共查询到20条相似文献,搜索用时 15 毫秒
1.
Zoe Diana Draelos MD Margarita Yatskayer MS Susana Raab MS & Christian Oresajo PhD 《Journal of Cosmetic Dermatology》2009,8(2):147-151
Background Diabetes is a multisystem disease caused by the presence of chronic hyperglycemia, which leads to increased oxidative stress. Many of the changes observed in type II diabetic patients can be traced to the increased production of advanced glycation end products, also known as AGEs. AGEs are produced as a result of a nonenzymatic reaction with glucose interacting with proteins, lipids, and nucleic acids. AGEs are also present in normal skin with advancing age and contribute to the senescence of many body organs, including the skin. Aims This research evaluated the effect of a topical product formulation containing blueberry extract, an AGE inhibitor, and C‐xyloside, a GAG synthesis stimulator, applied twice daily on the hand, arm, and facial skin of 20 type II diabetic females. Diabetic skin was chosen for evaluation because AGEs are found in increased concentration in diabetic skin, representing a model for accelerated aging. Materials and Methods This single‐center study enrolled 20 female type II diabetics aged 55+ years with mild to moderate fine lines, wrinkles, and hyperpigmentation on the face and hands. Subjects used the study product on their face, hand, and inner forearm twice daily for 12 weeks. Ordinal grading on a 4‐point scale (0 = none, 1 = mild, 2 =moderate, 3 = severe) of facial fine lines, wrinkles, firmness, radiance, skin tone, skin smoothness, hyperpigmentation, creping, density, sagging, and overall appearance was performed by the investigator at baseline, week 4, week 8, and week 12. Tolerability, subject assessments, digital photography, AGE measurements, skin caliper measurements, and corneometry were also performed at each time point. Results 19/20 subjects successfully completed the study. The presence of AGEs was documented by skin autofluorescence. The 12‐week duration of the study was insufficient to measure a change in skin AGEs, but longer application of the study product might produce different results. No tolerability issues were noted. There was a statistically significant increase in skin caliper measurements on the face (P = 0.004) and arm (P = 0.014) as well as corneometry measurements (P < 0.001) consistent with enhanced moisturization at week 12. The dermatologist investigator also found statistically significant improvement in fine lines (P = 0.01), firmness (P = 0.011), radiance (P < 0.001), skin tone (P = 0.014), skin smoothness (P < 0.001), creping (P < 0.004), and overall appearance (P < 0.001). Conclusion This study examined a topical product containing an AGE inhibitor and a GAG synthesis stimulator designed for the unique needs of diabetic skin. 相似文献
2.
Tomonobu Ezure Eiichiro Yagi Naomi Kunizawa Tetsuji Hirao Satoshi Amano 《Skin research and technology》2011,17(4):510-515
Background: Facial sagging is a well‐known morphological feature associated with aging and reduced dermal elasticity. Its morphological characteristics and mechanism have been studied in females, but it is unclear whether or not there is a gender difference. Aims: The aim of this study was to clarify the morphological characteristics of sagging and the mechanism of sagging formation in male faces as compared with female faces, focusing on changes in dermal elasticity. Methods: Faces of 98 healthy Japanese male volunteers, in their 20s–60s, were photographed at an angle of 45°. Upper and lower cheek sagging severity was evaluated by using photograph‐based grading criteria. In addition, new photograph‐based grading criteria of sagging severity at the lower eyelid were established and used. Dermal elasticity was measured using a non‐invasive, in vivo suction skin elasticity meter, Cutometer®. Furthermore, photographs of 108 healthy Japanese female volunteers in their 20s–60s were used to compare the difference in the morphological characteristics of sagging between males and females. Results: Male facial sagging was prominent at the lower eyelid, upper cheek and lower cheek. Sagging severity in the upper and lower cheek was almost the same between males and females at all ages, whereas sagging at the lower eyelid in males was significantly more severe than that in females after middle age. Although dermal extensibility (Uf) was not related to age, total deformation recovery (Ua), ?(amount of deformation) ?(Uf?Ua), overall elasticity of the skin including creep and creep recovery (Ua/Uf), net elasticity excluding viscoelastic creep (Ur/Ue), ratio of elastic recovery to total deformation (Ur/Uf) and ?(ratio of viscoelastic to elastic distention) ?(Uv/Ue) were all significantly negatively related to age in both men and women. Furthermore, as in female faces, male facial sagging was significantly negatively related to dermal elasticity parameters, such as ?(Uf?Ua), Ua/Uf, Ur/Ue and Ur/Uf. Conclusion: These results indicate that the morphology and areas of sagging in male faces are similar to those in females in the cheek, but sagging at the lower eyelid is more severe in males after middle age. Furthermore, the dermal elasticity of male facial skin decreased with age similar to that of females, and may therefore be associated with the sagging formation in male faces. 相似文献
3.
Background/purpose: Facial sagging is associated with aging, although the mechanism remains unclear. The aim of this study was to investigate the mechanism of facial sagging by examining the relationship of sagging severity to changes of skin elasticity, fat mass and facial muscle function at the cheek.
Methods: Faces of 108 healthy Japanese female volunteers, aged 20–60 years were photographed at an angle of 45°. Standard scores of sagging severity were established by analyzing the photographs. We examined the correlations of scored sagging levels with skin elasticity measured with a Cutometer MPA 580® , fat content estimated by bioelectrical impedance analysis and facial muscle function (lip sealing force and occlusal force) in middle-aged female volunteers (30–40 years) with a wide range of sagging scores.
Results: Because the upper, lower and lateral areas in the cheek may show severe sagging, a six-grade score of sagging severity was separately established for each area. Each score was significantly correlated positively with age (20–60 years). In middle-aged volunteers, the sagging scores in all three areas of the cheek were significantly and negatively associated with skin elasticity. Body fat percentage was significantly and positively correlated with the sagging scores in the lower and lateral areas, although the correlation was only weakly positive in the upper area. Mimetic muscle function, measured in terms of lip sealing pressure, was significantly and negatively correlated with the sagging score only at the upper area of the cheek, but masticatory muscle function, measured in terms of occlusal force pressure, was not associated with the sagging score.
Conclusions: Sagging may be associated with the reduction of skin elasticity and mimetic muscle function and increase of fat mass, but the relationships are different in different areas of the cheek. 相似文献
Methods: Faces of 108 healthy Japanese female volunteers, aged 20–60 years were photographed at an angle of 45°. Standard scores of sagging severity were established by analyzing the photographs. We examined the correlations of scored sagging levels with skin elasticity measured with a Cutometer MPA 580
Results: Because the upper, lower and lateral areas in the cheek may show severe sagging, a six-grade score of sagging severity was separately established for each area. Each score was significantly correlated positively with age (20–60 years). In middle-aged volunteers, the sagging scores in all three areas of the cheek were significantly and negatively associated with skin elasticity. Body fat percentage was significantly and positively correlated with the sagging scores in the lower and lateral areas, although the correlation was only weakly positive in the upper area. Mimetic muscle function, measured in terms of lip sealing pressure, was significantly and negatively correlated with the sagging score only at the upper area of the cheek, but masticatory muscle function, measured in terms of occlusal force pressure, was not associated with the sagging score.
Conclusions: Sagging may be associated with the reduction of skin elasticity and mimetic muscle function and increase of fat mass, but the relationships are different in different areas of the cheek. 相似文献
4.
Fengzhu Li MD Haowei Chen PhD Dongxiao Chen MD Bingjie Zhang MD Qingying Shi PhD Xihong He PhD Huabing Zhao PhD Fang Wang PhD 《Journal of Cosmetic Dermatology》2023,22(12):3340-3346
Background
Skin aging is a complex multifactorial progressive process. With age, intrinsic and extrinsic factors cause the loss of skin elasticity, with the formation of wrinkles, resulting in skin sagging through various pathways. A combination of multiple bioactive peptides could be used as a treatment for skin wrinkles and sagging.Objectives
This study aimed to evaluate the cosmetic efficacy of a multi-peptide eye serum as a daily skin-care product for improving the periocular skin of women within the ages of 20–45 years.Methods
The stratum corneum skin hydration and skin elasticity were assessed using a Corneometer CM825 and Skin Elastometer MPA580, respectively. The PRIMOS CR technique based on digital strip projection technology was used for skin image and wrinkle analysis around the “crow's feet” area. Self-assessment questionnaires were filled on Day 14 and 28 of product use.Results
This study included 32 subjects with an average age of 28.5 years. On Day 28, there was a significant decrease in the number, depth, and volume of wrinkles. Skin hydration, elasticity, and firmness increased continuously during the study period, consistent with typical anti-aging claims. A majority of the participants (75.00%) expressed overall satisfaction with their skin appearance after using the product. Most participants noted a visible skin improvement, with an increase in skin elasticity and smoothness, and confirmed the extensibility, applicability, and temperance of the product. No adverse reactions related to product use were observed.Conclusions
The multi-peptide eye serum uses a multi-targeted mechanism against skin aging to improve the skin appearance, making it an ideal choice for daily skincare. 相似文献5.
Hiroshi Ohshima Akihiro Tada Akiko Kanamaru Hisashi Akamatsu Yuji Sakai Masatoshi Itoh Hiromi Kanto 《Skin research and technology》2011,17(1):101-107
Background: Forces acting in facial skin have been suggested to show directionality. Non‐invasive methods of measuring this directionality may thus provide information related to aging processes. The Reviscometer® RVM600 device is capable of measuring directionality of forces on the skin. This device has not been used previously in a published study to evaluate changes in directionality of forces on facial skin with aging. Aim: The first objective of this pilot study was to investigate relationships between mechanical directionality using the Reviscometer® RVM600, the Cutometer® MPA580, and aging of the facial skin in a supine position. In addition, the study investigated relationships between mechanical directionality and ‘skin sagging,’ which may be caused by gravity. To validate this as a new measurement of mechanical directionality, we also performed double‐blinded trials on two groups of subjects, with one group using a product containing an anti‐aging substance and the other group using a placebo product without an anti‐aging substance. Methods: We examined 91 healthy Japanese women with a mean age of 48.5 years (range, 20–79 years) at the three sites on the face using the Reviscometer® RVM600 and the Cutometer® MPA580, and evaluation was performed for skin sagging in September and November 2008, and January 2009. The Reviscometer® RVM600 was used to measure resonance‐running time (RRT) every 10° from 0° to 350°. Evaluation of skin sagging was undertaken by making marks on the face and using face photographs taken in both sitting and supine positions to calculate the sagging index. Usage testing was conducted on 38 healthy Japanese women in a double‐blinded study with one group, using a preparation containing Yomogi AGEs Clearing (YAC) extract and another group using the same preparation without the YAC extract from October 2008 to April 2009. Mean age of these subjects was 44.0 years (range, 30–60 years). Measurements were taken at the three sites on the face using the Reviscometer® RVM600 and the Cutometer® MPA580 and sagging index. Results: A significant correlation was identified between RRT parameters and subject age at all three measurement sites. Significant correlations between sagging index and RRT values were found for 110–170° and 290–350° only at the center of the cheek. Significant differences in RRT values were noted for 110–150° and 300–350° at this site between subjects with and without the use of YAC extract. A similar trend was found in sagging index for this site alone between subjects with and without YAC extract. Conclusion: The use of non‐invasive procedures to measure skin mechanical parameters on the face in all directions may evaluate aging and effective preventive and restorative support. 相似文献
6.
Background: Ordinal severity scales illustrated by photographs have been widely developed to help dermatologists in evaluating skin problems or improvements. Numerous scales have been published, and none of them were used for assessing facial pores. Methods: A five-point photographic scale of facial pores was formulated, and photographs of pores on nasal ala from 128 female volunteers were acquired. Five dermatologists with similar experiences rated the 128 photographs independently using the reference photographs. Latent Class Models (LCM) were used to analyze the data. Firstly, we hypothesized that the conditional probabilities of the five dermatologists were identical to build the first LCM and without the restriction to formulate the second LCM. Conditional probability and posterior probability were also calculated. Results: The five-point scales were ambiguous as the raters actually had difficulties in distinguishing between some adjacent categories. Adjacent categories were pooled for reanalyzing, and the model fitted well. Conclusions: The newly developed photographic scale of Chinese facial pores should be redefined to improve their quality and reproducibility in future studies. Standardized scales for the measurement of aging and response to cosmetic therapy were essential for assessing diagnostic experiment. The LCM can effectively deal with diagnostic test of agreement and reproducibility. 相似文献
7.
8.
Background: The accentuated nasolabial folds (NLFs) is the most pronounced sign of aging. Non-ablative erbium:yttrium aluminum garnet laser (ER:YAG), Smooth mode was used for the treatment of mucosal tissue. It was reported that it is effective in facial rejuvenation.Aim: To assess the safety and the effectiveness of intraoral ER:YAG Smooth mode laser in the treatment of NLFs wrinkle. Materials and methods: A total of 20 patients with different grades of NLFs wrinkle treated with 2940 nm Er:YAG laser intraorally. Six sessions were done every 2 weeks. The efficacy was assessed by two blinded dermatologists. Photographs were taken at the baseline, end of treatment and 6 months after the final session to document visible changes in NLFs wrinkle. The assessment was based on Modified Fitzpatrick Wrinkle Scale (MFWS) and by comparing the photographs. Patient’s self-assessment and patient’s satisfaction were used for assessment of final results and any side effects associated to treatment were observed. Results: There was significant reduction of the NLFs wrinkle. The MFWS was significantly improved 6 months after treatment compared to before treatment (p < 0.001). At the end of the follow-up period, there was improvement in overall appearance of the wrinkles. Patient’s self -assessment and satisfaction demonstrated better cosmetic outcomes. Conclusion: Intraoral Er:YAG laser is safe, painless, and effective treatment option for NLFs wrinkle. 相似文献
9.
Young-Jun Choi Han-Saem Kim Joon Hong Min Jae-Hui Nam Ga-Young Lee 《Journal of cosmetic and laser therapy》2017,19(3):174-180
Background: Recently, the efficacy of autologous plasma filler for the reduction of facial wrinkles has been demonstrated. Objective: The aim of our study is to validate the efficacy and safety of autologous plasma filler in treating nasolabial fold wrinkles. Material and methods: Twenty Korean patients with moderate-to-severe nasolabial fold wrinkles were enrolled. The patients were treated with one session of autologous plasma filler. The wrinkle improvement effects were evaluated at 1-week, 4-week, 8-week, and 12-week after the treatment. Three assessment methods were applied. First, two independent dermatologists assessed cosmetic results using a 5-point wrinkle assessment scale. Second, global aesthetic improvement score was used for assessment of the final cosmetic results. Third, patient satisfaction was surveyed. Also, the adverse effects associated to treatment were observed. Results: Mean age of the patients was 44.5 years. The average 5-point wrinkle assessment scale score was significantly improved at 1, 4, 8, and 12 weeks after treatment, comparing to before treatment (p < 0.01). The patients’ average global aesthetic improvement score also indicated better cosmetic outcomes. Conclusion: The clinical improvement with sufficient patients’ satisfaction and no significant adverse events demonstrated that novel autologous plasma filler could be considered as efficient and safety treatment option for nasolabial fold wrinkles. 相似文献
10.
Background: Subcutaneous adipose tissue lies just beneath the dermal layer, but the interaction between the two is not well understood. Recently, we showed that the subcutaneous adipose layer affects dermal properties in an obese rodent model. Objective: To explore the influence of the subcutaneous adipose layer on dermal properties and morphology in humans. Methods: Subcutaneous adipose mass was measured by ultrasound using a Prosound alpha 5®, dermal elasticity was measured using an in vivo suction skin elasticity meter (Cutometer MPA 580®), and sagging severity were evaluated morphologically using photograph‐based grading criteria at the lower cheek in 70 Japanese female volunteers (age; 31–59, BMI; 17.1–36.2). The correlations among the results were examined. Results: Thickness of the subcutaneous adipose layer was significantly and negatively correlated with dermal elasticity parameters, i.e., elastic deformation, elastic deformation recovery, extensibility, total deformation recovery, ratio of viscoelasticity to elastic distention and overall elasticity, including creep and creep recovery. Furthermore, we investigated their influence on facial morphology, such as sagging. The subcutaneous adipose mass was significantly and positively correlated with sagging severity at the lower cheek (R=0.442, P<0.001), and there was a significant negative correlation between dermal elasticity and sagging severity (R=?0.358, P<0.01). Conclusion: These results indicate that increment of subcutaneous adipose mass impairs dermal elasticity, which in turn exacerbates sagging severity. 相似文献
11.
Dr. Yasser Helmy Ali 《Journal of cosmetic and laser therapy》2018,20(1):41-49
Background: Thread-lifting rejuvenation procedures have evolved again, with the development of absorbable threads. Although they have gained popularity among plastic surgeons and dermatologists, very few articles have been written in literature about absorbable threads. This study aims to evaluate two years’ outcome of thread lifting using absorbable barbed threads for facial rejuvenation. Methods: Prospective comparative stud both objectively and subjectively and follow-up assessment for 24 months. Results: Thread lifting for face rejuvenation has significant long-lasting effects that include skin lifting from 3–10 mm and high degree of patients’ satisfaction with less incidence rate of complications, about 4.8%. Augmented results are obtained when thread lifting is combined with other lifting and rejuvenation modalities. Conclusion: Significant facial rejuvenation is achieved by thread lifting and highly augmented results are observed when they are combined with Botox, fillers, and/or platelet rich plasma (PRP) rejuvenations. 相似文献
12.
Background
Since 1936, injectable carboxytherapy has been used for the treatment of circulatory issues and lack of tissue trophism. In the last 25 years, it has been applied to aesthetic issues, especially those related to the signs and symptoms of skin aging. Presently, carboxytherapy is available as a combination of transcutaneous gels that produce CO2 with benefit for atrophic skin.Objective
The objective of this study was to investigate the efficacy and safety of a topical carboxy mask on facial photoaging after short term use of 4 weeks and long term use of 10 weeks.Methods
The short term study was conducted for 14 days after 3 times weekly application of the facial mask for 1 h followed by a regression phase with evaluations at days 21 and 28. 11 healthy female subjects age 45–75 years were enrolled. Subjects applied the facial mask for 45 min, 3 times per week during the 2-week treatment period. The long term study was conducted for 10 weeks on 35 subjects 35–65 years with mild to moderate facial photoaging of Fitzpatrick skin types I–VI. Subjects underwent photography, elasticity, hydration, and VAS questionnaire assessments.Results
The short term 4 week study demonstrated improvement in laser-Doppler measured blood flow and skin hydration. The long term 10 week study demonstrated improvement in firmness (16%, p = 0.001), sagging (9%, p = 0.023), and overall skin appearance (12%, p = 0.002). These findings were supported by the retraction time decrease at week 10 (−10%, p = 0.05).Summary
The combination of two gels produced the liberation of CO2, which improved short term skin hydration after 4 weeks of use and improved longer term skin elasticity after 10 weeks of use. 相似文献13.
Gopaul R Knaggs HE Lephart JF Holley KC Gibson EM 《Journal of Cosmetic Dermatology》2010,9(3):196-201
Background There are many different visible signs of skin aging. These include wrinkles, hyperpigmentation, lack of firmness, poor texture, enlarged pores, and dryness. While there are many topical agents that claim to deliver wide‐spectrum anti‐aging benefits, few target all of the signs of skin aging to the same extent. Salicin, an extract from white willow bark, has been researched as a potent anti‐inflammatory agent when taken orally. Based on unpublished in‐house comprehensive consumer clinical studies, it is believed salicin may have anti‐aging capabilities when applied topically to human skin. Aim This research evaluated the effect of a topical serum formulation containing salicin at 0.5% on the visible signs of skin aging. Materials and Methods This single‐center study enrolled 30 female subjects, showing mild to moderate signs of aging, between the ages of 35 and 70 having Fitzpatrick skin types ranging between I and IV. Subjects used the study serum product containing 0.5% salicin on their face twice daily for 12 weeks. Ordinal grading on a nine‐point scale (0 = none, 1–3 = mild, 4–6 = moderate, 7–9 = severe) of facial fine lines, molted pigmentation, uneven skin tone, tactile roughness, global firmness appearance, jaw‐line contour, radiance, and overall appearance was performed by investigator at baseline, week 1, week 4, week 8, and week 12. Digital photography, ultrasound, cutometry, and corneometry measurements were also performed at each time point. Results Twenty‐nine of 30 subjects successfully completed the study. No tolerability issues were reported. The clinical investigator found statistically significant improvements in wrinkles, tactile roughness, pore size, radiance, and overall appearance at week 1 time point (P ≤ 0.05) against baseline and statistically significant improvements in mottled pigmentation, global firmness, and jaw‐line contour at week 4 time point (P ≤ 0.05) against baseline. Cutometry, corneometry, and ultrasound measurements showed significant improvements at week 12 time point (P ≤ 0.05) against baseline. Conclusion Based on the findings from this study, it can be concluded that salicin has the ability to reduce the visible signs of skin aging when applied topically. 相似文献
14.
Peirano RI Achterberg V Düsing HJ Akhiani M Koop U Jaspers S Krüger A Schwengler H Hamann T Wenck H Stäb F Gallinat S Blatt T 《Journal of Cosmetic Dermatology》2011,10(4):273-281
Background The dermal extracellular matrix provides stability and structure to the skin. With increasing age, however, its major component collagen is subject to degeneration, resulting in a gradual decline in skin elasticity and progression of wrinkle formation. Previous studies suggest that the reduction in cellular energy contributes to the diminished synthesis of cutaneous collagen during aging. Aims To investigate the potential of topically applied creatine to improve the clinical signs of skin aging by stimulating dermal collagen synthesis in vitro and in vivo. Patients/Methods Penetration experiments were performed with a pig skin ex vivo model. Effects of creatine on dermal collagen gene expression and procollagen synthesis were studied in vitro using cultured fibroblast‐populated collagen gels. In a single‐center, controlled study, 43 male Caucasians applied a face‐care formulation containing creatine, guarana extract, and glycerol to determine its influence on facial topometric features. Results Cultured human dermal fibroblasts supplemented with creatine displayed a stimulation of collagen synthesis relative to untreated control cells both on the gene expression and at the protein level. In skin penetration experiments, topically applied creatine rapidly reached the dermis. In addition, topical in vivo application of a creatine‐containing formulation for 6 weeks significantly reduced the sagging cheek intensity in the jowl area as compared to baseline. This result was confirmed by clinical live scoring, which also demonstrated a significant reduction in crow’s feet wrinkles and wrinkles under the eyes. Conclusions In summary, creatine represents a beneficial active ingredient for topical use in the prevention and treatment of human skin aging. 相似文献
15.
Hyuck Hoon Kwon Won-Yong Lee Sun Chul Choi Jae Yoon Jung Youin Bae 《Journal of cosmetic and laser therapy》2013,15(7-8):449-453
Background: Although various minimal invasive approaches are available for aging skin laxity, they alone may not lead to notably satisfactory results. Objective: To evaluate the effectiveness and safety of combination regimen with monopolar radiofrequency (MRF) and intense-focused ultrasound (IFUS) in facial lifting and tightening. Methods: Twenty-two Korean participants with aging face received a sequential single session of MRF and IFUS treatment. Objective and subjective assessments for improvement were performed at the 20-week post-treatment. Safety profiles were also recorded, and skin biopsies were taken at baseline and follow-up visit. Results: Based on the objective assessment for the overall facial skin tightening and laxity, 19 patients (90%) demonstrated “moderate” or better improvements (more than 25%) compared with baseline. Specifically, improvements of skin laxity and sagging, and droopy jaw line were more noticeable compared with that of superficial skin texture (P < 0.05). Subjective satisfactions were generally consistent with objective findings, and no serious adverse effect was observed. Histologic evaluation showed increased dermal collagen fibers throughout the dermis after treatments (P < 0.05). Conclusion: Combination treatment of MRF and IFUS has cumulative benefits for skin lifting and tightening with satisfactory safety profiles in Asian subjects. 相似文献
16.
H. Kim M. Kim Y. Quan T. Moon J. Mun H. Cho N. Park W. Moon K. Lee H. Kim J. Lee H. Ryoo H. Jung 《Skin research and technology》2012,18(1):70-76
Background: The novel hybrid retinoid, retinyl retinoate, is a synthetic material that was designed to reduce the side effects of retinoic acid and to increase the stability of retinol. The formulation of the retinyl retinoate, however, is required to enhance skin permeation, and thus to increase the anti‐wrinkle effect. Aim: To identify the efficacy of retinyl retinoate microsphere using biodegradable polymer as an anti‐aging agent of cosmetics in treating females over 30 years old with periorbital wrinkles. Methods: The retinyl retinoate microsphere was prepared using the biodegradable polymer; polylactic acid (PLA). We also conducted two clinical studies with a total of 44 Korean women for 12 weeks. In the first clinical study, 20 patients completed a 12‐week trial of cream A [3% PLA‐retinyl retinoate (2%) microsphere] applied twice daily to the face. In the second clinical study, 24 patients completed a 12‐week trial of cream B (0.06% retinyl retinoate) applied twice daily to the face. Efficacy was based on a global photodamage score, photographs, and image analysis using replicas and Visiometers every 4 weeks. Results: The PLA‐retinyl retinoate microsphere was more effective for the permeation of retinyl retinoate than retinyl retinoate in itself. The cream A, which contains 3% PLA‐retinyl retinoate (2%) microsphere, showed a statistically significant improvement in facial wrinkles (P<0.05) in 20 volunteers after only 4 weeks of application in a clinical trial test. The visual wrinkle improvement and the maximum roughness improvement rate (R2) for cream A was 6.05%, 8.03% higher than that of cream B which contains 0.06% retinyl retinoate, after 4 weeks. Conclusion: Retinyl retinoate has a potent anti‐wrinkle activity, and the PLA‐retinyl retinoate microsphere could be a useful cosmeceutical product for anti‐aging purposes. 相似文献
17.
Bruce M. Freedman 《Journal of cosmetic and laser therapy》2013,15(3):142-145
Background: Intense pulsed light therapy (IPL) has been associated with erythema and increased lipid peroxidation. Polyphenolic antioxidants have been shown to decrease inflammation and reduce oxidative stress in irradiated skin. Objective: To determine whether the topical application of polyphenolic antioxidants to IPL‐treated skin reduced the adverse effects of IPL exposure. Methods: In a split‐face study, 10 volunteers underwent three full‐face IPL treatments (16 J/cm2, 10ms, 560nm filter) spaced 3 weeks apart. A polyphenolic antioxidant solution was pneumatically applied to the left side of the face, beginning immediately before the first IPL treatment then weekly for six treatments. The lipid peroxide concentration, skin antioxidant level and skin moisture content were obtained before and after the study. Results: Skin treated with IPL alone contained a significantly higher concentration of lipid peroxides when compared to skin treated with IPL plus polyphenolic antioxidants (p<0.05). Skin treated with IPL alone contained a significantly lower level of polyphenolic antioxidants and had a significantly lower moisture content (p<0.05). Conclusions: In this study, the concurrent pneumatic topical application of polyphenolic antioxidants reduced lipid peroxidation and skin dehydration in IPL‐treated skin. Polyphenolic antioxidants may confer a protective effect on facial skin and enhance the effects of IPL therapy. 相似文献
18.
Background There has been great interest in improving the efficacy of nonablative technologies by combining them during facial skin rejuvenation. The purpose of this study was to determine whether the addition of topical polyphenolic antioxidants to an intense pulsed light (IPL) treatment regimen augmented the effects of facial IPL treatments. Methods Thirty female volunteers, ages 34–52, with skin phototypes 1–3 were randomly assigned into three groups: group A (n = 10) received three full‐face IPL treatments spaced 3 weeks apart; group B (n = 10) underwent 6‐weekly full‐face treatments of a pneumatically applied topical polyphenolic antioxidant solution; group C (n = 10) received the combination of the three full‐face IPL treatments and the six full‐face topical antioxidant applications. Skin biopsies, skin polyphenolic antioxidant levels, and skin moisture content levels were obtained and clinical efficacy variables were noted prior to and following the treatment period. Results Compared to group A, group C demonstrated significantly greater epidermal and papillary dermal thickness, decreased lipid peroxide concentration, increased skin moisture content, and increased polyphenolic antioxidants levels (P < 0.05). There was qualitative improvement in hydration, texture, and pore size. Compared to group B, group C demonstrated significantly greater papillary dermal thickness (P < 0.05), and qualitative improvement in reduction of fine lines, reduction of hyperpigmentation, and skin dullness. group B and group C had equivalent polyphenolic antioxidant levels, lipid peroxide concentration, and epidermal thickness. Conclusion The addition of polyphenolic antioxidants to an IPL regimen improved the clinical, biochemical, and histological changes seen following IPL treatment alone. These data support the use of multimodal therapy to create synergy and to optimize clinical outcomes in nonablative facial skin rejuvenation. 相似文献
19.
BACKGROUND/PURPOSE: Sagging of the face skin is a visible and unattractive characteristic of skin ageing. This phenomenon, due to both gravitational force and age-related alterations in the mechanical properties of skin, has never been quantitatively studied. The aim of this paper was, first, to define a method and a precise procedure allowing the objective measurement of this phenomenon and, second,to study how it is related to age. METHODS: We used an electronically controlled bed that allows the comparison of submental skin profiles in both the reclined and the upright positions. A parameter that characterises the sagging amplitude for an individual was defined and the reproducibility of measurement of this parameter was verified. RESULTS: Results, obtained from 66 female volunteers, demonstrated a statistically significant positive correlation between this new parameter and age, and also between this new parameter and the elastic recovery parameter of skin, as measured by torquemeter. CONCLUSION: Age-related changes of the skin's mechanical properties and of the various underlying skin tissues would explain this phenomenon. This new method and procedure should allow objective evaluation of the efficacy of any treatments (cosmetic, medical or surgical) proposed for rendering the appearance of people younger. 相似文献
20.
Gema P Sevilla Rachita S Dhurat Geetanjali Shetty Prashant P Kadam Satish M Totey 《Indian journal of dermatology》2015,60(5):520-Oct;60(5):520