Osteopetrosis is Associated With an Increased Risk for Intraoperative Periprosthetic Fracture in Total Hip Arthroplasty but not in Total Knee Arthroplasty

BackgroundOsteopetrosis is a rare, inherited disorder in which bone remodels to become pathologically dense. There has been a paucity of data evaluating medical and surgical complications following total hip arthroplasty (THA) and total knee arthroplasty (TKA) in this patient population. The objective of this study was to evaluate osteopetrosis as a potential risk factor for medical and surgical complications following THA and TKA.MethodsPatients who had a diagnosis of osteopetrosis and underwent THA or TKA from 2010 to 2020 were identified in a national database. A total of 534 THA and 972 TKA patients who had osteopetrosis were identified and compared with matched cohorts of 2,670 and 4,860 patients, respectively. The rates of postoperative medical and surgical complications, hospital readmissions, and emergency room visits were calculated. In addition, reimbursements and lengths of stay were determined. Osteopetrosis patients were then compared to a 5:1 matched cohort without osteopetrosis using logistic regression analyses to control for additional confounding factors.ResultsThe osteopetrosis THA group had a substantially higher incidence of intraoperative periprosthetic fracture compared to the matched cohort (1.12% versus 0.19%, Odds Ratio 5.88, P = .005). Patients who had a history of osteopetrosis were not found to be at a significantly increased risk for other investigated medical or surgical complications compared to matched controls following THA or TKA.ConclusionPatients who had a history of osteopetrosis undergoing elective primary THA are associated with a significantly increased risk for intraoperative periprosthetic fracture. Patients with a history of osteopetrosis undergoing elective primary TKA were not found to be at an increased risk for any of the investigated complications.     

Total hip arthroplasty in osteopetrosis using computer-assisted fluoroscopic navigation

Hybrid total hip arthroplasty with computer-assisted fluoroscopic navigation was performed on a patient with osteoarthritis due to an autosomal dominant form of osteopetrosis. The surgical procedures were difficult because the bone was extremely hard and brittle with obliteration of the medullary cavity. Especially, preparation of a femoral canal for the stem was technically challenging and required changes from a conventional surgical procedure. Therefore, we used a computer-assisted fluoroscopic navigation system to create the femoral cavity for the stem, and an accurate placement of the prosthesis was achieved. Navigation guidance can be a useful tool when performing arthroplasty in patients with hip osteoarthritis associated with osteopetrosis.     

Total Hip Arthroplasty in Patients With Osteopetrosis

BackgroundOsteopetrosis is an inherited bone disease associated with high risk of osteoarthritis and fracture non-union, which can lead to total hip arthroplasty (THA). Bone quality and morphology are altered in these patients, and there are limited data on results of THA in these patients. The goals of this study were to describe implant survivorship, clinical outcomes, radiographic results, and complications in patients with osteopetrosis undergoing primary THA.MethodsWe identified 7 patients (9 hips) with osteopetrosis who underwent primary THA between 1970 and 2017 utilizing our total joint registry. The mean age at index THA was 48 years and included two males and five females. The mean follow-up was 8 years.ResultsThe 10-year survivorship free from any revision or implant removal was 89%, with 1 revision and 1 resection arthroplasty secondary to periprosthetic femoral fractures. The 10-year survivorship free from any reoperation was 42%, with 4 additional reoperations (2 ORIFs for periprosthetic femoral fractures, 1 sciatic nerve palsy lysis of adhesions, 1 hematoma evacuation). Harris hip scores significantly increased at 5 years (P = .04). Five hips had an intraoperative acetabular fracture, and 1 had an intraoperative femur fracture. All postoperative femoral fractures occurred in patients with intramedullary diameter less than 5 mm at a level 10 cm distal to the lesser trochanter.ConclusionPrimary THA in patients with osteopetrosis is associated with good 10-year implant survivorship (89%), but a very high reoperation (58%) and periprosthetic femoral fracture rate (44%). Femoral fractures appear associated with smaller intramedullary diameters.     

Case report: A 10 years follow-up of periprosthetic femoral fracture after total hip arthroplasty in osteopetrosis

Osteopetrosis is an inherited disorder characterized by increased bone density and brittle bone quality. Degenerative changes often occur after the age of 40 in patients with osteopetrosis. Operative intervention is the primary treatment option if the clinical manifestation of secondary osteoarthritis is severe. A 44-year-old male suffering autosomal dominant osteopetrosis and progressive unilateral hip osteoarthritis required a total hip arthroplasty. However, there were several technical challenges associated with this procedure including creating a femoral medullary canal and developing a Vancouver type B2 periprosthetic femoral fracture postoperatively. To afford some experience for the management of similar cases, we here present our technical solutions to these problems.     

Resurfacing arthroplasty of the hip in osteopetrosis

A 34-year-old woman with a benign form of osteopetrosis developed osteoarthritis of the hip. In order to avoid the difficulties associated with inserting the femoral component of a conventional total hip arthroplasty, a hybrid metal-on-metal resurfacing was performed. There were several technical challenges associated with the procedure, including the sizing of the component, press-fit fixation of the acetabular component and femoral head preparation, as well as trying to avoid a fracture. No surgical complication occurred. After more than a year following surgery, the patient showed excellent clinical function and remained satisfied with the outcome. We conclude that the hybrid metal-on-metal resurfacing arthroplasty represents a valuable option for the treatment of patients with osteopetrosis and secondary hip osteoarthritis.     

Total joint arthroplasty in human immunodeficiency virus-positive patients: an alarming rate of early failure

The results of 21 total joint arthroplasties (13 knees, 8 hips) in 15 patients were reviewed. There were 13 men and 2 women with an average age of 38 years (range, 28 to 69 years). The mean follow-up period was 10.2 years (range, 2 to 23 years). Six patients died within an average of 10.6 years (range, 3 to 18 years) of joint arthroplasty. All patients died of AIDS. Deep infection developed in 6 joints. Knee Society scores improved significantly, but 13 repeat surgeries were required. An alarmingly high rate of complications was found after total knee and total hip arthroplasty in these patients with human immunodeficiency virus (HIV). Physicians and surgeons should be made aware of this high rate of complications after joint arthroplasty in patients with HIV and include a frank discussion of this information with their patients who are contemplating total joint arthroplasty.     

The use of the surgical epicondylaraxis in total knee arthroplasty

When performing total knee arthroplasty, there are many important technical factors to consider to maximize postoperative results. One important factor is the rotational orientation of the femoral component. Improper femoral component rotational positioning can lead to several potential complications, including poor patellofemoral tracking and varus-valgus instability of the knee in flexion. The use of an anatomic landmark, the surgical epicondylar axis, has been developed to aid the surgeon in determining proper rotational orientation of the femoral component in both primary and revision total knee arthroplasty.     

Osteoarthritis associated with osteopetrosis treated by total knee arthroplasty. Report of a case

Osteopetrosis is due to a defect in osteoclastic cell function and results in osteosclerosis and progressive obliteration of the marrow spaces. Early onset osteoarthritis is associated with osteopetrosis. The authors describe a case of early onset osteoarthritis associated with osteopetrosis treated by total knee arthroplasty. The marblelike quality of osteopetrotic bone makes surgical treatment of these patients technically challenging and requires modification of standard surgical technique.     

Occupational Hazards to the Joint Replacement Surgeon: How Can Technology Help Prevent Injury?

Occupational hazards pose varying threats to the joint replacement surgeon. Musculoskeletal pain due to the repetitive nature of performing joint arthroplasty is felt daily by most surgeons. The purpose of this paper is to offer a basic introduction and demonstrate the many ways technology utilized during total joint arthroplasty can help mitigate common occupational hazards for the arthroplasty surgeon. This paper guides readers through the evolution and drivers behind technology in joint arthroplasty, describes several technologies currently available, and discusses how certain aspects of this technology may work to improve surgeon and patient outcomes. We review how advanced technologies in arthroplasty may reduce physical and mental demand, improve reproducibility, and decrease complications. The decision to utilize advanced technology in joint arthroplasty is ultimately made on an individual level after careful consideration of available literature.     

人工膝关节置换术治疗重症膝关节疾病92例临床分析

目的探讨人工膝关节置换术(TKA)治疗重症膝关节疾病的临床疗效。方法1999年6月~2006年1月,对92例重症膝关节疾病(106膝)使用后稳定型TKA。其中10例(11膝)为类风湿性关节炎,2例(2膝)为创伤性关节炎,80例(93膝)为严重骨性关节炎,5例(5膝)合并外翻畸形,40例(50膝)并内翻畸形。所有患者进行10个月~6年(平均30个月)的随访,并应用HSS膝关节评分系统进行分析。结果手术优良率为94.2%,患者术后在疼痛、功能及关节活动度等方面都有明显改善,各种并发症的发生率低。结论TKA是治疗重症膝关节疾病的有效方法。     

Simultaneous management of ipsilateral gonarthritis and ununited tibial stress fracture: combined total knee arthroplasty and internal fixation

Nonunion of a proximal tibial stress fracture is rare and can be difficult to manage, especially if associated with ipsilateral gonarthritis. Three patients with nonunion of a proximal tibial stress fracture adjacent to an arthritic knee joint were managed by performing simultaneous total knee arthroplasty and internal fixation of the fracture site. The technique involved performing a total knee arthroplasty with angular correction at the site of the extra-articular and intra-articular deformity, bone grafting of the nonunion site, and stabilization of the fracture with a long uncemented intramedullary stemmed tibial component and a unicortical plate. Fibular ostectomy was required during the index surgery in 2 cases to achieve the desired angular correction. In all 3 patients, healing of the nonunion site and limb realignment was achieved. There were no complications or infections associated with the surgery. All patients progressed to full weight bearing at 3 months and had clinical and radiographic union of the nonunion site at 6 months.     

人工膝关节置换术治疗严重膝关节疾病的临床分析

目的：探讨人工膝关节置换术（TKA）治疗严重膝关节疾病的临床疗效。方法：2003年6月～2008年6月,对85例重症膝关节疾病（102膝）使用后稳定型TKA。其中9例（10膝）为类风湿性关节炎,76例（92膝）为晚期严重骨性关节炎,5例（5膝）合并外翻畸形,60例（67膝）并内翻畸形。所有患者进行12个月～5年（平均39个月）的随访,并应用HSS膝关节评分系统进行分析。结果：手术优良率为94．12％,患者术后红疼痛、功能及关节活动度等方面都有明显改善,各种并发症的发生率较低。结论：TKA是治疗严重膝关节疾病的有效方法,严格适应证的选择和正确进行TKA的手术操作是取得满意临床效果的保证。     

Medical Clearance Risk Rating as a Predictor of Perioperative Complications After Total Hip Arthroplasty

Hip arthroplasty has become the standard treatment of end-stage osteoarthritis. However, postoperative complications are the risks associated with joint arthroplasty, which most significantly impact patient results and the total cost of care. Currently, no predictive system has been developed for categorizing levels of risk for the development of postoperative complications in patients undergoing total hip arthroplasty. We examined the association between the medical clearance risk rating by the physician performing the preoperative clearance examination and postoperative complications after total hip arthroplasty. We have demonstrated a significant association between the medical clearance risk rating and postoperative urinary track infection, and the American Society of Anesthesiologist score but no significant association to other complications. This study presents a predictive patient characteristic that may help us identify among our patients the ones that may benefit from a personally tailored preoperative planning and evaluation but demonstrates further work is necessary to better predict the risk of complications after total hip arthroplasty.     

Biaxial total wrist arthropla

Arthrodesis is a reliable and predictable method of treating patients with symptomatic radiocarpal joint destructionand should be recommended in most cases. However, some patients are not able to compensate for the lack of wrist mobility associated with wrist fusion because of multiple joint arthroses as are commonly seen in patients with rheumatoid arthritis. For these patients, total wrist arthroplasty is best described as a higher risk and higher reward procedure. A recent review of 64 cases of total wrist arthroplasty found an 83% implant survival rate at a mean follow-up period of 6.5 years. Clinical results showed excellent patient satisfaction and very good pain relief and range of motion. Of the patients who failed arthroplasty and were eligible for revision total wrist arthroplasty, 80% elected revision arthroplasty over recommended arthrodesis. This report reviews patient selection, technique, postoperative management, management of complications, and expected outcome of biaxial total wrist arthroplasty.     

人工全膝关节置换术治疗重症膝关节疾病的临床疗效

目的：探讨人工全膝关节置换术治疗严重膝关节疾病的临床疗效及方法。方法：2004年6月-2009年6月，对92例重症膝关节疾病（106膝）使用后稳定型TKA。其中9例（10膝）为类风湿性关节炎，3例（3膝）为创伤性关节炎，80例（93膝）为晚期严重骨性关节炎，5例（5膝）合并外翻畸形，50例（60膝）合并内翻畸形。所有患者进行10个月．5年（平均30个月）的随访，并应用HSS膝关节评分系统进行分析。结果：手术优良率为94．34％，患者术后在膝关节疼痛、功能及关节活动度等方面都有明显改善，提高了生活质量，各种并发症的发生率低。结论：人工全膝关节置换术是治疗严重膝关节疾病的有效方法，严格适应证的选择、正确进行TKA的手术操作、各种并发症的防治和积极术后康复锻炼是取得满意临床效果的保证。     

Osteoarthritis of the ankle: the role of arthroplasty

Total ankle arthroplasty was developed to reduce pain and retain motion of the ankle joint in patients with osteoarthritis. The ankle joint has unique, complex anatomic and biomechanical characteristics that must be considered in a successful total ankle arthroplasty prosthesis. Initial designs from the 1960s to the 1970s had many failures. Current designs use two or three components, and recent reports on total ankle arthroplasty show consistent good to excellent intermediate clinical results, with up to 90% decreased pain and high patient satisfaction. The follow-up time of these studies is limited, however, and long-term studies with 10- to 15-year follow-ups are needed. Also, a wide variety of complications has been reported, including osteomyelitis and osteolysis. To limit the number of complications and improve clinical outcome of total ankle arthroplasty, careful patient selection and surgeon experience are important.     

Repeat 2-Stage Exchange for Infected Total Hip Arthroplasty : A Viable Option?

We investigated whether performing a repeat 2-stage exchange eradicates infection in patients who previously underwent 2-stage treatment for an infected total hip arthroplasty. We identified 15 patients who had failed a 2-stage total hip arthroplasty and underwent a planned repeat 2-stage between 2000 and 2009. Of the 15 patients, 8 were treated with a complete 2-stage procedure, whereas the remaining 7 patients were treated only with a first-stage resection of the infected implant. Of the 8 patients who underwent complete 2-stage exchange, 1 died because of in-hospital complications, and 1 had a recurrent infection. Repeat infection is highly associated with resistant organisms, obesity, and poor patient health. Of the 7 patients who underwent resection without reimplantation, 3 had a recurrent infection. Our data suggest that if infection can be adequately controlled after repeat resection of the joint prosthesis, reimplantation is a reasonable option.     

Total joint arthroplasty in the extremely elderly: hip and knee arthroplasty after entering the 89th year of life

The goal of this study was to evaluate the complications and efficacy of total joint arthroplasty in the extremely elderly and compare the survival with the normal age-matched population. One hundred one joint arthroplasties (45 total knee arthroplasties [TKAs], 56 total hip arthroplasties [THAs]) were performed in 83 patients 89 years old and older. Over an average follow-up period of 2.5 years, 26 (31%) of the patients died. Three patients (3.6%) died within the first 2 months' postoperatively. The perioperative medical complication rate (excluding deaths) was 14%. Significant improvements were noted in pain scores, Harris Hip Scores, and Knee Society Scores. The survival of patients in their nineties who undergo total joint arthroplasty is at least equal to the survival of an age-matched population for 2.5 years following surgery. With careful patient selection and patient care to minimize medical complications, total joint arthroplasty can be an excellent option for patients who are age 89 and older.     

Repeat 2-stage exchange for infected total hip arthroplasty: a viable option?

We investigated whether performing a repeat 2-stage exchange eradicates infection in patients who previously underwent 2-stage treatment for an infected total hip arthroplasty. We identified 15 patients who had failed a 2-stage total hip arthroplasty and underwent a planned repeat 2-stage between 2000 and 2009. Of the 15 patients, 8 were treated with a complete 2-stage procedure, whereas the remaining 7 patients were treated only with a first-stage resection of the infected implant. Of the 8 patients who underwent complete 2-stage exchange, 1 died because of in-hospital complications, and 1 had a recurrent infection. Repeat infection is highly associated with resistant organisms, obesity, and poor patient health. Of the 7 patients who underwent resection without reimplantation, 3 had a recurrent infection. Our data suggest that if infection can be adequately controlled after repeat resection of the joint prosthesis, reimplantation is a reasonable option.     

Total joint arthroplasty: When do fatal or near-fatal complications occur?

BACKGROUND: With the recent trend toward minimally invasive total joint arthroplasty and the increased emphasis on faster recovery and shorter hospital stays, it has become increasingly important to recognize the timing and severity of the various complications associated with elective total joint arthroplasty to ensure that early patient discharge is a safe practice. METHODS: We evaluated the systemic and local complications associated with primary unilateral lower-extremity arthroplasties performed during one year in 1636 patients. A total of 966 patients had a primary total hip arthroplasty, and 670 had a primary total knee arthroplasty. All complications that occurred in the hospital and for six weeks following the index surgery were recorded. The circumstances leading to the complications and the details of the therapeutic intervention for each complication were recorded. Analyses were performed to predict the factors that predispose patients to serious complications. RESULTS: One patient (0.06%) in the cohort died during the hospital stay. There were a total of 104 major (life-threatening) complications, including cardiac arrest (one), tachyarrhythmia (thirty-three), pulmonary edema or congestive heart failure (ten), myocardial infarction (six), hypotensive crisis (four), pulmonary embolus (twenty-five), acute renal failure (fourteen), stroke (six), bowel obstruction or perforation (three), and pneumothorax (one). There were seventeen major local complications. Ninety-four (90%) of the major complications occurred within four days after the index surgery. Although older age, increased body mass, and preexistent comorbidities were important predisposing factors for serious medical complications, 58% of the patients who had life-threatening complications develop had no identifiable predisposing factors. CONCLUSIONS: This study demonstrated that most of the complications of lower-extremity total joint replacement occur within the time-frame of the typical hospital stay. Given the serious nature of some of these complications and the inability to identify many of the patients who may be at risk, we caution against early discharge of patients from the hospital after elective total joint arthroplasty in the lower extremity.