骨嗜酸性肉芽肿临床病理分析

作者回顾性分析２６例骨嗜酸性肉芽肿的病理肉眼镜下改变，着重探讨其组织病理特点，指出本病性质属良性非肿瘤性病变，认为骨嗜酸性肉芽肿的病理分期有利于病理诊断及指导临床治疗，并提出病理活检在该病的诊断中有重要意义 。     

25例骨嗜酸性肉芽肿的诊断和治疗

目的：讨论骨嗜酸性肉芽肿的影像学特点及治疗，对该病的诊断、治疗方法和治疗效果进行总结。方法：分析1998年7月至2005年7月本院手术治疗的25例经病理证实的骨嗜酸性肉芽肿患者的临床资料及随访结果。结果：25例患者均经手术治疗。对患者随访8个月至6年，平均随访33个月，复查结果表明患者病灶均明显修复，未见病灶复发。结论：骨嗜酸性肉芽肿的影像学表观多种多样。部分病变有一定的特征性表现，具有诊断价值。外科治疗对该病是一种积极有效的手段。多数患者单纯肿瘤刮除植骨，或者骨水泥填充即可治愈肿瘤．部分患者病变具有较强的侵袭性，结合化疗可以控制肿瘤。     

颅骨嗜酸性肉芽肿X线诊断价值

目的探讨颅骨嗜酸性肉芽肿的X线诊断与鉴别诊断.方法回顾分析经病理证实31例颅骨嗜酸性肉芽肿的X线表现.结果31例患者共发现32个病灶,其中额骨14个;顶骨个12个;颞骨3个;枕骨3个.主要X线表现为边界清楚的溶骨性破坏;"双边征"或"斜边征";"钮扣样死骨"及软组织肿块.结论X线平片对颅骨嗜酸性肉芽肿具有诊断意义,仍为诊断本病的首选和基本方法.     

多发性骨嗜酸性肉芽肿1例报道

患者，男性，18岁。10年前因头痛就诊，头颅CT示：额顶骨骨质破坏，不规则膨出，给予手术切除及颅骨修补术，术后病理示嗜酸性肉芽肿。5年前因多处牙齿松动在本院口腔科就诊，X线片示上下颌骨多外骨三十，全麻下给予搔刮术，术后病理经北京医科大学口腔医院会诊是嗜酸性肉芽肿。     

15例胃嗜酸性肉芽肿临床分析

１５例胃嗜酸性肉芽肿临床分析广东医学院附院陈垦，苗瑞政胃嗜酸性肉芽肿是一种原因未明的瘤样增生性疾病。临床少见，极易误诊为胃溃疡或胃癌。我院１９８２年以来，经病理诊断的胃嗜酸性肉芽肿有１５例，现报告如下。临床资料一、一般资料：男１３例，女２例。年龄３４...     

脊椎嗜酸性肉芽肿9例报道

骨嗜酸性肉芽肿是侵袭骨胳病变为主或局限于骨的织织细胞增多症中最为良性的一种病损。因临床症状不典型,不易作出诊断,发生在脊椎的病损更为少见。我科自1963年～1982年共收治43例骨嗜酸性内芽肿,经病理或细胞学穿刺证实。其中9例位于脊椎。现报道如下:     

放射治疗骨嗜酸性肉芽肿5例报告

骨嗜酸性肉芽肿为少见疾病,是以组织细胞增生和嗜酸粒细胞浸润为特征,在骨内形成的肉芽肿病变。病因不明,好发于儿童及青少年。临床上可呈现单骨病灶、多骨病灶和一骨多发病灶。X线表现:在病变活动期以溶骨性破坏为主,愈合期呈现骨增生性改变。 我科自1987年～1990年共收治经病理证实的骨嗜酸性肉芽肿5例,其中男性4例,女性1例,年     

36 例颅骨嗜酸性肉芽肿的临床分析

 目的 探讨颅骨嗜酸性肉芽肿的临床表现、诊断与治疗的方法. 方法 对我科10年来收治的36例颅骨嗜酸性肉芽肿病例进行回顾性分析. 结果 所有患者均接受手术治疗,术后病理组织学检查有多量的Langerhans细胞增生和大量嗜酸性粒细胞.预后好,无复发. 结论 颅骨嗜酸性肉芽肿为良性病变, CT在诊断中具有重要价值.手术能加速病变痊愈,减少并发症.     

颌骨嗜酸性肉芽肿

骨嗜酸性肉芽肿是组织细胞增生症Ｘ三氏症中最为常见的一种，一般仅影响骨骼系统，颌骨是好发部位。该病治疗前的诊断较为困难，易误诊，手术与放疗是有效的治疗方法。笔者现报告５例，并复习文献，就其临床病理特征以及诊断和治疗进行分析讨论。     

放射治疗骨嗜酸性肉芽肿11例报告

放射治疗骨嗜酸性肉芽肿１１例报告周明骨嗜酸性肉芽肿是以组织细胞增生和嗜酸粒细胞浸润为特征的少见疾患，病因不明。我科１９８４年１０月至１９９１年６月收治１１例，总结报告如下。１临床资料１．１一般资料１１例患者中男７例，女４例，年龄８－３７岁，平均２３岁...     

An eosinophilic fibrohistiocytic lesion of bone marrow in a patient with Hodgkin's disease. A potential for morphologic confusion

The eosinophilic fibrohistiocytic lesion of bone marrow (EFLBM) is characterized by collections of elongated "fibrohistiocytic" cells in association with lymphocytes, eosinophils, and plasma cells. The fibrohistiocytic cells are mast cells, and many investigators include this lesion (EFLBM) as a localized form of mastocytosis. The etiology and clinical significance of these lesions remains unclear. The morphologic features of these lesions point to a wide differential diagnosis that includes Hodgkin's disease. Currently, however, there are no recorded cases of well-defined Hodgkin's disease with these lesions. A case of Hodgkin's disease in which such lesions complicated the interpretation of serial bone marrows is reported. This case illustrates how the presence of these lesions could potentially influence therapeutic intervention.     

股骨近端肿瘤与肿瘤样病变的影像学分析

目的 分析股骨近端肿瘤与肿瘤样病变的影像学表现,探讨其临床意义.方法 搜集49例在我院接受治疗并有病理结果的患者,术前均摄髋关节X线正位片,32例行CT检查,18例行MRI检查,回顾性分析股骨近端肿瘤与肿瘤样病变的影像学表现.结果 骨囊肿16例,骨纤维组织增殖症11例,骨巨细胞瘤8例,骨转移瘤5例,多发性骨髓瘤2例,嗜酸性肉芽肿2例.骨样骨瘤、内生软骨瘤、骨母细胞瘤、软骨母细胞瘤、骨肉瘤各1例,动脉瘤样骨囊肿2例均为伴发.所有病例在病变部位、数目、大小、形态、边界、内部结构、骨膜反应、软组织肿块及病理性骨折方面具有一些共性及特性.结论 股骨近端肿瘤样病变较骨肿瘤好发,多种影像学方法的联合使用在诊断与鉴别诊断中具有重要作用,有利于临床选择治疗方式、防止复发及评判预后.     

Diffuse lymphangiomatosis of bone

Two cases of lymphangiomatosis of bone, a very rare systemic condition characterized by both skeletal and parenchymal lesions, are presented. The skeletal changes have an appearance similar to haemangiomas in the spine, and soap-bubbly lesions in the flat bones. One case carried the diagnosis of eosinophilic granuloma for 18 years. The findings on MRI, which have not been previously well-established, are discussed.     

Solitary eosinophilic granulomar of the temporal lobe: case report and review of the literature

A solitary eosinophilic granuloma of the central nervous system is an unusual manifestation of histiocytosis X. A unique case of a solitary eosinophilic granuloma of the right temporal lobe without osseous involvement is described. A 20-year-old man presented with a grand mal seizure. Magnetic resonance imaging demonstrated an intraaxial enhancing mass in the right temporal lobe with marked vasogenic edema. A right temporal craniotomy was performed for resection of the lesion and the diagnosis of an eosinophilic granuloma was confirmed by histopathology. Follow-up MR imaging obtained 5 years following resection demonstrated no recurrence. Solitary eosinophilic granuloma should be considered in the differential diagnosis of enhancing mass lesions affecting the central nervous system. Although the natural history of solitary eosinophilic granulomas remains poorly defined, surgical treatment still remains the mainstay of therapy for these unifocal cerebral lesions.     

术中透视同轴套管通道骨骼病变微创活检术

目的探讨应用术中透视和同轴套管通道对骨骼病变进行微创活检的临床价值。方法对33例患者,其中四肢骨29例,髂骨4例,借助术中透视机定位,并用同轴套管软组织扩张系统通过皮肤小切口建立工作通道,钻开病变处骨质,髓核钳夹取病变内成形病变组织送检。结果33例患者都成功取出病变组织,病理检查均明确诊断,无一例严重并发症。结论术中透视同轴套管通道微创活检术可获得类似开放活检获取成形病变组织块的优点,活检阳性率和病检确诊率高,且患者创伤小,恢复快,并发症少,是一种经济简便,安全有效的诊断方法,值得进一步临床推广。     

股骨良性纤维组织细胞瘤一例报道

良性纤维组织细胞瘤（benign fibrous histiocytoma,BFH）多发生于皮肤、肌肉等软组织,而发生于骨的BFH极为少见。骨BFH大多发生于20岁以上青年患者．无明显性别差异.约40％发生于长骨,骨干和骨骺均可受累,约25％发生于骨盆,其它如肋骨、椎体、颅骨、骶骨、颌骨等少见1310现报道1例经手术病检证实的股骨BFH。     

嗜酸性膀胱炎2例临床分析

目的:探讨嗜酸性膀胱炎的临床表现及诊治方法。方法:对2例嗜酸性膀胱炎的临床资料进行回顾性分析。结果:2例均行经尿道病变电切术并辅以皮质激素、抗生素治疗。术后病理均为嗜酸性膀胱炎。随访1年,尿频、尿急症状消失,无镜下及肉眼血尿,影像学及膀胱镜检查未见膀胱占位性病变。结论:嗜酸性膀胱炎临床少见,确诊需要膀胱镜检查及组织活检,治疗为以切除病变组织和抗炎、抗过敏为主的治疗方法。     

Modifying Effects of Soybean Trypsin Inhibitor on Development of Eosinophilic Nodules and Basophilic Foci in the Exocrine Pancreas of Male Sprague-Dawley Rats Treated with 4-Hydroxyaminoquinoline 1-Oxide

Administration of 4-liydroxyaniinoquiiioline 1-oxide (HAQO) to rats results in development of 2 types of pancreatic acinar lesions, namely eosinophilic nodules and basophilic foci. To cast light on the biological character of these lesions, 5-week-old male Sprague-Dawley rats were given a single intravenous injection of HAQO at a dose of 7 mg/kg and, thereafter, fed soybean trypsin inhibitor (SBTI) at dose levels of 10% and 5%. At week 57, all rats were killed for pathological examination of pancreatic tissue. The incidence of eosinophilic nodules was significantly higher in the HAQO/ SBTI group than in the HAQO-alone group, whereas the basophilic acinar foci were observed to occur less frequently and to be smaller in the HAQO/SBTI-treated animals. Administration of SBTI is known to increase the blood level of cholecystokinin, a trophic factor for pancreatic acinar cells. Thus, the present findings suggest that long-term elevation of this endocrine factor can affect the two types of pancreatic acinar lesions in essentially different ways, namely enhancing development of eosinophilic nodules, while suppressing the occurrence of basophilic foci.