全角膜羊膜覆盖和绷带型角膜接触镜用于较大翼状胬肉切除术的疗效比较

目的：针对较大翼状胬肉,采用胬肉切除、角膜缘干细胞移植联合全角膜羊膜覆盖术,或胬肉切除和角膜缘干细胞移植术后配戴绷带型角膜接触镜进行治疗,观察两种方法的临床效果。

方法：将侵及瞳孔区的较大翼状胬肉40眼随机分成两组,一组行翼状胬肉切除、角膜缘干细胞移植术联合全角膜羊膜覆盖术(羊膜组),另一组行胬肉切除和角膜缘干细胞移植术后配戴绷带型角膜接触镜(绷带镜组),每组各20眼。比较两组患者手术时间,以及术后第1、3d,1、3wk眼部舒适程度和角膜愈合情况与随访复发情况等。

结果：平均手术时间：羊膜组为61.4±5.2min,绷带镜组为34.5±2.7min,绷带镜组手术时间明显缩短,两组差异有统计学意义(P<0.05)。两组患者的眼部舒适度在术后第1d无明显差异,但在术后第3d和术后1wk,绷带镜组患者的眼部舒适度明显优于羊膜组(P<0.01),至术后3wk时两组间差异无统计学意义(P>0.05)。术后3wk时两组患者的角膜愈合率评分分别为0.85±0.18分和1.15±0.18分,两组差异无统计学意义(P=0.25)。羊膜组有1眼胬肉复发。

结论：在侵及角膜的较大翼状胬肉治疗中,胬肉切除和角膜缘干细胞移植术后联合全角膜羊膜覆盖或术后配戴绷带型角膜接触镜均有助于缓解眼部不适症状和促进角膜创面修复,使用绷带型角膜接触镜患者更舒适,治疗更便捷。     

翼状胬肉切除联合角膜干细胞移植术后配戴绷带镜的效果评价

目的：评价翼状胬肉切除联合角膜干细胞移植术后配戴绷带镜的临床效果。

方法：本研究为前瞻性分析,选择2015-08/2018-02入我院行翼状胬肉切除联合角膜干细胞移植术患者110例110眼,随机数字表法将其分为对照组和观察组各55例55眼,对照组术后常规观察,观察组术后配戴绷带镜; 采用视觉模拟评分(VAS)比较术后1、3d,1wk的疼痛情况,采用荧光素钠染色法(FL)评估角膜上皮愈合情况及并发症发生率。

结果：观察组术后1、3d,1wk VAS评分和角膜上皮愈合评分均明显低于对照组,差异均有统计学意义(P<0.05)。两组并发症发生率比较,差异无统计学意义(P>0.05)。

结论：翼状胬肉切除联合角膜干细胞移植术后配戴绷带镜有较好的应用安全性和有效性,可减轻胬肉手术后疼痛,促进上皮愈合。     

翼状胬肉切除联合自体角膜缘结膜移植术后绷带镜的应用

目的：探讨翼状胬肉切除联合自体角膜缘结膜移植术后应用角膜绷带镜的临床效果。

方法：随机对照临床试验。选取2017-11/2018-10在我院眼科接受手术治疗的原发性翼状胬肉患者92例92眼,按随机数字表法分为角膜绷带镜组和弹性绷带组,每组各46眼。两组患者均接受翼状胬肉切除联合自体角膜缘结膜移植术,术毕角膜绷带镜组患者配戴角膜接触镜,弹性绷带组患者在术毕结膜囊内涂红霉素眼膏,弹性绷带包眼。裂隙灯显微镜观察术后第1、4、7d角膜上皮创面,对角膜上皮愈合情况进行评分; 运用评价视觉模拟评分法评价术后7d疼痛情况; 运用问卷评分法评价术后7d舒适情况(包括异物感、流泪)。

结果：术后第1d和第7d两组患者角膜上皮愈合情况无明显差异,而术后第4d角膜绷带镜组患者角膜上皮愈合优于弹性绷带组(P<0.05)。此外,角膜绷带镜组患者术后7d疼痛感评分低于弹性绷带组,眼部舒适度评分高于弹性绷带组(P<0.05)。

结论：角膜绷带镜不仅可以有效促进角膜上皮愈合,还可以有效减轻疼痛,提高眼部舒适感。     

角膜绷带镜固定角膜缘干细胞移植片在原发性翼状胬肉切除术中的应用

目的：评估无缝线角膜绷带镜固定角膜缘干细胞移植片法在原发性翼状胬肉切除术中的应用效果。

方法：选取我院于2019-01/12收治的双眼原发性翼状胬肉患者25例50眼进行前瞻性临床研究，术中随机对每位患者其中1眼采用无缝线角膜绷带镜固定角膜缘干细胞移植片(A组，25眼)，另1眼采用传统缝线法固定角膜缘干细胞移植片(B组，25眼)。记录两组患眼手术时间，术后随访6mo，观察两组患眼舒适感、移植物固定稳定性、并发症及复发情况。

结果：A组平均手术时间(13.5±2.1min)明显少于B组(26.6±7.2min)。术后1d，1、2wk，1、3、6mo，A组患眼疼痛、畏光、流泪、异物感、瘙痒等不适感均低于B组，至6mo后两组不适感均消失。A组术后角膜缘干细胞移植片稳定性良好，术后1、3mo并发症发生情况均少于B组。A组未见翼状胬肉复发，B组出现翼状胬肉复发1眼。

结论：原发性翼状胬肉切除术中应用无缝线角膜绷带镜固定角膜缘干细胞移植片简单便捷、安全有效，术后舒适感好，复发率低，与传统缝线法相比可缩短手术时间，有效减轻患者的痛苦。     

角膜绷带镜对复发性翼状胬肉术后角膜上皮愈合和疼痛评分及角膜规则度的影响

目的：研究角膜绷带镜对复发性翼状胬肉患者术后角膜上皮愈合、疼痛程度评分和角膜表面规则度的影响。

方法：回顾性病例研究。将2015-09/2017-09就诊于湖州师范学院附属第一医院并行手术治疗的64例64眼复发性翼状胬肉患者,根据术后是否使用角膜绷带镜分组,A组34眼术后配戴1wk角膜绷带镜,B组30眼术后不使用角膜绷带镜。采用荧光素钠角膜染色法评价翼状胬肉患者术后1d和1wk时角膜上皮愈合程度; 通过视觉模拟评分法评估患者术后2h,1d,1wk时疼痛程度; 采用角膜地形图系统分析术前及术后1mo时角膜表面规则指数、角膜表面不对称指数和角膜散光情况。

结果：A组患者术后1d,1wk时角膜上皮愈合评分与B组相比,差异均有统计学意义(P<0.01)。A组患者术后各时间点的疼痛程度评分均明显低于B组,差异均有统计学意义(P<0.01)。A组患者术前角膜表面规则指数、角膜表面不对称指数及角膜散光与B组相比,差异无统计学意义(P>0.05),而术后1mo时角膜表面规则指数、角膜表面不对称指数及角膜散光与B组相比,差异均有统计学意义(P<0.01)。

结论：复发性翼状胬肉患者术后配戴角膜绷带镜,有助于角膜上皮愈合,减轻术后刺激症状,改善角膜表面规则度,降低术后角膜散光。     

新鲜羊膜移植联合治疗性软性角膜接触镜在治疗翼状胬肉中的应用

目的：探讨新鲜羊膜移植联合治疗性软性角膜接触镜在治疗翼状胬肉中的临床效果,并总结其临床价值。

方法：回顾性分析2010-01/2011-06在我院行翼状胬肉切除联合新鲜羊膜移植术患者200例220眼,其中100例110眼联合配戴治疗性软性角膜接触镜(试验组),其余患者作为对照组(100例110眼),并对两组患者术后的临床效果进行比较分析。

结果：对照组术后角膜上皮修复时间为2～7(平均3.8)d,术后随访观察6～18mo,有9眼复发,复发率为8.2%; 试验组术后角膜上皮修复时间为1～5(平均2.5)d,随访观察6～18mo,其中有5眼复发,复发率为4.5%,两组疗效比较,差异有统计学意义(P<0.05)。同时,我们也发现配戴角膜接触镜后术后早期刺激症状明显减轻。

结论：翼状胬肉切除联合羊膜移植并配戴治疗性软性角膜接触镜的术后临床效果明显优于翼状胬肉切除联合新鲜羊膜移植术。配戴治疗性软性角膜接触镜可缩短术后角膜上皮的修复时间,可有效降低翼状胬肉术后的复发率,并且可以在一定程度上缓解术后因角膜上皮缺损而导致的畏光、流泪、异物感及眼痛等术后刺激症状。     

翼状胬肉扩大切除联合自体角膜缘干细胞移植术的效果观察

目的：观察翼状胬肉扩大切除联合自体角膜缘干细胞移植的手术效果。

方法：将59例60眼翼状胬肉患者,随机分为A,B两组,A组27例27眼行翼状胬肉单纯切除; B组32例33眼行翼状胬肉扩大切除联合自体角膜缘干细胞移植,比较两组复发率、角膜创面愈合时间、术后泪膜恢复情况。

结果：术后随访15～25(平均18±3.6)mo,A组复发8眼(30%),B组复发2眼(6%),B组术后角膜创面愈合时间较A组缩短,泪膜破裂时间长,两组差异具有统计学意义。

结论：翼状胬肉扩大切除联合自体角膜缘干细胞移植,角膜创面愈合快,术后复发率低,是一种安全、有效的方法。     

绷带型角膜接触镜在翼状胬肉切除联合新鲜羊膜移植术中的应用

目的：研究绷带型角膜接触镜在翼状胬肉切除联合新鲜羊膜移植中应用的临床效果。

方法：采用前瞻性对照病例研究,观察2016-01/06在沈阳何氏眼科医院接受翼状胬肉切除联合新鲜羊膜移植的患者600例600眼(双眼翼状胬肉患者,一次手术只做1眼)。按随机数字表法随机分为试验组和对照组,每组300例300眼。试验组在手术结束时配戴绷带型角膜接触镜,术后5d取出; 对照组不做任何处理。比较两组患者术后2h,1、3、5d的疼痛度,并观察术后1a时复发率情况。

结果：两组患者术后2h,1、2、3、5d疼痛程度评分：试验组患者疼痛程度评分均较对照组显著降低,差异有统计学意义(P<0.01)。两组患者术后1a时复发率比较,差异无统计学意义(P>0.05)。

结论：绷带型角膜接触镜可明显减轻翼状胬肉切除术后疼痛反应,但不能明显降低翼状胬肉切除术后的复发率。     

软性角膜接触镜在翼状胬肉切除联合自体角膜缘干细胞移植术后的应用

目的：探讨翼状胬肉切除联合自体角膜缘干细胞移植术后应用软性角膜接触镜的临床效果。

方法：选择单侧翼状胬肉患者90例90眼，按照随机数字表法分为两组：观察组45例45眼翼状胬肉切除联合自体角膜缘干细胞移植术后应用软性角膜接触镜，对照组45例45眼翼状胬肉切除联合自体角膜缘干细胞移植术后不应用软性角膜接触镜。对比两组患者角膜愈合时间，术后1、3、5、7d角膜刺激症状评分，术后 24、48h两组患者疼痛程度(VAS评分)，翼状胬肉复发率。

结果：对照组角膜愈合时间(5.38±1.67d)长于观察组(3.10±1.12d)； 术后角膜刺激症状评分、VAS评分高于观察组，差异有统计学意义(P<0.05)； 两组患者翼状胬肉复发率比较差异无统计学意义(P>0.05)。

结论：翼状胬肉切除联合自体角膜缘干细胞移植术后应用软性角膜接触镜可减少创面愈合时间，减轻术后角膜刺激症状，同时对胬肉复发率无影响。     

绷带镜在翼状胬肉切除联合结膜瓣移植术后的应用

目的:探讨绷带镜在翼状胬肉切除联合结膜瓣移植术后应用的临床效果.方法:前瞻、随机、对照性病例研究.收集2015-01/2016-01在我院诊断为原发性翼状胬肉拟接受翼状胬肉切除联合结膜瓣移植术患者共110例110眼,奇数者为绷带镜组(在翼状胬肉切除联合结膜瓣移植术后给予配戴绷带镜),偶数组为对照组(仅行翼状胬肉切除联合结膜瓣移植术).术后1、3、7d时采用VAS视觉模拟量表法评估术后疼痛程度,并观察术后患者角膜刺激症状;术后3d采用角膜荧光染色法检测角膜上皮修复情况;随访患者至术后1a,统计翼状胬肉复发情况.结果:术后1d绷带镜组疼痛评分(4.13±2.06分)较对照组(5.80±1.93分)明显减轻(t=4.391,P<0.001);术后3d绷带镜组疼痛评分(2.09±1.36分)较对照组(3.65±1.65分)明显减轻(t=5.422,P<0.001);术后7d绷带镜组和对照组疼痛评分无统计学差异(t=1.295,P=0.198).术后1d和3d时,绷带镜组刺激症状均较对照组减轻(P<0.05),而术后7d时绷带镜组与对照组比较无统计学差异(P=0.052).术后3d时角膜荧光染色面积,绷带镜组(0.33±0.37mm2)较对照组(2.73±2.21mm2)明显减小(t=7.921,P<0.001).术后1a翼状胬肉复发率,绷带镜组与对照组比较无统计学差异(P=1.000).结论:翼状胬肉切除联合结膜瓣移植术后配戴角膜绷带镜可以有效减轻患者术后疼痛和刺激症状,加速角膜上皮愈合,明显提高患者术后舒适度.     

针刺分离及针拨断线并结膜下注射5-Fu治疗青光眼术后早期无滤泡的高眼压

Objective To investigate the efficacy of bleb needle revision and suture cut with 5-FU subconjuctival injection near the bleb in reviving earlier non-filtering blebs with high lOP after glaucoma filtra-tion surgery. Methods Eighteen eyes of earlier non-filtering blebs with high lOP after glaneoma filtration surgery were treated with the technique of bleb needle separating adherence and cutting the suture of seleral flap with 5-FU subconjuctival injection near the bleb. Results Eleven eyes needed only once needle revision and suture cut,4 eyes repeated the therapeutics and 3 eyes failed at once. With 6-month follow-up,the IOP of 10 eyes were below 21 mmHg without any anti-glancoma drugs, 2 eyes needed adding 1-2 kinds of anti-glaucoma drugs, 1 eye needed 3 kinds of drugs,and 2 eyes needed re-operation to control the IOP below 21mmHg.With 12-month follow-up,the IOP of 8 eyes were below 21mmHg without any anti-glaucoma drugs,3 eyes needed adding 1-2 kinds of anti-glancoma drugs,2 eyes without follow-up. The mean IOP was 29.4±9.4mmHg before the treatment and that was 14.5±5.7mmHg after 6 months of the treatment,the difference was significant (P< 0.01 ). Conelusion It is safe and effective to treat earlier non-filtering blebs with high IOP after glaucoma filtration surgery with needle revision and suture cut combined with subconjunctival injection with 5-Fu, and it can be used as the routine method to treat the complication of earlier non-filtering blebs with high IOP.     

针刺分离及针拨断线并结膜下注射5-Fu治疗青光眼术后早期无滤泡的高眼压

Objective To investigate the efficacy of bleb needle revision and suture cut with 5-FU subconjuctival injection near the bleb in reviving earlier non-filtering blebs with high lOP after glaucoma filtra-tion surgery. Methods Eighteen eyes of earlier non-filtering blebs with high lOP after glaneoma filtration surgery were treated with the technique of bleb needle separating adherence and cutting the suture of seleral flap with 5-FU subconjuctival injection near the bleb. Results Eleven eyes needed only once needle revision and suture cut,4 eyes repeated the therapeutics and 3 eyes failed at once. With 6-month follow-up,the IOP of 10 eyes were below 21 mmHg without any anti-glancoma drugs, 2 eyes needed adding 1-2 kinds of anti-glaucoma drugs, 1 eye needed 3 kinds of drugs,and 2 eyes needed re-operation to control the IOP below 21mmHg.With 12-month follow-up,the IOP of 8 eyes were below 21mmHg without any anti-glaucoma drugs,3 eyes needed adding 1-2 kinds of anti-glancoma drugs,2 eyes without follow-up. The mean IOP was 29.4±9.4mmHg before the treatment and that was 14.5±5.7mmHg after 6 months of the treatment,the difference was significant (P< 0.01 ). Conelusion It is safe and effective to treat earlier non-filtering blebs with high IOP after glaucoma filtration surgery with needle revision and suture cut combined with subconjunctival injection with 5-Fu, and it can be used as the routine method to treat the complication of earlier non-filtering blebs with high IOP.     

针刺分离及针拨断线并结膜下注射5-Fu治疗青光眼术后早期无滤泡的高眼压

Objective To investigate the efficacy of bleb needle revision and suture cut with 5-FU subconjuctival injection near the bleb in reviving earlier non-filtering blebs with high lOP after glaucoma filtra-tion surgery. Methods Eighteen eyes of earlier non-filtering blebs with high lOP after glaneoma filtration surgery were treated with the technique of bleb needle separating adherence and cutting the suture of seleral flap with 5-FU subconjuctival injection near the bleb. Results Eleven eyes needed only once needle revision and suture cut,4 eyes repeated the therapeutics and 3 eyes failed at once. With 6-month follow-up,the IOP of 10 eyes were below 21 mmHg without any anti-glancoma drugs, 2 eyes needed adding 1-2 kinds of anti-glaucoma drugs, 1 eye needed 3 kinds of drugs,and 2 eyes needed re-operation to control the IOP below 21mmHg.With 12-month follow-up,the IOP of 8 eyes were below 21mmHg without any anti-glaucoma drugs,3 eyes needed adding 1-2 kinds of anti-glancoma drugs,2 eyes without follow-up. The mean IOP was 29.4±9.4mmHg before the treatment and that was 14.5±5.7mmHg after 6 months of the treatment,the difference was significant (P< 0.01 ). Conelusion It is safe and effective to treat earlier non-filtering blebs with high IOP after glaucoma filtration surgery with needle revision and suture cut combined with subconjunctival injection with 5-Fu, and it can be used as the routine method to treat the complication of earlier non-filtering blebs with high IOP.     

针刺分离及针拨断线并结膜下注射5-Fu治疗青光眼术后早期无滤泡的高眼压

Objective To investigate the efficacy of bleb needle revision and suture cut with 5-FU subconjuctival injection near the bleb in reviving earlier non-filtering blebs with high lOP after glaucoma filtra-tion surgery. Methods Eighteen eyes of earlier non-filtering blebs with high lOP after glaneoma filtration surgery were treated with the technique of bleb needle separating adherence and cutting the suture of seleral flap with 5-FU subconjuctival injection near the bleb. Results Eleven eyes needed only once needle revision and suture cut,4 eyes repeated the therapeutics and 3 eyes failed at once. With 6-month follow-up,the IOP of 10 eyes were below 21 mmHg without any anti-glancoma drugs, 2 eyes needed adding 1-2 kinds of anti-glaucoma drugs, 1 eye needed 3 kinds of drugs,and 2 eyes needed re-operation to control the IOP below 21mmHg.With 12-month follow-up,the IOP of 8 eyes were below 21mmHg without any anti-glaucoma drugs,3 eyes needed adding 1-2 kinds of anti-glancoma drugs,2 eyes without follow-up. The mean IOP was 29.4±9.4mmHg before the treatment and that was 14.5±5.7mmHg after 6 months of the treatment,the difference was significant (P< 0.01 ). Conelusion It is safe and effective to treat earlier non-filtering blebs with high IOP after glaucoma filtration surgery with needle revision and suture cut combined with subconjunctival injection with 5-Fu, and it can be used as the routine method to treat the complication of earlier non-filtering blebs with high IOP.     

针刺分离及针拨断线并结膜下注射5-Fu治疗青光眼术后早期无滤泡的高眼压

Objective To investigate the efficacy of bleb needle revision and suture cut with 5-FU subconjuctival injection near the bleb in reviving earlier non-filtering blebs with high lOP after glaucoma filtra-tion surgery. Methods Eighteen eyes of earlier non-filtering blebs with high lOP after glaneoma filtration surgery were treated with the technique of bleb needle separating adherence and cutting the suture of seleral flap with 5-FU subconjuctival injection near the bleb. Results Eleven eyes needed only once needle revision and suture cut,4 eyes repeated the therapeutics and 3 eyes failed at once. With 6-month follow-up,the IOP of 10 eyes were below 21 mmHg without any anti-glancoma drugs, 2 eyes needed adding 1-2 kinds of anti-glaucoma drugs, 1 eye needed 3 kinds of drugs,and 2 eyes needed re-operation to control the IOP below 21mmHg.With 12-month follow-up,the IOP of 8 eyes were below 21mmHg without any anti-glaucoma drugs,3 eyes needed adding 1-2 kinds of anti-glancoma drugs,2 eyes without follow-up. The mean IOP was 29.4±9.4mmHg before the treatment and that was 14.5±5.7mmHg after 6 months of the treatment,the difference was significant (P< 0.01 ). Conelusion It is safe and effective to treat earlier non-filtering blebs with high IOP after glaucoma filtration surgery with needle revision and suture cut combined with subconjunctival injection with 5-Fu, and it can be used as the routine method to treat the complication of earlier non-filtering blebs with high IOP.     

针刺分离及针拨断线并结膜下注射5-Fu治疗青光眼术后早期无滤泡的高眼压

Objective To investigate the efficacy of bleb needle revision and suture cut with 5-FU subconjuctival injection near the bleb in reviving earlier non-filtering blebs with high lOP after glaucoma filtra-tion surgery. Methods Eighteen eyes of earlier non-filtering blebs with high lOP after glaneoma filtration surgery were treated with the technique of bleb needle separating adherence and cutting the suture of seleral flap with 5-FU subconjuctival injection near the bleb. Results Eleven eyes needed only once needle revision and suture cut,4 eyes repeated the therapeutics and 3 eyes failed at once. With 6-month follow-up,the IOP of 10 eyes were below 21 mmHg without any anti-glancoma drugs, 2 eyes needed adding 1-2 kinds of anti-glaucoma drugs, 1 eye needed 3 kinds of drugs,and 2 eyes needed re-operation to control the IOP below 21mmHg.With 12-month follow-up,the IOP of 8 eyes were below 21mmHg without any anti-glaucoma drugs,3 eyes needed adding 1-2 kinds of anti-glancoma drugs,2 eyes without follow-up. The mean IOP was 29.4±9.4mmHg before the treatment and that was 14.5±5.7mmHg after 6 months of the treatment,the difference was significant (P< 0.01 ). Conelusion It is safe and effective to treat earlier non-filtering blebs with high IOP after glaucoma filtration surgery with needle revision and suture cut combined with subconjunctival injection with 5-Fu, and it can be used as the routine method to treat the complication of earlier non-filtering blebs with high IOP.     

针刺分离及针拨断线并结膜下注射5-Fu治疗青光眼术后早期无滤泡的高眼压

Objective To investigate the efficacy of bleb needle revision and suture cut with 5-FU subconjuctival injection near the bleb in reviving earlier non-filtering blebs with high lOP after glaucoma filtra-tion surgery. Methods Eighteen eyes of earlier non-filtering blebs with high lOP after glaneoma filtration surgery were treated with the technique of bleb needle separating adherence and cutting the suture of seleral flap with 5-FU subconjuctival injection near the bleb. Results Eleven eyes needed only once needle revision and suture cut,4 eyes repeated the therapeutics and 3 eyes failed at once. With 6-month follow-up,the IOP of 10 eyes were below 21 mmHg without any anti-glancoma drugs, 2 eyes needed adding 1-2 kinds of anti-glaucoma drugs, 1 eye needed 3 kinds of drugs,and 2 eyes needed re-operation to control the IOP below 21mmHg.With 12-month follow-up,the IOP of 8 eyes were below 21mmHg without any anti-glaucoma drugs,3 eyes needed adding 1-2 kinds of anti-glancoma drugs,2 eyes without follow-up. The mean IOP was 29.4±9.4mmHg before the treatment and that was 14.5±5.7mmHg after 6 months of the treatment,the difference was significant (P< 0.01 ). Conelusion It is safe and effective to treat earlier non-filtering blebs with high IOP after glaucoma filtration surgery with needle revision and suture cut combined with subconjunctival injection with 5-Fu, and it can be used as the routine method to treat the complication of earlier non-filtering blebs with high IOP.     

针刺分离及针拨断线并结膜下注射5-Fu治疗青光眼术后早期无滤泡的高眼压

Objective To investigate the efficacy of bleb needle revision and suture cut with 5-FU subconjuctival injection near the bleb in reviving earlier non-filtering blebs with high lOP after glaucoma filtra-tion surgery. Methods Eighteen eyes of earlier non-filtering blebs with high lOP after glaneoma filtration surgery were treated with the technique of bleb needle separating adherence and cutting the suture of seleral flap with 5-FU subconjuctival injection near the bleb. Results Eleven eyes needed only once needle revision and suture cut,4 eyes repeated the therapeutics and 3 eyes failed at once. With 6-month follow-up,the IOP of 10 eyes were below 21 mmHg without any anti-glancoma drugs, 2 eyes needed adding 1-2 kinds of anti-glaucoma drugs, 1 eye needed 3 kinds of drugs,and 2 eyes needed re-operation to control the IOP below 21mmHg.With 12-month follow-up,the IOP of 8 eyes were below 21mmHg without any anti-glaucoma drugs,3 eyes needed adding 1-2 kinds of anti-glancoma drugs,2 eyes without follow-up. The mean IOP was 29.4±9.4mmHg before the treatment and that was 14.5±5.7mmHg after 6 months of the treatment,the difference was significant (P< 0.01 ). Conelusion It is safe and effective to treat earlier non-filtering blebs with high IOP after glaucoma filtration surgery with needle revision and suture cut combined with subconjunctival injection with 5-Fu, and it can be used as the routine method to treat the complication of earlier non-filtering blebs with high IOP.     

针刺分离及针拨断线并结膜下注射5-Fu治疗青光眼术后早期无滤泡的高眼压

Objective To investigate the efficacy of bleb needle revision and suture cut with 5-FU subconjuctival injection near the bleb in reviving earlier non-filtering blebs with high lOP after glaucoma filtra-tion surgery. Methods Eighteen eyes of earlier non-filtering blebs with high lOP after glaneoma filtration surgery were treated with the technique of bleb needle separating adherence and cutting the suture of seleral flap with 5-FU subconjuctival injection near the bleb. Results Eleven eyes needed only once needle revision and suture cut,4 eyes repeated the therapeutics and 3 eyes failed at once. With 6-month follow-up,the IOP of 10 eyes were below 21 mmHg without any anti-glancoma drugs, 2 eyes needed adding 1-2 kinds of anti-glaucoma drugs, 1 eye needed 3 kinds of drugs,and 2 eyes needed re-operation to control the IOP below 21mmHg.With 12-month follow-up,the IOP of 8 eyes were below 21mmHg without any anti-glaucoma drugs,3 eyes needed adding 1-2 kinds of anti-glancoma drugs,2 eyes without follow-up. The mean IOP was 29.4±9.4mmHg before the treatment and that was 14.5±5.7mmHg after 6 months of the treatment,the difference was significant (P< 0.01 ). Conelusion It is safe and effective to treat earlier non-filtering blebs with high IOP after glaucoma filtration surgery with needle revision and suture cut combined with subconjunctival injection with 5-Fu, and it can be used as the routine method to treat the complication of earlier non-filtering blebs with high IOP.     

针刺分离及针拨断线并结膜下注射5-Fu治疗青光眼术后早期无滤泡的高眼压

Objective To investigate the efficacy of bleb needle revision and suture cut with 5-FU subconjuctival injection near the bleb in reviving earlier non-filtering blebs with high lOP after glaucoma filtra-tion surgery. Methods Eighteen eyes of earlier non-filtering blebs with high lOP after glaneoma filtration surgery were treated with the technique of bleb needle separating adherence and cutting the suture of seleral flap with 5-FU subconjuctival injection near the bleb. Results Eleven eyes needed only once needle revision and suture cut,4 eyes repeated the therapeutics and 3 eyes failed at once. With 6-month follow-up,the IOP of 10 eyes were below 21 mmHg without any anti-glancoma drugs, 2 eyes needed adding 1-2 kinds of anti-glaucoma drugs, 1 eye needed 3 kinds of drugs,and 2 eyes needed re-operation to control the IOP below 21mmHg.With 12-month follow-up,the IOP of 8 eyes were below 21mmHg without any anti-glaucoma drugs,3 eyes needed adding 1-2 kinds of anti-glancoma drugs,2 eyes without follow-up. The mean IOP was 29.4±9.4mmHg before the treatment and that was 14.5±5.7mmHg after 6 months of the treatment,the difference was significant (P< 0.01 ). Conelusion It is safe and effective to treat earlier non-filtering blebs with high IOP after glaucoma filtration surgery with needle revision and suture cut combined with subconjunctival injection with 5-Fu, and it can be used as the routine method to treat the complication of earlier non-filtering blebs with high IOP.