Poroid汗腺腺瘤一例

报告1例Poroid汗腺腺瘤。患者女，53岁。右手背肿块2个月，无自觉症状。组织病理显示，真皮内有一境界清楚的肿瘤，由囊腔和团块组成，团块由两种细胞构成，并可见向管腔分化。免疫组化显示肿瘤细胞CK阳性，管腔CK、CK7、EMA阳性。本病是汗孔瘤的一种，和其他类型的汗孔瘤是谱系的关系。     

Aggressive digital papillary adenoma: a case report

Aggressive digital papillary adenoma has only been identified as an entity within the past six years. Only forty patients have been reported in the literature with this lesion. The lesion is found three times more commonly on the hands than on the feet. The lesion typically enlarges slowly and is asymptomatic. Patients in half of the reported cases have experienced local recurrence after initial removal. The authors present a case of aggressive digital papillary adenoma of the foot.     

血管内乳头状内皮细胞增生

报告1例血管内乳头状内皮细胞增生.患者女,42岁.左手小指近端肿物伴疼痛半年余.皮肤科检查:左手小指近端见一隆起于皮面、直径约2 cm的结节,结节表面肤色正常,硬度适中,活动度小,与皮肤无明显粘连,压痛明显.皮损组织病理检查:皮下见大的血管管腔,并从管壁伸出乳头状突起,中轴为纤维组织增生,管腔内大量红细胞,并见大量内皮细胞增生,形成网状的血管管腔,可见深染略有多形的核,但无明显的核非典型性及有丝分裂象,团块中央部位可见含铁血黄素沉积,弹性纤维染色呈阳性.免疫组化染色CD31、CD34、FⅧ阳性.组织病理诊断:血管内乳头状内皮细胞增生.     

Intravascular papillary endothelial hyperplasia: a case report

A case of intravascular papillary endothelial hyperplasia occurring in a thirty-nine-year-old woman is described. Examination of an excisional biopsy specimen showed typical changes of intravascular papillary endothelial hyperplasia. Dermatologists should be aware of this benign vascular disorder, since it resembles a low-grade angiosarcoma.     

Multiple kerato-acanthoma: a case report

A case of multiple keratoacanthomas in a 36-year-old healthy seaman is presented. Four months prior to the onset of the disease the patient had been exposed to strong sunlight. Histopathological examination gave the diagnosis of keratoacanthoma.     

Ectopic hidradenoma papilliferum: a case report and review of the literature.

Hidradenoma papilliferum is a benign, cystic, papillary tumor that occurs almost exclusively in women on the skin of the anogenital region. Nonanogenital (ectopic) hidradenoma papilliferum are rare. We describe a 72-year-old white man with an enlarging nodule in the region of the right triceps muscle; microscopic examination showed a hidradenoma papilliferum. The median age of patients with ectopic hidradenoma papilliferum is between 1 to 2 decades older than the average age range of lesion onset in patients with anogenital hidradenoma papilliferum. In contrast to anogenital hidradenoma papilliferum, nearly one half of the patients with ectopic hidradenoma papilliferum are men. Ectopic hidradenoma papilliferum occurs most frequently (60%) in the head and neck region. Eighty-five percent of cases are 1.5 cm in the greatest diameter or smaller. The race, clinical features, pathologic features, treatment, and prognosis for hidradenoma papilliferum occurring in anogenital and ectopic locations are similar.     

Mucinous hidradenoma: a report of three cases

Mucinous cutaneous adnexal tumors are an uncommon occurrence. We describe three cases of mucinous hidradenoma characterized by diffuse and prominent mucinous cell proliferation and discuss the relevant literature. The patients (two men and one woman) ranged in age from 32 to 72 years. The lesions were completely excised, and all patients were alive without evidence of disease (follow-up interval 3-4 years). Case 1 presented as a 1.3-cm eyelid nodule and histology showed a mucinous apocrine hidradenoma with a proliferation of mucinous cells and apocrine glands. Case 2, from the shoulder of a 40-year-old man, was a 2.5-cm well-circumscribed nodule composed of hyperplastic villoglandular proliferation of mucinous cells with focal squamous whorls and focal columnar glandular cells showing decapitation secretion. The tumor was also interpretated as a mucinous hidradenoma, most likely of follicular-apocrine origin. Case 3 was a 3.0-cm scalp nodule. The histology showed a mucinous clear-cell hidradenoma composed of numerous mucinous glands amidst small squamous cells with clear cytoplasm and a hyalinized fibrovascular stroma.     

Multiple condylomata lata: a case report

An unusual form of secondary syphilis was reported, characterized by multiple papules involving the intertriginous areas. The skin biopsy was performed but was nondiagnostic. Later on, serologic tests confirmed the diagnosis. This patient is presented to emphasize the importance of considering syphilis in any patient with an at-risk sexual history and popular verrucous lesions of the skin folds.     

Multiple facial cylindromas: a case report

Cylindroma is a benign skin appendageal tumor arising from pluripotent stem cells in the folliculo-sebaceous-apocrine unit. Multiple cylindromas are usually seen as a component of Brooke-Spiegler syndrome (BSS) or as the only skin lesions of familial cylindromatosis (FC). The usual site of occurrence of such tumors is the scalp. We report a case of multiple cylindromas involving the face without any other feature of BSS and no family history supporting the possibility of FC. Multiple cylindromas of 7 years duration, confirmed by histopathological examination of multiple biopsies, were seen on the face of a 70-year-old woman. There was no history of similar lesions in any of her family members. Examination of the scalp revealed no lesions. Surgical excision of the larger lesions was performed to improve the facial appearance of the patient. This case is being reported for the unusual occurrence of multiple cylindromas only on the face without any features of BSS or FC.     

多发性皮肤平滑肌瘤一例

患者,女,50岁.左颈部、背部结节伴痒痛20余年,加重10余年.20年前因"子宫肌瘤"行"子宫全切术".组织病理活检考虑毛发平滑肌瘤.根据临床表现及组织病理学检查诊断为多发性皮肤平滑肌瘤.     

多发性外毛根鞘囊肿一例

患者,男,37岁。全身多发肿物20余年,破溃伴渗出3天。行肿物切除后给予组织病理检查,符合外毛根鞘囊肿。     

多发性Spitz痣一例

患儿,男,5岁。8个月时左侧鼻部出现米粒大褐色丘疹,逐渐增大成为红褐色结节,类似皮疹于左侧面部不断发生,病理检查示：真表皮交界处及真皮内弥散性梭形痣细胞浸润,呈对称分布,痣细胞巢垂直于表皮。免疫组化示：Ki-67（〈2%-3%＋）,HMB45（＋）,S-100（＋）。     

多重自身免疫综合征一例

患者，男，67岁。因“全身起疹伴痒1周”入院。1周前，无明显诱因下胸前出现淡红色斑，随后斑上出现数枚水疱、大疱、血疱，疱壁不易破裂伴有轻度瘙痒，逐渐累及双侧腋下、大腿内侧、臀部、双小腿。3天前口腔粘膜出现溃疡，于我院就诊，诊断为大疱性类天疱疮。患者既往有银屑病病史15年，白癜风病史5年余，关节病型银屑病3年。甲状腺功能检测：甲状腺球蛋白抗体 165.60IU/ml,抗甲状腺过氧化物酶抗体 152.90IU/ml，余未见异常。甲状腺超声：甲状腺回声欠均匀，局部回声减低，呈条索样改变，提示弥漫性改变。予甲泼尼龙、环磷酰胺及丙种球蛋白、白蛋白治疗两周后病情平稳，无新发水疱。     

Poroid hidradenoma in the hand: A case report and systematic review

Poroid hidradenoma (PH) is a rare benign neoplasm of the skin appendages. There are currently no guidelines for its management, and little information available regarding the natural history, treatment options, or outcomes. Systematic literature review identified 19 cases of isolated PH. Mean age at presentation was 54 years. Male to female ratio was 3:1, and the majority of cases were in the head and neck region. One‐third of lesions were painful or tender. Sizes varied from 0.11 × 0.9 × 0.2 cm (digit) to 6 cm (presternal region). Twelve cases were treated by surgical excision, while the remainder were biopsy specimens. Follow‐up was reported in five cases, with a median follow‐up of 1 year. No cases of local invasion or spread have been reported, although there was one case of possible recurrence identified 8 years after surgical excision. The presented case is the first to identify a PH on the hand, represents the smallest lesion to date, and was successfully treated by excision. We suggest that PHs be treated by excision and followed up for 6 to 12 months. Given one case of potential (but unconfirmed) recurrence, and no report of malignant transformation, we suggest that narrow margins may be appropriate.     

多发性骨髓瘤皮肤浸润一例

47岁男性多发性骨髓瘤(multiple myeloma,MM)患者化疗期间出现皮疹,经过皮肤活检、组织病理、免疫组化等手段确定系肿瘤皮肤浸润.由此回顾相关文献,并总结MM皮肤浸润临床表现、病理特点及治疗现状.     

Multiple minute digitate hyperkeratoses: a case report

Multiple minute digitate hyperkeratoses (MMDH) is a rare familial or acquired cutaneous eruption of filiform keratoses, typically across the trunk and extremities. Histopathology, distribution, and history can distinguish it from other digitate keratoses. We describe a case of MMDH and discuss it in relation to other disseminated digitate keratoses.     

多发性小汗腺血管瘤样错构瘤一例

报道1例多发性小汗腺血管瘤样错构瘤.小汗腺血管瘤样错构瘤是一种少见的皮肤肿瘤.病理表现为增多的小汗腺结构和大量血管成分.本例患儿8岁,左前臂多发性皮下结节伴疼痛4年,近1年局部出现多汗、多毛.经组织病理检查结合临床表现,诊断为小汗腺血管瘤样错构瘤.浅层x线照射后效果不明显,后进行分次手术切除,疗效较佳.提示治疗小汗腺血管错构瘤选择适当的手术方案是可行的.