急性白血病患者血清微量元素谱分析

采用ＤＣＰ－ＡＥＳ检测了４０例急性白血病（初发１８例，化疗后２２例）血清中锌、铜、铁、硒、镍、钛等１５种元素含量。结果显示：初发急性白血病患者血清锌、铁、硒、镍、钛均降低，铜、钙、镁、铜／锌比值均升高。化疗达ＣＲ后，血清锌、铜、铜／锌、硒均可正常，而化疗后ＮＲ组上述元素无改变。血清钙、镍、钛化疗后ＣＲ和ＮＲ组均无改善。表明微量元素与急性白血病转归相关。     

Some Mineral,trace Element and Heavy Metal Concentrations in Lung Cancer

Objective: We aimed to determine the relationship between some mineral, trace element and heavy metallevels in the patients of lung cancer by measuring serum levels of copper (Cu), lead (Pb), zinc (Zn), iron (Fe),cobalt (Co), cadmium (Cd), manganese (Mn), magnesium (Mg). Methods: A total of 50 lung cancer and humanhealth (30 lung cancer and 20 healthy human) were included in the study. Venous blood samples of each lungcancer were obtained, and serum Cu, Pb, Zn, Fe, Cd, Co, Mn, Mg levels were analysed by Atomic AbsorptionSpectrophotometer measurements. Results: Mg value measured in lung cancer group were lower than the controlgroup and this was statistically significant (P<0.01). Serum Cu level was significantly lower with lung cancercompared to healthy human (P<0.01). Pb level was significantly higher than those of controls (P<0.01). Theserum Zn level was significantly lower in serum of lung cancer group than controls (P<0.01). Serum Mn and Colevels were found increased in lung cancer group than controls (P<0.01). Cd value was higher in lung cancer butit was not statistically significant (p>0.01). The mean concentration of Fe in the serum of lung cancer patientswas higher than in the controls, but the difference was not significant (p>0.01). There was a positive correlationbetween Cd and Pb level, and between Mn and Fe levels in lung cancer. There was a negative correlation betweenCo and Zn levels of healthy human. There was a negative correlation between Co and Mg levels of lung cancer.Conclusions: Serum Cu, Pb, Zn, Fe, Mg, Co, Mn and Cd might be play a role in the patients of lung cancers.Zn may protective as potent lung cancer. In addition, it is suggested that low levels of zinc can induce thepathogenesis of lung cancer.     

Trace Elements,Heavy Metals and Other Biochemical Parameters in Malignant Glioma Patients

Aim: We aimed to assess relevance of mineral, trace element and heavy metal levels in patients with malignantgliomas. Methods: In this study, erythrocyte catalase (CAT), and carbonic anhydrase (CA), serum copper (Cu.),zinc (Zn), lead (Pb), iron (Fe), cadmium (Cd), cobalt (Co), manganese (Mn), and magnesium (Mg) levels weremeasured in 22 healthy humans and 22 malignant glioma patients. Metal concentrations were assessed by atomicadsorption spectrophotometry, while biochemical methods were used for CAT and CA. Results: The Cd, Fe, Mg,Mn, Pb and Zn levels were significantly elevated in the patients as a whole compared to controls(P<0.05), whileCu was decreased and Co demonstrated no change. Although mean CAT activity were significantly lowered, CAexhibited significant increase. Conclusions: The results of the current study indicate that antioxidant enzymesmay have a role in the genesis of considerable oxidative stress in patients with malignant glioma. CAT and CAseem to play particular roles in the pathophysiology of this disease.     

Serum Levels of Trace Elements in Patients with Prostate Cancer

Background: Trace elements are major components of biological structures; however, excessive levels ofthese elements can be toxic. Materials and Methods: In the present study, serum levels of trace elements weremeasured in 30 patients with newly diagnosed as prostate cancer and 32 healthy volunteer by using furnaceatomic absorption spectrophotometry. Results: It was found that there was an increase in serum levels of Co,Cu, Mg and Pb (p<0.05), whereas a decrease in serum levels of Fe, Mn, and Zn levels in patients with prostatecancer (p<0.05). Conclusions: These changes may be important in the pathogenesis of prostate cancers; however,further prospective studies are needed to identify relationships between prostate cancer and trace elements.     

急性白血病患者血清中锰镍镉铜锌及全血中铜锌锰的研究

用原子吸收光谱法测定３４例急性白血病患者和４０例正常人血清中锰（Ｍｎ）、镍（Ｎｉ）、铜（ｃｕ）、锌（ｚｎ）、镉（Ｃｄ）及全血中Ｃｕ、Ｚｎ和Ｍｎ的含量，观察到急性白血病的ＡＬＬ组和ＡＮＬＬ组患者血清、全血Ｃｕ的含量、铜锌比值（Ｃｕ／Ｚｎ）显著高于正常人（Ｐ＜０．００１）；血清、全血Ｚｎ、血清Ｍｎ含量均显著低于对照组（Ｐ＜０．００１，Ｐ＜０．０５）；血清Ｎｉ含量升高仅见于ＡＬＬ组（Ｐ＜０．０１）．血清铜含量升高与合髓白血病细胞增殖有关。     

急性白血病与血液中微量元素相关性的研究

目的 观察急性白血病患者急性期及缓解期血液中微量元素的动态变化以及铁和锌与化疗合用的效果。方法 应用高频等离子体反射光谱仪,对110例急性白血病患者和100例健康儿童血液中14种微量元素进行分析,并比较化疗加锌和铁治疗组及单纯化疗组的疗效。结果 急性期白血病患者血、铁、钙和锰水平低于正常儿童,而铜和镍水平明显高,尤以铜／锌比值增大显著,在疾病缓解期则下降接近正常水平;化疗加锌和铁治疗组病情开始缓解及完全缓解所需时间较单纯化疗组明显缩短。结论 白血病急性期血液中微量元素有明显变化,且化疗时加用铁和锌有促进疗效的作用。     

Pattern recognition on the trace element spectrum in gastric cancer and peptic ulcer

The trace element spectrum of gastric tissue and whole blood specimens from gastric cancer and peptic ulcer patients was recognized with pattern recognition technique in order to obtain the chemical information of gastric cancer. Thirty specimens were obtained from cancer patients in each of the 58 gastric tissues and 54 whole blood specimens. Five pathological types were divided into two groups: peptic ulcer and dysplasia as the ulcer group; well-differentiated, undifferentiated and mucinous carcinoma as the cancer group. The accuracy of recognizing the several spectra was 90%: nine trace element spectra (Cu, Zn, Ni, Co, Cr, Cd, Mn, Fe and Mg) for the tissue specimens from the cancer and ulcer groups; six (Cu, Zn, Mn, Co, Cr and Cd) for dysplasia and well-differentiated adenocarcinoma tissues; five (Cu, Ni, Cr, Cd and Fe) for the whole blood specimens from these two groups and six (Cu, Zn, Cr, Cd, Fe and Ni) for the whole blood specimens from dysplasia and peptic ulcer (including 10 normal individuals). The data were treated by non-linear mapping method and calculated by TRS-80 III type microcomputer.     

Research on serum levels of retinol, α-tocopherol β-carotene,and 12 elements in gastric dysplasia and gastric cancer patients

Serum levers of retinol, α-tocopherol, β-carotene and elements (Zn, Cu, Mn, Ca, Mg, Cr, Co, Cd, Mo, Se) were determined in 45 gastric cancer and 41 gastric dysplasia patients, and 48 normal subjects. The results showed that β-carotene and Se, Co were lower in gastric cancer patients than that in gastric dysplasia patients or in normal subjects, Ni and Cr levels were lower and Mn, Ca and Cd were higher in gastric cancer than in dysplasia patients. Zn, Fe, Cr, Cd were lower and Mn, Ca, Mg, Mo levels were higher in gastric cancer patients than in normal. The differences mentioned are statistically significant. The stepwise discriminant analysis of 10 variables (Mn, Fe, Ca, Cr, Mo, Co, Cd, Se, α-tocophrol, β-carotene) were used in identifying gastric cancer, with 100% of the positive rate. The potential protective effect of β-carotene and Se against gastric cancer is an interesting postulate. We suggest that optimum supplement of β-carotene and Se might will be beneficial to gastric dysplasia patients in preventing the development of gastric cancer.     

Serum trace element levels in patients with bladder cancer

Trace elements are essential components of biological structures, but they can be toxic at concentrations beyond those necessary for their biological functions. In the present study, groups of 35 patients with bladder cancer and 34 healthy volunteer controls were measured for trace elements using a furnace atomic absorption spectrophotometer. Serum levels of Cd, Ni and Co were increased (p<0.05) and Mn and Zn were decreased (p<0.05) in patients with bladder cancer. In the present study, a relationship was seen between the level of trace elements and the occurrence of bladder cancer, suggesting that an increase in the serum level of Cd, Ni, Co and a decrease in the levels of Zn and Mn might be important causes of bladder cancer occurrence; however, defining such a cause-and-effect relationship needs several prospective studies to be done, which seems necessary with regard to the high prevalence of this cancer.     

泌尿系肿瘤与肾炎患者血清和尿中铜锌锰镁含量变化的探讨

作者对２４例泌尿系恶性肿瘤病人、４５例肾炎病人的血清、尿液微量元素铜、锌、锰、镁进行了测定，结果显示：较之正常对照组，肾炎病人血清镁、尿、锌值明显升高，血清锌降低；恶性肿瘤病人血清铜、尿锌值明显升高，血清锌、尿锰值下降。这些指标对泌尿系恶性肿瘤的鉴别诊断及治疗有一定参考价值。     

微量元素铜,锌,镉,锰与肝硬化分期和肝癌相关性研究

测定了72例早、晚期肝硬化,20例肝癌和98例正常人血清中铜、锌、镉、锰含量,经Apple-Ⅱ型计算机统计分析,结果表明:早晚期肝硬化、肝癌患者血清中铜、锌、镉、锰、铜/锌和镉/锌比与对照组均有显著差异(P<0.01),且铜、锌、锰、镉/锌比在三组病人之间也有显著差异(P<0.001)。4种元素,两个比值单因素相关分析表明血清铜与锌呈高度正相关(γ=0.684),锰与铜、锌呈高度负相关(γ=-0.3233,-0.4013)。但经多因素逐步判别分析表明只有铜、锰与肝硬化进展和癌变有相关关系。即肝癌时血清铜最高,血清锰最低。     

包头地区乳腺肿瘤及其复发转移的血清微量元素变化研究

目的探讨9种微量元素与乳腺肿瘤的关系。方法采用原子吸收分光度计对81例健康女性志愿者、94例乳腺良性肿瘤患者、93例乳腺癌患者手术前后和38例乳腺癌复发转移患者血清中Fe、Zn、CU、Mn、Pb、Cd、Cr、Ni、Mo的含量进行测定。结果血清Fe、Zn、Cu、Mn、Pb随乳腺肿瘤病情加重呈明显升高趋势,与乳腺癌呈正相关,而Mo随病情的加重明显降低,与乳腺癌呈负相关。结论有6种微量元素与乳腺肿瘤的发病有显著关系,其中Fe、Zn、Cu、Mn、Pb可能是乳腺癌的危险因素,而Mo为乳腺癌的保护因素。     

回族血清中微量元素含量与胃癌的相关性研究

目的探讨回族血清中微量元素含量与胃癌的关系。方法采用原子吸收分光光度法对回族胃癌患者和回族非胃癌对照人群血清中锌(Zn)、铜(Cu)、铁(Fe)、镁(Mg)、钙(Ca)、锰(Mn)、镍(Ni)元素含量进行检测,并用SPSS统计软件对实验结果进行配对t检验分析。结果回族胃癌病例组血清中Cu、Cu/Zn、Mn均比对照组高,而Zn、Fe、Ca、Mg、Ni的含量低于对照组。配对t检验结果显示,血清中Cu、Zn、Cu/Zn、Ca、Mg含量差异有统计学意义(P<0.05)。结论回族胃癌的发生、发展与血清内微量元素变化密切相关。高Cu、Cu/Zn比值高以及低Zn、低Ca、低Mg是回族胃癌发生的危险因素。     

Determination of Metal Levels in Shamma (Smokeless Tobacco) with Inductively Coupled Plasma Mass Spectrometry (ICP-MS) in Najran,Saudi Arabia

Objective: The use of Shamma (smokeless tobacco) by certain groups is giving rise to health problems, including cancer, in parts of Saudi Arabia. Our objective was to determine metals levels in Shamma using inductively coupled plasma mass spectrometry (ICP-MS). Methods: Thirty-three samples of Shamma (smokeless tobacco) were collected, comprising four types: brown Shamma (n = 14.0), red Shamma (n = 9.0), white Shamma (n = 4.0), and yellow Shamma (n = 6.0). All samples were collected randomly from Shamma users in the city of Najran. Levels of 11 elements (Al, As, Cd, Co, Cr, Cu, Li, Mn, Ni, Pb, and Zn) were determined by ICP-MS. Results: A mixed standard (20 ppb) of all elements was used for quality control, and average recoveries ranged from 74.7% to 112.2%. The highest average concentrations were found in the following order: Al (598.8–812.2 μg/g), Mn (51.0–80.6 μg/g), and Ni (23.2–53.3 μg/g) in all four Shamma types. The lowest concentrations were for As (0.7–1.0 μg/g) and Cd (0.0–0.06 μg/g). Conclusions: The colour of each Shamma type reflects additives mixed into the tobacco. Cr and Cu were showed significant differences (P < 0.05) among Shamma types. Moreover, Pb levels are higher in red and yellow Shamma, which could be due to use (PbCrO4) as yellow colouring agent and lead tetroxide, Pb3O4 as a red colouring agent. The findings from this study can be used to raise public awareness about the safety and health effects of Shamma, which is clearly a source of oral exposure to metals.     

济南地区健康人与胃癌,肺癌患者发中13种元素的研究

要原子吸收分光光度法，检测了人发中１３种元素钠、钾、钠／钾。钙、镁、钙／镁。铜、锌、铁、锰、铅、镍、锶、铬、镉的含量。健康人头发样品采自济南市五区三县，包括工人、农民、干部、学生、及街道居民。年龄在１５－６０岁，均经严格体检，共计３６３人，作为对照组。癌患组、胃癌、肺癌经Ｘ线，内窥镜，病理学等检查确诊，按标准严格分组，共计１３３人。测定结果看出：癌患组钠、钾、钙、镁、及其比值与健康有明显差异，８７     

食管癌高低发区饮用水微量元素谱的多元分析

背景与目的： 研究食管癌高低发区饮用水中微量元素谱(Trace elements,TE),为食管癌(Esophageal cancer,EC)病因提供研究依据。材料与方法：采集食管癌高低发地区的饮用水样,用高频电感耦合等离子体发射光谱法(Inductively coupled plasma_atomic emission spectgrometry,ICP_AES)测定13种元素(Cd, Co, Cr, Cu, Fe, Mn, Mo, Ni, Pb, Se, Sr, V, Zn)含量,并进行t检验、相关分析、建立回归方程。 结果： 检测发现食管癌高低发区的水样中的微量元素谱不同,Fisher判别法,其识别准确率为93％。 结论： 不同环境水中微量元素对食管癌发生率有影响。     

急性白血病患者全血中微量元素研究

 目的 观察急性白血病患者血液中微量元素的动态变化。方法 用原子吸收光谱法测定50例急性白血病患者和40例正常人全血中铜（Cu）、锌（Zn）、锰（Mn）、铁（Fe）、钙（Ca）、镁（Mg）的含量,同时对20例患者缓解前后进行了动态观察。结果 急性白血病初发组及复发组全血Cu、Ca的含量、Cu／Zn比值显著高于正常组及缓解组,全血Zn,Fe,Mg的含量低于对照组及缓解组,全血Mn含量与正常组及缓解组无显著改变。结论 白血病急性期血液中微量元素有明显变化,全血Cu,Zn含量有更显著参考价值。     

海滩牵牛微量元素水平及形态分析

目的：研究海滩牵牛（Ipomoea stolonifera,IS）中微量元素Cu、Zn、Fe、Mn、Cr、Mg、Sr、Mo、Cd的水平及存在形态。方法：利用0．45μm滤膜、阳离子交换树脂、Amberlite XAD-2型大孔吸附树脂将其中含量较高的元素Cu、Zn、Fe、Mn、Mg分为悬浮态和可溶态、游离态和非游离态、有机态和无机态等不同形态,用原子吸收光谱法测定其在各级分中的含量。结果：Cu、Zn、Fe、Mn、Cr、Mg、Sr、Mo、Cd在各不同形态中分量与总量基本相符,Cu、Zn、Mg为IS的特征元素。对次级形态分析表叽cu、M趴Fe、Mn几乎均以游离态存在,只有极少部分为非游离态;而Zn的非游离态与游离态含量各占一半。Mg主要以有机态存在,而Mn主要以无机态存在,Cu、Zn、Fe则有机态和无机态各占一半。结论：海滩牵牛中存在多种与抗炎活性有关的微量元素,形成多种形态共处的混杂体系。     

启东肝癌与微量元素初步研究

启东是肝癌高发区,其水、土中铜、锌、锰、镍、钴、钼等微量元素富集。粮中铜、锌含量偏高,而硒、钼含量显著降低,与肝癌发病率呈负相关。肝癌高发区居民血液中铜、锌、锰、钴、铅等水平高于低发区,但血硒、钼水平却相反,显著低于低发区。肝癌高发区居民头发中铜、锌、锰均高于低发区,但钼却相反,低于低发区。肝癌惠者头发中铜比自然人群显著增加,但锰却相反。值得注意的是肝癌组织中缺钼或少钼。以上结果表明,肝癌与硒、钼密切相关,而与锰、镍等微量元素的关系有待深入探索。