治疗,对照组使用纳洛酮0.8mg静脉注射后,再使用0.8mg静滴。治疗组使用纳美芬0.2mg静脉注射后,再使用0.2mg静滴。观察两组患者用药后4h内患者的意识恢复情况及不良反应。结果治疗组患者的有效率和显著率较对照组明显。结论纳美芬在治疗急性酒精中毒中的作用显著,安全性高,不良反应少,值得临床推广。     

纳洛酮联合醒脑静治疗急性重度酒精中毒临床疗效分析

目的探讨纳洛酮联合醒脑静治疗急性重度酒精中毒的临床疗效。方法将116例急性重度酒精中毒患者随机分为对照组(56例)和观察组(60例),两组患者均接受常规治疗,同时给予对照组患者醒脑静治疗,观察组患者接受纳洛酮联合醒脑静治疗。比较两组的临床疗效及患者苏醒后临床症状。结果观察组治疗有效率显著高于对照组(88.3%vs 69.6%)(P<0.05);观察组患者清醒时间、症状缓解时间及出院时间显著早于对照组(P<0.05);观察组患者苏醒后头痛、头晕、恶心、呕吐等临床症状发生率显著低于对照组(P<0.05)。结论纳洛酮联合醒脑静治疗急性重度酒精中毒具有协同作用,疗效更为理想。     

醒脑静注射液治疗急性脑血管病昏迷80例临床观察

目的探讨醒脑静注射液治疗急性脑血管病临床疗效。方法传统西药治疗急性脑血管病昏迷患者76例（对照组）,与在西药治疗基础应用醒脑静注射液治疗的患者80例（观察组）比较。结果观察组总有效率80%,死亡率8.8%;对照组总有效率65.8%,病死率11.8%,两组差异有统计学意义（P〈0.05）。苏醒时间、GCS评分比较,观察组神经功能缺损改善明显优于对照组（P〈0.05或P〈0.01）。结论醒脑静注射液是治疗急性脑血管病昏迷有效药物,能改善昏迷、促使苏醒,值得进一步推广使用。     

纳洛酮联合醒脑静治疗急性重度酒精中毒的疗效对比观察

目的：分析纳洛酮联合醒脑静治疗急性重度酒精中毒的临床疗效.方法：回顾性分析我院2009年4月至2012年7月收治的120例急性重度酒精中毒患者的临床资料,其中,对照组50例患者在综合治疗的前提下,采用纳洛酮进行治疗,而观察组70例患者在对照组治疗的基础上采用联合醒脑静进行治疗,比较两组患者的临床疗效、苏醒时间及症状消失时间.结果：观察组患者的苏醒时间与症状消退时间分别为70.2±24.8min、247.9±48.2min,均明显低于对照组,且差异均具有统计学意义（P＜0.05）.观察组总有效率明显高于对照组,且差异具有统计学意义（P＜0.05）.结论：纳洛酮联合醒脑静治疗急性重度酒精性中毒患者具有较为确切的疗效,患者苏醒和症状消失迅速,值得临床推广应用.     

纳络酮联合醒脑静治疗急性酒精中毒疗效分析

目的观察纳络酮联合醒脑静治疗急性酒精中毒的临床疗效。方法 165例酒精中毒患者,随机分为纳络酮联合醒脑静治疗组,单用纳络酮组及对照组。观察意识恢复时间、运动恢复时间及醒后症状的发生率,并作比较。结果纳络酮联合醒脑静治疗组上述指标均明显短于其他2组（P〈0.01）。结论纳络酮联合醒脑静治疗急性酒精中毒疗效优越,值得推广。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.