血液流变学与衰老的分析

心血管病是中老年人的多发病，病死率很高，并已受到人们的重视。但尚未对机体衰老。尤其是心血管系统、血液系统衰老过程进行病因学探讨。我们通过体检从血液黏滞度的流变学角度探讨了中老年衰老过程中的改变，分析了血液流变学改变在心血管病发生和发展中的作用以及心血管病的预防措施等。     

正常妇女各年龄段血液流变性改变与绝经后妇女心血管病分析

目的：研究妇女各年龄段的血液流变性改变，探讨绝经后妇女心血 管病发生的血液流变学机制。方法：对２３９例健康女性进行血液流变学各项指标检 测，按年龄分为５组。结果：发现正常妇女血液流变学指标虽有随年龄增加而逐渐 增高的趋势，但从 ５０～５９岁年龄段开始出现多项指标的明显升高，与该年龄段前 组比较差异非常显著（Ｐ＜０．０１）．结论：５０岁后妇女的血液流变性改变与绝经后雌 激素水平下降有关，并与绝经后妇女心血管病发生有关。     

血液流变学与衰老的分析

心血管病是中老年人的多发病,病死率很高,并已受到人们的重视。但尚未对机体衰老,尤其是心血管系统、血液系统衰老过程进行病因学探讨。我们通过体检从血液黏滞度的流变学角度探讨了中老年衰老过程中的改变,分析了血液流变学改变在心血管病发生和发展中的作用以及心血管病的预防措施等。1　资料与方法　　对5 0 0例职业病与从业人员血液流变学进行分析。根据年龄分成3组2 0岁～为青年组,45岁～为中年组,60岁～85岁为老年组。采用天津医疗仪器厂生产的锥板式黏度计检测全血比黏度、血浆比黏度、体外血栓、血小板黏附率及红细胞电泳时间等指标…     

920例青壮年患者血液流变学的改变

本文从920例青壮年患者与500例健康体检人群的血液流变学指标改变的特点，发现各种不同症状的青壮年患者的血液流变学指标各有所改变。因此认为人类血液流变学变化而引起的各种血液系统疾病大都是在青壮年开始有血液流变学指标的改变。本文证明，青壮年是血液粘滞性和凝固性由正常转变为异常的重要时期，也是发生血液系统疾病的重要时期。在青壮年时期关注血液流变学指标的改变是预防疾病的重要措施。     

肾小球疾病患者的血液流变学与临床生化关系分析

在肾小球疾病的发生及发展过程中，患者血液流变性可出现异常．我们对４０例肾小球疾病患者的血液流变学及临床生化指标检测结果表明，血液流变学指标的改变与血生化指标明显相关，现将结果报告如下．     

短暂性脑缺血发作血液流变性改变和危险因素分析

目的 探讨短暂性脑缺血发作（TIA）的血液流变特性和危险因素.方法 选择57例短暂性脑缺血发作患者,分析其血液流变性改变和危险因素.结果 短暂性脑缺血患者全血黏度、血沉、血沉方程K值、红细胞聚集指数、红细胞刚性指数均高于正常对照组（P〈0.05或P〈0.01）;最常见的危险因素是高血压病、吸烟、酗酒、高甘油三酯血症.结论 短暂性脑缺血发作与血液流变性异常密切相关,在其发生发展过程中,血液流变性改变起着重要作用,血液流变学指标是TIA的有效观察指标;短暂性脑缺血易发生致死性脑卒中,公众应引起高度重视.     

无症状性心肌缺血与微循环血流变关系初探

本文观察冠心病（ＣＡＤ）无症状性心肌缺血（ＳＭＩ）１６０例血液流变性的主要改变为血液粘滞性增高、血液聚集性增高、血液凝固性增高等；微循环的主要改变为微血管中血流缓慢、红细胞聚集、管袢数减少、管袢畸形等。与同朗急性梗塞４８例比较有类似血液变－微循环改变。提出血液流变性改变对触发和恶化某些可导致心肌梗塞（ＡＭＩ）的血液动力学过程起重要作用，改善血液流变性、微循环是 ＣＡＤ治疗的一个重要方面。有关微循环－血液流变学指标的普查和监测，对 ＣＡＤ预测，治疗监测以及预防心肌梗塞，瘁死有重要意义。     

心血管疾病患者OX-LDL和血液流变指标的相关性研究

目的 探讨心血管疾病患者血浆氧化低密度脂蛋白(OX-LDL)和血液流变学指标的变化及其相互关系.方法 用酶联免疫吸附试验(ELISA)法测定65例冠心病患者、78例高血压患者和50例健康对照者血浆OX-LDL;平行测定血液流变学指标,并对OX-LDL与血液流变指标进行相关分析.结果 冠心病患者血浆OX-LDL浓度明显高于对照组(P＜0.05),血液流变学指标与健康对照组比较,高切全血黏度、低切全血黏度、红细胞聚集指数、红细胞刚性指数和红细胞变形指数差异均有统计学意义(P＜0.05);心血管病患者血浆OX-LDL浓度与血液流变异常指标呈正相关.结论 血浆OX-LDL与血液流变性异常可能与心血管病发病有关;血浆OX-LDL与血液流变学检测对于冠心病的诊断和治疗有一定意义.     

年龄对血液流变学指标的影响

年龄对血液流变学指标的影响聂德志薛宇红郑宏图马伯书朱景丽四平市中心医院检验科１３６０００靳树仁青岛市第八人民医院心外科血液流变学是研究血液生物力学性状，评估体内隐性血栓病变危险性的手段之一，对于预防心、脑血管病的发生，探讨衰老机制有重要意义，血液流变...     

中药黄芪对D-半乳糖衰老模型大鼠血液流变性的影响

目的研究黄芪对大鼠血液流变性的影响,筛选降低血液粘度的药物.方法以黄芪水煎剂灌服D-半乳糖衰老模型大鼠6周后检测各项血液流变学指标与模型组加以对照分析.结果灌服黄芪水煎剂组大鼠血液粘度较衰老模型组明显降低.结论黄芪具有降低血液粘度的作用.     

1340例石油职工血液流变学检测结果分析

目的 探讨中老年石油工人和机关职员的血液流变学指标变化。方法 测定工人764例和职员576例的血液流变学各项指标，并分职业和不同年龄段进行统计学分析研究。结果 职员组的血液流变学指标明显高于工人组(P＜0．05及0．001)，且两组均显示随年龄的增长血液粘度增加，但职员组增高的幅度较工人组大。结论 机关职员和石油工人的血液粘度有一定的差异，且显示随年龄的增长血液粘度相对增高，提示对中老年人进行血液流变监测，有利于疾病的早期发现和防治。     

Study of the Physical Condition of Middle-aged Office and Field Workers Aged 50 and Older

[Purpose] We investigated the physical condition of middle-aged workers in Korea by job category (office job vs. production job). [Subjects] In total, 3,650 middle-aged workers (production job, n = 2,615; office job, n = 1,035) ≥50 years of age from eight geographical areas were evaluated from 2007 to 2008. [Methods] The subjects’ subjective physical condition, exercise status, smoking status, and drinking status were investigated, and precise physical measurements, cardiovascular endurance, muscular strength, muscular endurance, flexibility, reflexes, and reactions were measured. [Results] Subjectively, the physical condition and exercise status of those with office jobs were superior to those of production job workers. Office workers exhibited a higher rate of drinking than production workers, and also had better cardiovascular endurance, muscular strength, muscular endurance, reflexes, and reactions. However, production workers were more flexible than office workers. [Conclusion] Middle-aged production job workers in Korea have poorer overall physical condition than middle-aged office job workers. The physical condition of middle-aged and elderly workers must be managed through various health management programs to secure a productive aging society.Key words: Elderly workers, Job category, Physical condition     

Noninvasive clinical investigation of the cardiovascular system in the critically ill

An understanding of fundamental principles of various modes of noninvasive cardiovascular monitoring is important in the investigation and management of acute cardiac illnesses found in the critically ill. The clinical application of electrocardiography, radiology, echocardiography, and nuclear medicine will be discussed as it applies to investigation and management of the cardiovascular system in these patients.     

围手术期血液流变学的影响因素

血液流变学是一个新兴的边缘学科,是研究血液在不同生理、病理及力学状态下的流动性、凝固性、血细胞的变形性、聚集性和粘附性以及它们间的相互关系,血流与血管壁之间的作用以及这种变化的物质基础。围手术期血液流变学的改变与外科病人术中及术后许多并发症的发生关系密切,其重要性得到了医疗界的公认。该文旨在对围手术期影响血液流变学的众多因素做一综述。     

心脏介入术后血管迷走神经反射的护理

探讨心脏介入术后血管迷走神经反射的预防护理。回顾性分析了500例心脏介入术后并发7例血管迷走神经反射。此反射好发于术后沙袋压迫穿刺点止血及拔除动静脉鞘管过程中。年老体弱、精神紧张、术前禁食时间长、术后补液量少为其主要诱发因素。此反射发生迅速、进展快、危险大,须针对发病特点、诱发因素,积极采取有效的预防护理措施。     

Self-paced exercise program for office workers: impact on productivity and health outcomes.

The impact of a self-paced exercise program on productivity and health outcomes of 32 adult workers in a large federal office complex was investigated during 3 months. Walking was the sole form of exercise. The first month, during which no walking occurred, was the control period. The second and third months were the experimental period. Participants were divided into three levels based on initial weight and self-determined walking distance goals. Productivity (using the Endicott Work Productivity Scale), walking distance (using a pedometer), and health outcomes (blood pressure, weight, pulse rate, and body fat percentage) were measured weekly. Results from this study, based on a paired t test analysis, suggest that although the self-paced exercise program had no impact on productivity, it lowered blood pressure and promoted weight loss. Further study using a larger sample and a controlled experimental design is recommended to provide conclusive evidence.     

桂西壮族健康成年人血液流变特性的调查研究及参考值的建立

目的分别测定桂西壮族不同年龄组1312名健康成年人（其中男性675名,女性637名）的血液流变学指标,初步分析桂西壮族健康成年人血液流变学特性,建立桂西健康成年人各年龄组的血液流变学正常参范围。方法用R80血液流变仪检测桂西壮族健康成年人1312例的血液流变学各项指标并统计,并与与仪器所提供的参考值作比较。结果不同年龄组间多项血液流变指标有显著性差异（P〈0．05）,同年龄不同性别之间全血粘度（30s^-1,5s^-1,1s^-1）等多项血液流变指标亦有显著差异（P〈0．05）,多项指标参考范围与仪器随带的正常参考范围有较大差异。结论分别统计不同区域、不同年龄、不同性别的参考值更能确切反应血液流变学指标的变化,对疾病的早期预防、诊断、治疗和预后更有参考价值。     

Prognostic factors in resistant hypertension: implications for cardiovascular risk stratification and therapeutic management

Resistant hypertension (RH) is defined as uncontrolled office blood pressure (BP) in spite of the use of at least three antihypertensive medications. Although its condition has a high prevalence, it is still understudied, and its prognosis is not well established. Some prospective studies evaluated the prognostic value of ambulatory BP monitoring, ECG and renal parameters. They pointed out that ambulatory BPs are important predictors of cardiovascular morbidity and mortality, whereas office BP has no prognostic value. The diagnosis of true RH and the nondipping pattern are also valuable predictors of cardiovascular outcomes. Moreover, several ECG (prolonged ventricular repolarization, serial changes in the strain pattern and left ventricular hypertrophy) and renal parameters (albuminuria and reduced glomerular filtration rate) are also powerful cardiovascular risk markers in RH. These markers and others yet unexplored, such as arterial stiffness and serum biomarkers, may improve cardiovascular risk stratification in these very high-risk patients.     

Prognostic factors in resistant hypertension: implications for cardiovascular risk stratification and therapeutic management

Resistant hypertension (RH) is defined as uncontrolled office blood pressure (BP) in spite of the use of at least three antihypertensive medications. Although its condition has a high prevalence, it is still understudied, and its prognosis is not well established. Some prospective studies evaluated the prognostic value of ambulatory BP monitoring, ECG and renal parameters. They pointed out that ambulatory BPs are important predictors of cardiovascular morbidity and mortality, whereas office BP has no prognostic value. The diagnosis of true RH and the nondipping pattern are also valuable predictors of cardiovascular outcomes. Moreover, several ECG (prolonged ventricular repolarization, serial changes in the strain pattern and left ventricular hypertrophy) and renal parameters (albuminuria and reduced glomerular filtration rate) are also powerful cardiovascular risk markers in RH. These markers and others yet unexplored, such as arterial stiffness and serum biomarkers, may improve cardiovascular risk stratification in these very high-risk patients.