Effect of risedronate on bone metabolism after total hip arthroplasty: a prospective randomised study

Aseptic loosening due to bone remodeling and osteolysis is the main reason for revision hip arthroplasty. At present, there is no established prophylaxis for this complication. On the other hand, it has been demonstrated that bisphosphonates prevent bone loss around total hip arthroplasties (THA). The aim of this study was to assess the efficacy of oral bisphosphonate risedronate for the prevention of deleterious changes in bone metabolism after hip replacement. Twenty-four patients who underwent THA were randomised to two treatment arms: 35 mg risedronate once weekly for 6 months (12 patients) and no treatment for controls (12 patients). Markers of bone turnover bone specific alkaline phosphatase, serum osteocalcin and urinary deoxypiridinoline were evaluated at baseline, third and sixth postoperative month. Dual energy X-ray absorptiometry of the nonsurgical hip was performed preoperatively and at 6 months postoperatively. There were no significant differences in clinical or radiographic findings between the two groups at either 3 or 6 months. In the two groups, all biochemical marker responses at the third postoperative month were suppressed compared with baseline. Values of bone resorption marker urinary deoxypiridinoline increased significantly at six months in the control group. For the 10 risedronate patients with bone densitometry bone mineral density reached 1.01% increase at 6 months. Administration of oral risedronate led to a significant reduction in bone metabolism at 6 months after hip replacement. This therapeutic strategy may improve the results and longevity of total hip arthroplasty. The beneficial effect of risedronate should be confirmed in further studies including larger number of patients and longer follow-up. The action of risedronate could prevent aseptic loosening of hip arthroplasty by preserving periprosthetic bone stock.     

Resurfacing arthroplasty of the hip

Currently, an increase in resurfacing arthroplasty in the treatment of hip osteoarthritis--especially in young adults--can be observed. New bearing technologies (mainly metal-on-metal surfaces) show better tribologic results than historical designs (e.g. the Wagner cup). At present, it is unclear whether these modifications and a definitively low dislocation rate--due to the large head diameter--can be supported by further good clinical results. The quantity as well as the quality of the available investigations prevents a definite opinion at the moment. Appropriate clinical studies with documented radiographic follow-up are necessary to compare the outcome of these new implants with standard techniques.     

Resurfacing arthroplasty of the hip

Summary As an alternative in total hip replacement the so called resurfacing arthroplasty of the hip is gaining wider acceptance. The procedure can be said to be a modernisation of the original Smith-Pedersen operation and is suggested in young people with degenerative hip disease, congenital hip dysplasia or Perthes' disease. The advantages are that the femoral head and neck are retained and thus no femoral stem prosthesis is necessary. The greatest disadvantage is that in case of socket loosening a secondary operation might not remain as successful as could the initial operation with a socket which is not as large as those recommended for the resurfacing procedure.In this presentation a preliminary report of a one-year material is presented together with a presentation of advantages, disadvantages, and the biomechanical appraisal of resurfacing of the hip. Fifteen patients with 17 hips have been operated and followed-up and by using the Merle d'Aubigne evaluation there was an improvement of some 3–4 points in pain, walking, and total motion. Patient opinion indicated 80% satisfaction. The management of two serious complications is also described.     

Total hip arthroplasty for developmental hip dysplasia

We reviewed 38 hip replacements in 33 female patients (mean age 55.3 years) with developmental hip dysplasia. One patient had died and the remaining 32 patients (36 hips) had a mean follow-up of 12.2 years (range 8–19 years). All hips were replaced using the Müller cemented implant, and in 32 hips bulk femoral head autograft was used. In 33 hips the socket was reconstructed at the level of the true acetabulum. Complications included one intra-operative femoral fracture and two early dislocations. Correction of leg length discrepancy was possible in 30 patients. The post-operative mean modified Merle d’Aubigne and Postel scores for pain, movement and walking were 5.9, 5, and 5.3 respectively. One cup was revised due to aseptic loosening at ten years. All grafts united, but minor graft resorption was noticed in 24 hips, moderate in 2 hips and major in 1 hip.

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Résumé Nous avons examiné 38 remplacements prothétiques de la hanche chez 33 femmes (age moyen 55,3 ans) avec une dysplasie de la hanche. Une patiente était décédée et les 32 autres (36 hanches) avaient un suivi moyen de 12,2 ans ( 8 à 19). Toutes les hanches ont eu un implant type Müller cimenté et pour 32 une autogreffe massive de tête fémorale a été utilisé. Pour 33 hanches la cavité a été reconstruite au niveau du paléo-cotyle. Les complications comprenaient une fracture fémorale opératoire et deux luxations précoces. La correction de l’inégalité de longueur des membres inférieurs était obtenue chez 30 malades. Le score postopératoire modifié de Merle d’Aubigné et Postel pour la douleur, la mobilité et la marche étaient en moyenne de 5,9, 5 et 5,3 respectivement. Une cupule a été révisée pour un descellement aseptique à 10 ans. Toutes les greffes ont consolidé, mais une résorption mineure de la greffe a été remarquée dans 24 hanches, une résorption modéré dans deux hanches et majeure dans une.

     

Minimally invasive total hip arthroplasty: a prospective randomized study

Patients without prior hip surgery and body mass index lower than 30 undergoing primary total hip arthroplasty were eligible to participate in a randomized prospective study comparing a minimally invasive with a standard approach. The patients were randomized to receive incisions of 8 cm (group A, n = 28) or 15 cm (group B, n = 32). The groups were similar demographically. Patients in group A had significantly less intraoperative blood loss (P < .003) and less total blood loss (P < .009). Fewer patients in group A limped at 6 weeks (P < .04). Operative time, transfusion requirements, narcotic usage, length of hospital stay, achievement of rehabilitation milestones, cane usage, and complications were similar in both groups. There was no difference between the groups at 1- and 2-year follow-up. Compared with a standard incision, patients who underwent a minimally invasive total hip arthroplasty demonstrated decreased blood loss and limped less at 6-week follow-up.     

Predictors for blood transfusion following total knee arthroplasty: a prospective randomised study

A prospective randomised study was conducted on 121 patients undergoing total knee arthroplasty, to identify factors predicting the need for postoperative transfusion. Patients were additionally distributed into two groups, one of which received local adrenaline into the surgical field before wound closure, while the other served as control. A statistically significant correlation was noted between preoperative haemoglobin level, haematocrit and erythrocyte count and the need for transfusion; haemoglobin level emerged as the main predictor. No correlation was observed with patients' age, sex, body mass index, blood pressure or number of comorbidities. Local administration of adrenaline into the surgical field did not result in any reduction in blood loss, nor did it modify transfusion requirements.     

Resurfacing arthroplasty of the hip in osteopetrosis

A 34-year-old woman with a benign form of osteopetrosis developed osteoarthritis of the hip. In order to avoid the difficulties associated with inserting the femoral component of a conventional total hip arthroplasty, a hybrid metal-on-metal resurfacing was performed. There were several technical challenges associated with the procedure, including the sizing of the component, press-fit fixation of the acetabular component and femoral head preparation, as well as trying to avoid a fracture. No surgical complication occurred. After more than a year following surgery, the patient showed excellent clinical function and remained satisfied with the outcome. We conclude that the hybrid metal-on-metal resurfacing arthroplasty represents a valuable option for the treatment of patients with osteopetrosis and secondary hip osteoarthritis.     

Resurfacing arthroplasty in osteonecrosis of the hip

Approximately 10% of the total hip replacements performed in the United States are for osteonecrosis. Resurfacing arthroplasty has received renewed interest, with several new designs being implanted worldwide. Proponents of resurfacing arthroplasty describe the advantages of bone conservation, preservation of joint mechanics, more physiologic loading of the bone, lower incidence of perioperative complications, and easier conversion to a secondary procedure if failure occurs. Critics recite previous poor results including high failure rates with femoral and acetabular loosening, osteonecrosis of the femoral head, femoral neck fracture, and loss of acetabular bone stock making the secondary revision procedure more difficult. This article attempts to clarify the advantages and disadvantages of the resurfacing concept as it applies to the treatment of osteonecrosis of the femoral head.     

One- or two-stage bilateral total hip arthroplasty: a prospective, randomised, controlled study in an Asian population

We compared the safety and outcome of one-stage bilateral total hip arthroplasty with those of a two-stage procedure during different admissions in a prospective, randomised controlled trial in an Asian population. Of 168 patients included in the study, 83 had a single- and 85 a two-stage procedure. Most of the patients (59.9%) suffered from inflammatory arthritis. The intra-operative complications, early systemic complications, the operating time, positioning of the components, the functional score, restoration of limb length and survival rates at 96 months were similar in the two groups. The total estimated blood loss was significantly lower in patients undergoing a one-stage procedure than in patients who had a two-stage procedure, but the transfusion requirements were significantly higher in the former group (p=0.001). The hospital stay was significantly shorter in the one-stage group, 7.25 days (sd 1.30; 5 to 20) compared with 10 days (sd 1.65; 8 to 24) in the two-stage group (p=0.023). We believe that a one-stage procedure is safe and appropriate in our population.     

Biomechanical reconstruction of the hip: a randomised study comparing total hip resurfacing and total hip arthroplasty

We have compared the biomechanical nature of the reconstruction of the hip in conventional total hip arthroplasty (THA) and surface replacement arthroplasty (SRA) in a randomised study involving 120 patients undergoing unilateral primary hip replacement. The contralateral hip was used as a control. Post-operatively, the femoral offset was significantly increased with THA (mean 5.1 mm; -2.8 to 11.6) and decreased with SRA (mean -3.3 mm; -8.9 to 8.2). Femoral offset was restored within sd 4 mm in 14 (25%) of those with THA and in 28 (57%) of the patients receiving SRA (p < 0.001). In the THA group, the leg was lengthened by a mean of 2.6 mm (-6.04 to +12.9), whereas it was shortened by a mean of 1.9 mm (-7.1 to +2.05) in the SRA group, compared with the contralateral side. Leg-length inequality was restored within sd 4 mm in 42 (86%) of the SRA and 33 (60%) of the THA patients. The radiological parameters of acetabular reconstruction were similar in both groups. Restoration of the normal proximal femoral anatomy was more precise with SRA. The enhanced stability afforded by the use of a large-diameter femoral head avoided over-lengthening of the limb or increased offset to improve soft-tissue tension as occurs sometimes in THA. In a subgroup of patients with significant pre-operative deformity, restoration of the normal hip anatomy with lower pre-operative femoral offset or significant shortening of the leg was still possible with SRA.     

Acetabular considerations during total hip arthroplasty for hip dysplasia

The wide spectrum of anatomic abnormalities that characterize hip dysplasia dictate the need for different reconstructive techniques when hip replacement is required. Multiple factors such as young age and high activity level of this patient population, coupled with the increased complexity of surgery, explain the somewhat elevated historical failure rate of hip arthroplasty in DDH and emphasize the need for careful analysis of each case and selection of the most appropriate reconstruction options. One particular problem specific to acetabular reconstruction is the deficient bone stock that may limit the ability to place the component fully on native bone at the true acetabular region. When standard techniques of reconstruction leave a significant portion of the component uncovered, the alternatives include acetabular augmentation with bone autograft, intentional high placement of the component, or medialization of the component with or without medial wall osteotomy. Uncemented sockets have provided promising midterm results with supplemental bone augmentation and are the authors' preferred method of treatment for hips with moderate dysplasia and anterolateral acetabular bone deficiency.     

Cementless mallory-head HA-coated hip arthroplasty for osteoarthritis in hip dysplasia

Sixty-three cementless Mallory-Head HA-coated femoral prostheses (Biomet, Warsaw, IN) were used in primary total hip arthroplasty in 50 patients with osteoarthritic hips because of congenital hip dysplasia. The implanted cup was also cementless (41 Harris Galante and 22 Ringlock). The patients were followed up for a mean period of 75.1 months (range, 44-110). Clinical and radiologic analysis were performed. Harris Hip Score increased from 42 to 90 points; 97% of the patients had no or only mild pain, and limping decreased from 90% to 20%. Complications were marginal: no infections, one habitual dislocation, one peroperative fracture of the femur, and one transient ischiadic nerve palsy. Two HG cups were revised for augmented polyethylene wear. Radiographically, no subsidence of the prosthesis or bone atrophy of the proximal femur could be detected. No correlations were found between the radiologic phenomena and the clinical outcome, but the tightness of the prosthesis fit had a definitive influence on the radiographic bone remodeling pattern. The cementless Mallory-Head HA-coated femoral prosthesis shows excellent clinical and radiological mid-term results in osteoarthritic hip dysplasia patients. There was no need for the use of a specially designed dysplasia femoral prosthesis.     

全髋关节置换术治疗成人髋关节发育不良的髋臼重建

目的探讨全髋关节置换术治疗成人髋关节发育不良（DDH）时不同方式髋臼重建对疗效的影响。方法 2000年1月至2007年10月,36例（44髋）先天性髋臼发育不良患者进行了全髋关节置换。年龄42～65岁,平均48岁。术前Harris评分平均为49.9分,双下肢长度差异平均为1.8 cm,髋关节平均活动度：屈曲59.6°,外展21.6°,内收13.9°,外旋10°,内旋8.2°。术中臼杯均安装于真臼处,髋臼内移14髋,髋臼内陷成形术18髋,自体股骨头结构性植骨12髋。髋臼侧均选用非骨水泥型假体。疗效评价：根据Harris评分分为优、良、可、差四级。结果所有患者均获得随访,随访时间1.8～9.2年,平均5.1年。平均Harris评分由术前的49.9分恢复到术后的90.1分,两者比较有统计学差异（P〈0.01,t=28.807）,其中评定为优23髋、良17髋、可4髋,术后优良率达90.9%。术后髋关节平均活动度：屈曲105°,外展35°,内收15.8°,外旋45°,内旋15°。本组病例无肺栓塞、深静脉血栓形成、感染等并发症发生。X线检查示假体无松动移位,无翻修病例。结论全髋关节置换术治疗成人髋臼发育不良采用恰当的髋臼重建结合非骨水泥型髋臼假体可获得满意中远期疗效。     

Resurfacing hip arthroplasty better preserves a normal gait pattern at increasing walking speeds compared to total hip arthroplasty

Background and purpose — Gait analysis performed under increased physical demand may detect differences in gait between total (THA) versus resurfacing hip arthroplasty (RHA), which are not measured at normal walking speed. We hypothesized that patients after RHA would reach higher walking speeds and inclines compared with THA. Additionally, an RHA would enable a more natural gait when comparing the operated with the healthy contralateral hip.

Patients and methods — From a randomized controlled trial comparing THA with RHA with at least 5 years’ follow-up patients with a UCLA score of more than 3 points (n = 34) were included for an instrumented treadmill gait analysis. 25 patients with a unilateral implant (primary analysis—16 THA versus 9 RHA) and 9 patients with a bilateral implant (sub-analysis—n = 5 RHA?+?THA; n = 4 THA?+?THA). Spatiotemporal parameters, ground reaction forces, and range of motion were recorded at increasing walking speeds and inclines. Functional outcome scores were obtained.

Results — At a normal walking speed of 1.1 m/s and at increasing inclines no differences were recorded in gait between the 2 groups with a unilateral hip implant. With increasing walking speed the RHA group reached a higher top walking speed (TWS) (adjusted difference 0.07 m/s, 95% CI –0.11 to 0.25) compared with THA. Additionally, RHA patients tolerated more weight on the operated side at TWS (155 N, CI 49–261) and as such weight-bearing approached the unaffected contralateral side. For the RHA group a “between leg difference” of 8 N (CI 3–245) was measured versus –129 N (CI –138 to –29) for THA (adjusted difference 144 N, CI 20–261). Hip flexion of the operated side at TWS was higher after RHA compared with THA (adjusted difference 8°, CI 1.7–14).

Interpretation — In this study RHA patients reached a higher walking speed, and preserved a more normal weight acceptance and a greater range of hip flexion against their contralateral healthy leg as compared with patients with a THA.     

全髋关节成形术治疗成人髋臼发育不良

目的：探讨治疗成人髋臼发育不良的新方法,方法：应用全髋关节成形术治疗成人髋臼发育不良30例患者33髋。结果：随访25例28髋,平均随 访5．3年,采用Harris髋关节评分标准,优13髋,良9髋,可4髋,差2髋,结论：术前准确测定髋臼骨质分布、制定周密的手术计划,术中正确重建髋臼,术后积极康复训练,患者大都可以取得满意的近期临床效果。     

Prevention of heterotopic bone formation after total hip arthroplasty: a prospective randomised study comparing postoperative radiation therapy with indomethacin medication

Heterotopic ossification (HO) after total hip arthroplasty is known to be a major complication with an impact on the functional outcome. Efforts have been made to prevent the occurrence of HO by means of either radiation therapy or pharmacotherapy. To date, there are no data available regarding the relative benefit of radiation versus medication with non-steroidal anti-inflammatory drugs. The objective of this study was to compare single-dose 600-cGy radiation therapy with indomethacin medication for their effect on the prevention of heterotopic bone formation after total hip arthroplasty. In all, 154 patients were included in the study. All patients underwent primary total hip arthroplasty due to osteoarthritis. Patients were randomly assigned to three different therapeutic groups. (a) The radiation group received a single radiation dose of 600 cGy between the 2nd and 4th postoperative day. (b) The indomethacin group received an oral application of indomethacin 2 × 50 mg per day from the 1st to 42nd postoperative day. (c) The control group received neither radiation nor indomethacin medication. There were significant group differences (P < 0.001). A least significant difference test (LSD) revealed that the mean of the control group was significantly different from that of the radiation and indomethacin groups. The 13 patients (8.4%) classified Brooker 3 or 4 were all in the control group. Again, this effect was statistically significant (chi-square, P < 0.001). In conclusion, this study demonstrated that both radiation and indomethacin therapy are effective in the prevention of postoperative HO. The choice for either one of the treatments has to be based on availability, contraindications, side-effects, practicability, standardisation and cost. Based on these considerations together with the results of this study, we currently use postoperative radiation with 600 cGy for all patients undergoing primary total hip arthroplasty. Received: 8 August 1998