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1.
自宝兴淫羊藿(Epimedium davidii Franch)中分离出8个黄酮类化合物,根据理化数据、光谱分析(UV,IR, 1HNMR, 13CNMR,MS)和水解实验证明,其中E 3,E 13和E 8分别为已知成分淫羊藿甙、淫羊藿素和苜蓿素。E 1,E 11、E 16和E 15是新黄酮类化合物,并证明结构,分别命名为宝藿甙-Ⅰ(baohuoside Ⅰ),宝藿甙-Ⅵ(baohuoside Ⅵ),宝藿甙-Ⅶ(baohuo side Ⅶ)和宝藿素(baohuosu)。E 17的结构待定。 相似文献
2.
The stabilizing effects of α-, β-, γ- and dimethyl-β-cyclodextrins (α-, β-, γ-and DM-β-CyDs) on the degradation of hydrocortisone 17-butyrate (HC-17B) in aqueous solution was investigated. HC-17B underwent a facile hydroxide ion-catalyzed rearrangement to the less active 21-butyrate ester by the apparent first-order kinetics, and maximum stability of HC-17B was obtained at around, pH 4.0. The stability of HC-17B was increased by inclusion complexation with α-, γ- and DM-β-CyD in the pH range of 2.0–8.0 examined, whereas β-CyD accelerated the degradation of HC-17B at the pH higher than 5.0. The effects of ionic strength, solvent, temperature and CyD concentration were also investigated. Stability constants and apparent degradation rate constants of HC-17B-γ-CyD and HC-17B-DM-β-CyD complexes were determined kinetically on the basis of 1∶1 complexation. The results suggested that the inclusion complexation with γ-CyD or DM-β-CyD was most useful means to enhance the stability of the steroid. 相似文献
3.
首次从喙果绞股蓝( Gymostemma yixingense CY Wu et SK Chen)中分得四个皂甙成分(Ⅰ~Ⅳ),经理化常数测定、光谱解析和化学方法确定了它们的结构。其中Ⅰ为新化合物,命名为喙果皂甙A(yixinosideA),Ⅱ,Ⅲ和Ⅳ分别鉴定为绞股蓝皂甙XLIVXLII(gypensideXLIV,XLII)和具明显调脂作用的人参皂甙Rb 1(ginsenosideRb 1)。此外,Ⅰ经酸水解得到一新皂甙元1β-羟基人参二醇(1β-hydroxylpanaxadiol)(Ⅴ)和一新次级甙,命名为喙果皂甙B(yixinosideB,VI)。 相似文献
4.
The methanol extract obtained from the aerial parts of Aceriphyllum rossii (Saxifragaceae) was fractionated into ethyl acetate (EtOAc), n-BuOH and H 2O layers through solvent fractionation. Repeated silica gel column chromatography of EtOAc and n-BuOH layers afforded six flavonol glycosides. They were identified as kaempferol 3- O-β-D-glucopyranoside (astragalin, 1), quercetin 3- O-β-D-glucopyranoside (isoquercitrin, 2), kaempferol 3- O-α-L-rhamnopyranosyl (1→6)-β-D-glucopyranoside ( 3), quercetin 3- O-α-L-rhamnopyranosyl (1→6)-β-D-glucopyrano-side (rutin, 4), kaempferol 3- O-[α-L-rhamnopyranosyl (1→4)-α-L-rhamnopyranosyl (1→6)-β-D-glucopyranoside] ( 5) and quercetin 3- O-[α-L-rhamnopyranosyl (1→4)-α-L-rhamnopyranosyl (1→6)-β-D-glucopyranoside] ( 6) on the basis of several spectral data. The antioxidant activity of the six compounds was investigated using two free radicals
such as the ABTS free radical and superoxide anion radical. Compound 1 exhibited the highest antioxidant activity in the ABTS 2,2-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) radical scavenging method. 100 mg/L of compound 1 was equivalent to 72.1±1.4 mg/L of vitamin C, and those of compounds 3 and 5 were equivalent to 62.7±0.5 mg/L and 54.3±1.3 mg/L of vitamin C, respectively. And in the superoxide anion radical scavenging
method, compound 5 exhibited the highest activity with an IC 50 value of 17.6 ± 0.3 μM. In addition, some physical and spectral data of the flavonoids were confirmed. 相似文献
5.
从叉蕊薯蓣( D.collettii HooK.f.)根茎的乙醇提取物分离到四个甾体皂甙,根据理化性质、光谱数据,推定化学结构为3-O-( β-D-葡萄吡喃糖)-约莫皂甙元(3-O-( β-D-glucopyranosyl)-yamogenin)[Ⅰ];3-O-[ α-L-鼠李吡喃糖(1→4)- β-D-葡萄吡喃糖]-约莫皂甙元(3-O-[ α-L-rahmnopyranosyl(1→4)-β-D-glucopyranosyl]-yamogenin)[Ⅱ];3-O-{ α-L-鼠李吡喃糖(1→4)-[ α-L-鼠李吡喃糖(1→2)]- β-D-葡萄吡喃糖}-约莫皂甙元(3-O-{ α-L-rhamnopyranosyl(1→4)-[ α-L-rhamnopyranosyl(1→2)]- β-D-glucopranosyl}-yamogenin)[Ⅲ];3-O-{ β-D-葡萄吡喃糖(1→3)-[ α-L-鼠李吡喃糖(1→2)3- β-D-葡萄吡喃糖}-约莫皂甙元(3-O-{β-D-glucopyranosyl(1→3)-[ α-L-rhamnopyranosyl(1→2)]- β-D-glucopyranosyl}-yamogenin)[Ⅳ]。其中Ⅰ为已知物,Ⅱ、Ⅲ、Ⅳ为首次从植物界得到的新甾体皂甙。 相似文献
6.
从民族药黑种草子( Semen nigellae)中分离得到七个化合物,其中两个为新化合物,分别命名为黑种草甙(nigeglanoside)和黑种草糖(nigelancae)。经理化常数测定和光谱解析确定其结构分别为山萘酚-3-O-β- D-吡喃半乳糖基(1→3)-β- D-吡喃葡萄糖基(1→3)-β- D-吡喃葡萄糖甙和2-O-α- D-吡喃半乳糖基(1→4)-β- D-吡喃葡萄糖基-β- D-呋喃果糖甙。另外五个已知化合物分别为附子碱的氯化物(fuzitinechloride)、常春藤皂甙、蔗糖(sucrose)、β-谷甾醇(β-sitosterol)和环劳顿醇(cyclolandenol)。 相似文献
7.
Two new dammarane-type triterpenoid saponins, namely ginsenoside Rk 6 ( 1) and ginsenoside-Rh 22 ( 2), were isolated from notoginseng medicinal fungal substance. The structures of 1 and 2 were established as 3 β,6 α,12 β,26-tetrahydroxydammar-20(21),24(25)( E)-diene-6- O- β- D-glucopyranoside and 3 β,6 α, 20( S)-trihydroxy-12( R),23( R)-expoxy-13( S),17( S)-dammar-24- ene-6- O- β- D-glucopyranoside on the basis of spectroscopic analysis and chemical analysis, respectively. 相似文献
8.
Abstract In the chemical investigation on the saponin composition of leaves and stems of Panax quinquefolium L., two new minor dammarane saponins, quinquenoside L 1 ( 1) and L 2 ( 2) have been isolated. By means of physico-chemical evidences and spectral analysis their structures were established as 3-O-[β- D-glucopyranosyl-(1-2)-β- D-glucopyranosyl]-20-O-β- D-glucopyranosy-dammara-23,25-diene-3β, 12β, 20(S)-triol ( 1) and 3-O-[β- D-glucopyranosyl-(1-2)-β- D-glucopyranosyl]-20-O-β- D- D-glucopyranosyl-(24Z)-dammar-24-ene-3β, 12β, 20(S), 26-tetraol ( 2). 相似文献
9.
Gastric tolerability, absorption and pharmacological activity of the non-steroidal anti-inflammatory drug 4-biphenylacetic acid (BPAA), as an inclusion complex with β-cyclodextrin (β-CyD) or chemically modified β-CyDs: 2,6-di- O-methyl-β-CyD (DM-β-CyD), 2,3,6-tri- O-methyl-β-CyD (TM-β-CyD) and 2-hydroxypropyl-β-CyD (HP-β-CyD), were investigated in the rat after oral administration. BPAA absorption, determined from area under the plasma concentration-time curve (AUC), was increased by complexation with all β-CyDs in the following order: DM-β-CyD > TM-β-CyD > HP-β-CyD > β-CyD. The carrageenan paw oedema test demonstrated a significant increase in anti-inflammatory activity of BPAA and the ED50 values, compared with BPAA alone, were reduced to about a third for the BPAA-DM-βCyD complex and halved for the others. BPAAA complexed with DM-β-CyD, HP-β-CyD or β-CyD showed better gastric tolerability compared with uncomplexed drug, whereas the BPAA-TM-β-CyD complex produced marked gastric lesions similar in extent to BPAA alone. TM-β-CyD (500mg kg ?1) and DM-β-CyD (1000mg kg ?1) caused gastric erosions 21 h after oral administration. The pharmacokinetic profiles of BPAA-β-CyD complexes have shown that DM-β-CyD is the most effective in enhancing the bioavailability of BPAA. 相似文献
10.
From the roots of Pulsatilla koreana, three monodesmosides(pulsatilla saponins A, B and D) and two bisdesmosides(pulsatilla saponins F and H) were isolated. The structure of these saponins have been determined as hederagenin 3-O-α-L-rhamnopyranosyl(1→2)-α-L-arabinopyranoside(A), hederagenin 3-O-β-D-glucopyranosyl(1→4)-α-L-arabinopyranoside(B), hederagenin 3-O-α-L-rhamnopyranosyl (1→2)-[β-D-glucopyranosyl(1→4)]-α-L-arabinopyranoside(D), 3-O-α-L-rhamnopyranosyl(1→2)-α-L-arabinopyranosyl hederagenin 28-O-α-L-rhamnopyranosyl(1→4)-β-D-glucopyranosyl(1→6)-β-D-glucopyranosyl ester (F) and 3-O-α-L-rhamnopyranosyl(1→2)-[β-D-glucopyranosyl(1→4)]-α-L-arabinopyranosyl hederagenin 28-O-α-L-rhamnopyranosyl(1→4)-β-D-glucopyranosyl(1→6)-β-D-glucopyranosyl ester(H) on the basis of chemical and spectral studies. Pulsatilla saponin B is the first report of its presence in plants but saponins A, D, F, and H have recently been isolated from the same genus P. cernua. 相似文献
11.
In the screening of biologically active constituents from medicinal plants, the 75% EtOH extract of the testas of Castanea mollissima Blume showed potent α-glucosidase inhibitory activity. By means of various chromatographic methods, the extract gave a new dammarane-type triterpene 1 along with 17 known compounds. The structure of 1 was determined to be 3β-acetoxy-20-oxo-21-nordammaran-23-oic acid by HRMS and NMR studies including 2D NMR experiments. The new compound and some known compounds showed potent α-glucosidase inhibitory activity with acarbose as a positive control. 相似文献
12.
自宝兴淫羊藿(Epimedium davidii Franch)全草中分离得十七个黄酮类化合物。确定了E 2,E 4,E 5,E 6,E 7,E 9,E 10,E 12和E 14的化学结构。其中五个为已知成分,即E 5为淫羊藿甙-C,E 9为淫羊藿甙-A,E 12为去甲淫羊藿素,E 4为金丝桃甙,E 14为山柰素-3-双鼠李糖甙。E 2,E 6,E 7和E 10是首次从植物中分离到的黄酮醇甙,分别命名为宝藿甙-Ⅱ,宝藿甙-Ⅲ,宝藿甙-Ⅳ和宝藿甙-Ⅴ。E 4和E 14在本属植物中系首次发现。 相似文献
13.
Two new dammarane-type triterpene saponins were isolated from the red American ginseng. The new saponins were named as pseudoginsenoside G 1 ( 1) and pseudoginsenoside G 2 ( 2). Their structures were elucidated by the combined analysis of NMR and mass spectrometry as 3- O-[β- d-glucopyranosyl-(1 → 2)-β- d-glucopyranosyl]-dammar-12-one-20 S,24 R-epoxy-3β,25-diol (pseudoginsenoside G 1) ( 1) and 3- O-[β- d-glucopyranosyl-(1 → 2)-β- d-glucopyranosyl]-dammar-12-one-20 S,24 S-epoxy-3β,25-diol (pseudoginsenoside G 2) ( 2). 相似文献
14.
Three triterpenoid saponins were isolated from the methanol extract of the stem bark of Kalopanax pictum Nakai var. magnificum (Araliaceae). The structures of these saponins were identified as hederagenin 3-O-α-L-arabinopyranoside, hederagenin-3-O-α-L-rhamnopyranosyl(1→2)-α-L-arabinopyranoside and 3-O-α-L-rhamnopyranosyl(1→2)-α-L-arabinopyranosyl hederagenin 28-O-α-L-rhamnopyranosyl(1→4)-β-D-glucopyranosyl(1→6)-β-D-glucopyranosyl ester. 相似文献
15.
A new steroidal saponin and three known saponins were isolated from the rhizomes of Dioscorea panthaica. Their structures were elucidated as 3- O-[α- l-rhamnopyranosyl-(1 → 2)-β- d-glucopyranosyl]-26- O-β- d-glucopyranosyl-20,22-seco-25( R)-furosta-5-ene-20,22-dione-3β,26-diol ( 1), pregnadienolone-3- O-β-chacotriside ( 2), pseudoprotodioscin ( 3), and dioscoreside D ( 4) mainly by NMR techniques and chemical methods. The inhibitory activities of the saponins against α-glucosidase were investigated, and compound 2 was found to exhibit potent activity with IC 50 values of 0.04 ± 0.01 mM. 相似文献
16.
A new minor sesquiterpene lactone glucoside, ixerin Z A ( 1), together with 16 known compounds, were isolated from the whole plants of Ixeris sonchifolia (Bge) Hance. The structure of 1 was elucidated as 1(10),3,11(13)-guaiatriene-12,6-olide-2-one-3- O-[6′-( p-metheoxyphenylacetyl)]-β-glucopyranoside on the basis of spectroscopic and chemical evidence. Compound 1 exhibited an inhibitory effect on K 562 cells. 相似文献
17.
Two new dammarane-type triterpenoid saponins, namely ginsenosides Rb 4 ( 1) and Rb 5 ( 2), were isolated from ginseng medicinal fungal substance. The structures of 1 and 2 were established as 3 β,12 β,20( S)-trihydroxydammar-24(25)- ene-3- O-[ α- d-glucopyranosyl-(1→4)- β- d-glucopyranosyl-(1→2)- β- d-glucopyranosyl]-20- O- β- d-glucopyranoside and 3 β,12 β,20( S)-trihydroxydammar-24(25)- ene-3- O-[ α- d-glucopyranosyl-(1→4)- α- d-glucopyranosyl-(1→4)- β- d-glucopyranosyl-(1→2)- β- d-glucopyranosyl]-20- O- β- d-glucopyranoside on the basis of spectroscopic analysis and chemical analysis, respectively. 相似文献
18.
Two new dammarane-type compounds were isolated from the leaves and stems of Panax quinquefolium L. The new compounds were named as pseudo-ginsenoside RT 6 ( 1) and pseudoginsengenin R 1 ( 2). The structures of the new compounds were elucidated by the combined analysis of NMR and HR-ESI-MS as (20 S,24 R)-6- O-β- d-glucopyranosyl-dammar-3-one-20,24-epoxy-6α,12β,25-triol ( 1) and (20 S,24 R)-dammar-3-one-20,24-epoxy-6α,12β,25-triol ( 2). 相似文献
19.
The chromatographic separation of MeOH extract from Clerodendron trichotomum Thunberg leaves led to the isolation of three phenylpropanoid compounds. Using spectroscopic methods, the structures of these
compounds were determined as β-(3′, 4′-dihydroxyphenyl)ethyl- O- α-L-rhamnopyranosyl (1→3)- β-D-(4- O-caffeoyl)-glucopyranoside, acteoside (verbascoside) ( 1), β-(3′, 4′-dihydroxyphenyl)ethyl- O- α-L-rhamnopyranosyl (1→3)- β-D-(6- O-caffeoyl)-glucopyranoside, isoacteoside ( 2), β-(3′, 4′-dihydroxyphenyl) ethyl- O- α-L-rhamnopyranosyl (1→3)- β-D-glucopyranoside, and decaffeoylacteoside ( 3). We measured the anti-inflammatory activity of these three phenylpropanoid compounds both in vitro (DPPH Reduction Assay, TBARS Assay on Cu 2+-induced oxidized LDL, PGE 2 assay) and in vivo (acetic acidinduced vascular permeability in mice and carrageenan-induced hind paw edema in rats). 80% methanol fraction
and acteoside had the activity. 相似文献
20.
Two new monoterpenoid glycosides, α-( E)-acaridiol 8- O-β- d-glucopyranoside ( 1) and α-( E)-acaridiol 9- O-β- d-glucopyranoside ( 2), as well as a new thiophen, 2-acetyl-3-hydroxy-5-(prop-1-ynyl)thiophen 3- O-β- d-glucopyranoside ( 3), were isolated from the roots of Eupatorium chinense. Their structures were determined on the basis of extensive spectroscopic and chemical analyses. 相似文献
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