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R. Madhavan M.D. Ishwar C. Verma M.R.C.P. M.A.M.S. Ramesh K. Puri M.D. D.C.H. Panna Choudhury M.D. D.C.H. 《Indian journal of pediatrics》1981,48(5):593-598
Nineteen cases of Indian childhood cirrhosis (ICC) were studied for determining prognostic indicators. Lower serum bilirubin
and high serum alkaline phosphatase were associated with good prognosis. Mere presence of hyaline did not influence the clinical
and biochemical parameters, however excess hyaline formation was associated with rapidly deteriorating course. Extent of reticulin
condensation had no specific significance, but extensive fibrosis was associated with low serum alkaline phosphatase level
and shorter survival period. There were six survivors in the study with a follow up upto 26 months and repeat liver biopsies
in most of them showed very little changes. 相似文献
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Fifty five histopathologically proved cases of Indian childhood cirrhosis (ICC) were studied for the effect of oral zinc oxide/zinc
sulphate therapy both in doses of 120 mg/day. Twenty six patients were given zinc oxide, 19 were given zinc sulphate and 10
cases served as control. Serum zinc was estimated by atomic absorption spectrophotometer (ASS). Serum zinc was low in all
the stages of ICC and was directly related to the severity of the disease. Serum zinc was 72±11μg/dl in stage I; 65±14μg/dl
in stage II; 57±18 μg/dl in stage III compared with 123±23μg/dl in normal children. Inspite of oral zinc therapy clinical
condition and liver histopathology advanced in all patients and they expired due to hepatic coma. It is concluded that hypozincemia
in ICC is a nonspecific finding and zinc therapy has no role in its management.
This study was carried out by research grant from Medical Research Center, Bombay Hospital Trust, Bombay—20. 相似文献
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Veena Kalra M.D. P. U. S. Sharma Ph.D. S. Roy M.D. O. P. Ghai M.D. F.A.M.S. 《Indian journal of pediatrics》1980,47(6):475-479
In fifteen patients with Indian childhood cirrhosis (I.C.C.) total lactic dehydrogenase (LDH) activity was increased as compared
with controls (P<0.001). The isoenzyme pattern in I.C.C. patients was quite distinctive from that observed in normal controls
and in patients with acute viral hepatitis. In I.C.C. there was a two fold increase in LDH isoenzyme-1, and a decrease in
LDH-2 and LDH-4. Sixty per cent patients with I.C.C. had abnormal bands between LDH-1 and 2 and LDH-2 and 3. Siblings of the
patients with I.C.C. had normal total LDH activity, and showed double ringed bands in the region of LDH 1–3. The abnormal
bands in patients of I.C.C. are explained on the basis of hybridization of LDH with other serum components. 相似文献
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Histopathological studies of liver cell showing necrosis, parenchymal cell injury and microsomal cell damage are known to
affect membrane bound enzymes such as gamma-glutamyl transpeptidase (GGTP), alkaline phosphatase (AP) and 5′-nucleotidase
(5′-NT). The significant rise in GGTP, AP and 5′-NT indicates the damage of microsomes of parenchymal cell in Indian Childhood
Cirrhosis (ICC) patients. SGPT/AP ratio may be an index for distinguishing ICC with other liver diseases. The isoenzyme pattern
of GGTP in sera of control and ICC subjects have one band prominent activity. Similarly biopsy samples of control and ICC
subjects show one prominent band of GGTP activity. The appearance of isoenzyme of GGTP in blood circulation is an index of
microsome damage, cell necrosis and parenchymal cell injury. The isoenzyme pattern of GGTP could be a diagnostic test for
ICC. 相似文献
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R. Trollmann D. Neureiter T. Lang H. G. Dörr R. Behrens 《European journal of pediatrics》1999,158(5):375-378
We report on a 3.8-year-old German girl who presented with signs of subacute liver failure based on a 4-month history. Investigations
done before admission excluded infectious, metabolic and immunological diseases. Laboratory findings were increased values
of aminotransferases, hyperbilirubinaemia, hyperammonaemia and deteriorated plasmatic coagulation. Caeruloplasmin and serum
copper concentrations were normal; however, urinary copper excretion was elevated (80 μg/l). Liver biopsy showed a micronodular
liver cirrhosis and an extremely high liver copper concentration (1400 μg/g dry weight). Epidemiological investigations revealed
an elevated copper concentration (8645 μg/l, normal: <2000) and a low pH value (6.3) of the drinking water supplied by copper
pipes. The girl had been exposed to copper-contaminated drinking water since the age of 2 years.
Conclusion Laboratory, histopathological findings and a proven chronic copper intoxication lead to the diagnosis of Indian childhood
cirrhosis in a German girl. Whereas this disease is mostly described in patients with increased copper intake in infancy,
our patient developed toxic liver cirrhosis with relatively late copper exposure. Indian childhood cirrhosis should be considered
in the differential diagnosis of early childhood liver cirrhosis.
Received: 4 February 1998 / Accepted in revised form: 16 July 1998 相似文献
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Nine histopathologically proved cases of ICC were treated with the immunopotentiating agent levamisole. Equal number of ICC
patients were on steroid treatment and served as controls. Fatal outcome was invariable in both groups. The duration of treatment
i.e. from beginning of treatment to death did not differ in the two groups. It is concluded that levamisole in the doses given
has no therapeutic value in ICC. 相似文献
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Summary and Conclusions Elastic tissue changes in the liver biopsy material of 49 cases of I.C.C. wsre studied using various staining reactions. The
changes in the hepatic elastica included thickening and coarsening of the elastic fibres in the walls of the blood vassels.
New elastic fibre formation was observed in an occasional and sometimes fibrosed and thickened bile duct. The significance
of these findings is briefiy discussed.
From the Department of Pathology and Bacteriology, S.P. Medical College, Bikaner (Rajasthan). 相似文献
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