依达拉奉治疗急性脑梗塞68例临床观察

目的：探讨依达拉奉治疗急性脑梗塞的临床疗效。方法：选取2013年12月至2015年12月收治的急性脑梗塞患者68例,随机分为两组各34例。对照组行常规治疗,观察组行依达拉奉治疗,对比两组治疗有效率、治疗前后 NIHSS 评分。结果：观察组总有效率高于对照组（P ＜0.05）;观察组治疗后 NIHSS 评分低于对照组（P ＜0.05）。结论：依达拉奉治疗急性脑梗塞可明显提高疗效,减轻神经功能缺损。     

依达拉奉治疗急性脑梗塞的效果观察

目的:探讨依达拉奉在治疗急性脑梗塞中的疗效及临床价值。方法:将我院近期收治的100例患者随机分为观察组和对照组各50例,对照组采用常规治疗,观察组在常规治疗的基础上使用依达拉奉治疗。结果:观察组在神经功能缺损评分方面明显优于对照组,差异具有统计学意义(P0.05)。两组在给药期间均未发生严重的不良反应。结论:依达拉奉治疗急性脑梗塞患者临床疗效显著,值得临床推广。     

依达拉奉联合尤瑞克林治疗急性脑梗塞63例临床疗效分析

目的分析依达拉奉联合尤瑞克林治疗急性脑梗塞的临床疗效。方法选择由我院确诊并收治的126例急性脑梗塞患者作为研究对象,按照数字随机分组的方法将患者分为观察组与对照组,每组各63例,对照组患者在常规治疗基础上给予应用依达拉奉治疗,观察组患者在常规治疗基础上给予依达拉奉联合尤瑞克林治疗,观察两组患者治疗前后的神经功能缺损评分,比较临床疗效。结果两组患者治疗后的NIHSS评分均较治疗前有所减少(P0.05),观察组患者治疗后的NIHSS评分及治疗总有效率均优于对照组患者(P0.05)。结论依达拉奉与尤瑞克林联合应用能够进一步提高脑梗塞的治疗效果,可在临床推广使用。     

依达拉奉治疗急性脑梗塞临床疗效观察45例

目的探讨依达拉奉治疗急性脑梗塞的临床疗效.方法90例急性脑梗塞患者随机分为依达拉奉加常规治疗组45例和常规治疗组45例,两组均于治疗14天后分别观察患者的疗效、意识状态和神经功能改善情况.结果治疗组总显效率82.22%,对照组总显效率60%(P<0.05).结论依达拉奉对急性脑梗塞有较好的治疗作用,疗效较单用常规治疗为优.     

依达拉奉治疗30例急性脑梗塞疗效观察

目的 观察依达拉奉治疗急性脑梗塞的临床疗效。方法 60例急性脑梗塞患者分为治疗组和对照组,每日均日服肠溶阿司匹林,治疗组应用依达拉奉,对照组采用葛根素等常规治疗方法,分别比较两组7天和14天的疗效。结果 依达拉奉治疗组治疗14天后神经功能缺损评分显著优于对照组（P〈0．05）,有效率为80．0％,显著高于对照组的53．3％（P〈0．05）。结论 依达拉奉治疗急性脑梗塞疗效确切。     

依达拉奉治疗急性脑梗塞100例

目的 观察依达拉奉治疗急性脑梗塞的疗效和安全性.方法 将200例急性脑梗塞患者随机分为治疗组(100例)和对照组(100例).对照组常规抗血小板及改善循环治疗.治疗组加用依达拉奉治疗.结果 治疗后2组评分均有改善,但治疗组改善更明显,与对照组比较差异有显著性.结论 依达拉奉治疗急性脑梗塞能有效改善神经功能,安全性高.     

依达拉奉治疗急性脑梗塞临床疗效观察

目的用常规药物对比，观察加用依达拉奉治疗急性脑梗塞的临床效果。方法71例急性脑梗塞患者随机分为治疗组和对照组。治疗组36例，对照纽35例。对照组用常规治疗方法（维脑路通、胞二磷胆碱等治疗），治疗组在常规治疗的基础上加用依达拉奉注射液30mg，静脉滴注，bid，2周后进行疗效评定。结果治疗组总有效率100％，显效率69．5％，其中基本痊愈10例，显著进步15例，进步11例；对照组总有效率80％，显效率343％，其中基本痊愈3例，显著进步9例，进步16例，无变化7例，两组间有显著性差异。结论依达拉奉是一种有效、安全的神经保护剂，可在急性脑梗塞的治疗中推广使用，对急性脑梗塞患者非常有益。     

依达拉奉治疗急性脑出血的临床效果分析

目的：探讨依达拉奉治疗急性脑出血的临床疗效。方法选取在我院就诊的80例急性脑出血患者，随机分为观察组、对照组，每组各40例。对照组采用常规治疗；观察组在此基础上采用依达拉奉治疗，2组疗程均为2周。治疗后对比2组患者的临床治疗效果。结果观察组总有效率明显高于对照组，差异有统计学意义（P〈0.05）。结论对急性脑出血患者采用依达拉奉治疗，疗效显著，值得临床推广应用。     

脑梗塞患者丁苯酞软胶囊联合依达拉奉的治疗效果观察

目的探讨对脑梗塞患者联合应用丁苯酞软胶囊和依达拉奉治疗的临床效果。方法选取2014年1月至2017年1月于我院诊疗的120例急性脑梗塞患者,随机分成两组。对照组给予其常规临床治疗,观察组在常规治疗之上,加以联合应用丁苯酞软胶囊和依达拉奉进行治疗,观察患者临床症状变化,并进行NIHSS评分,以对比分析不同的治疗方式下患者的诊疗有效率。结果观察组在常规治疗之上加用丁苯酞软胶囊和依达拉奉联合治疗后,有效率高达91.7%,远远优于对照组,其差异具有统计学意义(P0.01)。结论对于脑梗塞患者,联合应用丁苯酞软胶囊和依达拉奉治疗,其神经功能恢复较好,确实能提升患者的临床诊疗有效率,故推荐在脑梗塞临床治疗中优先应用。     

依达拉奉和奥扎格雷治疗急性脑梗塞的疗效观察

目的探讨依达拉奉和奥扎格雷治疗急性脑梗塞的疗效。方法选取2014年3月至2018年5月我院收治的100例急性脑梗塞患者,按照不同治疗方式将其分为对照组(n=50)和观察组(n=50),对照组患者给予依达拉奉治疗,观察组患者在对照组患者治疗基础上给予奥扎格雷治疗,观察两组患者临床疗效。结果观察组临床有效率明显高于对照组临床有效率,差异具有统计学意义(P0.05)。结论采取依达拉奉和奥扎格雷治疗急性脑梗塞临床疗效显著,能快速改善患者病症,促进患者康复。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.