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Renal cancers comprise a wide variety of neoplasms with quite different genetic and molecular characteristics and clinical behaviors. Several issues of significant note have arisen in association with our increased understanding of these tumors, including questions regarding early diagnosis, the evaluation of cystic lesions, the behavior of tumors occurring in young patients, and insights regarding the prognosis and best follow-up strategies for these tumors.  相似文献   

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Stent-graft design: the good, the bad and the ugly.   总被引:4,自引:0,他引:4  
10 years of experience with endovascular AAA repair has yielded important information regarding the relationship between stent-graft design and stent-graft performance. Commercially available systems differ in important ways. General conclusions regarding endovascular AAA repair need to be qualified by reference to a specific system, or systems. Nevertheless, one can draw conclusions regarding the observed effects of certain design features, some of which are common to several devices. For example: tapered, trackable delivery systems (< or =20 French in diameter) rarely fail to traverse tortuous iliac arteries: transmural barbs provide the most secure means of proximal attachment, column strength is of little value; proximal stent migration is becoming the primary late failure mode; modular stent-grafts are more versatile than unibody stent-grafts; fully-stented graft limbs are less prone to thrombosis than unstented graft limbs, iliac implantation and low porosity are associated with lower rates of aneurysm dilatation in the absence of endoleak (endotension); any movement between the angle of a stent and the overlying fabric will lead to graft erosion; unpolished (black) Nitinol is prone to fracture; and a long trunk/short limb combination is more stable than a short trunk/long limb combination.  相似文献   

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Purpose

The diagnosis of “closing” or “closed gastroschisis” is made when bowel is incarcerated within a closed or nearly closed ring of fascia, usually with associated bowel atresia. It has been described as having a high morbidity and mortality.

Methods

A retrospective review of closing gastroschisis cases (n?=?53) at six children's hospitals between 2000 and 2016 was completed after IRB approval.

Results

A new classification system for this disease was developed to represent the spectrum of the disease: Type A (15%): ischemic bowel that is constricted at the ring but without atresia; Type B (51%): intestinal atresia with a mass of ischemic, but viable, external bowel (owing to constriction at the ring); Type C (26%): closing ring with nonviable external bowel +/? atresia; and Type D (8%): completely closed defect with either a nubbin of exposed tissue or no external bowel. Overall, 87% of infants survived, and long-term data are provided for each type.

Conclusions

This new classification system better captures the spectrum of disease and describes the expected long-term results for counseling. Unless the external bowel in a closing gastroschisis is clearly necrotic, it should be reduced and evaluated later. Survival was found to be much better than previously reported.

Type of study

Retrospective case series with no comparison group.

Level of evidence

Level IV.  相似文献   

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Current health care trends include movements toward general health care reform and rapidly evolving changes affecting treatment of vascular disease. Government-sponsored programs and private coalitions increasingly influence practice management and patient care. Emerging organizational influences derive from public perceptions, policies, laws, and regulations intended to make health care safe, effective, patient centered, timely, efficient, and equitable. These trends energized methods of quality assessment, cost containment, and practice protocols over individual judgments and seek to exert increasing direction over clinical practice. Some evolving measures are good, some controversial, and some, without deliberate intent, may be harmful. This review considers evolving initiatives in the context of ethics of practice and practicalities of managing patients with vascular disease. Key issues include compliance with purely process-based measures, pay for performance, and assessment of quality outcomes. Strengths, weaknesses, opportunities, and potential threats to vascular practice are outlined.  相似文献   

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