BODE指数在我国农村慢性阻塞性肺疾病患者中的应用价值

目的 探讨我国农村地区慢性阻塞性肺疾病(COPD)患者BODE指数与生活质量的相关性及其应用价值.方法 选择广东省英德市九龙镇COPD稳定期患者26例.测定并计算其BODE指数各项目的评分.采用St George呼吸问卷(SGRQ)评价患者的生活质量.结果 患者BODE指数分级与SGRQ总分、症状分、活动分、影响分均具有相关性(r值分别为0.674、0.430、0.460、0.495,P均＜0.05);GOLD分级仅与SGRQ总分和活动分具有相关性(r值分别为0.447、0.418,P均＜0.05).多元线性逐步回归分析发现BODE指数中影响SGRQ总分的因素是6 min步行距离(t=-2.397,P=0.025)和呼吸困难(t=2.257,P=0.034).结论 农村COPD患者BODE指数和生活质量密切相关,BODE指数中6 min步行距离和呼吸困难对生活质量的影响最大.

Abstract：

Objective To evaluate the application value of BODE and the relationship between BODE index and life quality in patients with chronic obstructive pulmonary disease (COPD) in rural China. Methods A total of 26 rural patients with stable COPD were enrolled. BODE index and it's four components including body mass index ( BMI ), airflow obstruction ( FEV1 % ), dyspnea ( MMRC ) and exercise capacity ( 6MWD ) were calculated. St. Georgeps Respiratory Questionnaire (SGRQ) were used to evaluate health-related quality of life of these patients. Results The BODE index was significantly correlated with the SGRQ total score , symptom ,activity and impact score ( r = 0. 674,0. 430,0. 460,0. 495 respectively, Ps ＜ 0. 05 ). GOLD grade was only significantly correlated with the SGRQ total score and active score( r =0. 447,0. 418 ,Ps ＜0. 05 ). Stepwise liner multiple regression analysis showed that activity score of SGRRQ was an influence factor of BODE index. 6MWD of BODE index( t = - 2. 397, P = 0. 025 ) and MMRC ( t = 2. 257, P = 0. 034 ) were independently correlated with activity scores of SGRQ . Conclusion BODE index and life quality had significant relationship. 6MWD and MMRC of BODE index were the most powerful influence factors of life quality in rural COPD patients.     

比索洛尔对冠心病合并慢性阻塞性肺疾病患者BODE指数的影响

目的评价比索洛尔对冠心病合并慢性阻塞性肺疾病（COPD）患者BODE指数的影响。方法42例冠心病合并稳定期轻、中度COPD患者,给予比索洛尔口服,起始剂量1．25mg／d,逐步增加至5mg／d。治疗开始前及治疗60d后,分别检测BODE指数（BODEindex）的四个相关参数,即第1秒用力呼气容积占预计值百分比（（FEVI％pred）、功能性呼吸困难量表评分（MMRC）、6min步行距离（6MWD）、体重指数（BMI）,并计算BODE指数。结果治疗前后BODE指数及其四个相关参数分别为：FEV1％pred（68．05±7．32VS．67．38±7.13）;6MWD（322．834-65．72Vs．320．43±62．34）;MMRC（2．13±0．57VS．2．18±0．65）;BMI（20．58±3．52VS．20．26±3．07）;BODEindex（3．51±1．97vs．3．54±2．01）。（均为P〉0．05）。结论比索洛尔对冠心病合并稳定期轻、中度COPD患者的BODE指数无明显影响。     

圣乔治呼吸问卷与慢性阻塞性肺疾病稳定期患者客观指标的相关性研究

目的:研究圣乔治呼吸问卷(St George's respiratory questionnaire,SGRQ)与慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)稳定期患者客观指标的相关性。方法:对44例COPD稳定期患者进行SGRQ评分,并测定体质量指数(BMI)、一秒用力呼气容积/预计值(FEV1/pre%)、功能性呼吸困难分级(MMRC)、6分钟步行距离(6MWD)、BODE指数。结果:SGRQ总分及其3个组成部分(即呼吸症状、活动受限、疾病影响评分)均与FEV1%pre、MMRC、6MWD、BODE指数等客观指标显著相关,而与BMI无相关性。结论:SGRQ与COPD稳定期患者的FEV1%pre、MMRC、6MWD、BODE指数等客观指标显著相关。     

康复训练对稳定期慢阻肺患者生活质量和运动功能的影响

目的:研究康复训练结合家庭运动疗法对稳定期慢性阻塞性肺疾病(COPD)患者的生活质量和运动功能的影响。方法:80例COPD患者随机分为2组各40例。对照组患者采用药物治疗和健康宣教,观察组在此基础上加用综合康复训练。对2组患者分别用改良英国MRC呼吸困难指数(mMRC),FEV/正常预计值(%)(FEV1%)评估,6分钟步行距离(6MWD),BODE指数(BODE)进行运动功能的评估;采用日常生活能力评估量表(Borg)以及汉密尔顿焦虑量表(HAMA)和抑郁量表(HAMD)对患者的生活质量进行评估。结果:治疗6个月后,观察组FEV1%较治疗前及对照组有明显增加(P0.05),而对照组治疗前后比较差异无统计学意义;观察组mMRC较治疗前及对照组有明显降低(P0.05),而对照组治疗前后比较差异无统计学意义;2组患者6MWD较治疗前均有增加(P0.05),但观察组较对照组增加更为明显(P0.05);2组BODE和Borg评分较治疗前均有下降(P0.05),但观察组较对照组下降更为明显(P0.05)。治疗后,观察组HAMA及HAMD评分均较治疗前及对照组明显降低(P0.05),对照组治疗前后比较差异无统计学意义。结论:康复训练结合家庭运动疗法可以明显改善稳定期COPD患者的生活质量和运动功能。     

Study of peripheral muscle strength and severity indexes in individuals with chronic obstructive pulmonary disease

Background and Purpose. Individuals with chronic obstructive pulmonary disease (COPD) present reduced peripheral muscle strength, which leads to impaired mobility and increased mortality risk. However, it is not clear whether there is any relationship between muscle strength, muscle mass and the body mass index, airflow obstruction, dyspnea, exercise performance (BODE) index scale, which is considered to be the best predictor of survival for individuals with COPD. The BODE Index is a multidimensional system that measures body composition (B), airway obstruction (O), dyspnea perception (D) and the ability to exercise (E), and rates the severity of the major changes found in individuals with COPD. The objective of this study was to verify any relationship between the BODE Index, muscle mass and maximum muscle strengths of the upper limb (UL) and lower limb (LL) in subjects with moderate to very severe COPD. Methods. Twenty‐six individuals with moderate to very severe COPD were evaluated by body composition (body mass index and muscle mass), BODE Index, handgrip strength (HS) and one repetition maximum (1RM) test of the UL and LL. Results. There was a positive correlation (Pearson, p < 0.05) of peripheral muscle strength, evaluated by HS and 1RM (pectoral and triceps, round muscles and dorsal section, quadriceps), to muscle mass (0.74, 0.57, 0.74 and 0.62, respectively) and the distance walked in the six‐minute walking test (0.52, 0.50, 0.46 and 0.58, respectively), but no correlation of muscle strength was found to forced expiratory volume in one second to dyspnea or the BODE Index. Conclusion. In accordance with the results of this study, peripheral muscle strength as measured by HS and 1RM is not related to the severity indexes for COPD, unlike UL and LL muscle strength. Therefore, UL and LL measurements now have an additional importance in COPD evaluation. Copyright © 2010 John Wiley & Sons, Ltd.     

慢性阻塞性肺疾病评估测试问卷对慢性阻塞性肺疾病稳定期患者生活质量的评估价值

目的：探究慢性阻塞性肺疾病评估测试问卷（chronic obstructive pulmonary disease assessment test,CAT）对慢性阻塞性肺疾病（chronic obstructive pulmonary disease,COPD）稳定期患者生活质量的评估价值.方法：对40例COPD稳定期患者进行CAT评分以及圣乔治呼吸问卷（St George＇s respiratory questionnaire,SGRQ）评分,并测定体质量指数（BMI）、第1秒用力呼气容积/预计值（percentage of forced expiratory volume in 1 second in predicated value,FEV1％ pred）、改良的英国医学研究委员会呼吸困难量表（modified Medical Research Council dyspnea scale,MMRC）评分、6 min步行距离（six-minute walk distance,6MWD）、BODE（B为体质量指数,O为气道阻塞程度,D为呼吸困难分数,E为运动耐力）指数,并对结果进行相关性分析.结果：CAT评分与FEV1％pred、6MWD呈显著负相关（r分别为-0.71和-0.85,P＜0.01）,与MMRC评分、BODE指数呈显著正相关（r分别为0.78和0.83,P＜0.01）,与SGRQ总分及3个组成部分即呼吸症状、活动受限、疾病影响评分均呈显著正相关（r为0.92～0.97,P＜0.01）,与BMI无相关性.结论：CAT问卷可作为评估COPD稳定期患者生活质量的有效手段.     

The BODE index as a predictor of unfavourable prognosis in chronic obstructive pulmonary disease (by the results of a prospective study)

AIM: To determine the death risk factors in patients with chronic obstructive pulmonary disease (COPD) in the course of a follow-up and to study feasibility of BODE index use for prognosis in COPD patients. MATERIAL AND METHODS: A total of 86 COPD patients were followed up for 3-5 years. The examination included total blood count, ECG, estimation of body mass index, external respiration function, pulsoxymetry, measurement of dyspnea characteristics by MMRC scale, physical activity by a 6-min walk test. Within the follow-up time 19 patients died, 15 of them of the basic disease and its complications. RESULTS: The death risk was higher in elderly patients over 60 years of age with dyspnea duration over 10 years and smoking history over 40 years (> 50 packs/year). In COPD death risk prediction factors are the following: forced expiration volume for 1 second under 40%, SaO2 < 90%, the result of 6-min walk test < 300 m, systolic pressure in the pulmonary artery above 40 mmHg, right ventricular (RV) wall thickness > 0.7 cm, R V cavity size > 3.0 cm, relative delatation of the right atrium (index < 0.9), R V diastolic dysfunction, symptoms of circulatory decompensation, predisposition to a hyperkinetic type of circulation. When BODE index was compared to the above data, its reliability as a factor of death prognosis in COPD was higher. CONCLUSION: BODE index can be used as a simple integrative index of death risk in COPD.     

Which pulmonary function tests best differentiate between COPD phenotypes?

We are still at the early phase of finding useful phenotypes in COPD that can guide therapy. However, in a simple sense, "sick patients die." Many phenotypic measurements of severity correlate with mortality in COPD: FEV(1), the ratio of inspiratory capacity to total lung capacity (IC/TLC), diffusing capacity of the lung for carbon monoxide (D(LCO)), 6-min walk distance, and maximum oxygen (O(2)) consumption or maximum watts on exercise testing. However, composite parameters, such as the BODE index (body mass index, air flow obstruction, dyspnea, exercise capacity), perform better, likely because they capture different aspects of severity that affect functional impairment and risk of death. Bronchodilator responsiveness is just a relative feature that aids in distinction of asthma and COPD but is not diagnostic in this use. A normal D(LCO) helps to rule out exercise-induced O(2) desaturation, but those with a low D(LCO) and COPD need exercise measurements to confirm desaturation. Currently, pulmonary function tests (PFTs) alone do not define subsets who respond to particular therapies. The presence of air flow obstruction and its severity increase the risk of lung cancer in COPD patients. Inflammatory biomarkers (exhaled nitric oxide and eosinophilia in sputum or bronchoalveolar lavage fluid) help distinguish asthma from COPD. Genetics is a promising area to elucidate pathophysiology and treatment for asthma and COPD, but currently alpha-1 antitrypsin deficiency is the only genetically-determined phenotype that has relevance for COPD management. The best promise for the future seems to be in composite phenotypes or scores, both for distinguishing asthma from COPD, and for guiding therapeutic options. It may be better to throw out the old, limiting diagnostic concepts. If, instead, we start from outcomes of interest, perhaps we can work back to predictors of these outcomes, and organize new diagnostic entities that have predictive relevance for treatment choices, functional outcomes, and mortality.     

高分辨CT在慢性阻塞性肺疾病临床评价中的作用

目的探讨高分辨CT(HRCT)肺功能成像在慢性阻塞性肺疾病(COPD)临床评价中的作用,及其与BODE评分之间的相互关系。方法对32例稳定期COPD患者、22例正常对照进行肺功能检查、肺CT检查,比较HRCT的肺功能成像参数与PFT检查、BODE指数之间的相关性。结果COPD组的深吸气容积(Vin)与正常对照组的差异无统计学意义(P>0.05),深呼气容积(Vex)及像素指数均明显高于正常对照组(P<0.01),Vex和Vin均与FEV1/FVC呈负相关(P<0.05),与FEV1占预计值%无相关性(P>0.05),与BODE评分亦无相关性(P>0.05),Vex/Vin与BODE评分呈正相关(P<0.05)与FEV1/FVC无相关性(P>0.05),呼气相像素指数(PI-910ex)与FEV1占预计值%及FEV1/FVC均呈负相关(P<0.05),PI-910ex与BODE评分呈明显正相关(P<0.01),吸气相像素指数(PI-960in)与FEV1占预计值%、FEV1/FVC、BODE评分均无相关性(P>0.05)。结论CT肺功能测定,尤其在深呼气相,以-910Hu做为界定肺气肿与正常肺组织的阈值时的像素指数(PI-910in)与FEV1占预计值%、FEV1/FVC及BODE评分呈相关关系。     

肺功能训练和营养支持对慢性阻塞性肺疾病患者的效果

目的 探讨肺功能训练和营养支持在慢性阻塞性肺疾病（chronic obstructive pulmonary disease,COPD）患者稳定期护理中的效果.方法 选择2011年12月-2012年9月就诊于四川省自贡市第一人民医院的COPD患者42例,随机分为实验组22例和对照组20例.对照组予以常规护理和常规饮食,实验组在对照组基础上予以肺功能训练,并根据患者情况予以营养支持治疗.两组患者均予以8周治疗,采用改良的英国医学研究委员会呼吸困难指数（MMRC）评估患者呼吸困难程度,1秒用力呼气量（FEV1）/用力肺活量（FVC）评估患者气流受限程度,体质指数（BMI）评估患者营养状况,6 min步行试验（6 MWT）评估患者运动功能.结果 两组患者治疗前后MMRC评分、FEV1/FVC、BMI和6MWT比较差异均具有统计学意义（P＜0.05）.结论 肺功能训练合并营养支持治疗能够改善COPD患者营养状况,缓解患者呼吸困难及气流受阻程度,提高患者运动能力,有助于COPD患者的康复.     

噻托溴铵奥达特罗吸入喷雾剂治疗慢性阻塞性肺疾病的临床效果

目的 探讨噻托溴铵奥达特罗吸入喷雾剂治疗慢性阻塞性肺疾病（COPD）的临床效果。方法 选取2019年10月至2020年9月本院58例COPD患者作为研究对象,根据随机数字表法将其分为对照组和观察组,各29例。在常规治疗的基础上,对照组给予噻托溴铵治疗,观察组给予噻托溴铵奥达特罗吸入喷雾剂治疗。比较两组的血清炎症因子水平、BODE指数、肺功能指标、临床疗效、不良反应发生情况和生活质量。结果 治疗后,观察组的hs-CRP、IL-6、TNF-α水平低于对照组（P<0.05）。治疗后,观察组的BMI、FEV1%、mMRC、6MWD、BODE指数评分优于对照组（P<0.05）。治疗后,观察组的FEV1、FVC、PEF高于对照组（P<0.05）。观察组的治疗总有效率高于对照组（P<0.05）。两组的不良反应总发生率无显著差异（P>0.05）。治疗后,观察组的SGRQ评分低于对照组（P<0.05）。结论 噻托溴铵奥达特罗吸入喷雾剂治疗COPD患者的效果显著,可降低血清炎症因子水平,改善BODE指数、肺功能,提高生活质量。     

COPD: criteria for diagnosis and classification of disease severity

In the guideline proposed by WHO (GOLD) or by the Japanese Respiratory Society (RS), the diagnosis of COPD is simply made when FEV1/FVC (FEV %) of a given subject after inhalation of short-acting bronchodilator is below 70%. On the other hand, on grounds of measured FEV1/predicted FEV (%FEV1), the disease severity of COPD is categorized into four stages including I (mild), II (moderate), III (severe), and IV(very severe). In addition, very special category defined as stage zero (at-risk group) has been proposed in both guidelines. However, the above-mentioned criteria have many impediments as they are too simple for diagnosing and classifying COPD with a complicated pathophysiology. In this paragraph, the attempt is made not only to comment on the diagnosis criteria and classification of disease severity of COPD provided in GOLD and JRS guidelines but also to investigate the details of the impediments existing in both guidelines.     

家庭康复训练对慢性阻塞性肺疾病患者的影响

目的通过考察家庭康复训练对慢性阻塞性肺疾病(COPD)患者的影响,以探讨家庭康复锻炼的方法和效果。方法组织在1998-01/2002-12吉林军医学院附属中心医院接受治疗的COPD患者进行为期12周的以步行为主要锻炼内容的家庭康复训练。训练强度以往复运动实验(SWT)为准。测量记录肺功能、运动能力和呼吸困难等内容。结果训练12周后,康复训练组的FVC(%预期值),FEV(%预期值)和FEV1/FVC比率明显高于对照组(t=1.851～2.892,P<0.05);康复组患者SWT与对照组相比有明显改善(t=2.137～2.938,P<0.05);康复组患者的运动时间和距离明显高于对照组(t=2.892～2.912,P<0.01),心率和呼吸困难程度明显低于对照组(t=2.268～2.938,P<0.05)。结论简单的家庭康复训练,在COPD患者中取得了很好的训练效果,患者的运动能力和呼吸困难程度得到改善。     

肺康复疗法改善慢性阻塞性肺疾病运动和呼吸功能的临床研究

目的:观察肺康复疗法改善慢性阻塞性肺疾病(COPD)患者运动能力和呼吸困难的临床效果。方法:选取2014年至2018年收治的COPD患者100例,采用随机数字表法将其随机分为对照组( n＝50)和观察组( n＝50)。对照组患者给予常规药物治疗,观察组患者在此基础上增加包含健康指导、氧疗、呼吸生...     

Use of self-efficacy and dyspnea perceptions to predict functional performance in people with COPD.

This correlational and comparative study explored whether self-reports of self-efficacy and dyspnea perceptions predict the perceived level of functional performance in adults who have chronic obstructive pulmonary disease (COPD). The convenience sample included 97 Caucasian men (52) and women (45). Participants had to have a forced expiratory volume in 1 second (FEV1) of less than 70% predicted, and a FEV1/forced vital capacity (FVC) of less than 70%. Participants were recruited from pulmonary function laboratories and from better breather support groups in a Midwestern state. Three standardized, self-report instruments, COPD Self-Efficacy Scale (CSES), the Pulmonary Functional Status and Dyspnea Questionnaire (PFSDQ), and Functional Performance Inventory (FPI) were used to measure the participants' self-report of their perceptions of self-efficacy, dyspnea, and functional performance. Dyspnea predicted 38.1% of the variance in functional performance, with self-efficacy contributing an additional 6.5% to the variance in the total sample. Self-efficacy predicted 36.5% of the variance in functional performance in men, with dyspnea contributing an additional 7.2% to the variance. However, in women, only dyspnea was a significant predictor of functional performance, at 48.5% when both dyspnea and self-efficacy were entered as independent variables. To improve patients' perceptions of functional performance, nurses can use methods such as breathing techniques and upper- and lower-body exercises that increase optimal management of dyspnea. Nurses may increase the self-efficacy of managing dyspnea by helping patients master breathing techniques and exercise through coaching and providing vicarious experiences through patient support groups or pulmonary rehabilitation programs.     

Factor analysis of laboratory and clinical measurements of dyspnea in patients with chronic obstructive pulmonary disease

The primary purpose of this study was to determine if there are three distinct factors representing ratings of dyspnea during laboratory exercise, clinical ratings of dyspnea, and pulmonary function in patients with moderate to severe chronic obstructive pulmonary disease (COPD) (n = 92) using factor analysis. Subjects (mean age 66 +/- 7 yrs; FEV1% predicted 44.7 +/- 14.0) were randomly assigned to one of three treatment groups to test the effects of three education and exercise training programs. Outcomes were evaluated at baseline and at 2 months after the intervention. Dyspnea ratings with laboratory exercise (SOB) were measured during incremental (ITT) and endurance (ETT) treadmill tests, and a six-minute walk (6MW) using the modified Borg scale. Clinical measures of dyspnea were measured with the Baseline and Transitional Dyspnea Index (BDI/TDI), UCSD Shortness of Breath Questionnaire (SOBQ), Medical Research Council Dyspnea Scale (MRC), Dyspnea subscale of the Chronic Respiratory Questionnaire (CRQ-D), and a global dyspnea question. Pulmonary function parameters included FEV1% predicted, FEV1/FVC, and RV/TLC. The factor analysis yielded three factors that accounted for 58.7% of the total variance in the data: Factor 1, "Dyspnea with Laboratory Exercise" comprised ETT SOB end, ETT SOB isotime, ITTSOB end, ITT SOB isotime, ITT SOB/Time and ETT SOB/Time. Factor 2, "Clinical Dyspnea," comprised 6MW SOB, 6MW SOB/Feet, BDI, SOBQ, MRC, Global SOB, CRQ-D. Measures of airway resistance (FEV1% predicted, FEV1/FVC) and hyperinflation (RV/TLC) loaded on a third factor, "Pulmonary Function." An additional post hoc factor analysis with post-intervention data provided similar results. The Global SOB question and ITT SOB isostage variables were relatively more sensitive to change compared to the other outcome variables. We conclude that pulmonary function, clinical ratings of dyspnea, and laboratory ratings of dyspnea are three separate and independent factors and should be included in the routine clinical evaluation of patients with COPD.     

呼吸训练对稳定期慢性阻塞性肺疾病患者呼吸功能的影响

目的 探讨呼吸训练对稳定期慢性阻塞性肺疾病（COPD）患者肺功能及呼吸肌表面肌电图（RMS）的影响。 方法 将67例稳定期COPD患者按随机数字表法分为治疗组（36例）和对照组（31例）。对照组采用常规呼吸康复治疗,如缩唇呼吸、腹式呼吸、上肢上举训练等,治疗组在常规呼吸康复治疗基础上,使用肺功能训练仪进行呼吸训练,每周治疗5次,每次30min,共治疗6个月。分别于治疗前、治疗6个月后采用6分钟步行测试、COPD评估测试(CAT)、BODE指数评分、用力肺活量和1秒用力呼气流量及表面肌电图评定2组患者的运动能力、生活质量、肺功能及呼吸肌表面肌电信号的RMS。 结果 治疗前,2组患者的各项评定指标比较,差异无统计学意义（P>0.05）。治疗6个月后,两组患者的6分钟步行测试、CAT评分、BODE指数评分、呼吸肌表面肌电图的RMS较组内治疗前均有所改善（P<0.05）。与对照组比较,治疗组的6分钟步行测试、CAT评分、BODE指数评分、呼吸肌表面肌电信号的RMS改善程度更显著（P<0.05）;两组患者治疗6个月后,FVC和FEV1较治疗前改善,但无统计学意义（P>0.05）,两组患者治疗6个月后FVC和FEV1比较,差异亦无统计学意义（P>0.05）。 结论 呼吸训练可改善稳定期COPD患者的运动能力、生活质量、呼吸肌表面肌电图的RMS。     

Stage and prognosis of COPD

Clinical stages of chronic obstructive pulmonary disease(COPD) have been described in the guideline by American Thoracic Society(ATS), European Respiratory Society(ERS), and Japanese Respiratory Society. Recently, the clinical stage in GOLD(Global Initiative Obstructive Lung Disease) was also published in the guideline as an international standard. Although severity or clinical stages of COPD in ATS, ERS, and JRS guidelines is determined by only % predicted FEV1.0/FVC(%FEV1.0), GOLD guideline added clinical symptoms to %FEV1.0 for determining clinical stages of COPD. Prognosis is also correlated with %FEV1.0 in COPD patients. Prognosis of COPD patients shows a clear decline in proportion to that of %FEV1.0. However, pulmonary circulation disorder also affects the prognosis of COPD. Pulmonary hypertension is often found in severe COPD.     

集束化肺康复干预策略对慢性阻塞性肺疾病患者 BODE指数的影响

目的：探讨集束化肺康复干预策略对慢性阻塞性肺疾病患者 BODE 指数的影响。方法选择2011~2013年在本院呼吸内科出院的稳定期 COPD 患者29例,采用自身实验前后对照设计,入组前进行 BODE (B 体质指数、O 气流阻塞程度、D 呼吸困难严重程度、E 运动耐力)基数评估,给予集束化肺康复干预措施,包括患者评估、下肢运动训练、呼吸肌力量训练、健康宣教、心理和行为干预、营养支持指导,6个月后再进行生 BODE指数检测。结果 BODE 指数从(6.72±2.29)下降至(5.48±2.47)(P<0.01)。结论集束化肺康复干预策略能降低患者 BODE 指数。