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1.
Pierot L Bonafé A Bracard S Leclerc X;French Matrix Registry Investigators 《AJNR. American journal of neuroradiology》2006,27(8):1693-1699
BACKGROUND AND PURPOSE: Endovascular treatment of intracranial aneurysms by using detachable coils has become an accepted alternative to surgery. To reduce the rate of aneurysm recanalization after treatment, biologically active polyglycolic/polylactic acid-covered platinum coils have been proposed. A prospective and multicenter registry was conducted in France to evaluate the safety and short-term and long-term efficacy of Matrix detachable coils. This first analysis is focused on the safety and short-term efficacy. METHODS: Two hundred sixty-one patients having ruptured or unruptured aneurysms treated via endovascular approach were included in this registry. Patients with giant aneurysms or in poor clinical condition (Glasgow Coma Scale < 10) were excluded. Because of various protocol violations, clinical analysis was conducted in 236 patients having 244 aneurysms. Technical and clinical complications were systematically recorded. Angiographic analysis was performed by a core laboratory by using the Raymond Grading Scale on 224 patients having 232 aneurysms. RESULTS: Complete occlusion was achieved in 102 aneurysms (44.0%); neck remnant, in 58 aneurysms (25.0%); and aneurysm remnant, in 72 aneurysms (31.0%). Technical and clinical complications related to the procedure were encountered in 43 patients (18.2%). Postoperative modification of the clinical status was observed in 12 patients (5.1%). Two patients died (0.8%), 6 had a permanent deficit (2.5%), and 4 had a transient deficit (1.7%). Treatment-related mortality was 0.8% and permanent morbidity was 2.5%. CONCLUSION: Endovascular treatment of intracranial aneurysms by using Matrix detachable coils is feasible and demonstrated initial angiographic results and overall morbidity and mortality rates that are within the ranges found in the literature in the use of bare platinum coils. 相似文献
2.
目的 探讨可脱性弹簧圈在脑血管痉挛期 (4~ 14d)栓塞治疗颅内动脉瘤的方法及效果。方法 2 0 0 4年 3~ 8月共栓塞颅内动脉瘤 14例 ,其中颈内动脉瘤 1例 ,后交通动脉瘤 8例 ,前交通动脉瘤5例 ,所有患者均在 4~ 14d内采用DCS MATRIX材料进行栓塞。结果 11例栓塞 10 0 % ,2例栓塞 70 %~ 90 % ,1例栓塞 5 0 % ;其中有 6例发现有脑血管痉挛。结论 在脑血管痉挛期 ,血管内栓塞动脉瘤也是一种安全、微创、有效的治疗方法。 相似文献
3.
Introduction Endovascular aneurysm repair with coils has become a safe and effective alternative to surgical clipping. Efforts have been
made to create coils that will facilitate aneurysm healing and reduce recurrence. The purpose of this study was to review
the safety and durability of our aneurysm treatment using Matrix coils.
Methods A total of 39 aneurysms in 38 patients, aged 30 to 77 years, were treated using Matrix coils in 42 procedures. Two procedures
were unsuccessful, and 12 were done using only Matrix coils. Aneurysm volume, packing density and percentage length of Matrix
coils were calculated. The treatment results, procedural complication rate and clinical outcome were analyzed. Follow-up examinations
were available for 34 procedures with a mean follow-up of 4.9 months (maximum 13.5 months).
Results Angiographic results were similar to those following the use of platinum coils, with complete occlusion or a residual neck
in 82.5% of procedures. Six procedures (14%) were complicated with platelet aggregation. Recanalization occurred in 32% of
the patients. Nine patients (26%) had major recanalization and were retreated. One patient had a re-bleed 5 months after the
treatment resulting in severe disability. The mean packing density of 39.2% in the recanalized aneurysms was similar to that
in the nonrecanalized group.
Conclusion In our series, treatment with Matrix coils had a complication rate similar to that reported with platinum coils. However,
we had a higher percentage of major recanalizations requiring retreatment. We believe that the absorption of the polymer contributes
to the failure of formation of a stable scar within the aneurysm.
This paper was presented at the American Society of Neuroradiology 44th Annual Meeting, San Diego, as an oral presentation. 相似文献
4.
Follow-up of intracranial aneurysms treated with matrix detachable coils: a single-center experience 总被引:3,自引:0,他引:3
BACKGROUND AND PURPOSE: Matrix coils are polymer-coated bioactive coils used in treatment of intracranial aneurysms. The current study is aimed at evaluating the efficacy and safety of these coils in treatment of ruptured and unruptured aneurysms. METHODS: Seventy-seven consecutive patients with 84 aneurysms were included in the study. Forty-six aneurysms were treated with Matrix coils alone, and 38 were treated with Matrix coils in combination with other coils/devices. Angiographic follow-up was available in 64 patients with 70 aneurysms. Length of follow-up ranged from 6 to 28 months with mean of 10 months. Both postembolization and follow-up angiograms were graded on a 3-point Raymond scale. Aneurysms were classified as stable, improved, or recanalized based on the follow-up angiograms. Recanalization was considered major if it was saccular and its size would theoretically permit retreatment with coils. RESULTS: At the end of the initial procedure, 47 (56.0%) aneurysms showed complete occlusion (Raymond 1), 20 (23.8%) showed contrast filling the neck of the aneurysm (Raymond 2), and 16 (19.0%) showed contrast filling the sac of the aneurysm (Raymond 3). Of the 70 aneurysms in which follow-up angiograms were available, 55.7% remained stable in appearance, 20.0% showed improved occlusion, and 24.3% demonstrated recanalization; 8.6% demonstrated major recanalization. There were 2 aneurysm rebleeds (both incompletely packed); one resulted in death. CONCLUSION: Matrix coils are safe to use and the recanalization rate of aneurysms treated with these coils appears to be at least comparable with historical studies with Guglielmi detachable coils. 相似文献
5.
血管内支架结合电解可脱弹簧圈治疗颅内动脉瘤 总被引:36,自引:4,他引:36
目的 初步总结使用血管内支架结合电解可脱卸弹簧圈(GDC)治疗颅内梭形及宽颈动脉瘤的体会,探讨其适应证、方法、疗效及并发症。方法 5例颅内梭形动脉瘤及12例宽颈动脉瘤,首先将冠脉支架跨动脉瘤颈放置,通过支架的网孔将微导管送入动脉瘤腔,继续填塞GDC。结果 13例动脉瘤致密填塞,3例大部分填塞,1例支架未能送入颅内而单用弹簧圈部分栓塞,载瘤动脉通畅,临床效果优良。结论 联合使用支架及微弹簧圈是治疗颅内梭形及宽颈动脉瘤的有效方法,远期疗效需进一步随访。 相似文献
6.
Endovascular treatment of ruptured intracranial aneurysms with detachable coils: long-term clinical and serial angiographic results 总被引:25,自引:0,他引:25
PURPOSE: To evaluate the stability of aneurysm occlusion over time, the need for additional treatments, and the long-term clinical outcome of patients, with emphasis on late recurrences of bleeding. MATERIALS AND METHODS: The records of 160 patients with aneurysmal subarachnoid hemorrhage who were treated with coils were retrospectively reviewed. Follow-up angiography was performed 6 and 18 months after coil placement, and the results were classified as complete, near complete, and incomplete occlusion. RESULTS: Six (4%) of the 160 patients experienced procedural mortality or dependency. After a mean follow-up of 36 months, 134 (84%) patients had a good outcome. Outcome was independent of aneurysm size and location and timing of treatment. Reopening of the aneurysm occurred exclusively during the first 6 months after coil placement, mainly in aneurysms larger than 15 mm. Between 6 and 18 months, no change in aneurysm occlusion was observed. Additional coil placement was performed in 15 (9%) patients. After this second coil placement, nine (7%) aneurysms were still incompletely occluded. Additional therapy was performed in eight (5%) patients. Two recurrences of bleeding were observed in two incompletely occluded large aneurysms. No recurrences of bleeding occurred in patients with completely or near completely occluded aneurysms. CONCLUSION: Coil placement is an effective and safe treatment strategy for patients with aneurysmal subarachnoid hemorrhage. If aneurysm occlusion is sufficient at 6 months, the yield of further follow-up angiography is very low. 相似文献
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9.
Endovascular treatment of intracranial aneurysms with matrix coils: a preliminary study of immediate post-treatment results 总被引:2,自引:0,他引:2
Lubicz B Leclerc X Gauvrit JY Lejeune JP Pruvo JP 《AJNR. American journal of neuroradiology》2005,26(2):373-375
A new, coated bioactive coil has been developed to improve the long-term results of endovascular treatment of intracranial aneurysms. The purpose of this preliminary study was to assess the feasibility and safety of selective embolization of intracranial aneurysms with Matrix coils in 20 consecutive patients. 相似文献
10.
Endovascular treatment of middle cerebral artery aneurysms with electrolytically detachable coils 总被引:1,自引:0,他引:1
Doerfler A Wanke I Goericke SL Wiedemayer H Engelhorn T Gizewski ER Stolke D Forsting M 《AJNR. American journal of neuroradiology》2006,27(3):513-520
BACKGROUND AND PURPOSE: Middle cerebral artery (MCA) aneurysms often have an unfavorable aneurysm geometry that might limit endovascular therapy. Our purpose was to analyze the feasibility, safety, and efficacy of coil embolization in a consecutive series of MCA aneurysms chosen for endovascular treatment. PATIENTS AND TECHNIQUES: Of 235 MCA aneurysms seen at our institution during the past 5 years, 36 patients harboring 38 MCA aneurysms were primarily selected for coil embolization: 18 patients had an acute subarachnoid hemorrhage (SAH), 16 of which were due to a ruptured MCA aneurysm. SAH was classified according to Hunt and Hess grade: I (5), II (7), III (5), IV (0), and V (1). RESULTS: Complete occlusion could be achieved in 33 of 38 aneurysms. In 5 aneurysms, coil embolization was not performed because of an unfavorable aneurysm geometry with a wide neck or incorporation of adjacent branches (3) or failed because of insecure coil placement (1) or severe vasospasm (1). Procedural complications included coil protrusion into the parent artery (1), and thromboembolic M2 occlusion (5), with recanalization in 4 of 5 cases. Of 8 aneurysms with initial subtotal occlusion, 3 progressed to total occlusion during follow-up. Three aneurysms had to be retreated, and no patient rebled. Glasgow Outcome Scale at 6 months for the patients with SAH (17/18) was good recovery (12), moderate disability (4), severe disability (0), persistent vegetative state (0), and death (1); outcomes for patients with an incidental aneurysm (17/18) were good recovery (16) and moderate disability (1). CONCLUSION: Endovascular coil embolization can be performed safely and effectively in selected MCA aneurysms. Initial subtotal aneurysm occlusion might progress to total occlusion. 相似文献
11.
D Roy J Raymond A Bouthillier M W Bojanowski R Moumdjian G L'Esprance 《AJNR. American journal of neuroradiology》1997,18(7):1207
PURPOSETo evaluate the safety and efficacy of endovascular treatment of ophthalmic segment aneurysms with Guglielmi detachable coils (GDCs), as well as the primary indications for such treatment.METHODSWe conducted a prospective study of 26 patients with 28 aneurysms of the ophthalmic segment in whom treatment with GDCs was attempted. Anatomic results were measured by statistical analysis of variance for such factors as age, sex, presence of subarachnoid hemorrhage, anatomic type (ophthalmic or superior hypophyseal), size of aneurysmal sac, and width of aneurysmal neck. Clinical evaluation and control angiography were performed at 6 and 18 months.RESULTSOverall, complete occlusion was obtained in 14 aneurysms (50%) and small residual necks were left in 11 aneurysms (39%). Three treatment attempts failed (11%). Complete occlusion was obtained in 76% of small-necked aneurysms as opposed to 9% of aneurysms with a large neck. The best predictor of anatomic result was the size of the aneurysmal neck. Complete occlusion was obtained in 85% of superior hypophyseal aneurysms of the paraclinoid variant. One permanent complication was related to treatment.CONCLUSIONEndovascular treatment with GDCs appears to be a safe and efficient alternative approach for ophthalmic segment aneurysms, especially for paraclinoid variants of superior hypophyseal aneurysms, which tend to have a small neck. 相似文献
12.
A multicenter study of 705 ruptured intracranial aneurysms treated with Guglielmi detachable coils 总被引:18,自引:0,他引:18
Gallas S Pasco A Cottier JP Gabrillargues J Drouineau J Cognard C Herbreteau D 《AJNR. American journal of neuroradiology》2005,26(7):1723-1731
BACKGROUND AND PURPOSE: The long-term durability of Guglielmi detachable coil (GDC) embolization of cerebral aneurysms is still unknown. The purpose of this study was to evaluate the stability of anatomic occlusion of aneurysms treated with GDCs and assess the rate of recanalization and re-treatment. METHODS: A multicenter study involving 650 patients with 705 ruptured aneurysms treated with GDCs between January 1998 to May 2003 was conducted. During this period, 63% of ruptured aneurysms were treated by the endovascular technique. The morbidity and mortality associated with this technique, procedural feasibility, acute angiographic occlusion results, and long-term angiographic follow-up were assessed. RESULTS: Overall technical feasibility of GDC treatment was 96.9%. Upon admission, 25% of patients were Hunt and Hess grade IV or V. Acute angiographic results in 683 aneurysms demonstrated total occlusion in 496 cases (72.6%), subtotal occlusion in 171 cases (25.%), and incomplete occlusion in 16 cases (2.4%). All patients were controlled by angiography and MR imaging at 3 months, 1 year, and subsequent yearly examinations post-treatment. A second treatment was performed in 27 cases (recanalization, 4.7%). Long-term follow-up angiograms (mean, 36 months) were obtained in 571 aneurysms (95%). Of them, 422 aneurysms (73.9%) demonstrated complete occlusion, 148 aneurysms (25.9%) demonstrated subtotal occlusion, and only 1 aneurysm was incompletely occluded. Overall mortality was 11.4% for all patients, with procedural mortality evaluated at 1.4%. Overall morbidity was calculated at 8.6%. Only one rebleeding occurred in our study, with a second procedure performed without vital consequences for the patient. CONCLUSION: Our multicenter study confirms the stability of aneurysm embolization with GDC, with only 4.7% of aneurysms requiring re-treatment. 相似文献
13.
血管内支架治疗颅内动脉瘤 总被引:20,自引:5,他引:15
目的:探索使用血管内支架及血管内支架结合电解可脱卸弹簧圈(Guglielmi detachable coil,GDC)治疗颅内梭形及宽颈动脉瘤的可能性。方法:3例椎动脉颅内段梭形动脉瘤及6例宽颈动脉瘤,首先将冠脉支架跨动脉瘤颈放置,通过支架的网孔将微导管送入动脉瘤腔,填入GDC。结果:7例动脉瘤致密堵塞,2例大部堵塞,载瘤动脉通畅,临床效果优良。结论:联合使用支架及微弹簧圈是治疗颅内梭形及宽颈动脉瘤可选择的有效方法之一。 相似文献
14.
Introduction Aneurysms of the posterior cerebral artery (PCA) are rare, and most of the studies reported in the literature in which the
endovascular approach was applied were carried out on a limited number of patients with PCA aneurysms. We retrospectively
reviewed our cases of PCA aneurysms – at various locations and of differing shapes – that received endovascular treatment
and evaluated the treatment outcome.
Methods From January 1996 to December 2006, 13 patients (eight females and five males) with 17 PCA aneurysms (nine fusiform and eight
saccular) were treated using the endovascular approach. The age of the patients ranged from 20 to 67 years, with a mean age
of 44 years. Of the 13 patients, ten presented with intracranial hemorrhage, and one patient, with a large P2 aneurysm, presented
with trigeminal neuralgia; the aneurysms were asymptomatic in the remaining two patients.
Results All 13 patients were successfully treated, with only one procedure-related symptomatic complication. Seven patients were treated
by occlusion of the aneurysm and parent artery together; five patients, by selective embolization of the aneurysm; one patient,
by partial coiling. Although infarctions were found in two patients treated with selective embolization and in three patients
treated with parent artery occlusion, only one patient with a ruptured P2 aneurysm treated with parent artery occlusion developed
transient amnesia as an ischemic symptom.
Conclusion Posterior cerebral artery aneurysms can be treated safely with either occlusion of the aneurysm together with the PCA or with
a selective coil embolization. Infarctions may occur after endovascular treatment, but they are rarely the cause of a disabling
symptom. 相似文献
15.
Long-term angiographic follow-up of 169 intracranial berry aneurysms occluded with detachable coils. 总被引:51,自引:0,他引:51
PURPOSE: To evaluate the stability of aneurysm occlusion at follow-up angiography after endovascular treatment (EVT) with detachable coils in intracranial berry aneurysms. MATERIALS AND METHODS: A total of 203 berry aneurysms (< 1.5 cm) were treated with EVT. Follow-up angiography at least 3 months later was performed in 169 cases. RESULTS: Complete occlusion of the aneurysm sac and neck was achieved in 148 aneurysms, subtotal occlusion in 18, and incomplete occlusion in three. Recurrence occurred between 3 and 40 months in 20 (14%) of the 148 totally occluded aneurysms. A second treatment was performed in five cases, was scheduled in one, and failed in one. The small neck remnant increased in size but did not require any retreatment in three cases, and the size of the neck remnant remained stable in 10 cases. Remnant regrowth occurred in six of the 18 subtotally occluded aneurysms. A second treatment was performed in three. Of the 169 cases, last follow-up angiography showed total occlusion in 133 cases, subtotal in 30, and incomplete in six. No rebleeding occurred. CONCLUSION: A very small recurrence may be observed at the level of the neck of the aneurysm at long-term follow-up angiography despite achieving total occlusion initially with detachable coils. 相似文献
16.
A Fernandez Zubillaga G Guglielmi F Viuela G R Duckwiler 《AJNR. American journal of neuroradiology》1994,15(5):815
PURPOSETo devise a method to measure aneurysm neck size on angiographic films, and to correlate the sizes obtained with the extent of endovascular aneurysm occlusion, performed with electrically detachable coils.METHODSThe angiograms of 79 intracranial aneurysms treated by endovascular occlusion using electrically detachable coils were retrospectively analyzed. A method using the average reported caliber of the major intracranial vessels was applied to determine the aneurysm neck sizes on the diagnostic angiograms. The cases were divided into two groups according to neck size, 4 mm being the discriminative value for small and wide necks. The posttreatment angiogram of each case was analyzed to evaluate the degree of occlusion achieved by the technique.RESULTSNecks were successfully measured in 95% of the aneurysms. Complete aneurysm thrombosis was observed in 85% of the small-necked aneurysms and in 15% of the wide-necked aneurysms.CONCLUSIONSAccurate angiographic measurements of neck diameter can be obtained in most aneurysms. The size of an aneurysm neck correlates well with the results of the endovascular treatment. Small-necked aneurysms can be satisfactorily occluded with this technique. In wide-necked aneurysms this technique should be reserved for lesions having a high surgical risk. 相似文献
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18.
Endovascular treatment of anterior communicating artery aneurysms using Guglielmi detachable coils 总被引:12,自引:0,他引:12
The aim of this study was to evaluate endovascular treatment of anterior communicating artery aneurysms using Guglielmi detachable
coils GDC. To obtain long-term follow-up, we selected patients treated between October 1992 and March 1994. Among the 251
berry aneurysms treated by detachable coils at our institution, 36 were located at the anterior communicating artery and treated
with GDC. The most frequent clinical presentation in this group (86 %) was subarachnoid haemorrhage (30 cases). There were
23 aneurysms which were completely and 6 were partially occluded. We did not treat 7 aneurysms. In 3 cases, no endovascular
treatment was attempted either because the aneurysmal neck was not clearly distinct from the adjacent, or parent vessels (2
cases), or because the aneurysm sac was too small (1 case). In 4 cases, treatment failed because of atheroma of the cervical
and intracranial vessels. Complications were, in the majority of cases, related to clotting (3 cases) with a good outcome
in 2 cases and neurological sequelae in 1. In 1 case rupture of the aneurysm occurred during treatment. Endovascular packing
was continued until complete occlusion of the aneurysm was achieved and no clinical complication was observed after the treatment.
Two patients died as a result of complications of subarachnoid haemorrhage (vasospasm in one case, pulmonary complications
in the other). Endovascular treatment using GDC is an efficient technique for treating anterior communicating artery aneurysms
even in the acute phase of bleeding.
Received: 6 June 1995 Accepted: 25 August 1995 相似文献
19.
目的 探讨电解可解脱弹簧圈治疗颅内动脉瘤的手术指征、术前评估方法、技术操作要点、手术时机、并发症防治、治疗效果、存在的问题及临床应用前景。方法 72例患者 ,80枚颅内动脉瘤中 ,6 8例为破裂动脉瘤 ,4例为未破裂动脉瘤。动脉瘤部位在后交通动脉 2 0枚 ,前交通动脉 32枚 ,大脑中动脉 8枚 ,大脑后动脉 5枚 ,眼动脉 3枚 ,颈内动脉分叉处 3枚 ,基底动脉 5枚 ,小脑后下动脉 2枚 ,脉络膜前动脉 2枚。 72例患者中 ,Hunt Hess分级 :Ⅰ级 2 4例 ,Ⅱ级 2 5例 ,Ⅲ级 10例 ,Ⅳ级 9例 ,Ⅴ级 4例。72例患者分别采用单纯弹簧圈栓塞、血管内支架加弹簧圈栓塞、瘤颈重塑形技术栓塞和双导丝技术栓塞。蛛网膜下腔出血 (SAH)后 1周内治疗的患者 18例 ,2~ 3周内治疗的患者 2 9例 ,4周以后治疗的 2 1例。手术采用全麻并在术中适当控制血压 ,使收缩压不超过 110mmHg ,手术全程在DSA动态监视下完成。根据患者SAH的严重程度 ,采用术前或者术后给予脑室外引流、腰椎蛛网膜下腔引流或单纯腰椎穿刺释放血性脑脊液的方法 ,栓塞术后全部病例给予“3H”治疗。结果 动脉瘤完全闭塞 6 8枚 ,占 85 % ,栓塞程度 95 %~ 99%的 8枚 ,占 10 % ,栓塞程度达 90 %的 4个 ,占 5 %。全组死亡 2例 ,占 2 .78%。术中动脉瘤出血 2例 ,经弹簧 相似文献
20.
生物可吸收弹簧圈治疗颅内动脉瘤的初步结果 总被引:1,自引:0,他引:1
目的 评价新型弹簧圈 (Matrix)系统在颅内动脉瘤栓塞治疗中的安全性与效果。方法 应用含有生物可吸收材料的Matrix或结合电解可脱卸弹簧圈 (GDC)栓塞颅内动脉瘤 6 2例。结果 6 2例动脉瘤均成功栓塞 ,其中 2 9例单纯Matrix栓塞 ,33例为Matrix结合GDC栓塞 ,1 5例患者采用支架辅助血管成形术。 4 9例动脉瘤致密栓塞 ,1 3例为大部分栓塞。 1例动脉瘤术中破裂出血 ,2例发生血栓栓塞。 2例患者死亡 ,3例重残 ,其余患者恢复良好。 2例动眼神经麻痹在术后 2周得到明显缓解。 2 5例患者造影随访 (3~ 6个月 )结果稳定 ,无明显载瘤动脉狭窄。结论 Matrix栓塞治疗颅内动脉瘤是有效的 ,可缓解动脉瘤占位效应并预防动脉瘤的复发。但长期结果需要进一步随访 相似文献