传染性软疣58例临床及病理分析

目的：分析传染性软疣（Molluscum Contagiosum,MC）的临床病理特点.方法：收集58例MC患者的临床和病理资料进行综合分析.结果：MC发病男女比例约2.9∶1,多无自觉症状.皮疹成人多位于下腹部、股内侧和外生殖器部位,而儿童多在面、躯干和四肢.虽然MC为常见皮肤病,本组中发现其临床误诊率为46.6%.组织病理特征为小叶状、内生性生长的结节,角质形成细胞胞质中存在包涵体,即软疣小体,可继发感染或并发表皮囊肿等.结论：MC继发感染或并发表皮囊肿等其他皮肤损害时,临床表现多不典型,组织病理可确诊.     

传染性软疣并发表皮囊肿1例

传染性软疣是一种由传染性软疣病毒(属痘病毒)引起的病毒性皮肤病.少数患者可并发皮肤肿瘤.我们报告1例传染性软疣并发表皮囊肿及囊肿破裂伴异物肉芽肿样反应的患者,并探讨其发病机制,再次证实廖文俊等[1]提出的观点,认为传染性软疣病毒感染与表皮囊肿的形成有关.     

传染性软疣并发表皮囊肿1例

传染性软疣是一种常见的病毒性皮肤病，病变通常发生于表皮，而并发真皮部位病变者少见，我们见到1例传染性软疣并发表皮囊肿，现报道如下。     

足跖表皮样囊肿中存在乳头瘤病毒抗原

作者用抗乳头瘤病毒(PV)抗原免疫组化及电镜检查,发现1例足跖表皮样囊肿中存在PV抗原.患者男,21岁,左侧足跖出现结节并逐渐增大.既往无外伤史.检查见左足跖有一直径约13～17mm大小的坚实结节,略隆起皮面,表面轻度角化,无疣状损害.组织病理示,真皮下部可见表皮样囊肿,囊内充满角质物,囊壁鳞状上皮浅层及颗粒层许多细胞胞核周围可见嗜酸性均质性包涵体,这些细胞胞核较大,胞浆透明.角质层内许多角化     

阴茎传染性软疣1例

患者男，25岁，阴茎出现肤色小丘疹2周，不库不痛。皮肤科情况：阴茎背侧散在16个粟粒大半圆形肤色丘疹，质稍韧，表面无蜡样光泽，中央无脐窝。全身其它部位无皮疹。用小血管钳将丘疹挤破，可挤出白色酪状物。组织病理变化：表皮突增生肥大，真皮乳头受压而形成假包膜，棘细胞变性肥大，胞浆内有均质性圆形、椭圆形嗜酸性包涵体（软疣小体）。结合临床，诊断为阴茎传染性软疣。阴茎传染性软疣1例@张锐利$山东省威海市立医院皮肤科@殷翠玲$山东省威海市立医院皮肤科@田仲源$山东省威海市立医院皮肤科     

传染性软疣的临床与细胞学研究

对107例传染性软疣进行临床分析,测定了10例疣体的上皮细胞DNA含量,并对1例皮损作透射电镜观察。结果表明10例皮损表皮细胞核的DNA含量均为二倍体,而增殖指数较正常对照高。电镜下,传染性软疣的细胞核呈现空泡化,细胞浆内有大量病毒颗粒,这是本病易于传染的主要原因。     

包涵体疣

报告1例包涵体疣。患者男,65岁。因右手掌结节伴疼痛10 d就诊。10 d前患者发现右手掌有一红色丘疹,伴轻度疼痛,随后丘疹逐渐增大。发病前局部无明确外伤史。皮肤科检查:右手掌小鱼际表面可见一直径约1 cm大的红色结节,有压痛。皮损组织病理检查:表皮明显角化过度,棘层不规则肥厚,表皮部分角质形成细胞内可见大量嗜碱性包涵体。诊断:包涵体疣。     

表现为疣状斑块的传染性软疣1例

正1临床资料患儿男,10岁。左肘部疣状斑块4个月。4个月前无明显诱因患儿的左肘部出现米粒大丘疹,无自觉症状,后逐渐增大、增多,并融合成斑块,未予特殊处理。否认湿疹、神经性皮炎及左肘部局部皮肤破溃史,家族中也无类似病史,父母无性病病史。系统检查未见异常。皮肤科情况:左肘部见多个半球形肤色丘疹,融合成斑块,约4.0cm×5.0cm大小,隆起,表面角化,界清,其上见多个脐凹,质中,无触痛(图1)。皮损组织病理示:表皮呈梨形增生,并向下伸入真皮,表皮细胞浆内嗜酸性的软疣小体(图2)。诊断:传染性软疣。予刮匙刮除疣体,局部外搽     

表皮囊肿209例临床和病理分析

目的:分析表皮囊肿的临床和病理特点.方法: 对209例表皮囊肿患者进行临床资料和组织病理回顾性分析.结果:男女发病比例为1.9:1;发病年龄以20～50岁多见,占69.4%;除5例为多发外,均为单发皮下结节,病理上囊肿的囊壁由上皮细胞构成,囊腔内均可见层状角化物.临床正确诊断率为22.5%.结论:表皮囊肿是好发于青中年男性的良性病变,临床误诊率高(77.5%),确诊主要靠组织病理学.     

发疹性毳毛囊肿并发多发性脂囊瘤

患者女,17岁。颈部及胸部丘疹和结节3年。皮肤科检查:颈部及胸部可见多个肤色丘疹和结节,质地软。皮损组织病理检查:表皮大致正常,真皮内见2个囊腔样结构,1个囊壁为复层鳞状上皮,有颗粒层,囊内见毳毛毛干;另1个囊壁为复层鳞状上皮,无颗粒层,囊壁内表面为波浪状嗜伊红无定形物质。诊断:发疹性毳毛囊肿并发多发性脂囊瘤。     

Molluscum contagiosum occurring in an epidermal cyst--report of 3 cases.

We present three unusual cases of molluscum contagiosum occurring in epidermal cysts. All of them are asymptomatic, elevated, oval nodules diagnosed clinically as epidermal inclusion cyst or prurigo nodularis. Histology showed true epidermal cysts containing molluscum bodies throughout the cyst wall and some type of laminated material within the cyst itself. The lesion, in all three cases developed in the pubic area of young adult men.     

Solitary Giant Molluscum Contagiosum of the Sole

Abstract: Molluscum contagiosum of the sole is extremely rare and only three cases have been reported in the literature. We report a solitary giant molluscum contagiosum on the left sole of a 5-year-old boy, which should be clinically differentiated from plantar wart, eccrine poroma, epidermal cyst, foreign body granuloma, cryptococcal infection, and pyogenic granuloma.     

Central Pitting of Molluscum Contagiosum

Histological examination of 42 early lesions of molluscum contagiosum was performed. At the top of the molluscum papule, the epidermis cylindrically hung down into the dermis, thus forming an epidermal cylinder with a narrow canal. Acanthomatous change occurred at the bottom of the epidermal cylinder. Thirteen of the 42 molluscum lesions showed a direct connection with components of hair follicle. It is suggested that the central pitting of molluscum contagiosum may be the ostium of pilar infundibulum.     

Patient demographics and utilization of health care services for molluscum contagiosum

Our objective was to describe the demographics of molluscum contagiosum patients and physician utilization patterns in the United States. We obtained weighted data for office visits throughout the United States for molluscum contagiosum and common warts from the National Ambulatory Medical Care Survey (NAMCS) from 1990 to 1999. Outpatient visit data for patients diagnosed with molluscum contagiosum were analyzed using statistical software and compared to those for patients diagnosed with common warts. The main outcome measures studied were physician office visits by patients with molluscum contagiosum and patient demographic parameters including age, gender, and race. We found that health care utilization for molluscum contagiosum was the greatest for patients 相似文献   

Molluscum contagiosum in a cystically dilated follicular infundibulum

We report on the hardly known development of molluscum contagiosum in a cystically dilated follicular infundibulum. The molluscum virus infection extends over two thirds of the distal cyst wall, which a rudimentary hair root ends in.     

Disseminated and disfiguring molluscum contagiosum in a child

We report widely disseminated and disfiguring lesions of molluscum contagiosum occurring in a 4-year-old girl secondary to a primary immunodeficiency disorder. The child, born of consanguineous parents, had multiple, asymptomatic, raised, skin-colored and whitish lesions since 2 years of age. On physical examination she had growth retardation features with grade II protein energy malnutrition. Cutaneous examination revealed numerous, widespread, skin-colored to translucent, firm, umbilicated papules of varying sizes (pinpoint to larger than 10 mm). They were distributed bilaterally over all four limbs, including the dorsum of the hands and feet, trunk, face (including lips), eyelids, auriculae, and perineal and gluteal areas. In places, they were linearly disposed and had coalesced to form plaques. A biopsy specimen from a representative skin lesion (arm) demonstrated lobulated epidermal growth consisting of keratinocytes with large intracytoplasmic eosinophilic inclusion bodies and a central crater. These findings were consistent with the diagnosis of molluscum contagiosum. Topical therapies with phenol and trichloroacetic acid were ineffective The child succumbed to a fulminant systemic infection at home, 2 months after discharge from the hospital. The extent and distribution of molluscum contagiosum in our patient was remarkably vivid and has been hitherto reported only rarely.     

Molluscum Contagiosum-Induced Comedo and Secondary Abscess Formation

A 9-year-old boy had recurrent formation of fluctuating abscesses of the forearms, leading to surgical incisions. Histopathologic examinations revealed that the etiologic agent was a molluscum virus in the lower portion of a pilosebaceous follicle, which formed a comedo. The comedones developed into pustular and cystic lesions after the boy attempted to squeeze out the contents. Two different reaction patterns to molluscum contagiosum seem to be present: a lymphocyte-mediated immunologic reaction in normally regressing lesions, and an acute inflammatory reaction due to disruption of infected epidermal tissue into the dermis, as seen in this patient.     

艾滋病伴发传染性软疣1例

报道 1例 48岁女性晚期获得性免疫缺陷综合征 (艾滋病 )患者 ,面部、躯干和上肢伴发数目极多的传染性软疣 ,并经组织病理学证实。泛发性传染性软疣与患者感染人类免疫缺陷病毒 (HIV)后的免疫抑制密切相关 ,本文就传染性软疣在艾滋病诊断中的作用进行了讨论     

Proinflammatory properties of molluscum bodies

Molluscum contagiosum, a condition characterized by benign viral tumours, occasionally becomes inflamed and regresses spontaneously, an event probably initiated by a host cell-mediated immune rejection against the lesion, but it inevitably involves the disruption of the epidermal tissue to expose the molluscum bodies to the tissue fluids of the dermis. It has been suggested that the molluscum bodies induce inflammation by a mechanism similar to that involved in ruptured epidermal cysts or in acne. Despite the occasional development of inflammation in molluscum contagiosum, the proinflammatory properties of molluscum bodies have never been studied in vitro. Thus, in the present study we sought to determine whether molluscum bodies exert a proinflammatory effect by inducing neutrophil chemotaxis. When exposed to fresh serum in vitro, water-insoluble components of molluscum bodies activated the alternative complement pathway to produce chemotactic C5a/C5a des Arg. We also found that an aqueous extract of molluscum bodies exerted potent chemotactic activity for neutrophils. Remarkably high amounts of the immunoreactive proinflammatory cytokines IL-8 and GRO were present in the extract even when compared with psoriatic scale extracts. Gel filtration HPLC of the extract demonstrated the presence of neutrophil chemotactic activity over a wide range of molecular mass. These data suggest that disruption of the epidermal wall of molluscum bodies induces acute inflammatory changes by activation of the alternative complement pathway on exposure to the tissue fluids, and that the molluscum bodies themselves release proinflammatory cytokines and other neutrophil chemotactic factors on decomposition.     

Clinical remission of disseminated molluscum contagiosum infection in a patient with atopic dermatitis treated with dupilumab

Atopic dermatitis predisposes to skin infections, and on the other hand, some therapies used for atopic dermatitis may worsen viral infections whose lesions may be more diffuse and resistant to treatment. The authors present a patient with severe atopic dermatitis and disseminated molluscum contagiosum infection. The molluscum contagiosum did not clear with topical treatment, and it worsened her atopic dermatitis even more, so the authors started treatment with dupilumab. After two months, the patient's dermatitis went into clinical remission and there was resolution of the infection with no recurrence at the 12-month follow-up. Dupilumab is nowadays a promising treatment for severe atopic dermatitis. To our knowledge, only four reports of molluscum contagiosum during dupilumab therapy have been reported in the literature, with contrasting effects. According to the authors’ experience, treatment with dupilumab appears to be a safe alternative for patients with severe atopic dermatitis who are also infected with molluscum contagiosum, as opposed to other treatments such as systemic corticosteroids or cyclosporine.