百草枯中毒的急救护理

我院自2002年起共收治百草枯中毒5例,护理体会如下。 1 临床资料 本组均口服中毒,男2例,女3例,年龄18～40岁,平均31岁,均为农民。口服量10～130 ml,服药后到院时间30 min～3h。中毒后出现口腔黏膜糜烂、恶心、呕吐5例,咳嗽、进行性呼吸困难4例,上消化道出血5例,多脏器功能衰竭3例,死亡3例,治愈2例。[第一段]     

百草枯中毒的急救护理

目的:探讨口服百草枯中毒的急救护理方法.方法:回顾性分析2010年1月至2012年6月收治的急性百草枯中毒21例的临床护理资料.结果:经过彻底洗胃,快速大量补液,血液净化治疗,器官保护与支持,周到的心理护理,8例患者出院.结论:护理人员熟练掌握百草枯中毒的综合急救护理,可提高其抢救成功率.     

32例百草枯中毒的急救护理

总结了32例百草枯中毒患者的急救护理体会。认为在急救护理过程中早期反复彻底清除胃肠道毒物、减轻毒物对重要脏器组织的损害、加强对重要脏器功能的监测、作好口腔护理、心理护理和健康教育，有助于提高中毒患者的生存率和生存质量。     

急性百草枯中毒85例急救护理

目的:探讨急性百草枯中毒患者的急救护理措施。方法:对85例急性百草枯中毒患者进行急救护理,观察临床效果。结果:本组85例患者中存活56例,存活率为66%,其中能从事日常工作54例,生活自理2例;死亡29例,病死率为34%,均出现多器官衰竭。结论:急性百草枯中毒可损害多系统组织器官,早期积极救治和精心护理可提高患者生存率。     

25例百草枯中毒的急救护理

总结25例百草枯中毒的急救护理体会，主要护理措施包括立即洗胃，彻底清除毒物，迅速行血液灌洗＋血流透析，建立静脉通路给予药物治疗，严密观察病情变化，心理护理等，认为及时有效的治疗、周密的护理可降低病死率。     

36例百草枯中毒的急救护理

总结了36例百草似中毒病员的急救护理体会、认为在急救护理过程中早期反复彻底清除胃肠道毒物、减轻毒物对重要脏器组织的损害、加强对重要脏器功能的监测、作好口腔护理、心理护理和健康教育，有助于提高中毒患者的生存率和生存质量。     

百草枯中毒21例的急救与护理

目的：探讨百草枯中毒的急救和主要护理措施。方法：回顾性分析了21例百草枯中毒患者的临床资料。结果：治愈3例，死亡18例。结论：百草枯具有高致死率，对肝脏、肺脏有严重的损害，在急救护理过程中，采取早期反复彻底清除胃肠道毒物、尽早血液灌流、加速毒物排泄、作好口腔护理以及心理护理和健康教育等措施，有助于缩短患者救治时间，减少并发症，降低死亡率。     

百草枯中毒20例的急救与护理

目的总结百草枯中毒的急救与护理方法。方法回顾性分析20例百草枯中毒患者的临床资料。结果 20例中毒者治愈7例,死亡13例（急性呼吸衰竭7例,急性肾衰竭3例,自动出院3例随访死亡）。结论百草枯中毒无特效解毒药,早期采用减少毒物吸收、促进排泄的方法,可明显减轻患者的症状,减少死亡率。     

百草枯中毒20例的急救与护理

我院自2004—04～2009—05共收住百草枯中毒患者2C例,经积极抢救与护理,收到较好的效果。现将急救与护理干预介绍如下。     

百草枯中毒的急救和护理要点

目的:探讨百草枯中毒的急救和护理要点。方法:回顾性分析20例百草枯中毒病人的临床资料。结果:治愈9例,好转7例,死亡4例。结论:在急救护理过程中早期反复彻底清除胃肠道毒物、减轻毒物对重要脏器组织的损害、加强对重要脏器功能的监测、作好口腔护理、心理护理和健康教育,有助于缩短病人救治时间,防止并发症,减少死亡率。     

急性百草枯中毒29例临床分析

目的：探讨百草枯中毒的临床特点及救治方法。方法：对29例急性百草枯中毒住院患者的临床资料进行回顾性分析。结果：所调查患者中,1例转院继续治疗,12例好转出院,11例死亡,5例未愈出院,院内死亡率40%。结论：百草枯毒性大,无特效解毒药。口服中毒后及早进行彻底洗胃、导泻等清除体内毒物,同时应用抗自由基药物、使用大剂量糖皮质激素减轻肺组织损害、尽早和反复予以血液净化治疗,上述综合有效的治疗是减少中毒死亡的关键。     

百草枯中毒患者的急救护理

目的：探讨百草枯中毒抢救的护理措施,以降低其死亡率。方法：接诊患者后,立即进行洗胃,留置胃管反复洗胃,持续胃肠减压排除毒物,防止毒物继续吸收,减轻对重要脏器及组织的损害;重症患者气管插管与洗胃同时进行,及时进行血液灌流,吸附血液中的毒物,净化血液,做好心理护理和健康教育。结果：47例患者中治愈31例,死亡16例。结论：在百草枯中毒的抢救中,掌握并实施正确的洗胃技术,直接影响抢救成功率。     

姜黄素治疗急性百草枯中毒的临床研究

目的:探讨姜黄素治疗急性百草枯口服中毒的临床疗效。方法:选择2007年3月-2010年3月在院救治的急性百草枯口服中毒患者74例,分为常规治疗组、激素治疗组和姜黄素治疗组。3组均常规对症治疗,激素治疗组在此基础上给予地塞米松25mg,静脉注射,每日1次。姜黄素治疗组在此基础之上给予姜黄素500mg/kg,口服,每日1次。在治疗第3天、7天、21天进行疗效评价,并对各组患者所出现的并发症进行统计。常规治疗组、激素治疗组和姜黄素治疗组均根据服毒量分组比较(20%原液或相当量<50ml组和≥50ml组)。结果:中毒治疗第3天,7天,21天,各组相比较,激素治疗组和姜黄素治疗组存活率均明显比常规治疗组高(均P<0.05),而姜黄素治疗组生存率与激素治疗组相比差异无统计学意义(P>0.05)。各组并发症发生率,即肺纤维化、急性肾功能衰竭、肝功能衰竭、MODS、DIC等并发症在激素治疗组和姜黄素治疗组均明显低于常规治疗组(均P<0.05),而激素治疗组与姜黄素治疗组之间比较差异无统计学意义(P>0.05)。结论:对急性百草枯口服中毒患者给予姜黄素治疗,其存活率和严重并发症发生率得到一定程度的改善,初步显示较好的疗效。     

急性百草枯中毒的治疗进展

百草枯（paraquat,1,1-二甲基-4,4-联吡啶阳离子盐）,是目前应用最广泛的触灭型除草剂之一,动物属中等毒性,但对人的毒性却较高,成人估计致死量40mg／kg。百草枯中毒后可造成多个系统或器官损害,肺部最为严重,病死率极高,致病机制复杂且尚未完全明确,     

26例僧尼急性商陆中毒的急救与护理

总结26例僧尼商陆中毒的急救与护理.在这一特殊群体的救护中,重点是加强施行抢救的组织管理,快速建立急救系统,做好有效的催吐、洗胃、静脉输液排毒,密切观察病情变化,重视护患沟通,注意特异性护理、安全护理.26例中毒僧尼全部治愈出院.     

百草枯中毒的治疗及需要重视的若干问题

百草枯（paraquat,PQ）又名克芜踪、对草快,化学名称是1-1-二甲基-4-4-联吡啶阳离子盐,主要成分是1,1＇二甲基4,4＇二氯二吡啶,分子式为C12H14Cl2N2,是目前在世界范围内广泛使用的有机杂环类接触性脱叶剂及除草剂,易溶于水,微溶于酒精,在酸性及中性环境中稳定,遇碱易分解。     

血液灌流救治急性百草枯中毒的疗效观察

目的：观察血液灌流（HP）治疗急性百草枯中毒的临床效果,探讨其价值。方法：百草枯中毒患者22例,分为HP组14例和非HP组8例,均给予常规0．9％氯化钠溶液洗胃、20％甘露醇导泻、补液、对症等综合治疗,HP组在此基础上尽早给予HP治疗,对比观察2组的治疗效果。结果：HP组痊愈率、总有效率明显高于非HP组,有统计学意义（P〈0．01）,中毒后6h内与6h后行HP者治愈率统计学意义（P〈0．01）;HP组ARDS和MOF发生率及病死率明显低于非HP组,有统计学意义（P〈0．01）,存活病例平均住院时间明显低于非HP组,死亡病例平均生存时间明显高于非HP组,有统计学意义（P〈0．01）。结论：HP是救治急性百草枯中毒的有效方法,尽早应用HP可明显提高急性百草枯中毒患者治愈率,降低死亡率、减少并发症,而且安全可靠,不良反应少。     

Alveolar–arterial partial pressure difference as an early predictor for patients with acute paraquat poisoning

ObjectiveParaquat (PQ) is associated with high mortality rates in acute poisoning. This study aimed to determine the importance of the alveolar–arterial partial pressure difference (A-aDo₂) in the expected consequences of acute PQ poisoning.MethodsPatients who were hospitalized for PQ poisoning in 2018 were enrolled in this retrospective study. A-aDo₂ data were collected. Multivariate analysis was performed using binary logistic regression to determine whether A-aDo₂ is an independent risk factor for mortality from PQ.ResultsA total of 352 cases were analyzed. The mean PQ dose was 36.84 ± 50.30 mL (0.3–500 mL). There were 185 survivors and 167 non-survivors. The mean A-aDo₂ was not significantly correlated between survivors and non-survivors on day 1. However, there were significant differences in A-aDo₂ between survivors and non-survivors on days 3, 7, 14, and 21. Increased A-aDo₂ values were correlated with an increased mortality rate. The mean A-aDo₂ on day 14 showed the most significant difference between survivors and non-survivors.ConclusionOur study suggests that A-aDo₂ plays an important role as a reference index, which could be a useful predictor in assessing acute PQ poisoning, especially on the 14th day after onset of poisoning.     

Risk factors and optimal predictive scoring system of mortality for children with acute paraquat poisoning

BACKGROUNDThere is no suitable scoring system that can be used to predict mortality in children with acute paraquat intoxication (APP).AIMTo optimize a predictive scoring system for mortality in children with APP.METHODSA total of 113 children with APP from January 1, 2010 to January 1, 2020 were enrolled in this study. These patients were divided into survivors and non-survivors. We compared the clinical characteristics between the two groups and analyzed the independent prognostic risk factors. The survival rates of patients with different values of the pediatric critical illness score (PCIS) were assessed using kaplan-meier survival analysis. The best scoring system was established by using the area under the receiver operating characteristic curve analysis.RESULTSThe overall mortality rate was 23.4%. All non-survivors died within 20 days; 48.1% (13/27) died within 3 days, and 70.3% (19/27) died within 7 days. Compared to survivors, the non-survivors were older, had higher white blood cell count, alanine aminotransferase (ALT), aspartate aminotransferase, serum creatinine, blood urea nitrogen, glucose, and pediatric early warning score, and had lower platelet count, albumin, Serum sodium (Na⁺) and PCIS. ALT and PCIS were the independent prognostic risk factors for children with APP. The survival rate of children classified as extremely critical patients (100%) was lower than that of children classified as critical (60%) or noncritical (6.7%) patients. The specificity of ALT was high (96.51%), but the sensitivity was low (59.26%). The sensitivity and specificity of ALT combined with PCIS were high, 92.59% and 87.21%, respectively. The difference in mortality was significantly higher for ALT combined with PCIS (area under the receiver operating characteristic: 0.937; 95%CI: 0.875-0.974; P < 0.05).CONCLUSIONIn our study, ALT and PCIS were independent prognostic risk factors for children with APP. ALT combined with PCIS is an optimal predictive mortality scoring system for children with APP.     

急性百草枯中毒致药物性肝病影响因素的分析

目的：观察比较分析急性百草枯中毒致药物性肝病的影响因素。方法：选择2008-01-2013-12入住我院急诊科的急性百草枯中毒患者112例,根据急性百草枯中毒致肝损伤的的诊断标准判断患者是否发生药物性肝病,分为损伤组和对照组,对患者性别、年龄、口服剂量、是否接受超早期洗胃治疗、是否接受早期血液灌流治疗、是否接受CRRT治疗等因素对百草枯所致药物性肝病的影响进行Logistic回归分析。结果：2组患者性别、年龄差异无统计学意义,Logistic回归分析发现口服剂量、是否接受超早期洗胃治疗、是否接受早期血液灌流治疗、是否接受CRRT治疗与急性百草枯患者肝损伤的发生可能存在相关性（P〈0.05）。结论：百草枯的口服剂量对肝功能损伤的影响最大,及时给予超早期洗胃治疗、早期血液灌流治疗能减少患者肝功能损伤的发生。