三种不同手术方式对翼状胬肉的疗效比较

Objective Compared the clinical effect of simple excision of pterygium, limbal epithelium and conjunctiva autografting combined excision and combined excision of pterygium with stem cell transplantation of comeal limbus.Methods Two hundreds and ten cases(230 eyes) were divided into three groups according to operative method, the first group(75 eyes) were treated with simple excision, the secondgroup(77 eyes) were treated with limbal epithelium and conjunctiva autografting combined excision, the third group(78 eyes) were treated with combined excision of pterygium with stem cell transplantation of corneal limbus.Comea healing, limbal neovascular and tissue like pterygium hyperplasia were observed.Resulst: Following up was 4-28 months(averaged 14.30 ± 7.42). Recurrence rate was 26.67% in group A, 10.39% in group Band 8.97%in group C.The recurrence of epithelium in the group A was higher than those of the other two groups, But there were no significant differences between group B and group C .The average repair time of epithelium in the group C and group B were 2.30 ± 0.31 days and 6.15 ± 0.40 days ,the differences were remarkable in two groups(P< 0.05).Conclusions Limbal epithelium and conjunctiva autografting combined excision and combined excision of pterygium with stem cell transplantation of corneal limbus can reduce the recurrence significantly, the latter can lower the repair time of epithelium remarkably.     

Adenovirus-mediated delivery of p27^KIP1 to prevent wound healing after experimental glaucoma filtration surgery

Aim： The aim of the study was to evaluate the outcome of adenovirus-mediated p27^KIP1 （Ad-p27） expression on wound heal- ing after filtration surgery and to investigate the inhibition of cell proliferation induced by Ad-p27. Methods： We constructed the adenovirus recombinant vector Ad-p27 and administered it to a rabbit model of glaucoma filtration surgery by subconjunctival injection; phosphate-buffered saline （PBS） and mitomycin C （MMC） were used as controls. Intraocular pressure （IOP）, bleb scores, and anterior chamber depths were observed during a 28-d period. Histological examinations, fluorescence observations and Western blot analyses were evaluated. Results： Ad-p27 enhanced the surgical outcome and inhibited cell proliferation when compared with PBS. Bleb scores in the Ad-p27-treated eyes were higher than those in the PBS-treated eyes on d 7 （P〈0.01）, 14 （P〈0.01） and 21 （P〈0.05）. On d 28, IOP remained significantly decreased in the Ad-p27 group compared with the PBS group （P〈0.05）. However, no differences in bleb scores or IOPs were observed between the Ad-p27 and MMC groups. Histological analysis showed that total cell numbers were markedly reduced, and less scar tissue was observed at the surgical site in eyes treated with Ad-p27. The number of fibroblasts was decreased in Tenon＇s capsule in Ad-p27-treated eyes; however, a marked and diffuse signal from the green fluorescent protein （GFP） was observed in fibroblasts. Western blot analysis revealed a high level of p27^KIP1 expression in conjunctival epithelium （P〈0.01）, relatively high expression in superficial scleral stroma （P〈0.01）, and low expression in corneal epithelium in the Ad-p27 group. Conclusions： Ad-p27 administration significantly improves the outcome of filtration surgery and inhibits postoperative proliferation in rabbit eyes. These findings suggest that p27^KIP1 is a potential adjunctive agent for inhibition of wound healing after filtration surgery.     

纤溶酶联合血塞通注射液治疗急性脑梗死临床研究

Objective To explore the total curative effects of Xuesaitong injection combined whth fibrinogenase on acute cerebral infarction(ACI). Methods One hundred and twelve patients with ACI were randomly and equally divided into two groups, 56 cases in the treatment group were treated with Xuesaitong injection combined Fibrinogenase, while 56 cases in the control group were treated with compound danshen injection, once a day for 15days. Results Coagulation indicators of the treatment group was obviously better than that of the control group(P ＜0.05 or P ＜ 0.01 ). The total effective rate (91.1% ) of the treatment group was obviously higher than that of the control group( 69.6% )( P＜ 0.05 ). The Neurological deficit scores of therapy group were significantly improved (P ＜ 0.05). There was no obvious adverse reaction. Conclusion Xuesaitong injection combined fibrinogenase are remarkablyeffective and safe in treating ACI.     

纤溶酶联合血塞通注射液治疗急性脑梗死临床研究

Objective To explore the total curative effects of Xuesaitong injection combined whth fibrinogenase on acute cerebral infarction(ACI). Methods One hundred and twelve patients with ACI were randomly and equally divided into two groups, 56 cases in the treatment group were treated with Xuesaitong injection combined Fibrinogenase, while 56 cases in the control group were treated with compound danshen injection, once a day for 15days. Results Coagulation indicators of the treatment group was obviously better than that of the control group(P ＜0.05 or P ＜ 0.01 ). The total effective rate (91.1% ) of the treatment group was obviously higher than that of the control group( 69.6% )( P＜ 0.05 ). The Neurological deficit scores of therapy group were significantly improved (P ＜ 0.05). There was no obvious adverse reaction. Conclusion Xuesaitong injection combined fibrinogenase are remarkablyeffective and safe in treating ACI.     

子宫内膜异位症术后辅助药物治疗的临床研究

Objective To study the clinical effects and safety of mifepristone and gestrinone as postoperative auxiliary medicine to patients with endometriosis.Methods 120 patients were randomly divided into postoperation with mife~stone group,postoperation with gestrinone group and non-postoperation medicine group,40 cages for each group.A retrospective analysis was carried out to compare the clinical effects,adverse drug reaction and relapse conditions:Results The symptom of patients in all groups was impmved with remission in various degree.The adverse reaction of mifcpristone group was less than that of gestrinone group.And there was no significant difference in curative effects in these two groups(P＞0.05).But the curative effects of mffepristone and gestrinone groups were significantly better than that of nonpostoperation medicine group(P＞0.05).The recurrence rates of mifepristone,gestrinorle and nonpostoperatlon medicine groups were 15%.12.5%and 30%respectively.Conclusion It showed that the mlfepristone and gestdnone used as postoperative auxiliary medicine to patients with endometrinsis have the advantages of economic and practical,safe.effective,less adverse reaction,and can obviously reduce the recurrence rate,which is a effective method,     

子宫内膜异位症术后辅助药物治疗的临床研究

Objective To study the clinical effects and safety of mifepristone and gestrinone as postoperative auxiliary medicine to patients with endometriosis.Methods 120 patients were randomly divided into postoperation with mife~stone group,postoperation with gestrinone group and non-postoperation medicine group,40 cages for each group.A retrospective analysis was carried out to compare the clinical effects,adverse drug reaction and relapse conditions:Results The symptom of patients in all groups was impmved with remission in various degree.The adverse reaction of mifcpristone group was less than that of gestrinone group.And there was no significant difference in curative effects in these two groups(P＞0.05).But the curative effects of mffepristone and gestrinone groups were significantly better than that of nonpostoperation medicine group(P＞0.05).The recurrence rates of mifepristone,gestrinorle and nonpostoperatlon medicine groups were 15%.12.5%and 30%respectively.Conclusion It showed that the mlfepristone and gestdnone used as postoperative auxiliary medicine to patients with endometrinsis have the advantages of economic and practical,safe.effective,less adverse reaction,and can obviously reduce the recurrence rate,which is a effective method,     

氟伐他汀对缺血性脑卒中患者的疗效观察及护理措施

Objective To explore the effect and nursing main points of fluvastatin on the patients with cerebral arterial thrombosis. Methods Eighty-five patients with cerebral arterial thrombosis were randomly divided into three groups. Group Ⅰ was the negative control group. Group Ⅱ was the conventional-dose therapy group and group Ⅲ was the high-dose therapy group. Each group was treated with related therapy and care. The blood lipids in all groups were tested before the treatment, 4 weeks, 12 weeks and 24 weeks after the treatment; the carotid intima-media thickness (IMT) were measured by the Germany SEQUOIAS-512-B ultra machine before the treatment and 24 weeks after the treatment; At the same time, the side effects of fluvastatin were recorded. Results The results of blood lipid tests showed that the LDL, TC and TG in two treated groups were significantly decreased compared to negative control group (P<0.05). After treated for 24 weeks, the carotid intima-media thickness (IMT) in two treated groups were significantly reduced (P<0.05); the side effects of fluvastatin were infrequent and there was no significant different among the three groups (P>0.05). Conclusion The effects of different doses of fluvastatin on cerebral arterial thrombosis were significantly different. With the dose of fluvastatin increased, the serum LDL-L and TC reduced more obvious and the inhibition on carotid atherosclerosis shows more obvious, and the side effects did not increased.     

氟伐他汀对缺血性脑卒中患者的疗效观察及护理措施

Objective To explore the effect and nursing main points of fluvastatin on the patients with cerebral arterial thrombosis. Methods Eighty-five patients with cerebral arterial thrombosis were randomly divided into three groups. Group Ⅰ was the negative control group. Group Ⅱ was the conventional-dose therapy group and group Ⅲ was the high-dose therapy group. Each group was treated with related therapy and care. The blood lipids in all groups were tested before the treatment, 4 weeks, 12 weeks and 24 weeks after the treatment; the carotid intima-media thickness (IMT) were measured by the Germany SEQUOIAS-512-B ultra machine before the treatment and 24 weeks after the treatment; At the same time, the side effects of fluvastatin were recorded. Results The results of blood lipid tests showed that the LDL, TC and TG in two treated groups were significantly decreased compared to negative control group (P<0.05). After treated for 24 weeks, the carotid intima-media thickness (IMT) in two treated groups were significantly reduced (P<0.05); the side effects of fluvastatin were infrequent and there was no significant different among the three groups (P>0.05). Conclusion The effects of different doses of fluvastatin on cerebral arterial thrombosis were significantly different. With the dose of fluvastatin increased, the serum LDL-L and TC reduced more obvious and the inhibition on carotid atherosclerosis shows more obvious, and the side effects did not increased.     

氟伐他汀对缺血性脑卒中患者的疗效观察及护理措施

Objective To explore the effect and nursing main points of fluvastatin on the patients with cerebral arterial thrombosis. Methods Eighty-five patients with cerebral arterial thrombosis were randomly divided into three groups. Group Ⅰ was the negative control group. Group Ⅱ was the conventional-dose therapy group and group Ⅲ was the high-dose therapy group. Each group was treated with related therapy and care. The blood lipids in all groups were tested before the treatment, 4 weeks, 12 weeks and 24 weeks after the treatment; the carotid intima-media thickness (IMT) were measured by the Germany SEQUOIAS-512-B ultra machine before the treatment and 24 weeks after the treatment; At the same time, the side effects of fluvastatin were recorded. Results The results of blood lipid tests showed that the LDL, TC and TG in two treated groups were significantly decreased compared to negative control group (P<0.05). After treated for 24 weeks, the carotid intima-media thickness (IMT) in two treated groups were significantly reduced (P<0.05); the side effects of fluvastatin were infrequent and there was no significant different among the three groups (P>0.05). Conclusion The effects of different doses of fluvastatin on cerebral arterial thrombosis were significantly different. With the dose of fluvastatin increased, the serum LDL-L and TC reduced more obvious and the inhibition on carotid atherosclerosis shows more obvious, and the side effects did not increased.     

氟伐他汀对缺血性脑卒中患者的疗效观察及护理措施

Objective To explore the effect and nursing main points of fluvastatin on the patients with cerebral arterial thrombosis. Methods Eighty-five patients with cerebral arterial thrombosis were randomly divided into three groups. Group Ⅰ was the negative control group. Group Ⅱ was the conventional-dose therapy group and group Ⅲ was the high-dose therapy group. Each group was treated with related therapy and care. The blood lipids in all groups were tested before the treatment, 4 weeks, 12 weeks and 24 weeks after the treatment; the carotid intima-media thickness (IMT) were measured by the Germany SEQUOIAS-512-B ultra machine before the treatment and 24 weeks after the treatment; At the same time, the side effects of fluvastatin were recorded. Results The results of blood lipid tests showed that the LDL, TC and TG in two treated groups were significantly decreased compared to negative control group (P<0.05). After treated for 24 weeks, the carotid intima-media thickness (IMT) in two treated groups were significantly reduced (P<0.05); the side effects of fluvastatin were infrequent and there was no significant different among the three groups (P>0.05). Conclusion The effects of different doses of fluvastatin on cerebral arterial thrombosis were significantly different. With the dose of fluvastatin increased, the serum LDL-L and TC reduced more obvious and the inhibition on carotid atherosclerosis shows more obvious, and the side effects did not increased.