共查询到20条相似文献,搜索用时 15 毫秒
1.
Ya. V. Kostin L. N. Sernov I. Ya. Moiseeva N. N. Kulikova M. V. Shmyreva Y. G. Klimovich 《Bulletin of experimental biology and medicine》2000,130(5):1113-1115
High antiarrhythmic activity of a new Russian antiarrhythmic drug quaternidine in ventricular arrhythmia was studied in 96
coronary patients by Holter monitoring, bicycle ergometry, and echocardiography. The drug had a positive impact on local kinetics
in left-ventricular ischemic myocardium and some parameters of bicycle exercise test. The preparation possesses no arrhythmogenic
effect. Experiments on 30 random-bred rats showed that the drug reduced the necrotic zone under conditions of experimental
coronary occlusion. Experiments on 14 intact cats demonstrated that quaternidine had no effect on coronary bloodflow.
Translated fromByulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 130, No. 11, pp. 581–584, November, 2000 相似文献
2.
Pathogenesis of cardiac arrhythmia was determined by EEC changes after ATP-induced complete atrioventricular block. The re-entry
mechanism underlays extrasystoles with equal coupling intervals with complexes of ventricular substitution rhythms, which
transformed into paroxysmal tachycardia with equal R—R intervals, ventricular flutter, and ventricular fibrillation. Ectopic automaticity was characterized by extrasystole unrelated
to the complexes of substitutional rhythms, which was transformed into accelerated idioventricular rhythm and asystole. During
trigger activity, the extrasystoles were associated with complexes of basic rhythm and transformed themselves into torsades
de pointes and ventricular fibrillation.
__________
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 141, No. 4, pp. 382–385, April, 2006 相似文献
3.
I. I. Ahmetov I. A. Mozhayskaya E. V. Lyubaeva O. L. Vinogradova V. A. Rogozkin 《Bulletin of experimental biology and medicine》2008,146(5):630-632
The distribution of PPARG gene allele frequencies (Pro/Ala polymorphism) was studied in sportsmen specialized in speed and force athletics. A relationship
between genotypes and human muscle transverse section area was evaluated. The PPARG Ala allele was significantly more incident in athletes than in controls, the incidence increasing with higher athletic qualification.
A hypertrophic effect of PPARG Ala allele on muscle fibers was detected. Hence, the PPARG Pro12Ala polymorphism is associated with human motor activity.
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 146, No. 11, pp. 567–569, November, 2008 相似文献
4.
F. Kolar J. Nekar B. Ostadal L. N. Maslov D. L. Stakheev A. S. Tayurskaya Yu. B. Lishmanov 《Bulletin of experimental biology and medicine》2008,145(4):418-421
Mature Wistar rats were exposed to intermittent hypobaric hypoxia (5000 m, 6 h/day, 30 sessions). This mode of adaptation
enhanced heart tolerance to the arrhythmogenic action of 45-min coronary occlusion, but does not affect the infarction size/risk
area ratio. In some series, the rats were exposed to more severe intermittent hypobaric hypoxia (7000 m, 8 h/day, 6 weeks)
followed by 20-min coronary occlusion and 3-h reperfusion one day after the last hypoxia session. In this case, adaptation
reduced the infarction size/risk area ratio and enhanced cardiac tolerance to the arrhythmogenic effect of reperfusion, but
had no effect on the incidence of ventricular arrhythmia during ischemia. We found that the cardioprotective and antiarrhythmic
effects of adaptation to an altitude of 7000 m and the antiarrhythmic effect of 5000-m adaptation were mediated via activation
of KATP channels.
__________
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 145, No. 4, pp. 395–398, April, 2008 相似文献
5.
Yu. B. Lishmanov B. Yu. Kondrat’ev L. N. Maslov N. V. Naryzhnaya 《Bulletin of experimental biology and medicine》1997,123(2):130-132
Acute cold exposure (−20°C, 4 h) induces a transient decrease in the ventricular fibrillation threshold without morphological
and radionuclide signs of irreversible damage to cardiomyocytes. The agonist of μ-receptors DAGO, which reduces adrenoreactivity
of the myocardium, prevents the decrease in the ventricular fibrillation threshold induced by acute cold exposure.
Translated fromByulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 123, No. 2, pp. 154–157, February, 1997 相似文献
6.
Ashish Kumar Sharma Kunal Kishore Divya Sharma B.P Srinivasan Shyam Sunder Agarwal Ashok Sharma Santosh Kumar Singh Samir Gaur Vijay Singh Jatav 《生物医学研究杂志》2011,25(4):280-286
The present study investigated the antiarrhythmic activity of alcoholic extract of Tinospora cordifolia (T.cordifolia) in CaCl 2 induced arrhythmia.CaCl 2 (25 mg/kg) was administered by intravenous infusion (iv) to produce arrhythmia in rats.The animals were then treated with T.cordifolia extract (150,250,and 450 mg/kg) and verapamil (5 mg/kg,iv).Lead II electrocardiogram was monitored.Plasma calcium,sodium and potassium levels were measured.In CaCl 2 induced arrhythmia,heart rate was decreased by 41.10%,T.cordifolia at 150,300,and 450 mg/kg decreased the heart rate by 26.30%,29.16%,and 38.29%,respectively,and verapamil reduced the heart rate by 9.70% compared to the normal group.The PQRST waves were normalized and atrial and ventricular fibrillation was controlled in rats treated with verapamil and T.cordifolia.CaCl 2 increased calcium and sodium levels and decreased potassium levels in blood.T.cordifolia dose-dependently decreased calcium and sodium levels and increased potassium levels.Hence,T.cordifolia can be used in antiarrhythmic clinical settings and beneficial in atrial and ventricular fibrillation and flutter and may be indicated in ventricular tachyarrhythmia. 相似文献
7.
D. S. Ugdyzhekova Y. G. Davydova L. A. Maimeskulova R. Mechoulam 《Bulletin of experimental biology and medicine》2000,130(5):1087-1089
Intravenous injection of the selective cannabinoid receptor agonist HU-210 in doses of 0.05 and 0.25 mg/kg increased heart
resistance to arrhythmogenic effects of epinephrine, while intracerebroventricular infusion of this substance had no effect
on the incidence of epinephrine-induced arrhythmia. The selective antagonist of type I cannabinoid receptors SR141716A in
a dose of 3 mg/kg and ganglion blocker hexamethonium in a dose of 10 mg/kg did not modify the antiarrhythmic effect of HU-210.
This effect of HU-210 is probably related to activation of type II peripheral cannabinoid receptors.
Translated fromByulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 130, No. 11, pp. 552–554, November, 2000 相似文献
8.
A. M. Plotnikova Z. T. Shulgau T. M. Plotnikova O. I. Aliev N. I. Kulesh N. P. Mischenko S. A. Fedoreyev 《Bulletin of experimental biology and medicine》2009,147(2):204-207
Antithrombogenic and antiplatelet effects of a new drug, containing isoflavonoids (extract from the wood of Maackia amyrensis, a Far Eastern plant), were studied. A course (200 mg/kg intragastrically during 14 days) of Maackia amyrensis extract prevented intravascular clotting, initiated by application of 10% iron chloride solution on the vessel. The drug
increased antiaggregant activity of the vascular wall and potentiated endothelium-dependent vasodilatation in ovariectomied
rats. The reference drug ethinylestradiol (25 μg/kg intragastrically during 14 days) potentiated the antiaggregant effect
of the endothelium, but was inferior to Maackia amyrensis extract in the capacity to induce endothelium-dependent vasodilatation in ovariectomied rats.
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 147, No. 2, pp. 164-167, February, 2009 相似文献
9.
Matyushin AI Kaverina NV Shimanovskii NL Turilova AI 《Bulletin of experimental biology and medicine》2006,141(3):337-338
Estrone, estriol, and estradiol valerate exhibited antiarrhythmic activity in rats with aconitine-induced arrhythmia. Estrone
was most effective in this respect.
__________
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 141, No. 3, pp. 312–314, March, 2006 相似文献
10.
11.
P. A. Galenko-Yaroshevskii A. I. Khankoeva A. V. Uvarov A. Yu. Reznikov D. S. Galygo V. V. Bartashevich 《Bulletin of experimental biology and medicine》1996,122(6):1225-1227
The antiarrhythmic activity of befol (an isotoxic dose) is higher than (or comparable to) that of lidocaine and bonnecor in
atrial and ventricular arrhythmias induced by acute ischemia, reperfusion, myocardial infarction, or ouabain treatment. In
epinephrine-induced arrhythmia, befol is inferior to these drugs (except lidocaine) in activity and range of therapeutic action.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 12, pp. 665–668, December, 1996 相似文献
12.
Jean-Lou Justine 《Acta parasitologica / Witold Stefański Institute of Parasitology, Warszawa, Poland》2008,53(4):339-343
Pseudorhabdosynochus inversus sp. nov. is described from three specimens found in a halfmoon grouper, Epinephelus rivulatus, from the external slope of the barrier reef, New Caledonia, South Pacific. The new species is characterised by the structure
of its sclerotised vagina, which resembles that of P. epinepheli (Yamaguti, 1938) but has its primary chamber inverted, and by its measurements. The diplectanid fauna of E. rivulatus shows the same pattern as in other groupers, probably belonging to a clade in which fish species harbour both an abundant
species of the ‘Pseudorhabdosynochus cupatus group’ (here P. calathus Hinsinger et Justine, 2006) and a rare species (here P. inversus).
Résumé Pseudorhabdosynochus inversus sp. nov. est décrit de trois spécimens trouvés chez un mérou demi-lune, Epinephelus rivulatus, de la pente externe du récif barriPre, Nouvelle-Calédonie, Pacifique Sud. La nouvelle espPce est caractérisée par la structure de son vagin sclérifié, qui ressemble B celui de P. epinepheli (Yamaguti, 1938) mais a sa chambre primaire inversée, et par ses mensurations. La faune des Diplectanidae de E. rivulatus montre le mLme patron que chez d.autres mérous, probablement appartenant B un clade, chez lesquels les espPces de poissons hébergent B la fois une espPce abondante du groupe ‘Pseudorhabdosynochus cupatus’ (ici P. calathus Hinsinger et Justine, 2006) et une espPce rare (ici P. inversus).相似文献
13.
M. G. Pshennikova V. I. Kuznetsov S. V. Trishkin K. B. Vinnitskaya N. T. Vorob'eva V. A. Tyabenkova T. D. Bol'shakova L. I. Vinnitskii 《Bulletin of experimental biology and medicine》1995,120(1):681-684
Rats were adapted to the continuous action of moderate immobilization stress for 1, 5, and 15 days. Thereafter the threshold
of ventricular fibrillation and the heart rate were compared with biochemical indexes of adrenergic and cholinergic regulation
of the heart, namely, catecholamine, cAMP, and cGMP content, acetylcholinesterase and choline acetyltransferase activity,
the number and affinity of cardiac muscarinic receptors, and the catecholamine content in the adrenals. The threshold of ventricular
fibrillation fell on the 1st day due to a predominance of the adrenergic regulatory effect over the cholinergic. Adaptation
for 5 days is attended by a rise of the threshold of ventricular fibrillation to the norm and by marked bradycardia, both
these shifts being abolished by atropine. Elevation of the heart's resistance to arrhythmias stems from the prevalence of
cholinergic regulation. Equilibrium between the cholinergic and adrenergic effects on the heart was found as a results of
15-day adaptation. The normal threshold of ventricular fibrillation and the increased cardiac resistance to arrhythmia were
preserved and dictated largely by adaptive changes at the cardiomycyte level.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120. N
o
7, pp. 36–39, July, 1995
Presented by G. N. Kryzhanovskii, Member of the Russian Academy of Medical Sciences 相似文献
14.
O. I. Kukushkina L. K. Fedotkina V. P. Balashov L. A. Balykova A. A. Sosunov 《Bulletin of experimental biology and medicine》1999,127(5):460-462
On the model of occlusion/reperfusion arrhythmia in cats it was shown that repeated injections of the NO-synthase inhibitor
L-NAME decreased the incidence of occlusion arrhythmias (to 40%), eliminated reperfusion-induced ventricular fibrillation,
and drastically reduced the latency of occlusion arrhythmias. A single injection of L-NAME (20 mg/kg) immediately before ligation
of the coronary artery did not decrease the incidence of occlusion and reperfusion arrhythmias.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 5, pp. 509–511, May, 1999 相似文献
15.
The nucleotide sequence of the Leucania seperata (Ls) Nucleopolyhedrovirus (LsNPV) genome has been determined and analyzed. The circular dsDNA genome contains 168041 bp,
making it the largest NPV sequenced to date. The genome has a G + C content of 48.6% and encodes 169 predicted open reading
frames (ORFs), one unique repeat region, and eight homologous repeat regions that are divided into two groups. Of the genome,
82.8% encodes predicted ORFs including five dispersal ORFs that have a large overlaps (range in 149 ∼ 390 bp) with their adjacent
ORFs, respectively such as expression factor 10, 11, 5, 2 (lef-10, lef-11, lef-5, lef-2), and telokin-like protein-20 (tlp-20); 4.4% is in repeat regions; the remaining 12.8% of the genome comprises nonrepeat intergenic regions. LsNPV encodes homologues
of 133 ORFs identified previously in other baculoviruses. Other than 10 ‘baculovirus repeat ORFs’ (bro) and two ‘inhibitor of apoptosis’ (iap) genes, no duplicated ORFs were found. LsNPV lacks a homologue of the ubiquitin gene, which has been found in all fully sequenced
baculoviruses. Iap3 and p49, two genes were proven to be inhibitors of apoptosis by experiment, and are found in the LsNPV genome. It is not found in
other baculoviruses that two kinds of inhibitors of apoptosis present in a baculovirus genome.
The GenBank accession number of the LsNPV genome sequence is AY394490. 相似文献
16.
Rodney A. Bray Jean-Lou Justine 《Acta parasitologica / Witold Stefański Institute of Parasitology, Warszawa, Poland》2007,52(1):13-17
Pseudopycnadena tendu sp. nov. is described from the balistid Pseudobalistes fuscus from the waters off New Caledonia. It differs from the only other member of the genus P. fischthali Saad-Fares et Maillard, 1986, in its broad cirrus-sac, with the wide field of large gland-cells, its less nearly circular
body shape, its dorsal excretory pore, its shorter post-testicular region, its relatively larger ventral sucker and its smaller
eggs. The genus is re-defined to take these distinctions into account. Other opecoelid species reported from New Caledonia
are Allopodocotyle epinepheli (Yamaguti, 1942) from Epinephelus cyanopodus, E. fasciatus and E. merra, Cainocreadium epinepheli (Yamaguti, 1934) from E. coeruleopunctatus, E. fasciatus and Variola louti, Hamacreadium mutabile (Linton, 1910) from Lutjanus fulviflamma and L. kasmira, Helicometra epinepheli Yamaguti, 1934 from E. fasciatus and E. merra, Orthodena tropica Durio et Manter, 1968 from Lethrinus lentjan, Pacificreadium serrani (Nagaty et Abdel-Aal, 1962) from Plectropomus leopardus and Pseudoplagioporus interruptus Durio et Manter, 1968 from Lethrinus rubrioperculatus.
Résumé Pseudopycnadena tendu sp. nov. est décrit du baliste Pseudobalistes fuscus pêché en Nouvelle-Calédonie. L’espèce diffère du seul autre membre du genre, P. fischthali Saad-Fares et Maillard, 1986, par son sac du cirre plus épais avec un champ large de cellules glandulaires, sa forme du corps presque circulaire, son pore excréteur dorsal, sa partie post-testiculaire plus courte, sa ventouse ventrale relativement plus grande et ses œufs plus petits. Le genre est redéfini pour prendre en compte ces distinctions. D’autres Opecoelidae sont mentionnés de Nouvelle-Calédonie: Allopodocotyle epinepheli (Yamaguti, 1942) de Epinephelus cyanopodus, E. fasciatus et E. merra, Cainocreadium epinepheli (Yamaguti, 1934) de E. coeruleopunctatus, E. fasciatus et Variola louti, Hamacreadium mutabile (Linton, 1910) de Lutjanus fulviflamma et L. kasmira, Helicometra epinepheli Yamaguti, 1934 de E. fasciatus et E. merra, Orthodena tropica Durio et Manter, 1968 de Lethrinus lentjan, Pacificreadium serrani (Nagaty et Abdel-Aal, 1962) de Plectropomus leopardus et Pseudoplagioporus interruptus Durio et Manter, 1968 de Lethrinus rubrioperculatus.相似文献
17.
L. N. Maslov Yu. B. Lishmanov A. G. Arbuzov A. V. Krylatov E. V. Budankova Yu. N. Konkovskaya V. N. Burkova E. A. Severova 《Bulletin of experimental biology and medicine》2009,147(3):331-334
A course of treatment (16 mg/kg orally during 5 days) by Aralia mandshurica or Rhodiola rosea extracts reduced the incidence of ischemic and reperfusion ventricular arrhythmias during 10-min ischemia and 10-min reperfusion.
Extracts of Eleutherococcus senticosus, Leuzea carthamoides, and Panax ginseng did not change the incidence of ischemic and reperfusion arrhythmias. Chronic treatment by aralia, rhodiola, and eleutherococcus
elevated the ventricular fibrillation threshold in rats with postinfarction cardiosclerosis. Ginseng and leuzea did not change
this parameter in rats with postinfarction cardiosclerosis.
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 147, No. 3, pp. 303–306, March, 2009 相似文献
18.
The sex comb is one of the most rapidly evolving male-specific traits in Drosophila, making it an attractive model to study sexual selection and developmental evolution. Drosophila males use their sex combs to grasp the females’ abdomen and genitalia and to spread their wings prior to copulation. To test
the role of this structure in male mating success in Drosophila melanogaster, we genetically ablated the sex comb by expressing the female-specific isoform of the sex determination gene transformer in the tarsal segments of male legs. This technique does not remove the sex comb entirely, but simply restores the morphology
of its constituent bristles to the ancestral condition found in Drosophila species that lack sex combs. Direct observations and differences in long-term insemination rates show that the loss of the
sex comb strongly reduces the ability of males to copulate with females. Detailed analysis of video recordings indicates that
this effect is not due to changes in the males’ courtship behavior. Rapid evolution of sex comb morphology may be driven either
by changes in female preferences, or by co-evolution between sex combs and female external genitalia.
Edited by Yong-Kyu Kim. 相似文献
19.
Two of the 22 presently recognised African swine fever (ASF) virus p72 genotypes are genetically homogeneous and are associated with domestic pig cycles. Of these, genotype VIII comprises just
two p72 variants, designated ‘a’ and ‘b’ in this study, and is confined to four East African countries where it has caused numerous
outbreaks between 1961 and 2001. In order to resolve relationships within this homogeneous genotype, the central variable
region (CVR) of the 9RL open reading frame of 38 viruses was characterised and the resulting dataset complemented with seven published sequences.
Phylogenetic analysis of the 45 taxa resulted in seven discrete amino acid CVR lineages (A–G). CVR lineage F, 84 amino acids
in length and spanning a 40-year period, comprised 26 isolates from Malawi, Mozambique, Zambia and Zimbabwe. The second largest
lineage (E), consisted of 10 viruses causing outbreaks over a 10-year period in Zambia, Malawi and Mozambique whilst the remaining
five lineages were country-specific and represented by four or less viruses with a maximum circulation period of three years.
A combined p72-CVR analysis resulted in eight discrete lineages corresponding to eight unique p72-CVR combinations. One of these, b–F, appears to have arisen by convergent evolution or through an intra-genotypic recombination
event, as the individual p72 and CVR gene phylogenies are incongruent. This raises the possibility of intra-genotypic recombination in ASF viruses for
the first time. However, given the repetitive nature of the CVR region, convergent evolution cannot be excluded and may be
the more likely explanation. 相似文献
20.
Methuselah is a Drosophila mutant with a 35% increased lifespan. We examined the robustness of methuselah’s sensorimotor abilities in tethered flight as a function of age in experiments designed to test visuomotor synchronization
and phototaxis in simulated flight. A total of 282 flies from different age groups (4 hours to 70 days) and genotypes (mth and w1118) were individually tethered under an infrared laser-sensor system that digitally recorded wing-beat frequency (WBF). We found
that mth has a higher average WBF throughout most of its lifespan compared to parental control flies (w1118) and develops flight ability at a younger age. Its WBF at late life, however, is not significantly different than that of
its parental control line. We further found that mth entrains during flight to motion of a visual grating significantly better than its parental line. These findings suggest
that the mth gene not only delays chronological aging but enhances sensorimotor abilities critical to survival during early and middle,
but not late life.
Edited by Yong-Kyu Kim 相似文献