Severe hepatitis caused by cyproterone acetate.

A case of severe acute hepatitis caused by cyproterone acetate in a 71 year old man with prostatic carcinoma is reported with a review of the literature on hepatic reactions to this drug. The association between the use of cyproterone acetate and liver abnormalities is poorly documented. This is the fourth published report of adverse hepatic reaction to cyproterone acetate and it substantiates other evidence that cyproterone acetate is potentially hepatotoxic. Monitoring of liver function tests should be mandatory in patients receiving high doses of cyproterone acetate; the drug should be withdrawn immediately if abnormal liver function tests are found.     

Hepatotoxicity induced by cyproterone acetate： A report of three cases

INTRODUCTION Androgen deprivation therapy in the form of either orchiectomy or treatment with endogenous estrogens or luteinizing hormone releasing hormone (LHRH) analogues alone or coupled with antiandrogens, produces regression of prostate cancer cells …     

Acute hepatitis induced by cyclofenil: a case report.

The case of a 47-year old woman suffering from acute hepatitis caused by cyclofenil, a drug proposed for the treatment of anovulation and scleroderma, is presented. Hepatitis developed seven weeks after the beginning of administration of the drug and its course was reversible after withdrawal. The case is documented on the basis of liver histology and the exclusion of other causes of acute hepatitis.     

Alverine induced toxic hepatitis: a case report.

Drug-induced hepatotoxicity is an important cause of hepatocellular injury. Hepatic necrosis may range from asymptomatic elevations in transaminases to fulminant hepatic failure and death. Alverine is an antispasmodic drug which is especially used in patients with irritable bowel syndrome. Only a few cases of alverine associated hepatotoxicity have been reported previously. We present the case of a patient with alverine induced hepatotoxicity and cholestasis, which has only seldomly been reported in the literature.     

炔雌醇环丙孕酮致布加综合征1例

布加综合征是下腔静脉肝段和(或)肝静脉阻塞或狭窄导致门静脉及下腔静脉高压所引起的一系列临床症状群,常见于凝血机制不良、妊娠、口服避孕药、感染、外伤和肿瘤等.     

Severe acute cholangitis after endoscopic sphincterotomy induced by barium examination: A case report

Endoscopic sphincterotomy (EST) is considered as a possible etiological factor for severe cholangitis. We herein report a case of severe cholangitis after endoscopic sphincterotomy induced by barium examination. An adult male patient presented with epigastric pain was diagnosed as having choledocholithiasis by ultrasonography. EST was performed and the stone was completely cleaned. Barium examination was done 3 d after EST and severe cholangitis appeared 4 h later. The patient was recovered after treated with tienam for 4 d. Barium examination may induce severe cholangitis in patients after EST, although rare, barium examination should be chosen cautiously. Cautions should be also used when EST is performed in patients younger than 50 years to avoid the damage to the sphincter of Oddi.     

糖皮质激素治疗脓疱型银屑病引起重度脂肪肝1例报告

正1病例资料患者女性,47岁,2000年5月始因全身出现散在红斑伴脱屑、瘙痒,就诊于本院,诊断为银屑病,给予相关治疗后,病情好转。此后皮损时有复发,多于"感冒"后加重。2014年1月始患者全身红斑面积增大,脱屑增多,随后在红斑基础上出现密集针尖大小脓疱,就诊于当地医院,予以相关检查(肝功能、血糖、血脂、肝胆脾彩超未见明显异常),诊断为"脓疱型银屑病"。给予地塞米松10 mg/d静点,后因病情加重,地塞米松增     

Severe hypophosphataemia induced by glucose-insulin-potassium therapy. A case report and proposal for altered protocol

A case is described where severe hypophosphataemia was induced by a widely used protocol for glucose-insulin-potassium (GIK) infusion. Hypophosphataemia was found to be a universal sequel to the use of this infusion. A new regimen for administering this agent was designed, and shown to lack the potentially serious side effect of phosphate depletion.     

Carbamazepine-induced hepatitis. A case report

A 59 years old man jaundice, haemathologic disturbances and Splenomegaly, with epilepsy treated by Carbamazepine in the last 3 weeks is reported. He had a positive response to withdrawal carbamazepine and corticotherapy.     

吡喹酮治疗急性血吸虫病引起严重不良反应1例

张某,男,13岁,学生,居住血吸虫病流行区。2006年7月1日游泳接触疫水约3h,随后出现皮疹骚痒等症状,8月17日患儿在家自服南京制药厂生产的吡喹酮0．2g×2片,0．5h后出现胸闷、心慌、呼吸困难,当地医生给予地塞米松、葡萄糖酸钙、非那根等药物,症状好转。8月18日因发热、腹胀、脓血便、食欲减退,全身乏力等症状来本站诊治。[第一段]     

The role of corticosteroids in the treatment of cerebral schistosomiasis caused by Schistosoma mansoni: case report and discussion.

A 26-year-old Brazilian man was admitted to The Toronto Hospital with a headache and visual scintillation. His last travel to Brazil was five years previously. A computed tomography (CT) scan of the head showed an occipital mass with surrounding vasogenic edema. Occipital brain biopsy revealed Schistosoma mansoni eggs. The patient was treated with two doses of praziquantel (20 mg/kg) and dexamethasone (10 mg). His symptoms and occipital mass resolved. Cerebral schistosomiasis is, in part, caused by the host's inflammatory response to Schistosoma. Modes of treatment have included surgical resection, the antiparasitic drugs oxamniquine or praziquantel, and corticosteroids. Corticosteroids may diminish granulomatous inflammation, thereby preventing further tissue destruction, and there is evidence that they also reduce ova deposition. Our review of the literature supports prompt medical therapy in patients with cerebral schistosomiasis. While the minimally or asymptomatic individual may be treated with praziquantel alone, clinicians should consider adjunctive therapy with corticosteroids for patients with prominent neurologic signs or symptoms or mass lesions with evidence of surrounding edema on a CT scan or by magnetic resonance imaging.     

Severe laryngeal edema caused by Pseudoterranova species: A case report

Rationale:Severe laryngeal edema can cause upper airway obstruction, which is fatal. Pseudoterranova, an uncommon nematode of the family Anisakidae, predominantly invades the stomach after ingestion of the nematodes in raw or undercooked marine fish. There have been a few reports of development of severe laryngeal edema caused by the nematode invading the base of the tongue.Patient concerns:A 69-year-old Japanese woman complained of stuffy and scratchy throat for 8 hours and reported eating sashimi, fresh slices of raw jacopever, 4 days before the first visit.Diagnosis:Endoscopy revealed a white-yellowish wriggling worm at the left side of the base of the tongue and severe edema of the larynx.Interventions:The worm was extracted using endoscopic forceps. The patient was hospitalized and treated with intravenous injection of an antibiotic and steroid.Outcomes:The symptoms and laryngeal edema disappeared the next day. The worm was identified as a 4th-stage larva of Pseudoterranova spp based on morphologic features. The serum Anisakis-specific IgE antibody level was high, at 38.6 UA/mL.Lessons:Clinicians should be aware of the possibility of severe laryngeal edema due to invasion by anisakid nematodes in the pharyngolaryngeal area in cases involving previous ingestion of raw or uncooked marine fish.     

Acute cholestatic hepatitis induced by bupropion prescribed as pharmacological support to stop smoking. A case report

We report the first case of acute cholestatic hepatitis induced by bupropion. This antidepressant was taken by a 49-year-old female as adjuvant treatment to stop smoking. After 20 days of bupropion, the patient presented a symptomatology characterized by asthenia, nausea and scleral icterus and biochemical analyses showed a dramatic increase in direct bilirubin (up to 28 mg/dl) and transaminases (up to 68-fold normal limits). Antinuclear antibodies were positive (title = 1:80; speckled pattern). Biochemical analyses and antinuclear antibodies were normal two years earlier. The histology showed a pattern of acute hepatitis with involvement of bile ducts and with features of centrolobular cholestasis. Treatment with methylprednisolone was commenced and continued for 20 days. Liver enzymes and bilirubin returned to normal within two months of withdrawal of bupropion and remained normal during the 4-month follow-up. Antinuclear antibodies also became negative. Other causes of liver damage were excluded. Considering the clinical diagnostic scale for hepatotoxic adverse drug reaction, our patient showed a score compatible with the final diagnosis of bupropion-related cholestatic hepatitis.