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AILA M. RISSANEN 《Journal of internal medicine》1985,218(4):355-363
ABSTRACT. Occurrence of different clinical manifestations of coronary heart disease (CHD) was assessed among the parents and siblings of 309 men with CHD (case probands), including 103 men with fatal and 100 with nonfatal myocardial infarction (MI), and 106 men with angina pectoris (AP) and among the relatives of 106 reference men. CHD was equally common among relatives of all case probands. It was four times as common in case brothers and twice as common in case sisters as in the respective reference siblings. There were differences between the various case groups as to the predominant clinical manifestation of CHD. Cardiac deaths were commonest in the sibs of men with fatal MI, and uncomplicated angina in the men with AP. The familial resemblance in the clinical manifestations of CHD suggests familial influence in the mechanisms determining the clinical expression of the disease. 相似文献
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瘦素与冠心病的关系及其机制的研究进展 总被引:3,自引:0,他引:3
瘦素 (Leptin)又称“消脂素” ,是肥胖基因 (ob)的产物 ,由哺乳动物体内的白色脂肪细胞分泌 ,在血液中有游离态、结合态两种存在形式 ,其血液浓度与机体脂肪含量成正比。瘦素分泌受到体脂含量、脂肪细胞大小的影响 ,随体内脂肪储存增加而增加。它将脂肪组织中能量储存状况的信息传递至神经中枢 ,使机体适当调整食欲 ,维持机体能量平衡 ,诱导体重下降。瘦素需要与特异的瘦素受体结合方能发挥生物学效应。瘦素及其受体基因发生突变可导致肥胖、不育和胰岛素抵抗等症状。瘦素与肥胖、胰岛素抵抗的密切关系已从大量研究中得到证实。以下就瘦素… 相似文献
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Faisal Mahmood Khan Burak Kulaksizoglu Mehmet Cilingiroglu 《Current atherosclerosis reports》2010,12(2):105-109
Depression and coronary heart disease (CHD) are significant contributors to the burden of disease in both developed and developing
countries. Although depression seems to be a marker of increased risk after the diagnosis of CHD, it is currently unclear
whether depression can be considered as an independent risk factor and whether its treatment lowers the risk. We review the
data from prominent trials and recent analyses in regard to the association of depression with CHD. We also review some of
the mechanisms that might contribute to this association. 相似文献
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瘦素与冠心病发病机制的研究进展 总被引:1,自引:0,他引:1
瘦素是肥胖基因编码的一种蛋白质产物,主要由白色脂肪组织分泌,通过与其受体结合发挥抑制食欲、减少能量摄入、增加能量消耗的生物学作用.近年来大量临床研究显示瘦素与冠心痛的发生、发展密切相关,现就瘦素在冠心病发病中的作用机制作一综述. 相似文献
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血管新生与冠心病 总被引:2,自引:0,他引:2
冠心病是冠状动脉狭窄或闭塞导致心肌缺血 ,从而影响心功能的一类疾病。冠脉搭桥和成形术等介入性治疗方法的应用 ,使部分冠心病患者的临床症状和预后得以改善 ,但相当一部分不能进行这类治疗或发生术后再狭窄的患者 ,现尚无解决办法。目前 ,缺血性血管疾病的防治研究已从单纯改善病变血管供血转向如何促进侧枝循环的建立 ,被称为心血管药物搭桥术的促血管新生疗法 ,越来越引起人们的关注。1 血管生长的主要影响因素及其作用机理血管形成 (Angiogenesis)一词是由 Hertrg于1935年在描述胎盘组织中有大量新生微血管形成时创用的 ,Folkman在… 相似文献
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同型半胱氨酸和冠心病 总被引:18,自引:0,他引:18
自从 Mc Cully[1] ( 1 969年 )提出同型半胱氨酸血症可能与动脉粥样硬化有关的观点以来 ,国内外学者围绕这一问题开展了大量的研究。近年来发现高同型半胱氨酸血症是冠心病的一个独立危险因素。现就同型半胱氨酸的代谢及与冠心病的关系综述如下 :1 同型半胱氨酸的代谢同型半胱氨酸 ( Homocysteine;Hcy)又称高半胱氨酸 ,是一种含硫氨基酸 ,是蛋氨酸的中间代谢产物。蛋氨酸是一种含硫的必需氨基酸 ,每日食物中含蛋氨酸 1~ 2 g。成人每日所需蛋氨酸量为 0 .9g。蛋氨酸在三磷酸腺苷 ( ATP)参与下先形成 S-腺苷蛋氨酸。 S-腺苷蛋氨酸在甲基… 相似文献
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冠心病是由于冠状动脉狭窄或闭塞导致心肌缺血、坏死 ,造成各种临床症状和并发症。冠状动脉血管重建 ,使许多冠心病病人的临床症状得以改善 ,也使部分病人的寿命得到延长 ,但冠状动脉介入治疗有较高的再狭窄发生率 ,而血管旁路手术后移植血管仍有进行性动脉粥样硬化性闭塞的问题。对相当一部分不能进行血管重建治疗的病人 ,目前尚无解决办法。由此提出了促血管新生治疗的问题 ,即有无可能通过某些药物的治疗增加有功能的冠状动脉分支或侧支循环 ,达到恢复缺血心肌血供、改善病人症状和预后的目的。1 血管新生的过程冠心病发展过程中侧支形… 相似文献
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内皮功能障碍与冠心病 总被引:10,自引:0,他引:10
阐述了内皮的主要功能 ,详细地介绍了近年来国外关于内皮功能障碍与冠心病方面的研究情况 ,包括动脉粥样硬化、心肌梗死、再狭窄、心律失常等。此外 ,简单介绍了内皮功能的检测方法和治疗对冠心病内皮功能的影响 ,并对未来的研究方向提出了新的思考。 相似文献
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Sidney Goldstein 《Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy》1997,11(1):219-225
Since the development of beta-adrenergic blocking agents over 30 years ago, they have been established as an important therapeutic modality in the treatment of coronary heart disease. This article reviews the role of beta-blockers in the treatment of hypertension, angina, acute myocardial infarction, and heart failure. A number of multicenter studies indicate that beta-blockers have an important effect in decreasing morbidity and mortality in patients with hypertension and appear to have a relatively increased importance in elderly patients with hypertension. Although their long-term effects on the mortality of angina pectoris have not been fully investigated, investigations indicate that, compared with other drugs, beta-adrenergic blocking agents significantly decrease the frequency and duration of angina pectoris. The largest use of these drugs has been examined in the treatment of acute myocardial infarction. Two major trials, the Norwegian Timolol Trial and the Beta Blocker Heart Attack Trial, confirm the long-term benefit in patients following acute myocardial infarction. Their use in heart failure is under close investigation following a series of preliminary studies suggesting they may decrease mortality risk. Although the tolerability of these drugs has been questioned, careful examination of clinical trials indicate that they are relatively well tolerated. These observations emphasize the importance of beta-adrenergic blocking agents in hypertension, angina, and acute myocardial infarction and speak to a wider clinical use of these drugs. 相似文献